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Next Generation Instrument for In-Depth Analysis of Mitochondrial Fitness

Risultati finali

Intermediate Communication Plan

Report containing updated communication strategy and activities performed during Year 1 of the project.

Final Communication Plan

Report containing the final communication plan and all the activities and results performed during Year 1 and Year 2 of the project

Final SOPs and User’s Manual for each module

A compiled list of SOPs and protocols in the User Manual that will be posted online and accompany the NextGenO2k device

Website

Updated website with a dedicated section for NextGen-O2k Phase 2 project.

Pubblicazioni

Comparable respiratory activity in attached and suspended human fibroblasts.

Autori: Zdrazilova L, Hansikova H, Gnaiger E
Pubblicato in: MitoFit Preprints, Issue 2021.7, 2021
Editore: Oroboros Instruments

O2k-FluoRespirometer manual

Autori: Gnaiger E, Komlódi T, Schmitt S, Cecatto C, Gradl L, Gradl P
Pubblicato in: Mitochondrial Physiology Network, Issue 22.11(v9), 2021
Editore: Oroboros Instruments

Hepatitis C virus-linked mitochondrial dysfunction promotes hypoxia-inducible factor 1α-mediated glycolytic adaptation

Autori: Cardoso LHD and Tindle-Solomon L
Pubblicato in: O2k-brief, Issue 21/07/2020, 2020
Editore: Oroboros Instruments

Experimental oxygen concentration influences rates of mitochondrial hydrogen peroxide release from cardiac and skeletal muscle preparations

Autori: Komlodi T and Tindle-Solomon L
Pubblicato in: O2k-brief, Issue 24/06/2020, 2020
Editore: Oroboros Instruments

Mitochondrial dysfunction in peripheral blood mononuclear cells in early experimental and clinical acute pancreatitis. Pancreatology

Autori: Falaye T, Sobotka O and Tindle-Solomon L
Pubblicato in: O2k-brief, Issue 30/07/2020, 2020
Editore: Oroboros Instruments

NextGen-O2k: PB-Module manual

Autori: Di Marcello M, Merth A, Doerrier C, Schmitt S, Schwaninger H, Walter-Vracevic M, Gradl P, Gnaiger E
Pubblicato in: Mitochondrial Physiology Network, Issue 26.11, 2021
Editore: Oroboros Instruments

O2k Quality Control 1: Polarographic oxygen sensors and accuracy of calibration - DatLab 8.

Autori: Gnaiger E
Pubblicato in: Mitochondrial Physiology Network, Issue 06.03, 2021
Editore: Oroboros Instruments

Service of the polarographic oxygen sensor OroboPOS.

Autori: Gnaiger E
Pubblicato in: Mitochondrial Physiology Network, Issue 19.18B(v9), 2020
Editore: Oroboros Instruments

DatLab-guide through the menus

Autori: Gnaiger E, Cecatto C, Gradl L
Pubblicato in: Mitochondrial Physiology Network, Issue 26.06, 2021
Editore: Oroboros Instruments

O2k-Chamber cleaning SOP and Integrated Suction System (ISS).

Autori: Di Marcello M, Komlodi T, Schmitt S, Gnaiger E
Pubblicato in: Mitochondrial Physiology Network, Issue 19.03(v7), 2021
Editore: Oroboros Instruments

O2k-MultiSensor system with ion selective electrodes (ISE).

Autori: Komlodi T, Schmitt S, Gnaiger E
Pubblicato in: Mitochondrial Physiology Network, Issue 15.03(v9), 2021
Editore: Oroboros Instruments

Cell-permeable succinate rescues mitochondrial respiration in cellular models of statin toxicity

Autori: Cecatto C and Tindle-Solomon L
Pubblicato in: O2k-brief, Issue 27/04/2021, 2021
Editore: Oroboros Instruments

O2k-checklist: get started with an O2k-experiment

Autori: Doerrier C, Schmitt S, Cecatto C, Gnaiger E
Pubblicato in: Mitochondrial Physiology Network, Issue 20.04(v5), 2021
Editore: Oroboros Instruments

Bioenergetic cluster analysis – mitochondrial respiratory control in human fibroblasts

Autori: Gnaiger E
Pubblicato in: MitoFit Preprints, Issue 2021.8, 2021
Editore: Oroboros Instruments

Doxorubicin-transferrin conjugate alters mitochondrial homeostasis and energy metabolism in human breast cancer cells

Autori: Komlodi T and Tindle-Solomon L
Pubblicato in: O2k-brief, Issue 30/06/2021, 2021
Editore: Oroboros Instruments

