Descrizione del progetto
La marcatura isotopica è stata rivoluzionata attraverso nuovi catalizzatori e chimica del flusso modulare
Gli isotopi sono varianti dello stesso elemento chimico, con lo stesso numero di protoni ma un diverso numero di neutroni (e peso atomico o massa molecolare). Gli isotopi non comuni possono essere sostituiti con quelli standard in molecole di interesse. La stessa quantità di protoni (ed elettroni) li rende quasi uguali a livello chimico. Quindi, le molecole contenenti gli isotopi sostituiti possono essere rilevate con metodi analitici come la spettroscopia di massa e la risonanza magnetica nucleare (RMN). FLIX sta rendendo la creazione di molecole marcate con isotopo più semplice, veloce ed efficace con nuove generazioni di catalizzatori per lo scambio di isotopi insieme alla chimica del flusso. Il successo avrà un impatto enorme su svariati campi, dalla chimica sintetica alla diagnostica biomedica alla ricerca sui materiali.
Obiettivo
FLIX is a radically new concept for the ultimate-stage chemical isotopic labeling of high added-value molecules (drugs, biologics, smart materials) with stable isotopes. It utilizes the unique properties of new generations of catalysts, which specifically and selectively exchange predetermined atoms and chemical motifs of end-use organic compounds. The ultimate outcome of the project is to devise and build a modular and adaptable flow chemistry system for the straightforward and combinable isotopic labeling of complex chemicals and biologics. The ‘FLIX machinery’ will use a combination of specialized reactor modules operating under continuous flow conditions, either in closed-loop or open systems for the on-line H/D, C-12/C-13, N-14/N-15 and methoxy group direct isotopic exchanges with an unprecedented efficacy and without any chemical alteration of the molecules.
The project’s objectives are to: 1) develop new generations of organometallic catalysts for isotopic exchange reactions; 2) screen catalysts for the isotopic exchange on a relevant portfolio of organic molecules in batch and flow chemistries and assess catalyst robustness; 3) devise and validate the ‘combinable isotope labeling’ concept; 4) design and build an adaptable multi-module machinery for combinable chemical exchange labeling.
FLIX synergistically associates the expertise and innovation potential of a mixed academic/industrial multidisciplinary consortium. The project is expected to have a multi-billion Euro positive impact on all sectors using stable isotopes in particular: 1) drug innovation, by accelerating preclinical studies, de-risking clinical trials and fostering the development of novel deuterated ‘heavy drugs’; 2) design of new tracers for diagnostic imaging with improved biological properties; 3) streamlining the production of multi-labeled complex molecules for NMR studies; 4) the development of novel isotopically-enriched materials.
Campo scientifico
Programma(i)
Invito a presentare proposte
Vedi altri progetti per questo bandoBando secondario
H2020-FETOPEN-2018-2019-2020-01
Meccanismo di finanziamento
RIA - Research and Innovation actionCoordinatore
75015 PARIS 15
Francia