Investigating the role of the inner retina in age-related macular degeneration (AMD)

Información del proyecto

Retina Rhythm

Identificador del acuerdo de subvención: 864522

DOI

10.3030/864522

Fecha de la firma de la CE 4 Mayo 2020

Fecha de inicio 1 Julio 2020

Fecha de finalización 31 Marzo 2026

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 999 455,00

Aportación de la UE

€ 1 999 455,00

Coordinado por

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (32)

Matrix metalloproteinase-3 (MMP-3)–mediated gene therapy for glaucoma

Autores: Jeffrey O’Callaghan, Conor Delaney, Merissa O’Connor, Joseph van Batenburg-Sherwood, Martin Schicht, Elke Lütjen-Drecoll, Natalie Hudson, Sorcha Ni Dhubhghaill, Peter Humphries, Chris Stanley, Annahita Keravala, Thomas Chalberg, Matthew S. Lawrence, Matthew Campbell
Publicado en: Science Advances, Edición 9, 2024, ISSN 2375-2548
Editor: Science Advances
DOI: 10.1126/sciadv.adf6537

Imaging blood–brain barrier dysfunction in drug‐resistant epilepsy: A multi‐center feasibility study

Autores: Nir Cafri, Sheida Mirloo, Daniel Zarhin, Lyna Kamintsky, Yonatan Serlin, Laith Alhadeed, Ilan Goldberg, Mark A. Maclean, Ben Whatley, Ilia Urman, Colin P. Doherty, Chris Greene, Claire Behan, Declan Brennan, Matthew Campbell, Chris Bowen, Gal Ben‐Arie, Ilan Shelef, Britta Wandschneider, Matthias Koepp, Alon Friedman, Felix Benninger
Publicado en: Epilepsia, Edición 66, 2025, Página(s) 195-206, ISSN 0013-9580
Editor: Blackwell Publishing Inc.
DOI: 10.1111/epi.18145

Eyes on glutamate in angiogenesis and barrier formation

Autores: Yosuke Hashimoto, Matthew Campbell
Publicado en: Neuron, Edición 112, 2024, Página(s) 1895-1897, ISSN 0896-6273
Editor: Cell Press
DOI: 10.1016/j.neuron.2024.05.020

Vascular Expression of Permeability-Resistant Occludin Mutant Preserves Visual Function in Diabetes.

Autores: Andreia Goncalves, Alyssa Dreffs, Cheng-Mao Lin, Sarah Sheskey, Natalie Hudson, Jason Keil, Matthew Campbell, David A Antonetti
Publicado en: Diabetes, 2021, ISSN 0012-1797
Editor: American Diabetes Association
DOI: 10.2337/db20-1220

Blood-brain barrier disruption in Long COVID-associated cognitive impairment

Autores: Chris Greene, Ruairi Connolly, Declan Brennan, Aoife Laffan, Eoin O'Keeffe, Lilia Zaporojan, Emma Connolly, Cliona Ni Cheallaigh, Niall Conlon, Colin Doherty, Matthew Campbell
Publicado en: Nature Neuroscience, 2024, ISSN 1546-1726
Editor: Nature
DOI: 10.21203/rs.3.rs-2069710/v2

Pumilio-1 mediated translational control of claudin-5 at the blood-brain barrier

Autores: Yosuke Hashimoto, Chris Greene, Nicole Hanley, Natalie Hudson, David Henshall, Kieron J. Sweeney, Donncha F. O’Brien, Matthew Campbell
Publicado en: Fluids and Barriers of the CNS, Edición 21, 2024, ISSN 2045-8118
Editor: BioMed Central
DOI: 10.1186/s12987-024-00553-5

Fibrotic Changes to Schlemm's Canal Endothelial Cells in Glaucoma.

Autores: Kelly RA, Perkumas KM, Campbell M, Farrar GJ, Stamer WD, Humphries P, O'Callaghan J, O'Brien CJ.
Publicado en: Int J Mol Sci, 2021, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22179446

S100B, GFAP, UCH-L1 and NSE as predictors of abnormalities on CT imaging following mild traumatic brain injury: a systematic review and meta-analysis of diagnostic test accuracy.

Autores: Amoo M, Henry J, O'Halloran PJ, Brennan P, Husien MB, Campbell M, Caird J, Javadpour M, Curley GF.
Publicado en: Neurosurgical Review, 2021, ISSN 1437-2320
Editor: Springer
DOI: 10.1007/s10143-021-01678-z

Microglia-Neutrophil Interactions Drive Dry AMD-like Pathology in a Mouse Model.

