Investigating the role of the inner retina in age-related macular degeneration (AMD)

Project Information

Retina Rhythm

Grant agreement ID: 864522

DOI

10.3030/864522

EC signature date 4 May 2020

Start date 1 July 2020

End date 31 March 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 999 455,00

EU contribution

€ 1 999 455,00

Coordinated by

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (32)

Matrix metalloproteinase-3 (MMP-3)–mediated gene therapy for glaucoma

Author(s): Jeffrey O’Callaghan, Conor Delaney, Merissa O’Connor, Joseph van Batenburg-Sherwood, Martin Schicht, Elke Lütjen-Drecoll, Natalie Hudson, Sorcha Ni Dhubhghaill, Peter Humphries, Chris Stanley, Annahita Keravala, Thomas Chalberg, Matthew S. Lawrence, Matthew Campbell
Published in: Science Advances, Issue 9, 2024, ISSN 2375-2548
Publisher: Science Advances
DOI: 10.1126/sciadv.adf6537

Imaging blood–brain barrier dysfunction in drug‐resistant epilepsy: A multi‐center feasibility study

Author(s): Nir Cafri, Sheida Mirloo, Daniel Zarhin, Lyna Kamintsky, Yonatan Serlin, Laith Alhadeed, Ilan Goldberg, Mark A. Maclean, Ben Whatley, Ilia Urman, Colin P. Doherty, Chris Greene, Claire Behan, Declan Brennan, Matthew Campbell, Chris Bowen, Gal Ben‐Arie, Ilan Shelef, Britta Wandschneider, Matthias Koepp, Alon Friedman, Felix Benninger
Published in: Epilepsia, Issue 66, 2025, Page(s) 195-206, ISSN 0013-9580
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/epi.18145

Eyes on glutamate in angiogenesis and barrier formation

Author(s): Yosuke Hashimoto, Matthew Campbell
Published in: Neuron, Issue 112, 2024, Page(s) 1895-1897, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2024.05.020

Vascular Expression of Permeability-Resistant Occludin Mutant Preserves Visual Function in Diabetes.

Author(s): Andreia Goncalves, Alyssa Dreffs, Cheng-Mao Lin, Sarah Sheskey, Natalie Hudson, Jason Keil, Matthew Campbell, David A Antonetti
Published in: Diabetes, 2021, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db20-1220

Blood-brain barrier disruption in Long COVID-associated cognitive impairment

Author(s): Chris Greene, Ruairi Connolly, Declan Brennan, Aoife Laffan, Eoin O'Keeffe, Lilia Zaporojan, Emma Connolly, Cliona Ni Cheallaigh, Niall Conlon, Colin Doherty, Matthew Campbell
Published in: Nature Neuroscience, 2024, ISSN 1546-1726
Publisher: Nature
DOI: 10.21203/rs.3.rs-2069710/v2

Pumilio-1 mediated translational control of claudin-5 at the blood-brain barrier

Author(s): Yosuke Hashimoto, Chris Greene, Nicole Hanley, Natalie Hudson, David Henshall, Kieron J. Sweeney, Donncha F. O’Brien, Matthew Campbell
Published in: Fluids and Barriers of the CNS, Issue 21, 2024, ISSN 2045-8118
Publisher: BioMed Central
DOI: 10.1186/s12987-024-00553-5

Fibrotic Changes to Schlemm's Canal Endothelial Cells in Glaucoma.

Author(s): Kelly RA, Perkumas KM, Campbell M, Farrar GJ, Stamer WD, Humphries P, O'Callaghan J, O'Brien CJ.
Published in: Int J Mol Sci, 2021, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22179446

S100B, GFAP, UCH-L1 and NSE as predictors of abnormalities on CT imaging following mild traumatic brain injury: a systematic review and meta-analysis of diagnostic test accuracy.

