Nucleic Acids for Future Gene Editing, Immunotherapy and Epigenetic Sequence Modification

Informazioni relative al progetto

NATURE-ETN

ID dell’accordo di sovvenzione: 861381

DOI

10.3030/861381

Progetto chiuso

Data della firma CE 5 Febbraio 2020

Data di avvio 1 Aprile 2020

Data di completamento 30 Settembre 2024

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 4 041 816,48

Contributo UE

€ 4 041 816,48

Coordinato da

DUBLIN CITY UNIVERSITY
Ireland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Other (2)

Final project event

Final project event held and co-organised by the ESRs.

Training Modules

Training Modules completed.

Websites, patent fillings, videos etc. (1)

Project Website

Project Website live.

Pubblicazioni

Peer reviewed articles (29)

Tethering Carbohydrates to the Vinyliminium Ligand of Antiproliferative Organometallic Diiron Complexes

Autori: Schoch, S., Iacopini, D., Dalla Pozza, M., Di Pietro, S., Degano, I., Gasser, G., Di Bussolo, V., and Marchetti, F.
Pubblicato in: Organometallics, Numero 41, 5, 2022, Pagina/e 514–526, ISSN 0276-7333
Editore: American Chemical Society
DOI: 10.1021/acs.organomet.1c00519

Two‐Photon Polymerization: Fundamentals, Materials, and Chemical Modification Strategies

Autori: Seán O'Halloran, Abhay Pandit, Andreas Heise, Andrew Kellett
Pubblicato in: Advanced Science, Numero 10, 2023, ISSN 2198-3844
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/advs.202204072

Mapping the DNA Damaging Effects of Polypyridyl Copper Complexes with DNA Electrochemical Biosensors

Autori: Anna Banasiak, Nicolò Zuin Fantoni, Andrew Kellett and John Colleran
Pubblicato in: Molecules, 2022, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27030645

A Click Chemistry Approach to Targeted DNA Crosslinking with <i>cis</i>‐Platinum(II)‐Modified Triplex‐Forming Oligonucleotides

Autori: Joseph Hennessy, Bríonna McGorman, Zara Molphy, Nicholas P. Farrell, Daniel Singleton, Tom Brown, Andrew Kellett
Pubblicato in: Angewandte Chemie International Edition, Numero 61, 2023, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202110455

Orthogonal End Labelling of Oligonucleotides through Dual Incorporation of Click‐Reactive NTP Analogues

Autori: Eva S. Schönegger, Antony Crisp, Marco Radukic, Jonas Burmester, Thomas Frischmuth, Thomas Carell
Pubblicato in: ChemBioChem, Numero 25, 2024, ISSN 1439-4227
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202300701

Copper(II) and silver(I)-1,10-phenanthroline-5,6-dione complexes interact with double-stranded DNA: further evidence of their apparent multi-modal activity towards Pseudomonas aeruginosa

Autori: Galdino, A.C.M., Viganor, L., Pereira, M.M., Devereux, M., McCann, M., Branquinha, M.H., Molphy, Z., O’Carroll, S., Bain, C., Menounou, G., Kellett, A., and Dos Santos, A.L.S.
Pubblicato in: JBIC Journal of Biological Inorganic Chemistry, Numero 27, 2022, Pagina/e 201–213, ISSN 0949-8257
Editore: Springer Verlag
DOI: 10.1007/s00775-021-01922-3

Three's a crowd – stabilisation, structure, and applications of DNA triplexes

Autori: Maria Dalla Pozza, Ahmad Abdullrahman, Christine J. Cardin, Gilles Gasser, James P. Hall
Pubblicato in: Chemical Science, Numero 13, 2024, Pagina/e 10193-10215, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/d2sc01793h

A copper(<scp>ii</scp>) peptide helicate selectively cleaves DNA replication foci in mammalian cells

Autori: Ana Alcalde-Ordóñez, Natalia Barreiro-Piñeiro, Bríonna McGorman, Jacobo Gómez-González, David Bouzada, Francisco Rivadulla, M. Eugenio Vázquez, Andrew Kellett, José Martínez-Costas, Miguel Vázquez López
Pubblicato in: Chemical Science, Numero 14, 2024, Pagina/e 14082-14091, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/d3sc03303a

Chemical Synthesis of the Fluorescent, Cyclic Dinucleotides c^thGAMP

Autori: Simon Veth, Adrian Fuchs, Dilara Özdemir, Clemens Dialer, David Jan Drexler, Fabian Knechtel, Gregor Witte, Karl‐Peter Hopfner, Thomas Carell, Evelyn Ploetz
Pubblicato in: ChemBioChem, Numero 23, 2023, ISSN 1439-4227
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202200005

