Dna Damage REsponse: Actionabilities, Maps and Mechanisms

Informacje na temat projektu

DDREAMM

Identyfikator umowy o grant: 855741

DOI

10.3030/855741

Data podpisania przez KE 16 Grudnia 2019

Data rozpoczęcia 1 Marca 2020

Data zakończenia 31 Lipca 2026

Finansowanie w ramach

• EXCELLENT SCIENCE - European Research Council (ERC)

Koszt całkowity

€ 8 865 965,00

Wkład UE

€ 8 865 965,00

Koordynowany przez

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Publikacje

Peer reviewed articles (24)

Removal of TREX1 activity enhances CRISPR–Cas9-mediated homologous recombination

Autorzy: Mehmet E. Karasu, Eléonore Toufektchan, Yanyang Chen, Alessandra Albertelli, Grégoire Cullot, John Maciejowski, Jacob E. Corn
Opublikowane w: Nature Biotechnology, 2024, ISSN 1087-0156
Wydawca: Nature Publishing Group
DOI: 10.1038/s41587-024-02356-3

Transcription-coupled repair of DNA-protein cross-links depends on CSA and CSB

Autorzy: Christopher J Carnie, Aleida C Acampora, Aldo S Bader, Chimeg Erdenebat, Shubo Zhao, Elnatan Bitensky, Diana van den Heuvel, Avital Parnas, Vipul Gupta, Giuseppina D'Alessandro, Matylda Sczaniecka-Clift, Pedro Weickart, Fatih Aygenli, Maximilian J Gotz, Jacqueline Cordes, Isabel Esain-Garcia, Larry Melidis, Annelotte P Wondergem, Simon Lam, Maria S Robles, Shankar Balasubramanian, Sheera Adar, Mar
Opublikowane w: Nature Cell Biology, Numer 26, 2024, Strona(/y) 797–810, ISSN 1465-7392
Wydawca: Nature Publishing Group
DOI: 10.1038/s41556-024-01391-1

RNF25 confers mRNA damage tolerance by curbing activation of the integrated stress response

Autorzy: Shubo Zhao, Chloe S. Palma-Chaundler, Carla M. Engel, Jacqueline Cordes, Daniel Nixdorf, Michael Y. Luo, Selay Kaya, Aldwin Suryo Rahmanto, Diana van den Heuvel, Timur Mackens-Kiani, Pedro Weickert, Simon Lam, Vipul Gupta, Julia Philippou-Massier, Ivan Bagarić, Jonathan Bohlen, Graeme Hewitt, Martijn S. Luijsterburg, Roland Beckmann, Petra Beli, Danny D. Nedialkova, Christopher J. Carnie, Marion
Opublikowane w: Molecular Cell, Numer 86, 2026, Strona(/y) 1275-1292.e12, ISSN 1097-2765
Wydawca: Cell Press
DOI: 10.1016/j.molcel.2026.02.024

PnB Designer: a web application to design prime and base editor guide RNAs for animals and plants

Autorzy: Siegner SM, Karasu ME, Schröder MS, Kontarakis Z, Corn JE
Opublikowane w: BMC Bioinformatics, Numer Mar 2;22(1):101, 2021, ISSN 1471-2105
Wydawca: BioMed Central
DOI: 10.1186/s12859-021-04034-6

CCAR1 promotes DNA repair via alternative splicing

Autorzy: Mehmet E. Karasu, Leonard Jahnke, Brian J. Joseph, Yerkezhan Amerzhanova, Aleksei Mironov, Xuan Shu, Markus S. Schröder, Ana Gvozdenovic, Irene Sala, Mihaela Zavolan, Stefanie Jonas, Jacob E. Corn
Opublikowane w: Molecular Cell, Numer 84, 2024, Strona(/y) 2634-2647.e9, ISSN 1097-2765
Wydawca: Cell Press
DOI: 10.1016/j.molcel.2024.06.011

An SP110–SP100 axis is a critical regulator of promyelocytic leukaemia body dynamics and mitotic fidelity

Autorzy: Eric J. Aird, Julius Rabl, Tabea Knuesel, Kevin Groen, Samah W. Awwad, Boris Korablev, Lynn Scherpe, Waleed Al-Herz, Robin Hupfer, Mike Recher, Stephen P. Jackson, Benjamin G. Hale, Jacob E. Corn
Opublikowane w: Nature Cell Biology, Numer 28, 2026, Strona(/y) 684-695, ISSN 1465-7392
Wydawca: Nature Publishing Group
DOI: 10.1038/s41556-026-01916-w

