DNA helicases in genome maintenance: from molecular and cellular mechanisms to specific inhibitors as potential drugs

Risultati finali

List of Joint Supervisors and local academic Supervisors

Recruitment of ESRs
Training Events M1-M24

The following Training Events have been planned1TRIESTE Italy M13 Research Theoretical Course 1 1 day Transferable Skills Course 1 2 days Handson Practical Class 1 3 days2 DORTMUND Germany M20 Research Theoretical Course 2 2 days Transferable Skills Course 2 2 days Handson Practical Class 2 2 days

AntiHelix accounts on web social media
AntiHelix project website

Pubblicazioni

Genomic integrity and mitochondrial metabolism defects in Warsaw syndrome cells: a comparison with Fanconi anemia

Autori: Bottega R, Ravera S, Napolitano LMR, Chiappetta V, Zini N, Crescenzi B, Arniani S, Faleschini M, Cortone G, Faletra F, Medagli B, Sirchia F, Moretti M, de Lange J, Cappelli E, Mecucci C, Onesti S, Pisani FM, Savoia A.
Pubblicato in: Journal of cellular physiology, 2021, ISSN 0021-9541
Editore: John Wiley & Sons Inc.
DOI: 10.1002/jcp.30265

Folate stress induces SLX1- and RAD51-dependent mitotic DNA synthesis at the fragile X locus in human cells.

Autori: Garribba L, Bjerregaard VA, Gonçalves Dinis MM, Özer Ö, Wu W, Sakellariou D, Pena-Diaz J, Hickson ID, Liu Y.
Pubblicato in: Proceedings of the National Academy of Sciences of the United States of America, 2020, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1921219117

Spotlight on Warsaw Breakage Syndrome.

Autori: Francesca M Pisani
Pubblicato in: The Application of Clinical Genetics, Vol Volume 12, Pp 239-248 (2019), Numero 2, 2019, ISSN 1178-704X
Editore: Dove Medical Press Ltd
DOI: 10.2147/tacg.s186476

Functional Coupling between DNA Replication and Sister Chromatid Cohesion Establishment

Autori: Ana Boavida; Diana Santos; Mohammad Mahtab; Francesca M. Pisani
Pubblicato in: International Journal of Molecular Sciences, Vol 22, Iss 2810, p 2810 (2021), Numero 1, 2021, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22062810

Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion

Autori: van Schie JJM, Faramarz A, Balk JA, Stewart GS, Cantelli E, Oostra AB, Rooimans MA, Parish JL, de Almeida Estéves C, Dumic K, Barisic I, Diderich KEM, van Slegtenhorst MA, Mahtab M, Pisani FM, Te Riele H, Ameziane N, Wolthuis RMF, de Lange J.
Pubblicato in: Nature Communications, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-18066-8

The prevention and resolution of DNA replication–transcription conflicts in eukaryotic cells

Autori: Wei Wu; Ian D. Hickson; Ying Liu
Pubblicato in: Genome Instability & Disease, Numero 1, 2020, ISSN 2524-7662
Editore: Springer
DOI: 10.1007/s42764-020-00012-z

RTEL1 suppresses G-quadruplex-associated R-loops at difficult-to-replicate loci in the human genome

Autori: Wu W, Bhowmick R, Vogel I, Özer Ö, Ghisays F, Thakur RS, Sanchez de Leon E, Richter PH, Ren L, Petrini JH, Hickson ID, Liu Y
Pubblicato in: Nature structural and molecular biology, 2020, ISSN 1545-9993
Editore: Nature Publishing Group
DOI: 10.1038/s41594-020-0408-6

Role of the DDX11 DNA Helicase in Warsaw Breakage Syndrome Etiology

Autori: Ana Boavida; Francesca M. Pisani; Mohammad Mahtab; Diana Santos
Pubblicato in: International Journal of Molecular Sciences, Numero 1, 2021, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22052308

The Genome Stability Maintenance DNA Helicase DDX11 and Its Role in Cancer

Autori: Mohammad Mahtab; Ana Boavida; Diana Santos; Francesca M. Pisani
Pubblicato in: Genes, Numero 2, 2021, ISSN 2073-4425
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes12030395

Folate Deficiency Triggers the Abnormal Segregation of a Region With Large Cluster of CG-Rich Trinucleotide Repeats on Human Chromosome 2

Autori: Garribba L, Vogel I, Lerdrup M, Gonçalves Dinis MM, Ren L, Liu Y
Pubblicato in: Frontiers in genetics, 2021, ISSN 1664-8021
Editore: Frontiers Media
DOI: 10.3389/fgene.2021.695124

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