Author(s): Amoo M, Henry J, O'Halloran PJ, Brennan P, Husien MB, Campbell M, Caird J, Javadpour M, Curley GF.
Published in: Neurosurgical Review, 2021, ISSN 1437-2320
Publisher: Springer
DOI: 10.1007/s10143-021-01678-z

Microglia-Neutrophil Interactions Drive Dry AMD-like Pathology in a Mouse Model.

Author(s): Boyce M, Xin Y, Chowdhury O, Shang P, Liu H, Koontz V, Strizhakova A, Nemani M, Hose S, Zigler JS Jr, Campbell M, Sinha D, Handa JT, Kaarniranta K, Qian J, Ghosh S.
Published in: Cells, 2022, ISSN 2073-4409
Publisher: MDPI

The blood-retina barrier in health and disease

Author(s): Fionn O'Leary and Matthew Campbell
Published in: FEBS Journal, Issue Dec 18, 2021, ISSN 1742-464X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/febs.16330

Decreased CSF1R Signaling and the Accumulation of Reticular Pseudo-Drusen?

Author(s): Deirdre A Harford, Conor Delaney, Jeffrey O'Callaghan, Natalie Hudson, Ruairi Connolly, Sarah Doyle, Michael Farrell, Colin P Doherty, Mark Cahill, Matthew Campbell
Published in: OSLI Retina, Issue Dec;52(12):666-671., 2021, ISSN 2325-8160
Publisher: Slack Incorporated
DOI: 10.3928/23258160-20211101-01

The CLDN5 gene at the blood-brain barrier in health and disease

Author(s): Yosuke Hashimoto, Chris Greene, Arnold Munnich, Matthew Campbell
Published in: Fluids and Barriers of the CNS, Issue 20, 2023, ISSN 2045-8118
Publisher: BioMed Central
DOI: 10.1186/s12987-023-00424-5

Claudin-5: A Pharmacological Target to Modify the Permeability of the Blood-Brain Barrier.

Author(s): Hashimoto Y, Campbell M, Tachibana K, Okada Y, Kondoh M.
Published in: Biol Pharm Bull, 2021, ISSN 1347-5215
Publisher: J-Stage
DOI: 10.1248/bpb.b21-00408

Synergistic induction of blood-brain barrier properties

Author(s): Gergő Porkoláb, Mária Mészáros, Anikó Szecskó, Judit P. Vigh, Fruzsina R. Walter, Ricardo Figueiredo, Ildikó Kálomista, Zsófia Hoyk, Gaszton Vizsnyiczai, Ilona Gróf, Jeng-Shiung Jan, Fabien Gosselet, Melinda K. Pirity, Monika Vastag, Natalie Hudson, Matthew Campbell, Szilvia Veszelka, Mária A. Deli
Published in: PNAS, 2024, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1101/2023.02.09.527899

Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue.

Author(s): Dion-Albert L, Cadoret A, Doney E, Kaufmann FN, Dudek KA, Daigle B, Parise LF, Cathomas F, Samba N, Hudson N, Lebel M; Signature Consortium; Campbell M, Turecki G, Mechawar N, Menard C.
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-27604-x

Tight Junctions of the Neurovascular Unit

Author(s): Natalie Hudson, Matthew Campbell
Published in: Front Mol Neurosci, Issue Nov 19;14:752781, 2021, ISSN 1662-5099
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnmol.2021.752781

Methamphetamine enhances caveolar transport of therapeutic agents across the rodent blood-brain barrier

Author(s): Chang JH, Greene C, Frudd K, Araujo Dos Santos L, Futter C, Nichols BJ, Campbell M, Turowski P.
Published in: Cell Reports Medicine, 2022, ISSN 2666-3791
Publisher: Elsevier
DOI: 10.1016/j.xcrm.2021.100497

Non-canonical inflammasome activation mediates the adjuvanticity of nanoparticles

