Nucleic Acids for Future Gene Editing, Immunotherapy and Epigenetic Sequence Modification

Información del proyecto

NATURE-ETN

Identificador del acuerdo de subvención: 861381

DOI

10.3030/861381

Proyecto cerrado

Fecha de la firma de la CE 5 Febrero 2020

Fecha de inicio 1 Abril 2020

Fecha de finalización 30 Septiembre 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 4 041 816,48

Aportación de la UE

€ 4 041 816,48

Coordinado por

DUBLIN CITY UNIVERSITY
Ireland

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Other (2)

Final project event

Final project event held and co-organised by the ESRs.

Training Modules

Training Modules completed.

Websites, patent fillings, videos etc. (1)

Project Website

Project Website live.

Publicaciones

Peer reviewed articles (29)

Tethering Carbohydrates to the Vinyliminium Ligand of Antiproliferative Organometallic Diiron Complexes

Autores: Schoch, S., Iacopini, D., Dalla Pozza, M., Di Pietro, S., Degano, I., Gasser, G., Di Bussolo, V., and Marchetti, F.
Publicado en: Organometallics, Edición 41, 5, 2022, Página(s) 514–526, ISSN 0276-7333
Editor: American Chemical Society
DOI: 10.1021/acs.organomet.1c00519

Two‐Photon Polymerization: Fundamentals, Materials, and Chemical Modification Strategies

Autores: Seán O'Halloran, Abhay Pandit, Andreas Heise, Andrew Kellett
Publicado en: Advanced Science, Edición 10, 2023, ISSN 2198-3844
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/advs.202204072

Mapping the DNA Damaging Effects of Polypyridyl Copper Complexes with DNA Electrochemical Biosensors

Autores: Anna Banasiak, Nicolò Zuin Fantoni, Andrew Kellett and John Colleran
Publicado en: Molecules, 2022, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27030645

A Click Chemistry Approach to Targeted DNA Crosslinking with <i>cis</i>‐Platinum(II)‐Modified Triplex‐Forming Oligonucleotides

Autores: Joseph Hennessy, Bríonna McGorman, Zara Molphy, Nicholas P. Farrell, Daniel Singleton, Tom Brown, Andrew Kellett
Publicado en: Angewandte Chemie International Edition, Edición 61, 2023, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202110455

Orthogonal End Labelling of Oligonucleotides through Dual Incorporation of Click‐Reactive NTP Analogues

Autores: Eva S. Schönegger, Antony Crisp, Marco Radukic, Jonas Burmester, Thomas Frischmuth, Thomas Carell
Publicado en: ChemBioChem, Edición 25, 2024, ISSN 1439-4227
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202300701

Copper(II) and silver(I)-1,10-phenanthroline-5,6-dione complexes interact with double-stranded DNA: further evidence of their apparent multi-modal activity towards Pseudomonas aeruginosa

Autores: Galdino, A.C.M., Viganor, L., Pereira, M.M., Devereux, M., McCann, M., Branquinha, M.H., Molphy, Z., O’Carroll, S., Bain, C., Menounou, G., Kellett, A., and Dos Santos, A.L.S.
Publicado en: JBIC Journal of Biological Inorganic Chemistry, Edición 27, 2022, Página(s) 201–213, ISSN 0949-8257
Editor: Springer Verlag
DOI: 10.1007/s00775-021-01922-3

Three's a crowd – stabilisation, structure, and applications of DNA triplexes

Autores: Maria Dalla Pozza, Ahmad Abdullrahman, Christine J. Cardin, Gilles Gasser, James P. Hall
Publicado en: Chemical Science, Edición 13, 2024, Página(s) 10193-10215, ISSN 2041-6520
Editor: Royal Society of Chemistry
DOI: 10.1039/d2sc01793h

A copper(<scp>ii</scp>) peptide helicate selectively cleaves DNA replication foci in mammalian cells

Autores: Ana Alcalde-Ordóñez, Natalia Barreiro-Piñeiro, Bríonna McGorman, Jacobo Gómez-González, David Bouzada, Francisco Rivadulla, M. Eugenio Vázquez, Andrew Kellett, José Martínez-Costas, Miguel Vázquez López
Publicado en: Chemical Science, Edición 14, 2024, Página(s) 14082-14091, ISSN 2041-6520
Editor: Royal Society of Chemistry
DOI: 10.1039/d3sc03303a

Chemical Synthesis of the Fluorescent, Cyclic Dinucleotides c^thGAMP

Autores: Simon Veth, Adrian Fuchs, Dilara Özdemir, Clemens Dialer, David Jan Drexler, Fabian Knechtel, Gregor Witte, Karl‐Peter Hopfner, Thomas Carell, Evelyn Ploetz
Publicado en: ChemBioChem, Edición 23, 2023, ISSN 1439-4227
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202200005

