Nucleic Acids for Future Gene Editing, Immunotherapy and Epigenetic Sequence Modification

Project Information

NATURE-ETN

Grant agreement ID: 861381

DOI

10.3030/861381

Project closed

EC signature date 5 February 2020

Start date 1 April 2020

End date 30 September 2024

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 4 041 816,48

EU contribution

€ 4 041 816,48

Coordinated by

DUBLIN CITY UNIVERSITY
Ireland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Other (2)

Final project event

Final project event held and co-organised by the ESRs.

Training Modules

Training Modules completed.

Websites, patent fillings, videos etc. (1)

Project Website

Project Website live.

Publications

Peer reviewed articles (29)

Tethering Carbohydrates to the Vinyliminium Ligand of Antiproliferative Organometallic Diiron Complexes

Author(s): Schoch, S., Iacopini, D., Dalla Pozza, M., Di Pietro, S., Degano, I., Gasser, G., Di Bussolo, V., and Marchetti, F.
Published in: Organometallics, Issue 41, 5, 2022, Page(s) 514–526, ISSN 0276-7333
Publisher: American Chemical Society
DOI: 10.1021/acs.organomet.1c00519

Two‐Photon Polymerization: Fundamentals, Materials, and Chemical Modification Strategies

Author(s): Seán O'Halloran, Abhay Pandit, Andreas Heise, Andrew Kellett
Published in: Advanced Science, Issue 10, 2023, ISSN 2198-3844
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/advs.202204072

Mapping the DNA Damaging Effects of Polypyridyl Copper Complexes with DNA Electrochemical Biosensors

Author(s): Anna Banasiak, Nicolò Zuin Fantoni, Andrew Kellett and John Colleran
Published in: Molecules, 2022, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27030645

A Click Chemistry Approach to Targeted DNA Crosslinking with <i>cis</i>‐Platinum(II)‐Modified Triplex‐Forming Oligonucleotides

Author(s): Joseph Hennessy, Bríonna McGorman, Zara Molphy, Nicholas P. Farrell, Daniel Singleton, Tom Brown, Andrew Kellett
Published in: Angewandte Chemie International Edition, Issue 61, 2023, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202110455

Orthogonal End Labelling of Oligonucleotides through Dual Incorporation of Click‐Reactive NTP Analogues

Author(s): Eva S. Schönegger, Antony Crisp, Marco Radukic, Jonas Burmester, Thomas Frischmuth, Thomas Carell
Published in: ChemBioChem, Issue 25, 2024, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202300701

Copper(II) and silver(I)-1,10-phenanthroline-5,6-dione complexes interact with double-stranded DNA: further evidence of their apparent multi-modal activity towards Pseudomonas aeruginosa

Author(s): Galdino, A.C.M., Viganor, L., Pereira, M.M., Devereux, M., McCann, M., Branquinha, M.H., Molphy, Z., O’Carroll, S., Bain, C., Menounou, G., Kellett, A., and Dos Santos, A.L.S.
Published in: JBIC Journal of Biological Inorganic Chemistry, Issue 27, 2022, Page(s) 201–213, ISSN 0949-8257
Publisher: Springer Verlag
DOI: 10.1007/s00775-021-01922-3

Three's a crowd – stabilisation, structure, and applications of DNA triplexes

Author(s): Maria Dalla Pozza, Ahmad Abdullrahman, Christine J. Cardin, Gilles Gasser, James P. Hall
Published in: Chemical Science, Issue 13, 2024, Page(s) 10193-10215, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2sc01793h

A copper(<scp>ii</scp>) peptide helicate selectively cleaves DNA replication foci in mammalian cells

Author(s): Ana Alcalde-Ordóñez, Natalia Barreiro-Piñeiro, Bríonna McGorman, Jacobo Gómez-González, David Bouzada, Francisco Rivadulla, M. Eugenio Vázquez, Andrew Kellett, José Martínez-Costas, Miguel Vázquez López
Published in: Chemical Science, Issue 14, 2024, Page(s) 14082-14091, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3sc03303a

Chemical Synthesis of the Fluorescent, Cyclic Dinucleotides c^thGAMP

Author(s): Simon Veth, Adrian Fuchs, Dilara Özdemir, Clemens Dialer, David Jan Drexler, Fabian Knechtel, Gregor Witte, Karl‐Peter Hopfner, Thomas Carell, Evelyn Ploetz
Published in: ChemBioChem, Issue 23, 2023, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202200005

