Dna Damage REsponse: Actionabilities, Maps and Mechanisms

Información del proyecto

DDREAMM

Identificador del acuerdo de subvención: 855741

DOI

10.3030/855741

Fecha de la firma de la CE 16 Diciembre 2019

Fecha de inicio 1 Marzo 2020

Fecha de finalización 31 Julio 2026

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 8 865 965,00

Aportación de la UE

€ 8 865 965,00

Coordinado por

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (17)

Removal of TREX1 activity enhances CRISPR–Cas9-mediated homologous recombination

Autores: Mehmet E. Karasu, Eléonore Toufektchan, Yanyang Chen, Alessandra Albertelli, Grégoire Cullot, John Maciejowski, Jacob E. Corn
Publicado en: Nature Biotechnology, 2024, ISSN 1087-0156
Editor: Nature Publishing Group
DOI: 10.1038/s41587-024-02356-3

Transcription-coupled repair of DNA-protein cross-links depends on CSA and CSB

Autores: Christopher J Carnie, Aleida C Acampora, Aldo S Bader, Chimeg Erdenebat, Shubo Zhao, Elnatan Bitensky, Diana van den Heuvel, Avital Parnas, Vipul Gupta, Giuseppina D'Alessandro, Matylda Sczaniecka-Clift, Pedro Weickart, Fatih Aygenli, Maximilian J Gotz, Jacqueline Cordes, Isabel Esain-Garcia, Larry Melidis, Annelotte P Wondergem, Simon Lam, Maria S Robles, Shankar Balasubramanian, Sheera Adar, Mar
Publicado en: Nature Cell Biology, Edición 26, 2024, Página(s) 797–810, ISSN 1465-7392
Editor: Nature Publishing Group
DOI: 10.1038/s41556-024-01391-1

PnB Designer: a web application to design prime and base editor guide RNAs for animals and plants

Autores: Siegner SM, Karasu ME, Schröder MS, Kontarakis Z, Corn JE
Publicado en: BMC Bioinformatics, Edición Mar 2;22(1):101, 2021, ISSN 1471-2105
Editor: BioMed Central
DOI: 10.1186/s12859-021-04034-6

CCAR1 promotes DNA repair via alternative splicing

Autores: Mehmet E. Karasu, Leonard Jahnke, Brian J. Joseph, Yerkezhan Amerzhanova, Aleksei Mironov, Xuan Shu, Markus S. Schröder, Ana Gvozdenovic, Irene Sala, Mihaela Zavolan, Stefanie Jonas, Jacob E. Corn
Publicado en: Molecular Cell, Edición 84, 2024, Página(s) 2634-2647.e9, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2024.06.011

Recursive Editing improves homology-directed repair through retargeting of undesired outcomes

Autores: Möller, Lukas; Aird, Eric Jackson; id_orcid0000-0002-4873-042X; Schröder, Markus; id_orcid0000-0001-5942-1254; Kobel, Lena; id_orcid0000-0001-7949-141X; Kissling, Lucas; van de Venn, Lilly; Corn, Jacob; id_orcid0000-0002-7798-5309
Publicado en: Nature Communications, 13 (1), Edición 3, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-31944-7

Decitabine cytotoxicity is promoted by dCMP deaminase DCTD and mitigated by SUMO-dependent E3 ligase TOPORS

Autores: Christopher J Carnie, Maximilian J Götz, Chloe S Palma-Chaundler, Pedro Weickert, Amy Wanders, Almudena Serrano-Benitez, Hao-Yi Li, Vipul Gupta, Samah W Awwad, Christian J Blum, Matylda Sczaniecka-Clift, Jacqueline Cordes, Guido Zagnoli-Vieira, Giuseppina D’Alessandro, Sean L Richards, Nadia Gueorguieva, Simon Lam, Petra Beli, Julian Stingele, Stephen P Jackson
Publicado en: The EMBO Journal, Edición 43, 2024, Página(s) 2397-2423, ISSN 1460-2075
Editor: European Molecular Biology Organization, Nature Portfolio
DOI: 10.1038/s44318-024-00108-2

RAD54L2 counters TOP2-DNA adducts to promote genome stability.

Autores: D'Alessandro G, Morales-Juarez DA, Richards SL, Nitiss KC, Serrano-Benitez A, Wang J, Thomas JC, Gupta V, Voigt A, Belotserkovskaya R, Goh CG, Bowden AR, Galanty Y, Beli P, Nitiss JL, Zagnoli-Vieira G, Jackson SP.
Publicado en: Science advances, Edición eadl2108, 2023, Página(s) 9 (49), ISSN 2375-2548
Editor: American Association for the Advancement of Science
DOI: 10.1126/sciadv.adl2108

Clickable Cisplatin Derivatives as Versatile Tools to Probe the DNA Damage Response to Chemotherapy

Autores: Moretton A, Slyskova J, Simaan ME, Arasa-Verge EA, Meyenberg M, Cerrón-Infantes DA, Unterlass MM, Loizou JI
Publicado en: Frontiers in Oncology, 2022, ISSN 2234-943X
Editor: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.874201

Tissue specificity of DNA repair: the CRISPR compass

Autores: Joana Ferreira da Silva, Mathilde Meyenberg, Joanna I. Loizou
Publicado en: Trends in Genetics, Edición 37/11, 2021, Página(s) 958-962, ISSN 0168-9525
Editor: Elsevier BV
DOI: 10.1016/j.tig.2021.07.010

POLθ processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells

Autores: Schrempf A, Bernardo S, Arasa-Verge EA, Ramirez Otero MA, Wilson J, Kirchofer D, Timelthaler G, Ambros AM, Kaya A, Wieder M, Ecker GF, Winter GE, Costanzo V, Loizou JI
Publicado en: Cell Reports, Edición 41(9), 2022, Página(s) 111716, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2022.111716