Author(s): Natalia Muñoz-Wolf , Ross W Ward, Claire H Hearnden, Fiona A Sharp, Joan Geoghegan , Katie O'Grady, Craig P McEntee, Katharine A Shanahan, Coralie Guy, Andrew G Bowie, Matthew Campbell , Carla B Roces, Giulia Anderluzzi, Cameron Webb, Yvonne Perrie, Emma Creagh, Ed C Lavelle
Published in: Cell Reports Medicine, Issue 2, 2023, ISSN 2666-3791
Publisher: Elsevier

A loss of function mutation in <i>CLDN25</i> causing Pelizaeus-Merzbacher-like leukodystrophy

Author(s): Yosuke Hashimoto, Claude Besmond, Nathalie Boddaert, Arnold Munnich, Matthew Campbell
Published in: Human Molecular Genetics, Issue 33, 2024, Page(s) 1055-1063, ISSN 0964-6906
Publisher: Oxford University Press
DOI: 10.1093/hmg/ddae038

Vascular Expression of Permeability-Resistant Occludin Mutant Preserves Visual Function in Diabetes

Author(s): Andreia Goncalves; Alyssa Dreffs; Cheng-mao Lin; Sarah Sheskey; Natalie Hudson; Jason M. Keil; Matthew Campbell; David A. Antonetti
Published in: Diabetes, Issue 1, 2022, ISSN 1939-327X
Publisher: American Diabetes Association
DOI: 10.2337/figshare.14364086

Minocycline suppresses disease-associated microglia (DAM) in a model of photoreceptor cell degeneration.

Author(s): Ozaki E, Delaney C, Campbell M, Doyle SL.
Published in: Experimental Eye Research, 2022, ISSN 0014-4835
Publisher: Academic Press
DOI: 10.1016/j.exer.2022.108953

Permeability of the Blood-Brain Barrier after Traumatic Brain Injury: Radiological Considerations.

Author(s): Amoo M, O'Halloran PJ, Henry J, Ben Husien M, Brennan P, Campbell M, Caird J, Curley GF.
Published in: Journal of Neurotrauma, 2021, ISSN 1557-9042
Publisher: Mary Ann Liebert
DOI: 10.1089/neu.2020.7545

Microvascular stabilization via blood-brain barrier regulation prevents seizure activity

Author(s): Greene C, Hanley N, Reschke CR, Reddy A, Mäe MA, Connolly R, Behan C, O'Keeffe E, Bolger I, Hudson N, Delaney C, Farrell MA, O'Brien DF, Cryan J, Brett FM, Beausang A, Betsholtz C, Henshall DC, Doherty CP, Campbell M.
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-29657-y

Concussion susceptibility is mediated by spreading depolarization-induced neurovascular dysfunction.

Author(s): Parker E, Aboghazleh R, Mumby G, Veksler R, Ofer J, Newton J, Smith R, Kamintsky L, Jones CMA, O'Keeffe E, Kelly E, Doelle K, Roach I, Yang LT, Moradi P, Lin JM, Gleason AJ, Atkinson C, Bowen C, Brewer KD, Doherty CP, Campbell M, Clarke DB, van Hameren G, Kaufer D, Friedman A.
Published in: Brain, 2022, ISSN 1460-2156
Publisher: Oxford Academic
DOI: 10.1093/brain/awab450

Reversibly Modulating the Blood-Brain Barrier by Laser Stimulation of Molecular-Targeted Nanoparticles.

Author(s): Li X, Vemireddy V, Cai Q, Xiong H, Kang P, Li X, Giannotta M, Hayenga HN, Pan E, Sirsi SR, Mateo C, Kleinfeld D, Greene C, Campbell M, Dejana E, Bachoo R, Qin Z.
Published in: Nano Letters, 2021, ISSN 1530-6984
Publisher: American Chemical Society
DOI: 10.1021/acs.nanolett.1c02996

SARM1 Promotes Photoreceptor Degeneration in an Oxidative Stress Model of Retinal Degeneration