Recursive Editing improves homology-directed repair through retargeting of undesired outcomes

Autorzy: Möller, Lukas; Aird, Eric Jackson; id_orcid0000-0002-4873-042X; Schröder, Markus; id_orcid0000-0001-5942-1254; Kobel, Lena; id_orcid0000-0001-7949-141X; Kissling, Lucas; van de Venn, Lilly; Corn, Jacob; id_orcid0000-0002-7798-5309
Opublikowane w: Nature Communications, 13 (1), Numer 3, 2022, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-022-31944-7

Decitabine cytotoxicity is promoted by dCMP deaminase DCTD and mitigated by SUMO-dependent E3 ligase TOPORS

Autorzy: Christopher J Carnie, Maximilian J Götz, Chloe S Palma-Chaundler, Pedro Weickert, Amy Wanders, Almudena Serrano-Benitez, Hao-Yi Li, Vipul Gupta, Samah W Awwad, Christian J Blum, Matylda Sczaniecka-Clift, Jacqueline Cordes, Guido Zagnoli-Vieira, Giuseppina D’Alessandro, Sean L Richards, Nadia Gueorguieva, Simon Lam, Petra Beli, Julian Stingele, Stephen P Jackson
Opublikowane w: The EMBO Journal, Numer 43, 2024, Strona(/y) 2397-2423, ISSN 1460-2075
Wydawca: European Molecular Biology Organization, Nature Portfolio
DOI: 10.1038/s44318-024-00108-2

ERCC6L2 ensures repair fidelity for staggered-end DNA double-strand breaks

Autorzy: Eric J. Aird, Almudena Serrano-Benitez, Sebastian M. Siegner, Elda Cannavo, Rimma Belotserkovskaya, Nadia Gueorguieva, John Fielden, Grégoire Cullot, Sandra Ammann, Aldo S. Bader, Vipul Gupta, Geoffroy Andrieux, Rebecca Raab, Mónica Del Rey González, Toni Cathomen, Petr Cejka, Jacob E. Corn, Stephen P. Jackson
Opublikowane w: Nature Communications, Numer 17, 2026, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-026-69843-w

Loss of CTLH component MAEA impairs DNA repair and replication and leads to developmental delay

Autorzy: Søren H Hough, Satpal S Jhujh, Samah W Awwad, Oliver E Lewis, Simon Lam, John C Thomas, Thorsten Mosler, Aldo Bader, Lauren Bartik, Shane McKee, Shivarajan Amudhavalli, Estelle Colin, Nadirah Damseh, Emma Clement, Pilar Cacheiro, Anirban Majumdar, Damian Smedley, Joël Fluss, Rosalinda Giannini, Isabelle Thiffault, Guido Zagnoli Vieira, Rimma Belotserkovskaya, Stephen J Smerdon, Petra Beli, Yaron
Opublikowane w: EMBO Molecular Medicine, Numer 18, 2026, Strona(/y) 492-513, ISSN 1757-4684
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s44321-025-00352-x

RAD54L2 counters TOP2-DNA adducts to promote genome stability.

Autorzy: D'Alessandro G, Morales-Juarez DA, Richards SL, Nitiss KC, Serrano-Benitez A, Wang J, Thomas JC, Gupta V, Voigt A, Belotserkovskaya R, Goh CG, Bowden AR, Galanty Y, Beli P, Nitiss JL, Zagnoli-Vieira G, Jackson SP.
Opublikowane w: Science advances, Numer eadl2108, 2023, Strona(/y) 9 (49), ISSN 2375-2548
Wydawca: American Association for the Advancement of Science
DOI: 10.1126/sciadv.adl2108

USP37 prevents premature disassembly of stressed replisomes by TRAIP

Autorzy: Olga V. Kochenova, Giuseppina D’Alessandro, Domenic Pilger, Ernst Schmid, Sean L. Richards, Marcos Rios Garcia, Satpal S. Jhujh, Andrea Voigt, Vipul Gupta, Christopher J. Carnie, R. Alex Wu, Nadia Gueorguieva, Simon Lam, Grant S. Stewart, Johannes C. Walter, Stephen P. Jackson
Opublikowane w: Nature Communications, Numer 16, 2025, Strona(/y) 5333, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-025-60139-z