Novel Poxin Stable cGAMP‐Derivatives Are Remarkable STING Agonists

Autores: Samuele Stazzoni, Daniel F. R. Böhmer, Fabian Hernichel, Dilara Özdemir, Aikaterini Pappa, David Drexler, Stefan Bauernfried, Gregor Witte, Mirko Wagner, Simon Veth, Karl‐Peter Hopfner, Veit Hornung, Lars M. König, Thomas Carell
Publicado en: Angewandte Chemie International Edition, Edición 61, 2023, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202207175

Synthesis and Structure Elucidation of Glutamyl-Queuosine

Autores: Alexander Pichler, Markus Hillmeier, Matthias Heiss, Elsa Peev, Stylianos Xefteris, Barbara Steigenberger, Ines Thoma, Markus Müller, Marco Borsò, Axel Imhof, Thomas Carell
Publicado en: Journal of the American Chemical Society, Edición 145, 2023, Página(s) 25528-25532, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.3c10075

Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons

Autores: Franziska R. Traube, Dilara Özdemir, Hanife Sahin, Constanze Scheel, Andrea F. Glück, Anna S. Geserich, Sabine Oganesian, Sarantos Kostidis, Katharina Iwan, René Rahimoff, Grazia Giorgio, Markus Müller, Fabio Spada, Martin Biel, Jürgen Cox, Martin Giera, Stylianos Michalakis & Thomas Carell
Publicado en: Nature communications, 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-24353-9

Third‐Generation Sequencing of Epigenetic DNA

Autores: Bethany Searle, Markus Müller, Thomas Carell, Andrew Kellett
Publicado en: Angewandte Chemie, Edición 135, 2023, ISSN 0044-8249
Editor: Wiley-VCH
DOI: 10.1002/ange.202215704

Thiazole orange-carboplatin triplex-forming oligonucleotide (TFO) combination probes enhance targeted DNA crosslinking

Autores: Joseph Hennessy, Piotr Klimkowski, Daniel Singleton, Alex Gibney, Malou Coche, Nicholas P. Farrell, Afaf H. El-Sagheer, Tom Brown, Andrew Kellett
Publicado en: RSC Medicinal Chemistry, Edición 15, 2024, Página(s) 485-491, ISSN 2632-8682
Editor: Royal Society of Chemistry
DOI: 10.1039/d3md00548h

Rhenium(I) Tricarbonyl Complexes of 1,10-Phenanthroline Derivatives with Unexpectedly High Cytotoxicity

Autores: Lucy E. Enslin, Kallol Purkait, Maria Dalla Pozza, Bruno Saubamea, Pierre Mesdom, Hendrik G. Visser, Gilles Gasser, Marietjie Schutte-Smith
Publicado en: Inorganic Chemistry, Edición 62, 2023, Página(s) 12237-12251, ISSN 0020-1669
Editor: American Chemical Society
DOI: 10.1021/acs.inorgchem.3c00730

Probing a Major DNA Weakness: Resolving the Groove and Sequence Selectivity of the Diimine Complex Λ‐[Ru(phen)₂phi]²⁺

Autores: Tayler D. Prieto Otoya, Kane T. McQuaid, Joseph Hennessy, Georgia Menounou, Alex Gibney, Neil G. Paterson, David J. Cardin, Andrew Kellett, Christine J. Cardin
Publicado en: Angewandte Chemie International Edition, Edición 63, 2024, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202318863

Gradual evolution of a homo-<scp>l</scp>-peptide world on homo-<scp>d</scp>-configured RNA and DNA

Autores: Ewa Węgrzyn, Ivana Mejdrová, Thomas Carell
Publicado en: Chemical Science, Edición 15, 2024, Página(s) 14171-14176, ISSN 2041-6520
Editor: Royal Society of Chemistry
DOI: 10.1039/d4sc03384a

Click Chemistry Enables Rapid Amplification of Full-Length Reverse Transcripts for Long-Read Third Generation Sequencing

Autores: Eva S. Schönegger, Antony Crisp, Markus Müller, Jessica Fertl, Sascha Serdjukow, Stefano Croce, Michael Kollaschinski, Thomas Carell, Thomas Frischmuth
Publicado en: Bioconjugate Chemistry, Edición 33, 2023, Página(s) 1789-1795, ISSN 1043-1802
Editor: American Chemical Society
DOI: 10.1021/acs.bioconjchem.2c00353

Gene Editing with Artificial DNA Scissors

Autores: Alex Gibney, Andrew Kellett
Publicado en: Chemistry – A European Journal, Edición 30, 2024, ISSN 0947-6539
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202401621

Increasing the π-Expansive Ligands in Ruthenium(II) Polypyridyl Complexes: Synthesis, Characterization, and Biological Evaluation for Photodynamic Therapy Applications