Novel Poxin Stable cGAMP‐Derivatives Are Remarkable STING Agonists

Author(s): Samuele Stazzoni, Daniel F. R. Böhmer, Fabian Hernichel, Dilara Özdemir, Aikaterini Pappa, David Drexler, Stefan Bauernfried, Gregor Witte, Mirko Wagner, Simon Veth, Karl‐Peter Hopfner, Veit Hornung, Lars M. König, Thomas Carell
Published in: Angewandte Chemie International Edition, Issue 61, 2023, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202207175

Synthesis and Structure Elucidation of Glutamyl-Queuosine

Author(s): Alexander Pichler, Markus Hillmeier, Matthias Heiss, Elsa Peev, Stylianos Xefteris, Barbara Steigenberger, Ines Thoma, Markus Müller, Marco Borsò, Axel Imhof, Thomas Carell
Published in: Journal of the American Chemical Society, Issue 145, 2023, Page(s) 25528-25532, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.3c10075

Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons

Author(s): Franziska R. Traube, Dilara Özdemir, Hanife Sahin, Constanze Scheel, Andrea F. Glück, Anna S. Geserich, Sabine Oganesian, Sarantos Kostidis, Katharina Iwan, René Rahimoff, Grazia Giorgio, Markus Müller, Fabio Spada, Martin Biel, Jürgen Cox, Martin Giera, Stylianos Michalakis & Thomas Carell
Published in: Nature communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-24353-9

Third‐Generation Sequencing of Epigenetic DNA

Author(s): Bethany Searle, Markus Müller, Thomas Carell, Andrew Kellett
Published in: Angewandte Chemie, Issue 135, 2023, ISSN 0044-8249
Publisher: Wiley-VCH
DOI: 10.1002/ange.202215704

Thiazole orange-carboplatin triplex-forming oligonucleotide (TFO) combination probes enhance targeted DNA crosslinking

Author(s): Joseph Hennessy, Piotr Klimkowski, Daniel Singleton, Alex Gibney, Malou Coche, Nicholas P. Farrell, Afaf H. El-Sagheer, Tom Brown, Andrew Kellett
Published in: RSC Medicinal Chemistry, Issue 15, 2024, Page(s) 485-491, ISSN 2632-8682
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3md00548h

Rhenium(I) Tricarbonyl Complexes of 1,10-Phenanthroline Derivatives with Unexpectedly High Cytotoxicity

Author(s): Lucy E. Enslin, Kallol Purkait, Maria Dalla Pozza, Bruno Saubamea, Pierre Mesdom, Hendrik G. Visser, Gilles Gasser, Marietjie Schutte-Smith
Published in: Inorganic Chemistry, Issue 62, 2023, Page(s) 12237-12251, ISSN 0020-1669
Publisher: American Chemical Society
DOI: 10.1021/acs.inorgchem.3c00730

Probing a Major DNA Weakness: Resolving the Groove and Sequence Selectivity of the Diimine Complex Λ‐[Ru(phen)₂phi]²⁺

Author(s): Tayler D. Prieto Otoya, Kane T. McQuaid, Joseph Hennessy, Georgia Menounou, Alex Gibney, Neil G. Paterson, David J. Cardin, Andrew Kellett, Christine J. Cardin
Published in: Angewandte Chemie International Edition, Issue 63, 2024, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202318863

Gradual evolution of a homo-<scp>l</scp>-peptide world on homo-<scp>d</scp>-configured RNA and DNA

Author(s): Ewa Węgrzyn, Ivana Mejdrová, Thomas Carell
Published in: Chemical Science, Issue 15, 2024, Page(s) 14171-14176, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4sc03384a

Click Chemistry Enables Rapid Amplification of Full-Length Reverse Transcripts for Long-Read Third Generation Sequencing

Author(s): Eva S. Schönegger, Antony Crisp, Markus Müller, Jessica Fertl, Sascha Serdjukow, Stefano Croce, Michael Kollaschinski, Thomas Carell, Thomas Frischmuth
Published in: Bioconjugate Chemistry, Issue 33, 2023, Page(s) 1789-1795, ISSN 1043-1802
Publisher: American Chemical Society
DOI: 10.1021/acs.bioconjchem.2c00353

Gene Editing with Artificial DNA Scissors

Author(s): Alex Gibney, Andrew Kellett
Published in: Chemistry – A European Journal, Issue 30, 2024, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202401621

Increasing the π-Expansive Ligands in Ruthenium(II) Polypyridyl Complexes: Synthesis, Characterization, and Biological Evaluation for Photodynamic Therapy Applications