Clickable Cisplatin Derivatives as Versatile Tools to Probe the DNA Damage Response to Chemotherapy

Autorzy: Moretton A, Slyskova J, Simaan ME, Arasa-Verge EA, Meyenberg M, Cerrón-Infantes DA, Unterlass MM, Loizou JI
Opublikowane w: Frontiers in Oncology, 2022, ISSN 2234-943X
Wydawca: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.874201

Tissue specificity of DNA repair: the CRISPR compass

Autorzy: Joana Ferreira da Silva, Mathilde Meyenberg, Joanna I. Loizou
Opublikowane w: Trends in Genetics, Numer 37/11, 2021, Strona(/y) 958-962, ISSN 0168-9525
Wydawca: Elsevier BV
DOI: 10.1016/j.tig.2021.07.010

Genome-aware annotation of CRISPR guides validates targets in variant cell lines and enhances discovery in screens

Autorzy: Simon Lam, John C. Thomas, Stephen P. Jackson
Opublikowane w: Genome Medicine, Numer 16, 2024, Strona(/y) 139, ISSN 1756-994X
Wydawca: BioMed Central
DOI: 10.1186/s13073-024-01414-4

POLθ processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells

Autorzy: Schrempf A, Bernardo S, Arasa-Verge EA, Ramirez Otero MA, Wilson J, Kirchofer D, Timelthaler G, Ambros AM, Kaya A, Wieder M, Ecker GF, Winter GE, Costanzo V, Loizou JI
Opublikowane w: Cell Reports, Numer 41(9), 2022, Strona(/y) 111716, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2022.111716

Exploring the genetic space of the <scp>DNA</scp> damage response for cancer therapy through <scp>CRISPR</scp>‐based screens

Autorzy: Jordan Wilson; Joanna I. Loizou
Opublikowane w: Molecular Oncology, Numer 16(21), 2022, Strona(/y) 3778-3791, ISSN 1878-0261
Wydawca: Elsevier
DOI: 10.1002/1878-0261.13272

Prime editing efficiency and fidelity are enhanced in the absence of mismatch repair

Autorzy: J. Ferreira da Silva; G. P. Oliveira; E. A. Arasa-Verge; C. Kagiou; A. Moretton; G. Timelthaler; J. Jiricny; J. I. Loizou
Opublikowane w: Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022), Numer 2, 2022, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.3929/ethz-b-000533332

Clinical prospects of WRN inhibition as a treatment for MSI tumours.

Autorzy: Morales-Juarez, D.A., Jackson, S.P.
Opublikowane w: npj Precision Oncology, Numer 6, 2022, Strona(/y) 85, ISSN 2397-768X
Wydawca: Springer Nature
DOI: 10.1038/s41698-022-00319-y

Nurturing a revolution in DNA repair and cancer therapy through CRISPR–Cas screens

Autorzy: Samah W. Awwad, Almudena Serrano-Benitez, John C. Thomas, Vipul Gupta, Stephen P. Jackson
Opublikowane w: Nature Reviews Molecular Cell Biology, Numer Published: 13 February 2023, 2023, ISSN 1471-0072
Wydawca: Nature Publishing Group
DOI: 10.1038/s41580-022-00571-x

Tissue Specific DNA Repair Outcomes Shape the Landscape of Genome Editing

Autorzy: Mathilde Meyenberg, Joana Ferreira da Silva, Joanna I. Loizou
Opublikowane w: Frontiers in Genetics, Numer 12, 2021, Strona(/y) 728520, ISSN 1664-8021
Wydawca: Frontiers Media
DOI: 10.3389/fgene.2021.728520

WEE1 inhibitors synergise with mRNA translation defects via activation of the kinase GCN2

Autorzy: Jordan C. J. Wilson, JiaYi Zhu, Vanesa Vinciauskaite, Eloise G. Lloyd, Simon Lam, Alexandra Hart, Chen Gang Goh, Fadia Bou-Dagher, Hlib Razumkov, Lena Kobel, Zacharias Kontarakis, John Fielden, Moritz F. Schlapansky, Joanna I. Loizou, Andreas Villunger, Jacob E. Corn, Giulia Biffi, Glenn R. Masson, Stefan J. Marciniak, Aldo S. Bader, Stephen P. Jackson
Opublikowane w: Nature Communications, Numer 16, 2025, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-025-64050-5

