Descrizione del progetto
Rilevamento di marcatori metabolici negli organuli energetici
Tutte le cellule richiedono energia per svolgere le loro numerose funzioni. Stimolare l’efficienza delle vie metaboliche può migliorare la produzione di molecole per applicazioni biotecnologiche nella medicina o nell’industria. Data la sua importanza di vasta portata, la bioenergetica è emersa come un settore a sé stante, e mitocondri e cloroplasti svolgono un ruolo da protagonista. NextGen-O2k sta sviluppando una piattaforma multi-sensore omonima che aumenterà la riproducibilità e la risoluzione delle analisi relative ai marcatori metabolici molecolari nei mitocondri e nei cloroplasti. Lo strumento promette di ottimizzare il tempo e il denaro necessari per valutare l’idoneità funzionale di questi organuli, con importanti implicazioni per la salute umana e la biotecnologia industriale.
Obiettivo
Mitochondria and chloroplasts are key elements to face the new challenges of the millennia for biomedicine, biotechnology and to develop a sustainable bio-economy. Mitochondrial fitness is a key parameter for diagnosis and therapeutic applications on multiple human pathologies, such as neurodegenerative diseases, diabetes and cancer. On the other hand, the optimization of algal growth rate and metabolite production in biotechnology requires novel investigations and monitoring of the bioenergetic pathway control exerted by mitochondria and chloroplasts.
However, current technologies to study mitochondrial and chloroplast function are limited, providing segmented information, lacking inter-laboratory reproducibility and hindering our advance towards therapeutic and biotech interventions of cellular bioenergetics. As a result, the understanding of cellular bioenergetics for medical and algal biotechnology applications remains poor.
The overall objective of this project is to complete the development of NextGen-O2k and prepare its market launch in 2021. NextGen-O2k is a multi-sensor platform for in-depth study of mitochondrial and chloroplast functional fitness. In a compact and affordable device, we have integrated several sensors for detecting multiple key parameters of bioenergetics, with superior resolution and reproducibility.
With NextGen-O2k we will provide researchers with a tool able to improve knowledge about mitochondrial dysfunction and chloroplast photosynthesis, while bringing savings in experimental time, samples and funds.
NextGen-O2k project is a step forward towards understanding mitochondrial implication in human pathologies and in the optimization of biomass production in many areas of biotechnology. Our focus in on generating knowledge about mitochondrial function and dysfunction, chloroplast photosynthesis and algal metabolism, while contributing to address the science reproducibility crisis.
Campo scientifico
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Invito a presentare proposte
Vedi altri progetti per questo bandoBando secondario
H2020-SMEInst-2018-2020-2
Meccanismo di finanziamento
SME-2 - SME instrument phase 2Coordinatore
6020 Innsbruck
Austria
L’organizzazione si è definita una PMI (piccola e media impresa) al momento della firma dell’accordo di sovvenzione.