REcreating the ideal Niche: environmental control Of cell Identity in Regenerating and diseased muscles

Informazioni relative al progetto

RENOIR

ID dell’accordo di sovvenzione: 860034

DOI

10.3030/860034

Progetto chiuso

Data della firma CE 30 Giugno 2020

Data di avvio 1 Maggio 2020

Data di completamento 30 Aprile 2025

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 3 482 325,18

Contributo UE

€ 3 482 325,18

Coordinato da

UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA
Italy

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Websites, patent fillings, videos etc. (2)

Facebook page linked to the Website

A Facebook page linked to the Website will allow ESRs to interact more informally

RENOIR website, (intranet and public access)

A Website will be developed for the network and maintained by the Coordinator.It will be composed of 2 main sections: 1) an intranet area, accessible only to members RENOIR, used for internal communication within the network, as repository of unpublished scientific material and a discussion forum for ESR; 2) a public area that will contain information related to: research/training activities, including a section dedicated to the broad public, list and agenda of meetings, workshops, seminars and local PhD programmes, protocols employed within the network, links to press releases, links to OA data of RENOIR, link to relevant scientific and non-scientific Webpages, including the partner organization PPO and other patients organizations. A monthly newsletter will be published and sent upon subscription.

Documents, reports (7)

ESRs recruitment

The selected candidates will be approved by the Supervisory Board The respect of the formal criteria of research experience and mobility will be centrally checked by the Coordinator and Recruitment Board and will represent the preliminary condition for the admission to the selection procedure ESR recruitment will ben completed at month 6All ESR willl be assigned to one supervisor and one cosupervisorsThe recruitment procedure and how it follows art 32 of Grant Agreement the list of the recruited ESRs gender balance the list of supervisor and cosupervisors will be provided

List of YouTube tutorials

ESRs will organise Youtube tutorial addressed to the public. We will have a list of these tutorials.

Publications at least one for each ERS as first author in high impact factor OA journals (IF>5)

Given that all partners have a solid track record in terms of publications, each ESR will publish an article at least as first author in high impact factor OA journals (IF>5)

At least 3 publications in very high impact factor OA journals (IF>10)

High quality scientific journals will be targeted to disseminate the novel results. We will publish at least 3 publications in very high impact factor OA journals (IF>10)

Publication of a Wikipedia Article

A Wikipedia article on muscle regeneration and fibrosis will be prepared and published

Public advertisement of the RENOIR ESR open positions

The RB will ensure wide distribution of the advertisement at both national and international levels, including publication on Euraxess (ec.europa.eu/euraxess), EMBO, RENOIR and the beneficiaries’ websites, and through mailing lists based on the scientific collaborations of colleagues within the participant institutions

List of the courses on transferable skills organised by the consortium

The TB will supervise the organization of the Transferable skills courses together with the beneficiary responsible for them.RRI session, the Woman in Science seminar and the Open-science event during the RENOIR Opening (CBR, UNIMIB, mo.7). Business Models and Business Model Canvas Course (CHB, mo. 7, 20, 36). Oral/writing skill course (HMGB, mo. 12). EMBO Laboratory Management Course (CNR, mo. 20); Ethical and legal issues linked to the use of animal models in biomedical research (UPF, mo 31); Entrepreneurship, Exploitation, Commercialization and Translation to Clinic, that include the event “How to successfully translate research findings into clinics” (EDEN, TRDF, ITF and CHB, mo. 37).A list of all the courses organised will be provided.

Open Research Data Pilot (1)

RENOIR genomic/epigenomic data

RENOIR genomic/epigenomic data from RNA sequencing will be archived and made accessible through dedicated open access platforms, namely the Gene Expression Omnibus (GEO, https://www.ncbi.nlm.nih.gov/geo/ ) and the Sequence Read Archive (SRA, https://www.ncbi.nlm.nih.gov/sra/). Data types and formats, naming convention, data storage and backup, GDPR application to personal data, privacy and security issues will be aspects fully addressed in the DMP.

Pubblicazioni

Peer reviewed articles (12)

The acidic intrinsically disordered region of the inflammatory mediator HMGB1 mediates fuzzy interactions with CXCL12

Autori: Malisa Vittoria Mantonico, Federica De Leo, Giacomo Quilici, Liam Sean Colley, Francesco De Marchis, Massimo Crippa, Rosanna Mezzapelle, Tim Schulte, Chiara Zucchelli, Chiara Pastorello, Camilla Carmeno, Francesca Caprioglio, Stefano Ricagno, Gabriele Giachin, Michela Ghitti, Marco Emilio Bianchi, Giovanna Musco
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-45505-7

An effective method for culturing functional human corneal endothelial cells using a xenogeneic free culture medium