Novel Poxin Stable cGAMP‐Derivatives Are Remarkable STING Agonists

Autori: Samuele Stazzoni, Daniel F. R. Böhmer, Fabian Hernichel, Dilara Özdemir, Aikaterini Pappa, David Drexler, Stefan Bauernfried, Gregor Witte, Mirko Wagner, Simon Veth, Karl‐Peter Hopfner, Veit Hornung, Lars M. König, Thomas Carell
Pubblicato in: Angewandte Chemie International Edition, Numero 61, 2023, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202207175

Synthesis and Structure Elucidation of Glutamyl-Queuosine

Autori: Alexander Pichler, Markus Hillmeier, Matthias Heiss, Elsa Peev, Stylianos Xefteris, Barbara Steigenberger, Ines Thoma, Markus Müller, Marco Borsò, Axel Imhof, Thomas Carell
Pubblicato in: Journal of the American Chemical Society, Numero 145, 2023, Pagina/e 25528-25532, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.3c10075

Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons

Autori: Franziska R. Traube, Dilara Özdemir, Hanife Sahin, Constanze Scheel, Andrea F. Glück, Anna S. Geserich, Sabine Oganesian, Sarantos Kostidis, Katharina Iwan, René Rahimoff, Grazia Giorgio, Markus Müller, Fabio Spada, Martin Biel, Jürgen Cox, Martin Giera, Stylianos Michalakis & Thomas Carell
Pubblicato in: Nature communications, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-24353-9

Third‐Generation Sequencing of Epigenetic DNA

Autori: Bethany Searle, Markus Müller, Thomas Carell, Andrew Kellett
Pubblicato in: Angewandte Chemie, Numero 135, 2023, ISSN 0044-8249
Editore: Wiley-VCH
DOI: 10.1002/ange.202215704

Thiazole orange-carboplatin triplex-forming oligonucleotide (TFO) combination probes enhance targeted DNA crosslinking

Autori: Joseph Hennessy, Piotr Klimkowski, Daniel Singleton, Alex Gibney, Malou Coche, Nicholas P. Farrell, Afaf H. El-Sagheer, Tom Brown, Andrew Kellett
Pubblicato in: RSC Medicinal Chemistry, Numero 15, 2024, Pagina/e 485-491, ISSN 2632-8682
Editore: Royal Society of Chemistry
DOI: 10.1039/d3md00548h

Rhenium(I) Tricarbonyl Complexes of 1,10-Phenanthroline Derivatives with Unexpectedly High Cytotoxicity

Autori: Lucy E. Enslin, Kallol Purkait, Maria Dalla Pozza, Bruno Saubamea, Pierre Mesdom, Hendrik G. Visser, Gilles Gasser, Marietjie Schutte-Smith
Pubblicato in: Inorganic Chemistry, Numero 62, 2023, Pagina/e 12237-12251, ISSN 0020-1669
Editore: American Chemical Society
DOI: 10.1021/acs.inorgchem.3c00730

Probing a Major DNA Weakness: Resolving the Groove and Sequence Selectivity of the Diimine Complex Λ‐[Ru(phen)₂phi]²⁺

Autori: Tayler D. Prieto Otoya, Kane T. McQuaid, Joseph Hennessy, Georgia Menounou, Alex Gibney, Neil G. Paterson, David J. Cardin, Andrew Kellett, Christine J. Cardin
Pubblicato in: Angewandte Chemie International Edition, Numero 63, 2024, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202318863

Gradual evolution of a homo-<scp>l</scp>-peptide world on homo-<scp>d</scp>-configured RNA and DNA

Autori: Ewa Węgrzyn, Ivana Mejdrová, Thomas Carell
Pubblicato in: Chemical Science, Numero 15, 2024, Pagina/e 14171-14176, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/d4sc03384a

Click Chemistry Enables Rapid Amplification of Full-Length Reverse Transcripts for Long-Read Third Generation Sequencing

Autori: Eva S. Schönegger, Antony Crisp, Markus Müller, Jessica Fertl, Sascha Serdjukow, Stefano Croce, Michael Kollaschinski, Thomas Carell, Thomas Frischmuth
Pubblicato in: Bioconjugate Chemistry, Numero 33, 2023, Pagina/e 1789-1795, ISSN 1043-1802
Editore: American Chemical Society
DOI: 10.1021/acs.bioconjchem.2c00353

Gene Editing with Artificial DNA Scissors

Autori: Alex Gibney, Andrew Kellett
Pubblicato in: Chemistry – A European Journal, Numero 30, 2024, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202401621

Increasing the π-Expansive Ligands in Ruthenium(II) Polypyridyl Complexes: Synthesis, Characterization, and Biological Evaluation for Photodynamic Therapy Applications

