Dna Damage REsponse: Actionabilities, Maps and Mechanisms

PnB Designer: a web application to design prime and base editor guide RNAs for animals and plants

Author(s): Siegner SM, Karasu ME, Schröder MS, Kontarakis Z, Corn JE
Published in: BMC Bioinformatics, Issue Mar 2;22(1):101, 2021, ISSN 1471-2105
Publisher: BioMed Central
DOI: 10.1186/s12859-021-04034-6

Recursive Editing improves homology-directed repair through retargeting of undesired outcomes

Author(s): Möller, Lukas; Aird, Eric Jackson; id_orcid0000-0002-4873-042X; Schröder, Markus; id_orcid0000-0001-5942-1254; Kobel, Lena; id_orcid0000-0001-7949-141X; Kissling, Lucas; van de Venn, Lilly; Corn, Jacob; id_orcid0000-0002-7798-5309
Published in: Nature Communications, 13 (1), Issue 3, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-31944-7

Decitabine cytotoxicity is promoted by dCMP deaminase DCTD and mitigated by SUMO-dependent E3 ligase TOPORS

Author(s): Christopher J Carnie, Maximilian J Götz, Chloe S Palma-Chaundler, Pedro Weickert, Amy Wanders, Almudena Serrano-Benitez, Hao-Yi Li, Vipul Gupta, Samah W Awwad, Christian J Blum, Matylda Sczaniecka-Clift, Jacqueline Cordes, Guido Zagnoli-Vieira, Giuseppina D’Alessandro, Sean L Richards, Nadia Gueorguieva, Simon Lam, Petra Beli, Julian Stingele, Stephen P Jackson
Published in: The EMBO Journal, Issue 43, 2024, Page(s) 2397-2423, ISSN 1460-2075
Publisher: European Molecular Biology Organization, Nature Portfolio
DOI: 10.1038/s44318-024-00108-2

RAD54L2 counters TOP2-DNA adducts to promote genome stability.

Author(s): D'Alessandro G, Morales-Juarez DA, Richards SL, Nitiss KC, Serrano-Benitez A, Wang J, Thomas JC, Gupta V, Voigt A, Belotserkovskaya R, Goh CG, Bowden AR, Galanty Y, Beli P, Nitiss JL, Zagnoli-Vieira G, Jackson SP.
Published in: Science advances, Issue eadl2108, 2023, Page(s) 9 (49), ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.adl2108

Clickable Cisplatin Derivatives as Versatile Tools to Probe the DNA Damage Response to Chemotherapy

Author(s): Moretton A, Slyskova J, Simaan ME, Arasa-Verge EA, Meyenberg M, Cerrón-Infantes DA, Unterlass MM, Loizou JI
Published in: Frontiers in Oncology, 2022, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.874201

Tissue specificity of DNA repair: the CRISPR compass

Author(s): Joana Ferreira da Silva, Mathilde Meyenberg, Joanna I. Loizou
Published in: Trends in Genetics, Issue 37/11, 2021, Page(s) 958-962, ISSN 0168-9525
Publisher: Elsevier BV
DOI: 10.1016/j.tig.2021.07.010

POLθ processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells

Author(s): Schrempf A, Bernardo S, Arasa-Verge EA, Ramirez Otero MA, Wilson J, Kirchofer D, Timelthaler G, Ambros AM, Kaya A, Wieder M, Ecker GF, Winter GE, Costanzo V, Loizou JI
Published in: Cell Reports, Issue 41(9), 2022, Page(s) 111716, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2022.111716

Exploring the genetic space of the <scp>DNA</scp> damage response for cancer therapy through <scp>CRISPR</scp>‐based screens

Author(s): Jordan Wilson; Joanna I. Loizou
Published in: Molecular Oncology, Issue 16(21), 2022, Page(s) 3778-3791, ISSN 1878-0261
Publisher: Elsevier
DOI: 10.1002/1878-0261.13272

Prime editing efficiency and fidelity are enhanced in the absence of mismatch repair

Author(s): J. Ferreira da Silva; G. P. Oliveira; E. A. Arasa-Verge; C. Kagiou; A. Moretton; G. Timelthaler; J. Jiricny; J. I. Loizou
Published in: Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022), Issue 2, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.3929/ethz-b-000533332

Clinical prospects of WRN inhibition as a treatment for MSI tumours.

Author(s): Morales-Juarez, D.A., Jackson, S.P.
Published in: npj Precision Oncology, Issue 6, 2022, Page(s) 85, ISSN 2397-768X
Publisher: Springer Nature
DOI: 10.1038/s41698-022-00319-y

Nurturing a revolution in DNA repair and cancer therapy through CRISPR–Cas screens

Author(s): Samah W. Awwad, Almudena Serrano-Benitez, John C. Thomas, Vipul Gupta, Stephen P. Jackson
Published in: Nature Reviews Molecular Cell Biology, Issue Published: 13 February 2023, 2023, ISSN 1471-0072
Publisher: Nature Publishing Group
DOI: 10.1038/s41580-022-00571-x

Tissue Specific DNA Repair Outcomes Shape the Landscape of Genome Editing

Author(s): Mathilde Meyenberg, Joana Ferreira da Silva, Joanna I. Loizou
Published in: Frontiers in Genetics, Issue 12, 2021, Page(s) 728520, ISSN 1664-8021
Publisher: Frontiers Media
DOI: 10.3389/fgene.2021.728520

Unrepaired base excision repair intermediates in template <scp>DNA</scp> strands trigger replication fork collapse and <scp>PARP</scp> inhibitor sensitivity

Author(s): Serrano-Benitez, Almudena; Wells, Sophie E; Drummond-Clarke, Lylah; Russo, Lilian C; Thomas, John Christopher; Leal, Giovanna A; Farrow, Mark; Edgerton, James Michael; Balasubramanian, Shankar; Yang, Ming; Frezza, Christian; Gautam, Amit; Brazina, Jan; Burdova, Kamila; Hoch, Nicolas C; Jackson, Stephen P; Caldecott, Keith W
Published in: EMBO Journal, Issue 42 (18), 2023, Page(s) e113190, ISSN 1460-2075
Publisher: European Molecular Biology Organization, Nature Portfolio
DOI: 10.15252/embj.2022113190

Targeting the DNA Repair Enzyme Polymerase θ in Cancer Therapy

Author(s): Anna Schrempf, Jana Slyskova, Joanna I. Loizou
Published in: Trends in Cancer, Issue VOLUME 7, ISSUE 2, FEBRUARY 01, 2021, 2020, Page(s) 98-111, ISSN 2405-8033
Publisher: ELSEVIER BV
DOI: 10.1016/j.trecan.2020.09.007

Decomposing the mutational landscape of cancer genomes with RepairSig

Author(s): SaraBernardo, Mathilde Meyenberg, Joanna I.Loizou
Published in: Cell Systems, Issue Volume 12, Issue 10, 20 October 2021, 2021, Page(s) 953-955, ISSN 2405-4720
Publisher: Cell Press
DOI: 10.1016/j.cels.2021.09.009

TREX1 restricts CRISPR-Cas9 genome editing in human cells

Author(s): Mehmet E. Karasu; Eléonore Toufektchan; John Maciejowski; Jacob E. Corn
Published in: Crossref, Issue 3, 2022
Publisher: Biorxiv
DOI: 10.1101/2022.12.12.520063

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