Dna Damage REsponse: Actionabilities, Maps and Mechanisms

Project Information

DDREAMM

Grant agreement ID: 855741

DOI

10.3030/855741

EC signature date 16 December 2019

Start date 1 March 2020

End date 31 July 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 8 865 965,00

EU contribution

€ 8 865 965,00

Coordinated by

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (17)

Removal of TREX1 activity enhances CRISPR–Cas9-mediated homologous recombination

Author(s): Mehmet E. Karasu, Eléonore Toufektchan, Yanyang Chen, Alessandra Albertelli, Grégoire Cullot, John Maciejowski, Jacob E. Corn
Published in: Nature Biotechnology, 2024, ISSN 1087-0156
Publisher: Nature Publishing Group
DOI: 10.1038/s41587-024-02356-3

Transcription-coupled repair of DNA-protein cross-links depends on CSA and CSB

Author(s): Christopher J Carnie, Aleida C Acampora, Aldo S Bader, Chimeg Erdenebat, Shubo Zhao, Elnatan Bitensky, Diana van den Heuvel, Avital Parnas, Vipul Gupta, Giuseppina D'Alessandro, Matylda Sczaniecka-Clift, Pedro Weickart, Fatih Aygenli, Maximilian J Gotz, Jacqueline Cordes, Isabel Esain-Garcia, Larry Melidis, Annelotte P Wondergem, Simon Lam, Maria S Robles, Shankar Balasubramanian, Sheera Adar, Mar
Published in: Nature Cell Biology, Issue 26, 2024, Page(s) 797–810, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-024-01391-1

PnB Designer: a web application to design prime and base editor guide RNAs for animals and plants

Author(s): Siegner SM, Karasu ME, Schröder MS, Kontarakis Z, Corn JE
Published in: BMC Bioinformatics, Issue Mar 2;22(1):101, 2021, ISSN 1471-2105
Publisher: BioMed Central
DOI: 10.1186/s12859-021-04034-6

CCAR1 promotes DNA repair via alternative splicing

Author(s): Mehmet E. Karasu, Leonard Jahnke, Brian J. Joseph, Yerkezhan Amerzhanova, Aleksei Mironov, Xuan Shu, Markus S. Schröder, Ana Gvozdenovic, Irene Sala, Mihaela Zavolan, Stefanie Jonas, Jacob E. Corn
Published in: Molecular Cell, Issue 84, 2024, Page(s) 2634-2647.e9, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2024.06.011

Recursive Editing improves homology-directed repair through retargeting of undesired outcomes

Author(s): Möller, Lukas; Aird, Eric Jackson; id_orcid0000-0002-4873-042X; Schröder, Markus; id_orcid0000-0001-5942-1254; Kobel, Lena; id_orcid0000-0001-7949-141X; Kissling, Lucas; van de Venn, Lilly; Corn, Jacob; id_orcid0000-0002-7798-5309
Published in: Nature Communications, 13 (1), Issue 3, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-31944-7

Decitabine cytotoxicity is promoted by dCMP deaminase DCTD and mitigated by SUMO-dependent E3 ligase TOPORS

Author(s): Christopher J Carnie, Maximilian J Götz, Chloe S Palma-Chaundler, Pedro Weickert, Amy Wanders, Almudena Serrano-Benitez, Hao-Yi Li, Vipul Gupta, Samah W Awwad, Christian J Blum, Matylda Sczaniecka-Clift, Jacqueline Cordes, Guido Zagnoli-Vieira, Giuseppina D’Alessandro, Sean L Richards, Nadia Gueorguieva, Simon Lam, Petra Beli, Julian Stingele, Stephen P Jackson
Published in: The EMBO Journal, Issue 43, 2024, Page(s) 2397-2423, ISSN 1460-2075
Publisher: European Molecular Biology Organization, Nature Portfolio
DOI: 10.1038/s44318-024-00108-2

RAD54L2 counters TOP2-DNA adducts to promote genome stability.

Author(s): D'Alessandro G, Morales-Juarez DA, Richards SL, Nitiss KC, Serrano-Benitez A, Wang J, Thomas JC, Gupta V, Voigt A, Belotserkovskaya R, Goh CG, Bowden AR, Galanty Y, Beli P, Nitiss JL, Zagnoli-Vieira G, Jackson SP.
Published in: Science advances, Issue eadl2108, 2023, Page(s) 9 (49), ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.adl2108

Clickable Cisplatin Derivatives as Versatile Tools to Probe the DNA Damage Response to Chemotherapy

Author(s): Moretton A, Slyskova J, Simaan ME, Arasa-Verge EA, Meyenberg M, Cerrón-Infantes DA, Unterlass MM, Loizou JI
Published in: Frontiers in Oncology, 2022, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.874201

Tissue specificity of DNA repair: the CRISPR compass

Author(s): Joana Ferreira da Silva, Mathilde Meyenberg, Joanna I. Loizou
Published in: Trends in Genetics, Issue 37/11, 2021, Page(s) 958-962, ISSN 0168-9525
Publisher: Elsevier BV
DOI: 10.1016/j.tig.2021.07.010

POLθ processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells

Author(s): Schrempf A, Bernardo S, Arasa-Verge EA, Ramirez Otero MA, Wilson J, Kirchofer D, Timelthaler G, Ambros AM, Kaya A, Wieder M, Ecker GF, Winter GE, Costanzo V, Loizou JI
Published in: Cell Reports, Issue 41(9), 2022, Page(s) 111716, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2022.111716

Exploring the genetic space of the <scp>DNA</scp> damage response for cancer therapy through <scp>CRISPR</scp>‐based screens

Author(s): Jordan Wilson; Joanna I. Loizou
Published in: Molecular Oncology, Issue 16(21), 2022, Page(s) 3778-3791, ISSN 1878-0261
Publisher: Elsevier
DOI: 10.1002/1878-0261.13272

Prime editing efficiency and fidelity are enhanced in the absence of mismatch repair

Author(s): J. Ferreira da Silva; G. P. Oliveira; E. A. Arasa-Verge; C. Kagiou; A. Moretton; G. Timelthaler; J. Jiricny; J. I. Loizou
Published in: Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022), Issue 2, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.3929/ethz-b-000533332

Clinical prospects of WRN inhibition as a treatment for MSI tumours.