Autori: Maria Dalla Pozza, Pierre Mesdom, Ahmad Abdullrahman, Tayler D. Prieto Otoya, Philippe Arnoux, Céline Frochot, Germain Niogret, Bruno Saubaméa, Pierre Burckel, James P. Hall, Marcel Hollenstein, Christine J. Cardin, Gilles Gasser
Pubblicato in: Inorganic Chemistry, Numero 62, 2023, Pagina/e 18510-18523, ISSN 0020-1669
Editore: American Chemical Society
DOI: 10.1021/acs.inorgchem.3c02606

Synthesis and Biological Profiling of Quinolino-Fused 7-Deazapurine Nucleosides

Autori: Marianne Fleuti, Tania Sanchez-Quirante, Lenka Poštová Slavětínská, Eva Tloušt'ová, Michal Tichý, Soňa Gurská, Petr Džubák, Marián Hajdúch, Michal Hocek
Pubblicato in: ACS Omega, Numero 9, 2024, Pagina/e 20557-20570, ISSN 2470-1343
Editore: ACS Publications
DOI: 10.1021/acsomega.4c02031

A prebiotically plausible scenario of an RNA–peptide world

Autori: Müller, Felix; Escobar, Luis; Xu, Felix; Wegrzyn, Ewa; Nainyté, Milda; Amatov, Tynchtyk; Chan, Chun-Yin; Pichler, Alexander; Carell, Thomas
Pubblicato in: Nature, Numero 605, 2022, ISSN 1548-7091
Editore: Nature Publishing Group
DOI: 10.1038/s41586-022-04676-3

Click and Cut: a click chemistry approach to developing oxidative DNA damaging agents

Autori: Natasha McStay, Creina Slator, Vandana Singh, Alex Gibney, Fredrik Westerlund, Andrew Kellett
Pubblicato in: Nucleic Acids Research, 2021, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkab817

Supersensitive Multifluorophore RNA‐FISH for Early Virus Detection and Flow‐FISH by Using Click Chemistry

Autori: Nada Raddaoui, Stefano Croce, Florian Geiger, Alexander Borodavka, Leonhard Möckl, Samuele Stazzoni, Bastien Viverge, Christoph Bräuchle, Thomas Frischmuth, Hanna Engelke, Thomas Carell
Pubblicato in: ChemBioChem, Numero 21, 2023, Pagina/e 2214-2218, ISSN 1439-4227
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202000081

The Plasma Membrane Purinoreceptor P2K1/DORN1 Is Essential in Stomatal Closure Evoked by Extracellular Diadenosine Tetraphosphate (Ap4A) in Arabidopsis thaliana

Autori: Jędrzej Dobrogojski, Van Hai Nguyen, Joanna Kowalska, Sławomir Borek, Małgorzata Pietrowska-Borek
Pubblicato in: International Journal of Molecular Sciences, Numero 24, 2023, Pagina/e 16688, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms242316688

Re-pairing DNA: binding of a ruthenium phi complex to a double mismatch

Autori: Tayler D. Prieto Otoya, Kane T. McQuaid, Neil G. Paterson, David J. Cardin, Andrew Kellett, Christine J. Cardin
Pubblicato in: Chemical Science, Numero 15, 2024, Pagina/e 9096-9103, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/d4sc01448k

Design and <i>in vitr</i> <i>o</i> anticancer assessment of a click chemistry-derived dinuclear copper artificial metallo-nuclease

Autori: Simon Poole, Obed Akwasi Aning, Vickie McKee, Thomas Catley, Aaraby Yoheswaran Nielsen, Helge Thisgaard, Pegah Johansson, Georgia Menounou, Joseph Hennessy, Creina Slator, Alex Gibney, Alice Pyne, Bríonna McGorman, Fredrik Westerlund, Andrew Kellett
Pubblicato in: Nucleic Acids Research, Numero 53, 2025, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkae1250

A Click Chemistry‐Based Artificial Metallo‐Nuclease

Autori: Alex Gibney, Raphael E. F. de Paiva, Vandana Singh, Robert Fox, Damien Thompson, Joseph Hennessy, Creina Slator, Christine J. McKenzie, Pegah Johansson, Vickie McKee, Fredrik Westerlund, Andrew Kellett
Pubblicato in: Angewandte Chemie, Numero 135, 2023, ISSN 0044-8249
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202305759

The beneficial effect of cyclohexyl substituent on the <i>in vitro</i> anticancer activity of diiron vinyliminium complexes

Autori: Sara Benetti, Maria Dalla Pozza, Lorenzo Biancalana, Stefano Zacchini, Gilles Gasser, Fabio Marchetti
Pubblicato in: Dalton Transactions, Numero 52, 2024, Pagina/e 5724-5741, ISSN 1477-9226
Editore: Royal Society of Chemistry
DOI: 10.1039/d3dt00186e