Magnesium Green for fluorometric measurement of ATP production does not interfere with mitochondrial respiration

Autori: Cardoso LHD, Doerrier C, Gnaiger
Pubblicato in: Bioenergetics Communications, Issue 2021.1, 2020
Editore: Oroboros Instruments

Oncogenic HSP60 regulates mitochondrial oxidative phosphorylation to support Erk1/2 activation during pancreatic cancer cell growth

Autori: Cecatto C and Tindle-Solomon L
Pubblicato in: O2k-brief, Issue 18/11/2020, 2020
Editore: Oroboros Instruments

Laboratory protocol: isolation of mouse heart mitochondria

Autori: Komlodi T, Cardoso LHD, Gnaiger E
Pubblicato in: Mitochondrial Physiology Network, Issue 20.068v2), 2021
Editore: Oroboros Instruments

High-resolution respirometry for chloroplast and mitochondrial bioenergetics in Chlamydomonas reinhardtii ― towards biotechnology exploitations

Autori: Huete-Ortega M, Di Marcello M, Iglesias-Gonzalez J, Gnaiger E
Pubblicato in: MitoFit Preprints, 2020
Editore: Oroboros Instruments

Magnesium Green for fluorometric measurement of ATP production does not interfere with mitochondrial respiration.

Autori: Cardoso LHD, Doerrier C, Gnaiger E
Pubblicato in: MitoFit Preprints, Issue 2021.1, 2021
Editore: Oroboros Instruments

Effects of ultramarathon running on mitochondrial function of platelets and oxidative stress parameters: a pilot study

Autori: Cecatto C and Tindle-Solomon L
Pubblicato in: O2k-brief, Issue 16/09/2021, 2021
Editore: Oroboros Instruments

O2k-Specifications for respirometry and comprehensive OXPHOS analysis

Autori: Gnaiger E
Pubblicato in: Mitochondrial Physiology Network, Issue 18.10(09), 2019, Page(s) 1-8
Editore: Oroboros Instruments

O2k Quality Control 2: Instrumental oxygen background correction and accuracy of oxygen flux

Autori: Fasching M, Gnaiger E
Pubblicato in: Mitochondrial Physiology Network, Issue 14.06(08), 2020, Page(s) 1-16
Editore: Oroboros Instruments

NextGen-O2k: Q-Module Manual

Autori: Komlodi T, Cardoso LHD, Gollner M, Merth A, Hunger M, Iglesias-Gonzalez J, Doerrier C, Tindle-Solomon L, Schwaninger H, Walter-Vracevic M, Gradl P, Moore AL, Gnaiger E
Pubblicato in: Mitochondrial Physiology Network, Issue 24.12(02), 2020, Page(s) 1-21
Editore: Oroboros Instruments

DatLab 8.0: Cyclic voltammetry manual

Autori: Komlodi T, Cardoso LHD, Haider M, Tindle-Solomon L, Iglesias-Gonzalez J, Gnaiger E
Pubblicato in: Mitochondrial Physiology Network, Issue 24.16(01), 2019, Page(s) 1-10
Editore: Oroboros Instruments

Oxygen flux analysis with DatLab 7.4

Autori: Cardoso LHD, Antunes D, Iglesias-Gonzalez J, Komlodi T, Doerrier C, Garcia-Souza LF, Gnaiger E, Sobotka O
Pubblicato in: Mitochondrial Physiology Network, Issue 24.06(02), 2020, Page(s) 1-11
Editore: Oroboros Instruments

Hydrogen peroxide flux analysis using Amplex Ultra Red assay in MiR05-Kit with DatLab 7.4

Autori: Komlodi T, Iglesias-Gonzalez J, Cardoso LHD, Sobotka O, Gnaiger E
Pubblicato in: Mitochondrial Physiology Network, Issue 24.10(02), 2020, Page(s) 1-6
Editore: Oroboros Instruments

Data analysis of mitochondrial membrane potential estimation using safranin

Autori: Komlodi T, Fasching M, Antunes D, Iglesias-Gonzalez J, Sobotka O, Gnaiger E
Pubblicato in: Mitochondrial Physiology Network, Issue 24.08(02), 2020, Page(s) 1-8
Editore: Oroboros Instruments

Data analysis of mitochondrial membrane potential estimation using various fluorescence dyes

Autori: Komlodi T, Antunes D, Iglesias-Gonzalez J, Sobotka O, Gnaiger E
Pubblicato in: Mitochondrial Physiology Network, Issue 24.09(02), 2020, Page(s) 1-5
Editore: Oroboros Instruments