Unrepaired base excision repair intermediates in template <scp>DNA</scp> strands trigger replication fork collapse and <scp>PARP</scp> inhibitor sensitivity

Autorzy: Serrano-Benitez, Almudena; Wells, Sophie E; Drummond-Clarke, Lylah; Russo, Lilian C; Thomas, John Christopher; Leal, Giovanna A; Farrow, Mark; Edgerton, James Michael; Balasubramanian, Shankar; Yang, Ming; Frezza, Christian; Gautam, Amit; Brazina, Jan; Burdova, Kamila; Hoch, Nicolas C; Jackson, Stephen P; Caldecott, Keith W
Opublikowane w: EMBO Journal, Numer 42 (18), 2023, Strona(/y) e113190, ISSN 1460-2075
Wydawca: European Molecular Biology Organization, Nature Portfolio
DOI: 10.15252/embj.2022113190

Targeting the DNA Repair Enzyme Polymerase θ in Cancer Therapy

Autorzy: Anna Schrempf, Jana Slyskova, Joanna I. Loizou
Opublikowane w: Trends in Cancer, Numer VOLUME 7, ISSUE 2, FEBRUARY 01, 2021, 2020, Strona(/y) 98-111, ISSN 2405-8033
Wydawca: ELSEVIER BV
DOI: 10.1016/j.trecan.2020.09.007

Non-peer reviewed articles (1)

Decomposing the mutational landscape of cancer genomes with RepairSig

Autorzy: SaraBernardo, Mathilde Meyenberg, Joanna I.Loizou
Opublikowane w: Cell Systems, Numer Volume 12, Numer 10, 20 October 2021, 2021, Strona(/y) 953-955, ISSN 2405-4720
Wydawca: Cell Press
DOI: 10.1016/j.cels.2021.09.009

Other (5)

A GCN1-independent activator of the kinase GCN2

Autorzy: JiaYi Zhu, Giulia Emanuelli, Glenn R Masson, Vanesa Vinciauskaite, Henriette Willems, Andrew Lim, Christopher Alan Brown, David Winpenny, Murray Clarke, Rebecca Gilley, Fergus Preston, Jordan Wilson, Aldo Bader, Taufiq Rahman, Joseph E Chambers, John Skidmore, Nicholas W Morrell, Stefan J Marciniak
Opublikowane w: bioRxiv, 2026
Wydawca: openRxiv
DOI: 10.1101/2025.06.29.662197

Comprehensive Interrogation of Synthetic Relationships in the Human DNA Damage Response

Autorzy: John Fielden, Sebastian M Siegner, Danielle N Gallagher, Markus S Schröder, Maria Rosaria Dello Stritto, Simon Lam, Lena Kobel, Moritz F Schlapansky, Stephen P. Jackson, Petr Cejka, Marco Jost, Jacob E Corn
Opublikowane w: 2023
Wydawca: bioRxiv
DOI: 10.1101/2023.08.18.553865

SP110 sequestration of SP100 protects against toxic filaments during innate immune signaling

Autorzy: Eric J. Aird, Julius Rabl, Tabea Knuesel, Lynn Scherpe, Daniel Boehringer, Jacob E. Corn
Opublikowane w: 2024
Wydawca: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.04.03.587867

TREX1 restricts CRISPR-Cas9 genome editing in human cells

Autorzy: Mehmet E. Karasu; Eléonore Toufektchan; John Maciejowski; Jacob E. Corn
Opublikowane w: Crossref, Numer 3, 2022
Wydawca: Biorxiv
DOI: 10.1101/2022.12.12.520063

Cell-stereotyped DNA repair outcomes are widespread during genome editing

Autorzy: Moritz F. Schlapansky, Markus S. Schröder, Antonio J. Santinha, Tanja Rothgangl, Eleonora I. Ioannidi, Grégoire Cullot, Bohdan Lewkow, German Camargo Ortega, Ahmed Nouraiz, Dominic Mailänder, Louisa Selbert, Simon Lam, Aitana Egea, Jiyung J. Shin, Matteo Bordi, Mark DeWitt, Ana Gvozdenovic, Stephen P. Jackson, Timm Schroeder, Helmuth Gehart, Gerald Schwank, Randall J. Platt, Jacob E. Corn
Opublikowane w: BioRxiv, 2026
Wydawca: openRxiv
DOI: 10.1101/2025.10.23.684114