Dna Damage REsponse: Actionabilities, Maps and Mechanisms

Información del proyecto

DDREAMM

Identificador del acuerdo de subvención: 855741

DOI

10.3030/855741

Fecha de la firma de la CE 16 Diciembre 2019

Fecha de inicio 1 Marzo 2020

Fecha de finalización 31 Julio 2026

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 8 865 965,00

Aportación de la UE

€ 8 865 965,00

Coordinado por

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (24)

Removal of TREX1 activity enhances CRISPR–Cas9-mediated homologous recombination

Autores: Mehmet E. Karasu, Eléonore Toufektchan, Yanyang Chen, Alessandra Albertelli, Grégoire Cullot, John Maciejowski, Jacob E. Corn
Publicado en: Nature Biotechnology, 2024, ISSN 1087-0156
Editor: Nature Publishing Group
DOI: 10.1038/s41587-024-02356-3

Transcription-coupled repair of DNA-protein cross-links depends on CSA and CSB

Autores: Christopher J Carnie, Aleida C Acampora, Aldo S Bader, Chimeg Erdenebat, Shubo Zhao, Elnatan Bitensky, Diana van den Heuvel, Avital Parnas, Vipul Gupta, Giuseppina D'Alessandro, Matylda Sczaniecka-Clift, Pedro Weickart, Fatih Aygenli, Maximilian J Gotz, Jacqueline Cordes, Isabel Esain-Garcia, Larry Melidis, Annelotte P Wondergem, Simon Lam, Maria S Robles, Shankar Balasubramanian, Sheera Adar, Mar
Publicado en: Nature Cell Biology, Edición 26, 2024, Página(s) 797–810, ISSN 1465-7392
Editor: Nature Publishing Group
DOI: 10.1038/s41556-024-01391-1

RNF25 confers mRNA damage tolerance by curbing activation of the integrated stress response

Autores: Shubo Zhao, Chloe S. Palma-Chaundler, Carla M. Engel, Jacqueline Cordes, Daniel Nixdorf, Michael Y. Luo, Selay Kaya, Aldwin Suryo Rahmanto, Diana van den Heuvel, Timur Mackens-Kiani, Pedro Weickert, Simon Lam, Vipul Gupta, Julia Philippou-Massier, Ivan Bagarić, Jonathan Bohlen, Graeme Hewitt, Martijn S. Luijsterburg, Roland Beckmann, Petra Beli, Danny D. Nedialkova, Christopher J. Carnie, Marion
Publicado en: Molecular Cell, Edición 86, 2026, Página(s) 1275-1292.e12, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2026.02.024

PnB Designer: a web application to design prime and base editor guide RNAs for animals and plants

Autores: Siegner SM, Karasu ME, Schröder MS, Kontarakis Z, Corn JE
Publicado en: BMC Bioinformatics, Edición Mar 2;22(1):101, 2021, ISSN 1471-2105
Editor: BioMed Central
DOI: 10.1186/s12859-021-04034-6

CCAR1 promotes DNA repair via alternative splicing

Autores: Mehmet E. Karasu, Leonard Jahnke, Brian J. Joseph, Yerkezhan Amerzhanova, Aleksei Mironov, Xuan Shu, Markus S. Schröder, Ana Gvozdenovic, Irene Sala, Mihaela Zavolan, Stefanie Jonas, Jacob E. Corn
Publicado en: Molecular Cell, Edición 84, 2024, Página(s) 2634-2647.e9, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2024.06.011

An SP110–SP100 axis is a critical regulator of promyelocytic leukaemia body dynamics and mitotic fidelity

Autores: Eric J. Aird, Julius Rabl, Tabea Knuesel, Kevin Groen, Samah W. Awwad, Boris Korablev, Lynn Scherpe, Waleed Al-Herz, Robin Hupfer, Mike Recher, Stephen P. Jackson, Benjamin G. Hale, Jacob E. Corn
Publicado en: Nature Cell Biology, Edición 28, 2026, Página(s) 684-695, ISSN 1465-7392
Editor: Nature Publishing Group
DOI: 10.1038/s41556-026-01916-w

Recursive Editing improves homology-directed repair through retargeting of undesired outcomes