Autores: Boyce M, Xin Y, Chowdhury O, Shang P, Liu H, Koontz V, Strizhakova A, Nemani M, Hose S, Zigler JS Jr, Campbell M, Sinha D, Handa JT, Kaarniranta K, Qian J, Ghosh S.
Publicado en: Cells, 2022, ISSN 2073-4409
Editor: MDPI

The blood-retina barrier in health and disease

Autores: Fionn O'Leary and Matthew Campbell
Publicado en: FEBS Journal, Edición Dec 18, 2021, ISSN 1742-464X
Editor: Blackwell Publishing Inc.
DOI: 10.1111/febs.16330

Decreased CSF1R Signaling and the Accumulation of Reticular Pseudo-Drusen?

Autores: Deirdre A Harford, Conor Delaney, Jeffrey O'Callaghan, Natalie Hudson, Ruairi Connolly, Sarah Doyle, Michael Farrell, Colin P Doherty, Mark Cahill, Matthew Campbell
Publicado en: OSLI Retina, Edición Dec;52(12):666-671., 2021, ISSN 2325-8160
Editor: Slack Incorporated
DOI: 10.3928/23258160-20211101-01

The CLDN5 gene at the blood-brain barrier in health and disease

Autores: Yosuke Hashimoto, Chris Greene, Arnold Munnich, Matthew Campbell
Publicado en: Fluids and Barriers of the CNS, Edición 20, 2023, ISSN 2045-8118
Editor: BioMed Central
DOI: 10.1186/s12987-023-00424-5

Claudin-5: A Pharmacological Target to Modify the Permeability of the Blood-Brain Barrier.

Autores: Hashimoto Y, Campbell M, Tachibana K, Okada Y, Kondoh M.
Publicado en: Biol Pharm Bull, 2021, ISSN 1347-5215
Editor: J-Stage
DOI: 10.1248/bpb.b21-00408

Synergistic induction of blood-brain barrier properties

Autores: Gergő Porkoláb, Mária Mészáros, Anikó Szecskó, Judit P. Vigh, Fruzsina R. Walter, Ricardo Figueiredo, Ildikó Kálomista, Zsófia Hoyk, Gaszton Vizsnyiczai, Ilona Gróf, Jeng-Shiung Jan, Fabien Gosselet, Melinda K. Pirity, Monika Vastag, Natalie Hudson, Matthew Campbell, Szilvia Veszelka, Mária A. Deli
Publicado en: PNAS, 2024, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1101/2023.02.09.527899

Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue.

Autores: Dion-Albert L, Cadoret A, Doney E, Kaufmann FN, Dudek KA, Daigle B, Parise LF, Cathomas F, Samba N, Hudson N, Lebel M; Signature Consortium; Campbell M, Turecki G, Mechawar N, Menard C.
Publicado en: Nature Communications, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-27604-x

Tight Junctions of the Neurovascular Unit

Autores: Natalie Hudson, Matthew Campbell
Publicado en: Front Mol Neurosci, Edición Nov 19;14:752781, 2021, ISSN 1662-5099
Editor: Frontiers Research Foundation
DOI: 10.3389/fnmol.2021.752781

Methamphetamine enhances caveolar transport of therapeutic agents across the rodent blood-brain barrier

Autores: Chang JH, Greene C, Frudd K, Araujo Dos Santos L, Futter C, Nichols BJ, Campbell M, Turowski P.
Publicado en: Cell Reports Medicine, 2022, ISSN 2666-3791
Editor: Elsevier
DOI: 10.1016/j.xcrm.2021.100497

Non-canonical inflammasome activation mediates the adjuvanticity of nanoparticles

Autores: Natalia Muñoz-Wolf , Ross W Ward, Claire H Hearnden, Fiona A Sharp, Joan Geoghegan , Katie O'Grady, Craig P McEntee, Katharine A Shanahan, Coralie Guy, Andrew G Bowie, Matthew Campbell , Carla B Roces, Giulia Anderluzzi, Cameron Webb, Yvonne Perrie, Emma Creagh, Ed C Lavelle
Publicado en: Cell Reports Medicine, Edición 2, 2023, ISSN 2666-3791
Editor: Elsevier

A loss of function mutation in <i>CLDN25</i> causing Pelizaeus-Merzbacher-like leukodystrophy

Autores: Yosuke Hashimoto, Claude Besmond, Nathalie Boddaert, Arnold Munnich, Matthew Campbell
Publicado en: Human Molecular Genetics, Edición 33, 2024, Página(s) 1055-1063, ISSN 0964-6906
Editor: Oxford University Press
DOI: 10.1093/hmg/ddae038

Vascular Expression of Permeability-Resistant Occludin Mutant Preserves Visual Function in Diabetes

Autores: Andreia Goncalves; Alyssa Dreffs; Cheng-mao Lin; Sarah Sheskey; Natalie Hudson; Jason M. Keil; Matthew Campbell; David A. Antonetti
Publicado en: Diabetes, Edición 1, 2022, ISSN 1939-327X
Editor: American Diabetes Association
DOI: 10.2337/figshare.14364086

Minocycline suppresses disease-associated microglia (DAM) in a model of photoreceptor cell degeneration.