Autores: Maria Dalla Pozza, Pierre Mesdom, Ahmad Abdullrahman, Tayler D. Prieto Otoya, Philippe Arnoux, Céline Frochot, Germain Niogret, Bruno Saubaméa, Pierre Burckel, James P. Hall, Marcel Hollenstein, Christine J. Cardin, Gilles Gasser
Publicado en: Inorganic Chemistry, Edición 62, 2023, Página(s) 18510-18523, ISSN 0020-1669
Editor: American Chemical Society
DOI: 10.1021/acs.inorgchem.3c02606

Synthesis and Biological Profiling of Quinolino-Fused 7-Deazapurine Nucleosides

Autores: Marianne Fleuti, Tania Sanchez-Quirante, Lenka Poštová Slavětínská, Eva Tloušt'ová, Michal Tichý, Soňa Gurská, Petr Džubák, Marián Hajdúch, Michal Hocek
Publicado en: ACS Omega, Edición 9, 2024, Página(s) 20557-20570, ISSN 2470-1343
Editor: ACS Publications
DOI: 10.1021/acsomega.4c02031

A prebiotically plausible scenario of an RNA–peptide world

Autores: Müller, Felix; Escobar, Luis; Xu, Felix; Wegrzyn, Ewa; Nainyté, Milda; Amatov, Tynchtyk; Chan, Chun-Yin; Pichler, Alexander; Carell, Thomas
Publicado en: Nature, Edición 605, 2022, ISSN 1548-7091
Editor: Nature Publishing Group
DOI: 10.1038/s41586-022-04676-3

Click and Cut: a click chemistry approach to developing oxidative DNA damaging agents

Autores: Natasha McStay, Creina Slator, Vandana Singh, Alex Gibney, Fredrik Westerlund, Andrew Kellett
Publicado en: Nucleic Acids Research, 2021, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkab817

Supersensitive Multifluorophore RNA‐FISH for Early Virus Detection and Flow‐FISH by Using Click Chemistry

Autores: Nada Raddaoui, Stefano Croce, Florian Geiger, Alexander Borodavka, Leonhard Möckl, Samuele Stazzoni, Bastien Viverge, Christoph Bräuchle, Thomas Frischmuth, Hanna Engelke, Thomas Carell
Publicado en: ChemBioChem, Edición 21, 2023, Página(s) 2214-2218, ISSN 1439-4227
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202000081

The Plasma Membrane Purinoreceptor P2K1/DORN1 Is Essential in Stomatal Closure Evoked by Extracellular Diadenosine Tetraphosphate (Ap4A) in Arabidopsis thaliana

Autores: Jędrzej Dobrogojski, Van Hai Nguyen, Joanna Kowalska, Sławomir Borek, Małgorzata Pietrowska-Borek
Publicado en: International Journal of Molecular Sciences, Edición 24, 2023, Página(s) 16688, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms242316688

Re-pairing DNA: binding of a ruthenium phi complex to a double mismatch

Autores: Tayler D. Prieto Otoya, Kane T. McQuaid, Neil G. Paterson, David J. Cardin, Andrew Kellett, Christine J. Cardin
Publicado en: Chemical Science, Edición 15, 2024, Página(s) 9096-9103, ISSN 2041-6520
Editor: Royal Society of Chemistry
DOI: 10.1039/d4sc01448k

Design and <i>in vitr</i> <i>o</i> anticancer assessment of a click chemistry-derived dinuclear copper artificial metallo-nuclease

Autores: Simon Poole, Obed Akwasi Aning, Vickie McKee, Thomas Catley, Aaraby Yoheswaran Nielsen, Helge Thisgaard, Pegah Johansson, Georgia Menounou, Joseph Hennessy, Creina Slator, Alex Gibney, Alice Pyne, Bríonna McGorman, Fredrik Westerlund, Andrew Kellett
Publicado en: Nucleic Acids Research, Edición 53, 2025, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkae1250

A Click Chemistry‐Based Artificial Metallo‐Nuclease

Autores: Alex Gibney, Raphael E. F. de Paiva, Vandana Singh, Robert Fox, Damien Thompson, Joseph Hennessy, Creina Slator, Christine J. McKenzie, Pegah Johansson, Vickie McKee, Fredrik Westerlund, Andrew Kellett
Publicado en: Angewandte Chemie, Edición 135, 2023, ISSN 0044-8249
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202305759

The beneficial effect of cyclohexyl substituent on the <i>in vitro</i> anticancer activity of diiron vinyliminium complexes

Autores: Sara Benetti, Maria Dalla Pozza, Lorenzo Biancalana, Stefano Zacchini, Gilles Gasser, Fabio Marchetti
Publicado en: Dalton Transactions, Edición 52, 2024, Página(s) 5724-5741, ISSN 1477-9226
Editor: Royal Society of Chemistry
DOI: 10.1039/d3dt00186e