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CORDIS - Forschungsergebnisse der EU
CORDIS

Innovative strategies for cancer prevention with focus on sex hormone signaling and chronic inflammation

Projektbeschreibung

Innovatives Ausbildungsnetzwerk für neue Präventionsstrategien gegen häufige Krebsarten

Zwei wichtige Einflussfaktoren auf das Krebsrisiko sind chronische Entzündungen und die Anzahl zirkulierender Sexualhormone. Vor mehr als 150 Jahren beobachteten Wissenschaftler in Tumoren erstmals entzündungsfördernde Zellen und das Entstehen von Tumoren an chronischen Entzündungsherden, was einen Zusammenhang nahe legt. Nach Jahren epidemiologischer Forschungen geht man davon aus, dass bis zu einem Viertel aller Krebserkrankungen auf chronische Infektionen oder andere chronische Entzündungen zurückgehen. Zudem wird ein starker Zusammenhang zwischen der Menge zirkulierender Sexualhormone und Krebserkrankungen weiblicher Geschlechtsorgane vermutet. Das Projekt CANCERPREV vermittelt Nachwuchsforschern modernste mathematische und experimentelle Techniken für neue Leitlinien zur Prävention von Krebserkrankungen an Geschlechts- und anderen Organen.

Ziel

Incidence and prevalence of many cancer types are significantly increasing worldwide, with substantial differences between the sexes. Environmental influences in concert with genetic and epigenetic factors are still poorly understood.
Simultaneously, more sophisticated and expensive treatments cannot be afforded by society, increasing urgency of efforts in cancer prevention.
CANCERPREV is an innovative interdisciplinary research and training program gathering seven academic beneficiaries and nine partner organizations : (one leading pharmaceutical company, one leading technology company, a health insurance, an internationally known nursing school, three foundations and two universities) in nine European countries. CANCERPREV aims to establish new strategies in cancer prevention, with a focus on two key determinants of cancer risk: sex hormone signaling and chronic inflammation, in breast and skin as benchmarks of early steps of cancer development in organs with reproductive and non-reproductive functions, respectively.
Fifteen Early Stage Researchers (ESRs) will benefit from the complementary expertise of participating organizations and Principal Investigators in: basic cancer research, xenografts and genetic mouse models, bioinformatics and mathematical algorithms, epidemiology / human genetics, biomarkers, pharmacological approaches, behavioral / societal issues and outreach.
This network provides ESRs with unique future career opportunities in both academic and private sectors, through research training for PhD thesis projects with secondments and short and long visits to other participating research institutions, and yearly courses / formal lectures on various aspects of cancer prevention, including global health and occupational / behavioral issues. CANCERPREV will ensure that more knowledge and ideas are converted into products and services, and that a new generation of scientists is trained to contribute to the knowledge-based economy and society.

Koordinator

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Netto-EU-Beitrag
€ 843 829,92
Adresse
BATIMENT CE 3316 STATION 1
1015 Lausanne
Schweiz

Auf der Karte ansehen

Region
Schweiz/Suisse/Svizzera Région lémanique Vaud
Aktivitätstyp
Higher or Secondary Education Establishments
Links
Gesamtkosten
€ 843 829,92

Beteiligte (6)