Dna Damage REsponse: Actionabilities, Maps and Mechanisms

Informazioni relative al progetto

DDREAMM

ID dell’accordo di sovvenzione: 855741

DOI

10.3030/855741

Data della firma CE 16 Dicembre 2019

Data di avvio 1 Marzo 2020

Data di completamento 31 Luglio 2026

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 8 865 965,00

Contributo UE

€ 8 865 965,00

Coordinato da

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (24)

Removal of TREX1 activity enhances CRISPR–Cas9-mediated homologous recombination

Autori: Mehmet E. Karasu, Eléonore Toufektchan, Yanyang Chen, Alessandra Albertelli, Grégoire Cullot, John Maciejowski, Jacob E. Corn
Pubblicato in: Nature Biotechnology, 2024, ISSN 1087-0156
Editore: Nature Publishing Group
DOI: 10.1038/s41587-024-02356-3

Transcription-coupled repair of DNA-protein cross-links depends on CSA and CSB

Autori: Christopher J Carnie, Aleida C Acampora, Aldo S Bader, Chimeg Erdenebat, Shubo Zhao, Elnatan Bitensky, Diana van den Heuvel, Avital Parnas, Vipul Gupta, Giuseppina D'Alessandro, Matylda Sczaniecka-Clift, Pedro Weickart, Fatih Aygenli, Maximilian J Gotz, Jacqueline Cordes, Isabel Esain-Garcia, Larry Melidis, Annelotte P Wondergem, Simon Lam, Maria S Robles, Shankar Balasubramanian, Sheera Adar, Mar
Pubblicato in: Nature Cell Biology, Numero 26, 2024, Pagina/e 797–810, ISSN 1465-7392
Editore: Nature Publishing Group
DOI: 10.1038/s41556-024-01391-1

RNF25 confers mRNA damage tolerance by curbing activation of the integrated stress response

Autori: Shubo Zhao, Chloe S. Palma-Chaundler, Carla M. Engel, Jacqueline Cordes, Daniel Nixdorf, Michael Y. Luo, Selay Kaya, Aldwin Suryo Rahmanto, Diana van den Heuvel, Timur Mackens-Kiani, Pedro Weickert, Simon Lam, Vipul Gupta, Julia Philippou-Massier, Ivan Bagarić, Jonathan Bohlen, Graeme Hewitt, Martijn S. Luijsterburg, Roland Beckmann, Petra Beli, Danny D. Nedialkova, Christopher J. Carnie, Marion
Pubblicato in: Molecular Cell, Numero 86, 2026, Pagina/e 1275-1292.e12, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2026.02.024

PnB Designer: a web application to design prime and base editor guide RNAs for animals and plants

Autori: Siegner SM, Karasu ME, Schröder MS, Kontarakis Z, Corn JE
Pubblicato in: BMC Bioinformatics, Numero Mar 2;22(1):101, 2021, ISSN 1471-2105
Editore: BioMed Central
DOI: 10.1186/s12859-021-04034-6

CCAR1 promotes DNA repair via alternative splicing

Autori: Mehmet E. Karasu, Leonard Jahnke, Brian J. Joseph, Yerkezhan Amerzhanova, Aleksei Mironov, Xuan Shu, Markus S. Schröder, Ana Gvozdenovic, Irene Sala, Mihaela Zavolan, Stefanie Jonas, Jacob E. Corn
Pubblicato in: Molecular Cell, Numero 84, 2024, Pagina/e 2634-2647.e9, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2024.06.011

An SP110–SP100 axis is a critical regulator of promyelocytic leukaemia body dynamics and mitotic fidelity

Autori: Eric J. Aird, Julius Rabl, Tabea Knuesel, Kevin Groen, Samah W. Awwad, Boris Korablev, Lynn Scherpe, Waleed Al-Herz, Robin Hupfer, Mike Recher, Stephen P. Jackson, Benjamin G. Hale, Jacob E. Corn
Pubblicato in: Nature Cell Biology, Numero 28, 2026, Pagina/e 684-695, ISSN 1465-7392
Editore: Nature Publishing Group
DOI: 10.1038/s41556-026-01916-w

Recursive Editing improves homology-directed repair through retargeting of undesired outcomes