Exploring the genetic space of the <scp>DNA</scp> damage response for cancer therapy through <scp>CRISPR</scp>‐based screens

Autores: Jordan Wilson; Joanna I. Loizou
Publicado en: Molecular Oncology, Edición 16(21), 2022, Página(s) 3778-3791, ISSN 1878-0261
Editor: Elsevier
DOI: 10.1002/1878-0261.13272

Prime editing efficiency and fidelity are enhanced in the absence of mismatch repair

Autores: J. Ferreira da Silva; G. P. Oliveira; E. A. Arasa-Verge; C. Kagiou; A. Moretton; G. Timelthaler; J. Jiricny; J. I. Loizou
Publicado en: Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022), Edición 2, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.3929/ethz-b-000533332

Clinical prospects of WRN inhibition as a treatment for MSI tumours.

Autores: Morales-Juarez, D.A., Jackson, S.P.
Publicado en: npj Precision Oncology, Edición 6, 2022, Página(s) 85, ISSN 2397-768X
Editor: Springer Nature
DOI: 10.1038/s41698-022-00319-y

Nurturing a revolution in DNA repair and cancer therapy through CRISPR–Cas screens

Autores: Samah W. Awwad, Almudena Serrano-Benitez, John C. Thomas, Vipul Gupta, Stephen P. Jackson
Publicado en: Nature Reviews Molecular Cell Biology, Edición Published: 13 February 2023, 2023, ISSN 1471-0072
Editor: Nature Publishing Group
DOI: 10.1038/s41580-022-00571-x

Tissue Specific DNA Repair Outcomes Shape the Landscape of Genome Editing

Autores: Mathilde Meyenberg, Joana Ferreira da Silva, Joanna I. Loizou
Publicado en: Frontiers in Genetics, Edición 12, 2021, Página(s) 728520, ISSN 1664-8021
Editor: Frontiers Media
DOI: 10.3389/fgene.2021.728520

Unrepaired base excision repair intermediates in template <scp>DNA</scp> strands trigger replication fork collapse and <scp>PARP</scp> inhibitor sensitivity

Autores: Serrano-Benitez, Almudena; Wells, Sophie E; Drummond-Clarke, Lylah; Russo, Lilian C; Thomas, John Christopher; Leal, Giovanna A; Farrow, Mark; Edgerton, James Michael; Balasubramanian, Shankar; Yang, Ming; Frezza, Christian; Gautam, Amit; Brazina, Jan; Burdova, Kamila; Hoch, Nicolas C; Jackson, Stephen P; Caldecott, Keith W
Publicado en: EMBO Journal, Edición 42 (18), 2023, Página(s) e113190, ISSN 1460-2075
Editor: European Molecular Biology Organization, Nature Portfolio
DOI: 10.15252/embj.2022113190

Targeting the DNA Repair Enzyme Polymerase θ in Cancer Therapy

Autores: Anna Schrempf, Jana Slyskova, Joanna I. Loizou
Publicado en: Trends in Cancer, Edición VOLUME 7, ISSUE 2, FEBRUARY 01, 2021, 2020, Página(s) 98-111, ISSN 2405-8033
Editor: ELSEVIER BV
DOI: 10.1016/j.trecan.2020.09.007

Non-peer reviewed articles (1)

Decomposing the mutational landscape of cancer genomes with RepairSig

Autores: SaraBernardo, Mathilde Meyenberg, Joanna I.Loizou
Publicado en: Cell Systems, Edición Volume 12, Edición 10, 20 October 2021, 2021, Página(s) 953-955, ISSN 2405-4720
Editor: Cell Press
DOI: 10.1016/j.cels.2021.09.009

Other (5)

USP37 prevents premature disassembly of stressed replisomes by TRAIP

Autores: Olga V Kochenova, Giuseppina D'Alessandro, Domenic Pilger, Ernst Schmid, Sean L Richards, Marcos Rios Garcia, Satpal S Jhujh, Andrea Voigt, Vipul Gupta, Christopher J Carnie, R Alex Wu, Nadia Gueorguieva, Grant S Stewart, Johannes C Walter, Stephen P Jackson
Publicado en: BioRXiv, 2024, ISSN 2692-8205
Editor: BioRXiv
DOI: 10.1101/2024.09.03.611025

Comprehensive Interrogation of Synthetic Relationships in the Human DNA Damage Response

Autores: John Fielden, Sebastian M Siegner, Danielle N Gallagher, Markus S Schröder, Maria Rosaria Dello Stritto, Simon Lam, Lena Kobel, Moritz F Schlapansky, Stephen P. Jackson, Petr Cejka, Marco Jost, Jacob E Corn
Publicado en: 2023
Editor: bioRxiv
DOI: 10.1101/2023.08.18.553865

Genome-aware annotation of CRISPR guides validates targets in variant cell lines and enhances discovery in screens

Autores: Simon Lam, John C. Thomas, Stephen P. Jackson
Publicado en: bioRxiv, 2024, ISSN 2692-8205
Editor: bioRXiv
DOI: 10.1101/2024.01.14.575203

SP110 sequestration of SP100 protects against toxic filaments during innate immune signaling

Autores: Eric J. Aird, Julius Rabl, Tabea Knuesel, Lynn Scherpe, Daniel Boehringer, Jacob E. Corn
Publicado en: 2024
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.04.03.587867

TREX1 restricts CRISPR-Cas9 genome editing in human cells

Autores: Mehmet E. Karasu; Eléonore Toufektchan; John Maciejowski; Jacob E. Corn
Publicado en: Crossref, Edición 3, 2022
Editor: Biorxiv
DOI: 10.1101/2022.12.12.520063