Autores: Möller, Lukas; Aird, Eric Jackson; id_orcid0000-0002-4873-042X; Schröder, Markus; id_orcid0000-0001-5942-1254; Kobel, Lena; id_orcid0000-0001-7949-141X; Kissling, Lucas; van de Venn, Lilly; Corn, Jacob; id_orcid0000-0002-7798-5309
Publicado en: Nature Communications, 13 (1), Edición 3, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-31944-7

Decitabine cytotoxicity is promoted by dCMP deaminase DCTD and mitigated by SUMO-dependent E3 ligase TOPORS

Autores: Christopher J Carnie, Maximilian J Götz, Chloe S Palma-Chaundler, Pedro Weickert, Amy Wanders, Almudena Serrano-Benitez, Hao-Yi Li, Vipul Gupta, Samah W Awwad, Christian J Blum, Matylda Sczaniecka-Clift, Jacqueline Cordes, Guido Zagnoli-Vieira, Giuseppina D’Alessandro, Sean L Richards, Nadia Gueorguieva, Simon Lam, Petra Beli, Julian Stingele, Stephen P Jackson
Publicado en: The EMBO Journal, Edición 43, 2024, Página(s) 2397-2423, ISSN 1460-2075
Editor: European Molecular Biology Organization, Nature Portfolio
DOI: 10.1038/s44318-024-00108-2

ERCC6L2 ensures repair fidelity for staggered-end DNA double-strand breaks

Autores: Eric J. Aird, Almudena Serrano-Benitez, Sebastian M. Siegner, Elda Cannavo, Rimma Belotserkovskaya, Nadia Gueorguieva, John Fielden, Grégoire Cullot, Sandra Ammann, Aldo S. Bader, Vipul Gupta, Geoffroy Andrieux, Rebecca Raab, Mónica Del Rey González, Toni Cathomen, Petr Cejka, Jacob E. Corn, Stephen P. Jackson
Publicado en: Nature Communications, Edición 17, 2026, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-026-69843-w

Loss of CTLH component MAEA impairs DNA repair and replication and leads to developmental delay

Autores: Søren H Hough, Satpal S Jhujh, Samah W Awwad, Oliver E Lewis, Simon Lam, John C Thomas, Thorsten Mosler, Aldo Bader, Lauren Bartik, Shane McKee, Shivarajan Amudhavalli, Estelle Colin, Nadirah Damseh, Emma Clement, Pilar Cacheiro, Anirban Majumdar, Damian Smedley, Joël Fluss, Rosalinda Giannini, Isabelle Thiffault, Guido Zagnoli Vieira, Rimma Belotserkovskaya, Stephen J Smerdon, Petra Beli, Yaron
Publicado en: EMBO Molecular Medicine, Edición 18, 2026, Página(s) 492-513, ISSN 1757-4684
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s44321-025-00352-x

RAD54L2 counters TOP2-DNA adducts to promote genome stability.

Autores: D'Alessandro G, Morales-Juarez DA, Richards SL, Nitiss KC, Serrano-Benitez A, Wang J, Thomas JC, Gupta V, Voigt A, Belotserkovskaya R, Goh CG, Bowden AR, Galanty Y, Beli P, Nitiss JL, Zagnoli-Vieira G, Jackson SP.
Publicado en: Science advances, Edición eadl2108, 2023, Página(s) 9 (49), ISSN 2375-2548
Editor: American Association for the Advancement of Science
DOI: 10.1126/sciadv.adl2108

USP37 prevents premature disassembly of stressed replisomes by TRAIP

Autores: Olga V. Kochenova, Giuseppina D’Alessandro, Domenic Pilger, Ernst Schmid, Sean L. Richards, Marcos Rios Garcia, Satpal S. Jhujh, Andrea Voigt, Vipul Gupta, Christopher J. Carnie, R. Alex Wu, Nadia Gueorguieva, Simon Lam, Grant S. Stewart, Johannes C. Walter, Stephen P. Jackson
Publicado en: Nature Communications, Edición 16, 2025, Página(s) 5333, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-025-60139-z

Clickable Cisplatin Derivatives as Versatile Tools to Probe the DNA Damage Response to Chemotherapy