Autori: Möller, Lukas; Aird, Eric Jackson; id_orcid0000-0002-4873-042X; Schröder, Markus; id_orcid0000-0001-5942-1254; Kobel, Lena; id_orcid0000-0001-7949-141X; Kissling, Lucas; van de Venn, Lilly; Corn, Jacob; id_orcid0000-0002-7798-5309
Pubblicato in: Nature Communications, 13 (1), Numero 3, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-31944-7

Decitabine cytotoxicity is promoted by dCMP deaminase DCTD and mitigated by SUMO-dependent E3 ligase TOPORS

Autori: Christopher J Carnie, Maximilian J Götz, Chloe S Palma-Chaundler, Pedro Weickert, Amy Wanders, Almudena Serrano-Benitez, Hao-Yi Li, Vipul Gupta, Samah W Awwad, Christian J Blum, Matylda Sczaniecka-Clift, Jacqueline Cordes, Guido Zagnoli-Vieira, Giuseppina D’Alessandro, Sean L Richards, Nadia Gueorguieva, Simon Lam, Petra Beli, Julian Stingele, Stephen P Jackson
Pubblicato in: The EMBO Journal, Numero 43, 2024, Pagina/e 2397-2423, ISSN 1460-2075
Editore: European Molecular Biology Organization, Nature Portfolio
DOI: 10.1038/s44318-024-00108-2

ERCC6L2 ensures repair fidelity for staggered-end DNA double-strand breaks

Autori: Eric J. Aird, Almudena Serrano-Benitez, Sebastian M. Siegner, Elda Cannavo, Rimma Belotserkovskaya, Nadia Gueorguieva, John Fielden, Grégoire Cullot, Sandra Ammann, Aldo S. Bader, Vipul Gupta, Geoffroy Andrieux, Rebecca Raab, Mónica Del Rey González, Toni Cathomen, Petr Cejka, Jacob E. Corn, Stephen P. Jackson
Pubblicato in: Nature Communications, Numero 17, 2026, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-026-69843-w

Loss of CTLH component MAEA impairs DNA repair and replication and leads to developmental delay

Autori: Søren H Hough, Satpal S Jhujh, Samah W Awwad, Oliver E Lewis, Simon Lam, John C Thomas, Thorsten Mosler, Aldo Bader, Lauren Bartik, Shane McKee, Shivarajan Amudhavalli, Estelle Colin, Nadirah Damseh, Emma Clement, Pilar Cacheiro, Anirban Majumdar, Damian Smedley, Joël Fluss, Rosalinda Giannini, Isabelle Thiffault, Guido Zagnoli Vieira, Rimma Belotserkovskaya, Stephen J Smerdon, Petra Beli, Yaron
Pubblicato in: EMBO Molecular Medicine, Numero 18, 2026, Pagina/e 492-513, ISSN 1757-4684
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s44321-025-00352-x

RAD54L2 counters TOP2-DNA adducts to promote genome stability.

Autori: D'Alessandro G, Morales-Juarez DA, Richards SL, Nitiss KC, Serrano-Benitez A, Wang J, Thomas JC, Gupta V, Voigt A, Belotserkovskaya R, Goh CG, Bowden AR, Galanty Y, Beli P, Nitiss JL, Zagnoli-Vieira G, Jackson SP.
Pubblicato in: Science advances, Numero eadl2108, 2023, Pagina/e 9 (49), ISSN 2375-2548
Editore: American Association for the Advancement of Science
DOI: 10.1126/sciadv.adl2108

USP37 prevents premature disassembly of stressed replisomes by TRAIP

Autori: Olga V. Kochenova, Giuseppina D’Alessandro, Domenic Pilger, Ernst Schmid, Sean L. Richards, Marcos Rios Garcia, Satpal S. Jhujh, Andrea Voigt, Vipul Gupta, Christopher J. Carnie, R. Alex Wu, Nadia Gueorguieva, Simon Lam, Grant S. Stewart, Johannes C. Walter, Stephen P. Jackson
Pubblicato in: Nature Communications, Numero 16, 2025, Pagina/e 5333, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-025-60139-z

Clickable Cisplatin Derivatives as Versatile Tools to Probe the DNA Damage Response to Chemotherapy

