DNA helicases in genome maintenance: from molecular and cellular mechanisms to specific inhibitors as potential drugs

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List of Joint Supervisors and local academic Supervisors

Recruitment of ESRs
Training Events M1-M24

The following Training Events have been planned1TRIESTE Italy M13 Research Theoretical Course 1 1 day Transferable Skills Course 1 2 days Handson Practical Class 1 3 days2 DORTMUND Germany M20 Research Theoretical Course 2 2 days Transferable Skills Course 2 2 days Handson Practical Class 2 2 days

AntiHelix accounts on web social media
AntiHelix project website

Publications

Genomic integrity and mitochondrial metabolism defects in Warsaw syndrome cells: a comparison with Fanconi anemia

Auteurs: Bottega R, Ravera S, Napolitano LMR, Chiappetta V, Zini N, Crescenzi B, Arniani S, Faleschini M, Cortone G, Faletra F, Medagli B, Sirchia F, Moretti M, de Lange J, Cappelli E, Mecucci C, Onesti S, Pisani FM, Savoia A.
Publié dans: Journal of cellular physiology, 2021, ISSN 0021-9541
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/jcp.30265

Folate stress induces SLX1- and RAD51-dependent mitotic DNA synthesis at the fragile X locus in human cells.

Auteurs: Garribba L, Bjerregaard VA, Gonçalves Dinis MM, Özer Ö, Wu W, Sakellariou D, Pena-Diaz J, Hickson ID, Liu Y.
Publié dans: Proceedings of the National Academy of Sciences of the United States of America, 2020, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.1921219117

Spotlight on Warsaw Breakage Syndrome.

Auteurs: Francesca M Pisani
Publié dans: The Application of Clinical Genetics, Vol Volume 12, Pp 239-248 (2019), Numéro 2, 2019, ISSN 1178-704X
Éditeur: Dove Medical Press Ltd
DOI: 10.2147/tacg.s186476

Functional Coupling between DNA Replication and Sister Chromatid Cohesion Establishment

Auteurs: Ana Boavida; Diana Santos; Mohammad Mahtab; Francesca M. Pisani
Publié dans: International Journal of Molecular Sciences, Vol 22, Iss 2810, p 2810 (2021), Numéro 1, 2021, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22062810

Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion

Auteurs: van Schie JJM, Faramarz A, Balk JA, Stewart GS, Cantelli E, Oostra AB, Rooimans MA, Parish JL, de Almeida Estéves C, Dumic K, Barisic I, Diderich KEM, van Slegtenhorst MA, Mahtab M, Pisani FM, Te Riele H, Ameziane N, Wolthuis RMF, de Lange J.
Publié dans: Nature Communications, 2020, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-020-18066-8

The prevention and resolution of DNA replication–transcription conflicts in eukaryotic cells

Auteurs: Wei Wu; Ian D. Hickson; Ying Liu
Publié dans: Genome Instability & Disease, Numéro 1, 2020, ISSN 2524-7662
Éditeur: Springer
DOI: 10.1007/s42764-020-00012-z

RTEL1 suppresses G-quadruplex-associated R-loops at difficult-to-replicate loci in the human genome

Auteurs: Wu W, Bhowmick R, Vogel I, Özer Ö, Ghisays F, Thakur RS, Sanchez de Leon E, Richter PH, Ren L, Petrini JH, Hickson ID, Liu Y
Publié dans: Nature structural and molecular biology, 2020, ISSN 1545-9993
Éditeur: Nature Publishing Group
DOI: 10.1038/s41594-020-0408-6

Role of the DDX11 DNA Helicase in Warsaw Breakage Syndrome Etiology

Auteurs: Ana Boavida; Francesca M. Pisani; Mohammad Mahtab; Diana Santos
Publié dans: International Journal of Molecular Sciences, Numéro 1, 2021, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22052308

The Genome Stability Maintenance DNA Helicase DDX11 and Its Role in Cancer

Auteurs: Mohammad Mahtab; Ana Boavida; Diana Santos; Francesca M. Pisani
Publié dans: Genes, Numéro 2, 2021, ISSN 2073-4425
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes12030395

Folate Deficiency Triggers the Abnormal Segregation of a Region With Large Cluster of CG-Rich Trinucleotide Repeats on Human Chromosome 2

Auteurs: Garribba L, Vogel I, Lerdrup M, Gonçalves Dinis MM, Ren L, Liu Y
Publié dans: Frontiers in genetics, 2021, ISSN 1664-8021
Éditeur: Frontiers Media
DOI: 10.3389/fgene.2021.695124

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