Author(s): Luke Gibbons; Ema Ozaki; Chris Greene; Anne Trappe; Michael Carty; Judith A. Coppinger; Andrew G. Bowie; Matthew Campbell; Sarah L. Doyle
Published in: Frontiers in Neuroscience, Issue 1, 2022, ISSN 1662-453X
Publisher: Frontiers
DOI: 10.3389/fnins.2022.852114

Recurrent de novo mutations in CLDN5 induce an anion-selective blood-brain barrier and alternating hemiplegia

Author(s): Greene C, Hanley N, Reschke CR, Reddy A, Mäe MA, Connolly R, Behan C, O'Keeffe E, Bolger I, Hudson N, Delaney C, Farrell MA, O'Brien DF, Cryan J, Brett FM, Beausang A, Betsholtz C, Henshall DC, Doherty CP, Campbell M.
Published in: Brain, 2022, ISSN 1460-2156
Publisher: Oxford Academic
DOI: 10.1093/brain/awac215

Interleukin-33 regulates metabolic reprogramming of the retinal pigment epithelium in response to immune stressors.

Author(s): Scott LM, Vincent EE, Hudson N, Neal C, Jones N, Lavelle EC, Campbell M, Halestrap AP, Dick AD, Theodoropoulou S.
Published in: JCI Insight, 2021, ISSN 2379-3708
Publisher: Journal of Clinical Investigation
DOI: 10.1172/jci.insight.129429

Systemic delivery of antagomirs during blood-brain barrier disruption is disease-modifying in experimental epilepsy.

Author(s): Reschke CR, Silva LFA, Vangoor VR, Rosso M, David B, Cavanagh BL, Connolly NMC, Brennan GP, Sanz-Rodriguez A, Mooney C, Batool A, Greene C, Brennan M, Conroy RM, Rüber T, Prehn JHM, Campbell M, Pasterkamp RJ, Henshall DC.
Published in: Molecular Therapy, 2021, ISSN 1525-0016
Publisher: Nature Publishing Group
DOI: 10.1016/j.ymthe.2021.02.021

Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment

Author(s): Chris Greene, Ruairi Connolly, Declan Brennan, Aoife Laffan, Eoin O’Keeffe, Lilia Zaporojan, Jeffrey O’Callaghan, Bennett Thomson, Emma Connolly, Ruth Argue, James F. M. Meaney, Ignacio Martin-Loeches, Aideen Long, Cliona Ni Cheallaigh, Niall Conlon, Colin P. Doherty, Matthew Campbell
Published in: Nature Neuroscience, Issue 27, 2024, Page(s) 421-432, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-024-01576-9

Attenuated CSF-1R signalling drives cerebrovascular pathology

Author(s): Conor Delaney, Michael Farrell, Colin P Doherty, Kiva Brennan, Eoin O'Keeffe, Chris Greene, Kieva Byrne, Eoin Kelly Niamh Birmingham, Paula Hickey, Simon Cronin, Savvas N Savvides, Sarah L Doyle, Matthew Campbell
Published in: EMBO Molecular Medicine, Issue Feb 5;13(2):e12889, 2021, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202012889

Non-canonical inflammasome activation mediates the adjuvanticity of nanoparticles

Author(s): Natalia Muñoz-Wolf , Ross W Ward, Claire H Hearnden, Fiona A Sharp, Joan Geoghegan , Katie O'Grady, Craig P McEntee, Katharine A Shanahan, Coralie Guy, Andrew G Bowie, Matthew Campbell , Carla B Roces, Giulia Anderluzzi, Cameron Webb, Yvonne Perrie, Emma Creagh, Ed C Lavelle
Published in: Cell Reports Medicine, 2022, ISSN 2666-3791
Publisher: Elsevier

Book chapters (1)

Immunohistochemical Analysis of Tight Junction Proteins.

Author(s): Greene C, Campbell M.
Published in: Methods in Molecular Biology, 2022, Page(s) 2022;2492:307-314, ISSN 1064-3745
Publisher: Springer