Autori: Moretton A, Slyskova J, Simaan ME, Arasa-Verge EA, Meyenberg M, Cerrón-Infantes DA, Unterlass MM, Loizou JI
Pubblicato in: Frontiers in Oncology, 2022, ISSN 2234-943X
Editore: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.874201

Tissue specificity of DNA repair: the CRISPR compass

Autori: Joana Ferreira da Silva, Mathilde Meyenberg, Joanna I. Loizou
Pubblicato in: Trends in Genetics, Numero 37/11, 2021, Pagina/e 958-962, ISSN 0168-9525
Editore: Elsevier BV
DOI: 10.1016/j.tig.2021.07.010

Genome-aware annotation of CRISPR guides validates targets in variant cell lines and enhances discovery in screens

Autori: Simon Lam, John C. Thomas, Stephen P. Jackson
Pubblicato in: Genome Medicine, Numero 16, 2024, Pagina/e 139, ISSN 1756-994X
Editore: BioMed Central
DOI: 10.1186/s13073-024-01414-4

POLθ processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells

Autori: Schrempf A, Bernardo S, Arasa-Verge EA, Ramirez Otero MA, Wilson J, Kirchofer D, Timelthaler G, Ambros AM, Kaya A, Wieder M, Ecker GF, Winter GE, Costanzo V, Loizou JI
Pubblicato in: Cell Reports, Numero 41(9), 2022, Pagina/e 111716, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2022.111716

Exploring the genetic space of the <scp>DNA</scp> damage response for cancer therapy through <scp>CRISPR</scp>‐based screens

Autori: Jordan Wilson; Joanna I. Loizou
Pubblicato in: Molecular Oncology, Numero 16(21), 2022, Pagina/e 3778-3791, ISSN 1878-0261
Editore: Elsevier
DOI: 10.1002/1878-0261.13272

Prime editing efficiency and fidelity are enhanced in the absence of mismatch repair

Autori: J. Ferreira da Silva; G. P. Oliveira; E. A. Arasa-Verge; C. Kagiou; A. Moretton; G. Timelthaler; J. Jiricny; J. I. Loizou
Pubblicato in: Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022), Numero 2, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.3929/ethz-b-000533332

Clinical prospects of WRN inhibition as a treatment for MSI tumours.

Autori: Morales-Juarez, D.A., Jackson, S.P.
Pubblicato in: npj Precision Oncology, Numero 6, 2022, Pagina/e 85, ISSN 2397-768X
Editore: Springer Nature
DOI: 10.1038/s41698-022-00319-y

Nurturing a revolution in DNA repair and cancer therapy through CRISPR–Cas screens

Autori: Samah W. Awwad, Almudena Serrano-Benitez, John C. Thomas, Vipul Gupta, Stephen P. Jackson
Pubblicato in: Nature Reviews Molecular Cell Biology, Numero Published: 13 February 2023, 2023, ISSN 1471-0072
Editore: Nature Publishing Group
DOI: 10.1038/s41580-022-00571-x

Tissue Specific DNA Repair Outcomes Shape the Landscape of Genome Editing

Autori: Mathilde Meyenberg, Joana Ferreira da Silva, Joanna I. Loizou
Pubblicato in: Frontiers in Genetics, Numero 12, 2021, Pagina/e 728520, ISSN 1664-8021
Editore: Frontiers Media
DOI: 10.3389/fgene.2021.728520

WEE1 inhibitors synergise with mRNA translation defects via activation of the kinase GCN2

Autori: Jordan C. J. Wilson, JiaYi Zhu, Vanesa Vinciauskaite, Eloise G. Lloyd, Simon Lam, Alexandra Hart, Chen Gang Goh, Fadia Bou-Dagher, Hlib Razumkov, Lena Kobel, Zacharias Kontarakis, John Fielden, Moritz F. Schlapansky, Joanna I. Loizou, Andreas Villunger, Jacob E. Corn, Giulia Biffi, Glenn R. Masson, Stefan J. Marciniak, Aldo S. Bader, Stephen P. Jackson
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-025-64050-5

Unrepaired base excision repair intermediates in template <scp>DNA</scp> strands trigger replication fork collapse and <scp>PARP</scp> inhibitor sensitivity