Mitochondrial respiratory states and rates

Autori: Gnaiger E, Aasander Frostner E, Abdul Karim N, Abdel-Rahman EA, Abumrad NA, Acuna-Castroviejo D, Adiele RC, Ahn B, Alencar MB, Ali SS, Almeida A, Alton L, Alve sMG, Amati F, Amoedo ND, Amorim R, Andreadou I, Antunes D, Aragó M, Aral C, Arandarčikaitė O,Arias Reyes C, Armand AS, Arnould T, Avram VF, Bailey DM, Bairam A, Bajpeyi S, Bajzikova M, Bakker BM, Banni A, Bardal T, Barlow J, Bastos Sant'
Pubblicato in: MitoFit Preprint Archives, 2019
Editore: Oroboros Instruments

Mitochondrial physiology

Autori: Gnaiger E, Aasander Frostner E, Abdul Karim N, Abdel-Rahman EA, Abumrad NA, Acuna-Castroviejo D, Adiele RC, Ahn B, Alencar MB, Ali SS, Almeida A, Alton L, Alve sMG, Amati F, Amoedo ND, Amorim R, Andreadou I, Antunes D, Aragó M, Aral C, Arandarčikaitė O,Arias Reyes C, Armand AS, Arnould T, Avram VF, Bailey DM, Bairam A, Bajpeyi S, Bajzikova M, Bakker BM, Banni A, Bardal T, Barlow J, Bastos Sant'
Pubblicato in: Bioenergetics Communications, 2020
Editore: Oroboros Instruments

Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers

Autori: Doerrier C, Gama-Perez P, Distefano G, Pesta D, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen P, Larsen S, Gnaiger E, Garcia-Roves PM
Pubblicato in: MitoFit Preprint Archives, 2019
Editore: Oroboros Instruments

Partitioning between cytochrome c oxidase and alternative oxidase studied by oxygen kinetics of dark respiration in Chlamydomonas reinhardtii: a microalgae model organism

Autori: Di Marcello M, Iglesias-Gonzalez J, Meszaros A, Haider M, Gnaiger E, Huete-Ortega M
Pubblicato in: MitoFit Preprint Archives, 2019
Editore: Oroboros Instruments

Generating reference values on mitochondrial respiration in permeabilized muscle fibers

Autori: Chabi Béatrice, Ost M, Gama-Perez P, Dahdah N, Lemieux H, Holody CD, Carpenter RG, Tepp K, Puurand M, Kaambre T, Dubouchaud H, Cortade F, Pesta D, Calabria E, Casado M, Fernandez-Ortiz M, Acuña-Castroviejo D, Villena JA, Grefte S, Keijer J, O'Brien K, Sowton A, Murray AJ, Campbell MD, Marcinek DJ, Nollet E, Wüst R, Dayanidhi S, Gnaiger E, Doerrier C, Garcia-Roves PM
Pubblicato in: MitoFit Preprint Archives, 2019
Editore: Oroboros Instruments

Commitment to reproducibility in targeting mitochondrial respiratory control: basic and advanced applications of the O2k-FluoRespirometer

Autori: Doerrier C, Di Marcello M, Gnaiger E
Pubblicato in: 2020
Editore: Foundation for Translational Myology

Endogenous quinones sustain a moderate NADH oxidation by Complex I during anoxia

Autori: Ravasz D, Bui D, Kitayev A, Greenwood B, Hill C, Komlodi T, Doerrier C, Ozohanics O, Moore AL, Gnaiger E, Kiebish M, Kolev K, Seyfried TN, Willis WT, Narain N, Adam-Vizi V, Chinopoulos C
Pubblicato in: 2019
Editore: Mitochondrial Physiology Network

Succinate dehydrogenase is a source of reactive oxygen species in plants and regulates development and stress responses

Autori: Huete-Ortega M
Pubblicato in: O2k-brief, Issue 2019-06-05, 2019
Editore: Oroboros Instruments

Regulation of ATP production: dependence on calcium concentration and respiratory state

Autori: Cardoso L
Pubblicato in: O2k-brief, Issue 2019-06-12, 2019
Editore: Oroboros Instruments

Mitochondrial respiration in peripheral blood mono nuclear cells correlates with depressive sub-symptoms and severity of major depression

Autori: Garcia-Souza LF
Pubblicato in: O2k-brief, Issue 2019-06-19, 2019
Editore: Oroboros Instruments