Autores: Moretton A, Slyskova J, Simaan ME, Arasa-Verge EA, Meyenberg M, Cerrón-Infantes DA, Unterlass MM, Loizou JI
Publicado en: Frontiers in Oncology, 2022, ISSN 2234-943X
Editor: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.874201

Tissue specificity of DNA repair: the CRISPR compass

Autores: Joana Ferreira da Silva, Mathilde Meyenberg, Joanna I. Loizou
Publicado en: Trends in Genetics, Edición 37/11, 2021, Página(s) 958-962, ISSN 0168-9525
Editor: Elsevier BV
DOI: 10.1016/j.tig.2021.07.010

Genome-aware annotation of CRISPR guides validates targets in variant cell lines and enhances discovery in screens

Autores: Simon Lam, John C. Thomas, Stephen P. Jackson
Publicado en: Genome Medicine, Edición 16, 2024, Página(s) 139, ISSN 1756-994X
Editor: BioMed Central
DOI: 10.1186/s13073-024-01414-4

POLθ processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells

Autores: Schrempf A, Bernardo S, Arasa-Verge EA, Ramirez Otero MA, Wilson J, Kirchofer D, Timelthaler G, Ambros AM, Kaya A, Wieder M, Ecker GF, Winter GE, Costanzo V, Loizou JI
Publicado en: Cell Reports, Edición 41(9), 2022, Página(s) 111716, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2022.111716

Exploring the genetic space of the <scp>DNA</scp> damage response for cancer therapy through <scp>CRISPR</scp>‐based screens

Autores: Jordan Wilson; Joanna I. Loizou
Publicado en: Molecular Oncology, Edición 16(21), 2022, Página(s) 3778-3791, ISSN 1878-0261
Editor: Elsevier
DOI: 10.1002/1878-0261.13272

Prime editing efficiency and fidelity are enhanced in the absence of mismatch repair

Autores: J. Ferreira da Silva; G. P. Oliveira; E. A. Arasa-Verge; C. Kagiou; A. Moretton; G. Timelthaler; J. Jiricny; J. I. Loizou
Publicado en: Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022), Edición 2, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.3929/ethz-b-000533332

Clinical prospects of WRN inhibition as a treatment for MSI tumours.

Autores: Morales-Juarez, D.A., Jackson, S.P.
Publicado en: npj Precision Oncology, Edición 6, 2022, Página(s) 85, ISSN 2397-768X
Editor: Springer Nature
DOI: 10.1038/s41698-022-00319-y

Nurturing a revolution in DNA repair and cancer therapy through CRISPR–Cas screens

Autores: Samah W. Awwad, Almudena Serrano-Benitez, John C. Thomas, Vipul Gupta, Stephen P. Jackson
Publicado en: Nature Reviews Molecular Cell Biology, Edición Published: 13 February 2023, 2023, ISSN 1471-0072
Editor: Nature Publishing Group
DOI: 10.1038/s41580-022-00571-x

Tissue Specific DNA Repair Outcomes Shape the Landscape of Genome Editing

Autores: Mathilde Meyenberg, Joana Ferreira da Silva, Joanna I. Loizou
Publicado en: Frontiers in Genetics, Edición 12, 2021, Página(s) 728520, ISSN 1664-8021
Editor: Frontiers Media
DOI: 10.3389/fgene.2021.728520

WEE1 inhibitors synergise with mRNA translation defects via activation of the kinase GCN2

Autores: Jordan C. J. Wilson, JiaYi Zhu, Vanesa Vinciauskaite, Eloise G. Lloyd, Simon Lam, Alexandra Hart, Chen Gang Goh, Fadia Bou-Dagher, Hlib Razumkov, Lena Kobel, Zacharias Kontarakis, John Fielden, Moritz F. Schlapansky, Joanna I. Loizou, Andreas Villunger, Jacob E. Corn, Giulia Biffi, Glenn R. Masson, Stefan J. Marciniak, Aldo S. Bader, Stephen P. Jackson
Publicado en: Nature Communications, Edición 16, 2025, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-025-64050-5