Author(s): Morales-Juarez, D.A., Jackson, S.P.
Published in: npj Precision Oncology, Issue 6, 2022, Page(s) 85, ISSN 2397-768X
Publisher: Springer Nature
DOI: 10.1038/s41698-022-00319-y

Nurturing a revolution in DNA repair and cancer therapy through CRISPR–Cas screens

Author(s): Samah W. Awwad, Almudena Serrano-Benitez, John C. Thomas, Vipul Gupta, Stephen P. Jackson
Published in: Nature Reviews Molecular Cell Biology, Issue Published: 13 February 2023, 2023, ISSN 1471-0072
Publisher: Nature Publishing Group
DOI: 10.1038/s41580-022-00571-x

Tissue Specific DNA Repair Outcomes Shape the Landscape of Genome Editing

Author(s): Mathilde Meyenberg, Joana Ferreira da Silva, Joanna I. Loizou
Published in: Frontiers in Genetics, Issue 12, 2021, Page(s) 728520, ISSN 1664-8021
Publisher: Frontiers Media
DOI: 10.3389/fgene.2021.728520

Unrepaired base excision repair intermediates in template <scp>DNA</scp> strands trigger replication fork collapse and <scp>PARP</scp> inhibitor sensitivity

Author(s): Serrano-Benitez, Almudena; Wells, Sophie E; Drummond-Clarke, Lylah; Russo, Lilian C; Thomas, John Christopher; Leal, Giovanna A; Farrow, Mark; Edgerton, James Michael; Balasubramanian, Shankar; Yang, Ming; Frezza, Christian; Gautam, Amit; Brazina, Jan; Burdova, Kamila; Hoch, Nicolas C; Jackson, Stephen P; Caldecott, Keith W
Published in: EMBO Journal, Issue 42 (18), 2023, Page(s) e113190, ISSN 1460-2075
Publisher: European Molecular Biology Organization, Nature Portfolio
DOI: 10.15252/embj.2022113190

Targeting the DNA Repair Enzyme Polymerase θ in Cancer Therapy

Author(s): Anna Schrempf, Jana Slyskova, Joanna I. Loizou
Published in: Trends in Cancer, Issue VOLUME 7, ISSUE 2, FEBRUARY 01, 2021, 2020, Page(s) 98-111, ISSN 2405-8033
Publisher: ELSEVIER BV
DOI: 10.1016/j.trecan.2020.09.007

Non-peer reviewed articles (1)

Decomposing the mutational landscape of cancer genomes with RepairSig

Author(s): SaraBernardo, Mathilde Meyenberg, Joanna I.Loizou
Published in: Cell Systems, Issue Volume 12, Issue 10, 20 October 2021, 2021, Page(s) 953-955, ISSN 2405-4720
Publisher: Cell Press
DOI: 10.1016/j.cels.2021.09.009

Other (5)

USP37 prevents premature disassembly of stressed replisomes by TRAIP

Author(s): Olga V Kochenova, Giuseppina D'Alessandro, Domenic Pilger, Ernst Schmid, Sean L Richards, Marcos Rios Garcia, Satpal S Jhujh, Andrea Voigt, Vipul Gupta, Christopher J Carnie, R Alex Wu, Nadia Gueorguieva, Grant S Stewart, Johannes C Walter, Stephen P Jackson
Published in: BioRXiv, 2024, ISSN 2692-8205
Publisher: BioRXiv
DOI: 10.1101/2024.09.03.611025

Comprehensive Interrogation of Synthetic Relationships in the Human DNA Damage Response

Author(s): John Fielden, Sebastian M Siegner, Danielle N Gallagher, Markus S Schröder, Maria Rosaria Dello Stritto, Simon Lam, Lena Kobel, Moritz F Schlapansky, Stephen P. Jackson, Petr Cejka, Marco Jost, Jacob E Corn
Published in: 2023
Publisher: bioRxiv
DOI: 10.1101/2023.08.18.553865

Genome-aware annotation of CRISPR guides validates targets in variant cell lines and enhances discovery in screens

Author(s): Simon Lam, John C. Thomas, Stephen P. Jackson
Published in: bioRxiv, 2024, ISSN 2692-8205
Publisher: bioRXiv
DOI: 10.1101/2024.01.14.575203

SP110 sequestration of SP100 protects against toxic filaments during innate immune signaling

Author(s): Eric J. Aird, Julius Rabl, Tabea Knuesel, Lynn Scherpe, Daniel Boehringer, Jacob E. Corn
Published in: 2024
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.04.03.587867

TREX1 restricts CRISPR-Cas9 genome editing in human cells

Author(s): Mehmet E. Karasu; Eléonore Toufektchan; John Maciejowski; Jacob E. Corn
Published in: Crossref, Issue 3, 2022
Publisher: Biorxiv
DOI: 10.1101/2022.12.12.520063