Mitochondrial respiratory control and early defects of oxidative phosphorylation in the failing human heart

Autori: Gnaiger E and Iglesias-Gonzalez J
Pubblicato in: O2k-brief, Issue 2019-06-26, 2019
Editore: Oroboros Instruments

High intensity exercise inhibits carnitine palmoyltranferase-I sensitivity to L-carnitine

Autori: Krumschnable G
Pubblicato in: O2k-brief, Issue 2019-07-02, 2019
Editore: Oroboros Instruments

Rapid kinetics of changes in oxygen consumption rate in thrombin-stimulated platelets measured by high-resolution respirometry

Autori: Garcia-Souza LF
Pubblicato in: O2k-brief, Issue 2019-07-09, 2019
Editore: Oroboros Instruments

Direct effects of phenformin on metabolism/bioenergetics and viability of SH-SY5Y neuroblastoma cells

Autori: Bastos AC
Pubblicato in: O2k-brief, 2019
Editore: Oroboros Instruments

Selective disruption of respiratory supercomplexes as a new strategy to supress Her2high breast cancer

Autori: Bastos AC
Pubblicato in: O2k-brief, Issue 2019-07-24, 2019
Editore: Oroboros Instruments

Endogenous myoglobin in breast cancer is hypoxia-inducible by alternate transcription and functions to impair mitochondrial activity: a role in tumor suppression?

Autori: Iglesias-Gonzalez J
Pubblicato in: O2k-brief, Issue 2019-07-31, 2019
Editore: Oroboros Instruments

6-Hydroxidopamine induces different mitochondrial bioenergetics response in brain regions of rat

Autori: Iglesias-Gonzalez J
Pubblicato in: O2k-brief, Issue 2019-08-07, 2019
Editore: Oroboros Instruments

Non-canonical BAD activity regulates breast cancer cells and tumor growth via 14-3-3 binding and mitochondrial metabolism

Autori: Tindle-Solomon L
Pubblicato in: O2k-brief, Issue 2019-10-25, 2019
Editore: Oroboros Instruments

Measurement of ADP-ATP exchange in relation to mitochondrial transmembrane potential and oxygen consumption

Autori: Tindle-Solomon L
Pubblicato in: O2k-brief, Issue 2019-11-28, 2019
Editore: Oroboros Instruments

Analysis of respiratory capacity in brain tissue preparations: high-resolution respirometry for intact hippocampal slices

Autori: Tindle-Solomon L
Pubblicato in: O2k-brief, Issue 2019-11-12, 2019
Editore: Oroboros Instruments

Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis

Autori: Antunes D and Tindle-Solomon L
Pubblicato in: O2k-brief, Issue 2020-01-20, 2020
Editore: Oroboros Instruments

The metabolite BH4 controls T cell proliferation in autoimmunity and cancer

Autori: Garcia-Souza LF and Tindle-Solomon L
Pubblicato in: O2k-brief, Issue 2020-02-04, 2020
Editore: Oroboros Instruments

Effects of aging and exercise training on mitochondrial function and apoptosis in the rat heart

Autori: Cecatto C and Tindle-Solomon L
Pubblicato in: O2k-brief, Issue 2020-03-18, 2020
Editore: Oroboros Instruments

Effect of initial aging and high-fat/high-fructose diet on mitochondrial bioenergetics and oxidative status in rat brain

Autori: Antunes D and Tindle-Solomon L
Pubblicato in: O2k-brief, Issue 2020-03-05, 2020
Editore: Oroboros Instruments

Muscle-derived GDF15 drives diurnal anorexia and systemic metabolic remodeling during mitochondrial stress

Autori: Antunes D and Tindle-Solomon L
Pubblicato in: O2k-brief, Issue 2020-04-03, 2020
Editore: Oroboros Instruments

Respiratory chain signaling is essential for adaptive remodeling following cardiac ischaemia

Autori: Komlodi T and Tindle-Solomon L
Pubblicato in: O2k-brief, Issue 2020-05-15, 2020
Editore: Oroboros Instruments

OXPHOS remodeling n high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation

Autori: Bastos AC and Tindle-Solomon L
Pubblicato in: O2k-brief, Issue 2020-05-28, 2020
Editore: Oroboros Instruments

Peripheral mitochondrial dysfunction in Alzheimer’s disease: focus on lymphocytes.