Autori: S. Alonso-Alonso, N. Vázquez, M. Chacón, N. Caballero-Sánchez, S. Del Olmo-Aguado, C. Suárez, B. Alfonso-Bartolozzi, L. Fernández-Vega-Cueto, L. Nagy, J. Merayo-Lloves, A. Meana
Pubblicato in: Scientific Reports, Numero 13, 2023, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-023-46590-2

Editorial: Cross-talk between heterogeneous cell types in skeletal muscle: implications for glucose metabolism

Autori: Noemí Caballero-Sánchez, Nathan Winn, Jose Cesar Rosa Neto, Laszlo Nagy
Pubblicato in: Frontiers in Endocrinology, Numero 14, 2023, ISSN 1664-2392
Editore: Frontiers Media SA
DOI: 10.3389/fendo.2023.1185725

The transcriptional control of the VEGFA-VEGFR1 (FLT1) axis in alternatively polarized murine and human macrophages

Autori: Apolka Domokos, Zsofia Varga, Karoly Jambrovics, Noemí Caballero-Sánchez, Eniko Szabo, Gergely Nagy, Beata Scholtz, Laszlo Halasz, Eszter Varadi, Krisztian P. Bene, Anett Mazlo, Attila Bacsi, Viktoria Jeney, Gabor J. Szebeni, Laszlo Nagy, Zsolt Czimmerer
Pubblicato in: Frontiers in Immunology, Numero 14, 2023, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/fimmu.2023.1168635

CRIPTO-based micro-heterogeneity of mouse muscle satellite cells enables adaptive response to regenerative microenvironment

Autori: Ombretta Guardiola, Francescopaolo Iavarone, Chiara Nicoletti, Maurizio Ventre, Cristina Rodríguez, Laura Pisapia, Gennaro Andolfi, Valentina Saccone, Eduardo J. Patriarca, Pier Lorenzo Puri, Gabriella Minchiotti
Pubblicato in: Developmental Cell, Numero 58, 2023, Pagina/e 2896-2913.e6, ISSN 1534-5807
Editore: Cell Press
DOI: 10.1016/j.devcel.2023.11.009

Design of artificial vascular devices: Hemodynamic evaluation of shear-induced thrombogenicity

Autori: Thomas Feaugas, Gwenyth Newman, Silvia Tea Calzuola, Alison Domingues, William Arditi, Constance Porrini, Emmanuel Roy, Cecile M. Perrault
Pubblicato in: Frontiers in Mechanical Engineering, Numero 9, 2023, ISSN 2297-3079
Editore: Frontiers Media SA
DOI: 10.3389/fmech.2023.1060580

Cellular interactions and microenvironment dynamics in skeletal muscle regeneration and disease

Autori: Cristina Rodríguez, Filipa Timóteo-Ferreira, Gabriella Minchiotti, Silvia Brunelli, Ombretta Guardiola
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 12, 2024, ISSN 2296-634X
Editore: Frontiers
DOI: 10.3389/fcell.2024.1385399

TNAP expressing adventitial pericytes contribute to myogenesis during foetal development

Autori: I. Fancello, S. Willett, C. Castiglioni, S. Amer, S. Santoleri, L. Bragg, F. Galli, G. Cossu
Pubblicato in: Vascular Pharmacology, Numero 159, 2025, Pagina/e 107489, ISSN 1537-1891
Editore: Elsevier BV
DOI: 10.1016/j.vph.2025.107489

Benefits and pathologies associated with the inflammatory response

Autori: Pawandeep Singh, Bénédicte Chazaud
Pubblicato in: Experimental Cell Research, 2021, ISSN 1090-2422
Editore: Elsevier
DOI: 10.1016/j.yexcr.2021.112905

Regenerative inflammation: When immune cells help to re‐build tissues

Autori: Noemí Caballero‐Sánchez, Sergio Alonso‐Alonso, Laszlo Nagy
Pubblicato in: The FEBS Journal, Numero 291, 2024, Pagina/e 1597-1614, ISSN 1742-464X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/febs.16693

CXCR4/CXCL12 Activities in the Tumor Microenvironment and Implications for Tumor Immunotherapy

Autori: Rosanna Mezzapelle, Manuela Leo, Francesca Caprioglio, Liam S. Colley, Andrea Lamarca, Lina Sabatino, Vittorio Colantuoni, Massimo P. Crippa, Marco E. Bianchi
Pubblicato in: Cancers, Numero 14, 2024, Pagina/e 2314, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14092314

STAT3 inhibition recovers regeneration of aged muscles by restoring autophagy in muscle stem cells

Autori: Giorgia Catarinella, Andrea Bracaglia, Emilia Skafida, Paola Procopio, Veronica Ruggieri, Cristina Parisi, Marco De Bardi, Giovanna Borsellino, Luca Madaro, Pier Lorenzo Puri, Alessandra Sacco, Lucia Latella
Pubblicato in: Life Science Alliance, Numero 7, 2024, Pagina/e e202302503, ISSN 2575-1077
Editore: EMBO Press
DOI: 10.26508/lsa.202302503