DNA helicases in genome maintenance: from molecular and cellular mechanisms to specific inhibitors as potential drugs

Información del proyecto

AntiHelix

Identificador del acuerdo de subvención: 859853

DOI 10.3030/859853

Fecha de la firma de la CE 9 Agosto 2019

Fecha de inicio 1 Octubre 2019

Fecha de finalización 30 Septiembre 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total € 3 508 622,28

Aportación de la UE € 3 508 622,28

Coordinado por

CONSIGLIO NAZIONALE DELLE RICERCHE
Italy

Resultado final

Documents, reports (1)

List of Joint Supervisors and local academic Supervisors

Other (2)

Recruitment of ESRs
Training Events M1-M24

The following Training Events have been planned1TRIESTE Italy M13 Research Theoretical Course 1 1 day Transferable Skills Course 1 2 days Handson Practical Class 1 3 days2 DORTMUND Germany M20 Research Theoretical Course 2 2 days Transferable Skills Course 2 2 days Handson Practical Class 2 2 days

Websites, patent fillings, videos etc. (2)

AntiHelix accounts on web social media
AntiHelix project website

Publicaciones

Peer reviewed articles (10)

Genomic integrity and mitochondrial metabolism defects in Warsaw syndrome cells: a comparison with Fanconi anemia

Autores: Bottega R, Ravera S, Napolitano LMR, Chiappetta V, Zini N, Crescenzi B, Arniani S, Faleschini M, Cortone G, Faletra F, Medagli B, Sirchia F, Moretti M, de Lange J, Cappelli E, Mecucci C, Onesti S, Pisani FM, Savoia A.
Publicado en: Journal of cellular physiology, 2021, ISSN 0021-9541
Editor: John Wiley & Sons Inc.
DOI: 10.1002/jcp.30265

Folate stress induces SLX1- and RAD51-dependent mitotic DNA synthesis at the fragile X locus in human cells.

Autores: Garribba L, Bjerregaard VA, Gonçalves Dinis MM, Özer Ö, Wu W, Sakellariou D, Pena-Diaz J, Hickson ID, Liu Y.
Publicado en: Proceedings of the National Academy of Sciences of the United States of America, 2020, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1921219117

Spotlight on Warsaw Breakage Syndrome.

Autores: Francesca M Pisani
Publicado en: The Application of Clinical Genetics, Vol Volume 12, Pp 239-248 (2019), Edición 2, 2019, ISSN 1178-704X
Editor: Dove Medical Press Ltd
DOI: 10.2147/tacg.s186476

Functional Coupling between DNA Replication and Sister Chromatid Cohesion Establishment

Autores: Ana Boavida; Diana Santos; Mohammad Mahtab; Francesca M. Pisani
Publicado en: International Journal of Molecular Sciences, Vol 22, Iss 2810, p 2810 (2021), Edición 1, 2021, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22062810

Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion

Autores: van Schie JJM, Faramarz A, Balk JA, Stewart GS, Cantelli E, Oostra AB, Rooimans MA, Parish JL, de Almeida Estéves C, Dumic K, Barisic I, Diderich KEM, van Slegtenhorst MA, Mahtab M, Pisani FM, Te Riele H, Ameziane N, Wolthuis RMF, de Lange J.
Publicado en: Nature Communications, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-18066-8

The prevention and resolution of DNA replication–transcription conflicts in eukaryotic cells

Autores: Wei Wu; Ian D. Hickson; Ying Liu
Publicado en: Genome Instability & Disease, Edición 1, 2020, ISSN 2524-7662
Editor: Springer
DOI: 10.1007/s42764-020-00012-z

RTEL1 suppresses G-quadruplex-associated R-loops at difficult-to-replicate loci in the human genome

Autores: Wu W, Bhowmick R, Vogel I, Özer Ö, Ghisays F, Thakur RS, Sanchez de Leon E, Richter PH, Ren L, Petrini JH, Hickson ID, Liu Y
Publicado en: Nature structural and molecular biology, 2020, ISSN 1545-9993
Editor: Nature Publishing Group
DOI: 10.1038/s41594-020-0408-6

Role of the DDX11 DNA Helicase in Warsaw Breakage Syndrome Etiology

Autores: Ana Boavida; Francesca M. Pisani; Mohammad Mahtab; Diana Santos
Publicado en: International Journal of Molecular Sciences, Edición 1, 2021, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22052308

The Genome Stability Maintenance DNA Helicase DDX11 and Its Role in Cancer

Autores: Mohammad Mahtab; Ana Boavida; Diana Santos; Francesca M. Pisani
Publicado en: Genes, Edición 2, 2021, ISSN 2073-4425
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes12030395

Folate Deficiency Triggers the Abnormal Segregation of a Region With Large Cluster of CG-Rich Trinucleotide Repeats on Human Chromosome 2

Autores: Garribba L, Vogel I, Lerdrup M, Gonçalves Dinis MM, Ren L, Liu Y
Publicado en: Frontiers in genetics, 2021, ISSN 1664-8021
Editor: Frontiers Media
DOI: 10.3389/fgene.2021.695124