Autori: Garcia-Souza LF and Tindle-Solomon L
Pubblicato in: O2k-brief, Issue 2020-04-16, 2020
Editore: Oroboros Instruments

High-Fat diet activates liver iPLA2γ generating eicosanoids that mediate metabolic stress

Autori: Komlodi T and Tindle-Solomon L
Pubblicato in: O2k-brief, Issue 15/06/2021, 2021
Editore: Oroboros Instruments

Platelet mitochondrial respiration, endogenous coenzyme Q10 and oxidative stress in patients with chronic kidney disease

Autori: Falaye T, Sobotka O and Tindle-Solomon L
Pubblicato in: O2k-brief, Issue 29/05/2020, 2020
Editore: Oroboros Instruments

NextGen-O2k manual

Autori: Gnaiger E, Cardoso LHD, Cecatto C, Niedenzu W, Haider M, Gollner M, Merth A, Schwaninger H, Walter-Vracevic M, Gradl P
Pubblicato in: Mitochondrial Physiology Network, Issue 26.13, 2021
Editore: Oroboros Instruments

Measurement of mitochondrial ATP production using Magnesium Green: DL-Protocols and data analysis with DatLab 7.4

Autori: Cardoso LHD, Komlodi T, Gnaiger E
Pubblicato in: Mitochondrial Physiology Network, Issue 26.10, 2021
Editore: Oroboros Instruments

NextGen-O2k: NADH-Module manual

Autori: Doerrier C, Schwaninger H, Walter-Vracevic M, Haider M, Niedenzu W, Komlódi T, Gradl P, Gnaiger E
Pubblicato in: Mitochondrial Physiology Network, Issue 26.12, 2021
Editore: Oroboros Instruments

Hippocampal growth factor and myokine cathepsin B expression following aerobic and resistance training in 3xTg-AD mice

Autori: Cecatto C and Tindle-Solomon L
Pubblicato in: O2k-brief, Issue 18/09/2020, 2020
Editore: Oroboros Instruments

Adaptation of mitochondrial substrate flux in a mouse model of nonalcoholic fatty liver disease

Autori: Komlodi T and Tindle-Solomon L
Pubblicato in: O2k-brief, Issue 04/01/2021, 2021
Editore: Oroboros Instruments

An mtDNA mutant mouse demonstrates that mitochondrial deficiency can result in autism endophenotypes

Autori: Komlodi T and Tindle-Solomon L
Pubblicato in: O2k-brief, Issue 29/03/2021, 2021
Editore: Oroboros Instruments

Ex vivo mitochondrial respiration parallels biochemical response to ibrutinib in CLL cells

Autori: Komlodi T and Tindle-Solomon L
Pubblicato in: O2k-brief, Issue 16/08/2021, 2021
Editore: Oroboros Instruments

Oxygen dependence of photosynthesis and light-enhanced dark respiration studied by High-Resolution PhotoRespirometry

Autori: Went N, Di Marcello M, Gnaiger E
Pubblicato in: MitoFit Preprints, Issue 2021.5, 2021
Editore: Oroboros Instruments

The elementary unit — canonical reviewer's comments on: Bureau International des Poids et Mesures

Autori: Gnaiger E
Pubblicato in: MitoFit Preprints, Issue 2021.4(v2), 2021
Editore: Oroboros Instruments

Colon cancer cell differentiation by sodium butyrate modulates metabolic plasticity of Caco-2 cells via alteration of phosphotransfer network

Autori: Komlodi T and Tindle-Solomon L
Pubblicato in: O2k-brief, Issue 09/06/2021, 2019
Editore: Oroboros Instruments

Titration-Injection microPump TIP2k manual.

Autori: Gradl L, Gradl P, Gnaiger E
Pubblicato in: Mitochondrial Physiology Network, Issue 12.10(v9), 2021
Editore: Oroboros Instruments

Coupling and pathway control of coenzyme Q redox state and respiration in isolated mitochondria

Autori: Komlódi T, Cardoso LHD, Doerrier C, Moore AL, Rich PR, Gnaiger E
Pubblicato in: MitoFit Preprints, Issue 2021.2(v4), 2021
Editore: Oroboros Instruments

Mitochondrial respiration of platelets: comparison of isolation methods.

Autori: Vernerova A, Garcia-Souza LF, Soucek O, Kostal M, Rehacek V, Krcmova LK, Gnaiger E, Sobotka O
Pubblicato in: MitoFit Preprints, Issue 2021.6, 2021
Editore: Oroboros Instruments

Mitochondrial pathways and respiratory control

Autori: Gnaiger E
Pubblicato in: Bioenergetics Communicatoins, Issue 2020.2, 2020, ISBN 978-3-9504814-2-6
Editore: Bioenergetics Communicatoins

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