Unrepaired base excision repair intermediates in template <scp>DNA</scp> strands trigger replication fork collapse and <scp>PARP</scp> inhibitor sensitivity

Autores: Serrano-Benitez, Almudena; Wells, Sophie E; Drummond-Clarke, Lylah; Russo, Lilian C; Thomas, John Christopher; Leal, Giovanna A; Farrow, Mark; Edgerton, James Michael; Balasubramanian, Shankar; Yang, Ming; Frezza, Christian; Gautam, Amit; Brazina, Jan; Burdova, Kamila; Hoch, Nicolas C; Jackson, Stephen P; Caldecott, Keith W
Publicado en: EMBO Journal, Edición 42 (18), 2023, Página(s) e113190, ISSN 1460-2075
Editor: European Molecular Biology Organization, Nature Portfolio
DOI: 10.15252/embj.2022113190

Targeting the DNA Repair Enzyme Polymerase θ in Cancer Therapy

Autores: Anna Schrempf, Jana Slyskova, Joanna I. Loizou
Publicado en: Trends in Cancer, Edición VOLUME 7, ISSUE 2, FEBRUARY 01, 2021, 2020, Página(s) 98-111, ISSN 2405-8033
Editor: ELSEVIER BV
DOI: 10.1016/j.trecan.2020.09.007

Non-peer reviewed articles (1)

Decomposing the mutational landscape of cancer genomes with RepairSig

Autores: SaraBernardo, Mathilde Meyenberg, Joanna I.Loizou
Publicado en: Cell Systems, Edición Volume 12, Edición 10, 20 October 2021, 2021, Página(s) 953-955, ISSN 2405-4720
Editor: Cell Press
DOI: 10.1016/j.cels.2021.09.009

Other (5)

A GCN1-independent activator of the kinase GCN2

Autores: JiaYi Zhu, Giulia Emanuelli, Glenn R Masson, Vanesa Vinciauskaite, Henriette Willems, Andrew Lim, Christopher Alan Brown, David Winpenny, Murray Clarke, Rebecca Gilley, Fergus Preston, Jordan Wilson, Aldo Bader, Taufiq Rahman, Joseph E Chambers, John Skidmore, Nicholas W Morrell, Stefan J Marciniak
Publicado en: bioRxiv, 2026
Editor: openRxiv
DOI: 10.1101/2025.06.29.662197

Comprehensive Interrogation of Synthetic Relationships in the Human DNA Damage Response

Autores: John Fielden, Sebastian M Siegner, Danielle N Gallagher, Markus S Schröder, Maria Rosaria Dello Stritto, Simon Lam, Lena Kobel, Moritz F Schlapansky, Stephen P. Jackson, Petr Cejka, Marco Jost, Jacob E Corn
Publicado en: 2023
Editor: bioRxiv
DOI: 10.1101/2023.08.18.553865

SP110 sequestration of SP100 protects against toxic filaments during innate immune signaling

Autores: Eric J. Aird, Julius Rabl, Tabea Knuesel, Lynn Scherpe, Daniel Boehringer, Jacob E. Corn
Publicado en: 2024
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.04.03.587867

TREX1 restricts CRISPR-Cas9 genome editing in human cells

Autores: Mehmet E. Karasu; Eléonore Toufektchan; John Maciejowski; Jacob E. Corn
Publicado en: Crossref, Edición 3, 2022
Editor: Biorxiv
DOI: 10.1101/2022.12.12.520063

Cell-stereotyped DNA repair outcomes are widespread during genome editing

Autores: Moritz F. Schlapansky, Markus S. Schröder, Antonio J. Santinha, Tanja Rothgangl, Eleonora I. Ioannidi, Grégoire Cullot, Bohdan Lewkow, German Camargo Ortega, Ahmed Nouraiz, Dominic Mailänder, Louisa Selbert, Simon Lam, Aitana Egea, Jiyung J. Shin, Matteo Bordi, Mark DeWitt, Ana Gvozdenovic, Stephen P. Jackson, Timm Schroeder, Helmuth Gehart, Gerald Schwank, Randall J. Platt, Jacob E. Corn
Publicado en: BioRxiv, 2026
Editor: openRxiv
DOI: 10.1101/2025.10.23.684114