Autori: Serrano-Benitez, Almudena; Wells, Sophie E; Drummond-Clarke, Lylah; Russo, Lilian C; Thomas, John Christopher; Leal, Giovanna A; Farrow, Mark; Edgerton, James Michael; Balasubramanian, Shankar; Yang, Ming; Frezza, Christian; Gautam, Amit; Brazina, Jan; Burdova, Kamila; Hoch, Nicolas C; Jackson, Stephen P; Caldecott, Keith W
Pubblicato in: EMBO Journal, Numero 42 (18), 2023, Pagina/e e113190, ISSN 1460-2075
Editore: European Molecular Biology Organization, Nature Portfolio
DOI: 10.15252/embj.2022113190

Targeting the DNA Repair Enzyme Polymerase θ in Cancer Therapy

Autori: Anna Schrempf, Jana Slyskova, Joanna I. Loizou
Pubblicato in: Trends in Cancer, Numero VOLUME 7, ISSUE 2, FEBRUARY 01, 2021, 2020, Pagina/e 98-111, ISSN 2405-8033
Editore: ELSEVIER BV
DOI: 10.1016/j.trecan.2020.09.007

Non-peer reviewed articles (1)

Decomposing the mutational landscape of cancer genomes with RepairSig

Autori: SaraBernardo, Mathilde Meyenberg, Joanna I.Loizou
Pubblicato in: Cell Systems, Numero Volume 12, Numero 10, 20 October 2021, 2021, Pagina/e 953-955, ISSN 2405-4720
Editore: Cell Press
DOI: 10.1016/j.cels.2021.09.009

Other (5)

A GCN1-independent activator of the kinase GCN2

Autori: JiaYi Zhu, Giulia Emanuelli, Glenn R Masson, Vanesa Vinciauskaite, Henriette Willems, Andrew Lim, Christopher Alan Brown, David Winpenny, Murray Clarke, Rebecca Gilley, Fergus Preston, Jordan Wilson, Aldo Bader, Taufiq Rahman, Joseph E Chambers, John Skidmore, Nicholas W Morrell, Stefan J Marciniak
Pubblicato in: bioRxiv, 2026
Editore: openRxiv
DOI: 10.1101/2025.06.29.662197

Comprehensive Interrogation of Synthetic Relationships in the Human DNA Damage Response

Autori: John Fielden, Sebastian M Siegner, Danielle N Gallagher, Markus S Schröder, Maria Rosaria Dello Stritto, Simon Lam, Lena Kobel, Moritz F Schlapansky, Stephen P. Jackson, Petr Cejka, Marco Jost, Jacob E Corn
Pubblicato in: 2023
Editore: bioRxiv
DOI: 10.1101/2023.08.18.553865

SP110 sequestration of SP100 protects against toxic filaments during innate immune signaling

Autori: Eric J. Aird, Julius Rabl, Tabea Knuesel, Lynn Scherpe, Daniel Boehringer, Jacob E. Corn
Pubblicato in: 2024
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.04.03.587867

TREX1 restricts CRISPR-Cas9 genome editing in human cells

Autori: Mehmet E. Karasu; Eléonore Toufektchan; John Maciejowski; Jacob E. Corn
Pubblicato in: Crossref, Numero 3, 2022
Editore: Biorxiv
DOI: 10.1101/2022.12.12.520063

Cell-stereotyped DNA repair outcomes are widespread during genome editing

Autori: Moritz F. Schlapansky, Markus S. Schröder, Antonio J. Santinha, Tanja Rothgangl, Eleonora I. Ioannidi, Grégoire Cullot, Bohdan Lewkow, German Camargo Ortega, Ahmed Nouraiz, Dominic Mailänder, Louisa Selbert, Simon Lam, Aitana Egea, Jiyung J. Shin, Matteo Bordi, Mark DeWitt, Ana Gvozdenovic, Stephen P. Jackson, Timm Schroeder, Helmuth Gehart, Gerald Schwank, Randall J. Platt, Jacob E. Corn
Pubblicato in: BioRxiv, 2026
Editore: openRxiv
DOI: 10.1101/2025.10.23.684114