Author(s): Maria Dalla Pozza, Pierre Mesdom, Ahmad Abdullrahman, Tayler D. Prieto Otoya, Philippe Arnoux, Céline Frochot, Germain Niogret, Bruno Saubaméa, Pierre Burckel, James P. Hall, Marcel Hollenstein, Christine J. Cardin, Gilles Gasser
Published in: Inorganic Chemistry, Issue 62, 2023, Page(s) 18510-18523, ISSN 0020-1669
Publisher: American Chemical Society
DOI: 10.1021/acs.inorgchem.3c02606

Synthesis and Biological Profiling of Quinolino-Fused 7-Deazapurine Nucleosides

Author(s): Marianne Fleuti, Tania Sanchez-Quirante, Lenka Poštová Slavětínská, Eva Tloušt'ová, Michal Tichý, Soňa Gurská, Petr Džubák, Marián Hajdúch, Michal Hocek
Published in: ACS Omega, Issue 9, 2024, Page(s) 20557-20570, ISSN 2470-1343
Publisher: ACS Publications
DOI: 10.1021/acsomega.4c02031

A prebiotically plausible scenario of an RNA–peptide world

Author(s): Müller, Felix; Escobar, Luis; Xu, Felix; Wegrzyn, Ewa; Nainyté, Milda; Amatov, Tynchtyk; Chan, Chun-Yin; Pichler, Alexander; Carell, Thomas
Published in: Nature, Issue 605, 2022, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-04676-3

Click and Cut: a click chemistry approach to developing oxidative DNA damaging agents

Author(s): Natasha McStay, Creina Slator, Vandana Singh, Alex Gibney, Fredrik Westerlund, Andrew Kellett
Published in: Nucleic Acids Research, 2021, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkab817

Supersensitive Multifluorophore RNA‐FISH for Early Virus Detection and Flow‐FISH by Using Click Chemistry

Author(s): Nada Raddaoui, Stefano Croce, Florian Geiger, Alexander Borodavka, Leonhard Möckl, Samuele Stazzoni, Bastien Viverge, Christoph Bräuchle, Thomas Frischmuth, Hanna Engelke, Thomas Carell
Published in: ChemBioChem, Issue 21, 2023, Page(s) 2214-2218, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202000081

The Plasma Membrane Purinoreceptor P2K1/DORN1 Is Essential in Stomatal Closure Evoked by Extracellular Diadenosine Tetraphosphate (Ap4A) in Arabidopsis thaliana

Author(s): Jędrzej Dobrogojski, Van Hai Nguyen, Joanna Kowalska, Sławomir Borek, Małgorzata Pietrowska-Borek
Published in: International Journal of Molecular Sciences, Issue 24, 2023, Page(s) 16688, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms242316688

Re-pairing DNA: binding of a ruthenium phi complex to a double mismatch

Author(s): Tayler D. Prieto Otoya, Kane T. McQuaid, Neil G. Paterson, David J. Cardin, Andrew Kellett, Christine J. Cardin
Published in: Chemical Science, Issue 15, 2024, Page(s) 9096-9103, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4sc01448k

Design and <i>in vitr</i> <i>o</i> anticancer assessment of a click chemistry-derived dinuclear copper artificial metallo-nuclease

Author(s): Simon Poole, Obed Akwasi Aning, Vickie McKee, Thomas Catley, Aaraby Yoheswaran Nielsen, Helge Thisgaard, Pegah Johansson, Georgia Menounou, Joseph Hennessy, Creina Slator, Alex Gibney, Alice Pyne, Bríonna McGorman, Fredrik Westerlund, Andrew Kellett
Published in: Nucleic Acids Research, Issue 53, 2025, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkae1250

A Click Chemistry‐Based Artificial Metallo‐Nuclease

Author(s): Alex Gibney, Raphael E. F. de Paiva, Vandana Singh, Robert Fox, Damien Thompson, Joseph Hennessy, Creina Slator, Christine J. McKenzie, Pegah Johansson, Vickie McKee, Fredrik Westerlund, Andrew Kellett
Published in: Angewandte Chemie, Issue 135, 2023, ISSN 0044-8249
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202305759

The beneficial effect of cyclohexyl substituent on the <i>in vitro</i> anticancer activity of diiron vinyliminium complexes

Author(s): Sara Benetti, Maria Dalla Pozza, Lorenzo Biancalana, Stefano Zacchini, Gilles Gasser, Fabio Marchetti
Published in: Dalton Transactions, Issue 52, 2024, Page(s) 5724-5741, ISSN 1477-9226
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3dt00186e