Autores: Ozaki E, Delaney C, Campbell M, Doyle SL.
Publicado en: Experimental Eye Research, 2022, ISSN 0014-4835
Editor: Academic Press
DOI: 10.1016/j.exer.2022.108953

Permeability of the Blood-Brain Barrier after Traumatic Brain Injury: Radiological Considerations.

Autores: Amoo M, O'Halloran PJ, Henry J, Ben Husien M, Brennan P, Campbell M, Caird J, Curley GF.
Publicado en: Journal of Neurotrauma, 2021, ISSN 1557-9042
Editor: Mary Ann Liebert
DOI: 10.1089/neu.2020.7545

Microvascular stabilization via blood-brain barrier regulation prevents seizure activity

Autores: Greene C, Hanley N, Reschke CR, Reddy A, Mäe MA, Connolly R, Behan C, O'Keeffe E, Bolger I, Hudson N, Delaney C, Farrell MA, O'Brien DF, Cryan J, Brett FM, Beausang A, Betsholtz C, Henshall DC, Doherty CP, Campbell M.
Publicado en: Nature Communications, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-29657-y

Concussion susceptibility is mediated by spreading depolarization-induced neurovascular dysfunction.

Autores: Parker E, Aboghazleh R, Mumby G, Veksler R, Ofer J, Newton J, Smith R, Kamintsky L, Jones CMA, O'Keeffe E, Kelly E, Doelle K, Roach I, Yang LT, Moradi P, Lin JM, Gleason AJ, Atkinson C, Bowen C, Brewer KD, Doherty CP, Campbell M, Clarke DB, van Hameren G, Kaufer D, Friedman A.
Publicado en: Brain, 2022, ISSN 1460-2156
Editor: Oxford Academic
DOI: 10.1093/brain/awab450

Reversibly Modulating the Blood-Brain Barrier by Laser Stimulation of Molecular-Targeted Nanoparticles.

Autores: Li X, Vemireddy V, Cai Q, Xiong H, Kang P, Li X, Giannotta M, Hayenga HN, Pan E, Sirsi SR, Mateo C, Kleinfeld D, Greene C, Campbell M, Dejana E, Bachoo R, Qin Z.
Publicado en: Nano Letters, 2021, ISSN 1530-6984
Editor: American Chemical Society
DOI: 10.1021/acs.nanolett.1c02996

SARM1 Promotes Photoreceptor Degeneration in an Oxidative Stress Model of Retinal Degeneration

Autores: Luke Gibbons; Ema Ozaki; Chris Greene; Anne Trappe; Michael Carty; Judith A. Coppinger; Andrew G. Bowie; Matthew Campbell; Sarah L. Doyle
Publicado en: Frontiers in Neuroscience, Edición 1, 2022, ISSN 1662-453X
Editor: Frontiers
DOI: 10.3389/fnins.2022.852114

Recurrent de novo mutations in CLDN5 induce an anion-selective blood-brain barrier and alternating hemiplegia

Autores: Greene C, Hanley N, Reschke CR, Reddy A, Mäe MA, Connolly R, Behan C, O'Keeffe E, Bolger I, Hudson N, Delaney C, Farrell MA, O'Brien DF, Cryan J, Brett FM, Beausang A, Betsholtz C, Henshall DC, Doherty CP, Campbell M.
Publicado en: Brain, 2022, ISSN 1460-2156
Editor: Oxford Academic
DOI: 10.1093/brain/awac215

Interleukin-33 regulates metabolic reprogramming of the retinal pigment epithelium in response to immune stressors.

Autores: Scott LM, Vincent EE, Hudson N, Neal C, Jones N, Lavelle EC, Campbell M, Halestrap AP, Dick AD, Theodoropoulou S.
Publicado en: JCI Insight, 2021, ISSN 2379-3708
Editor: Journal of Clinical Investigation
DOI: 10.1172/jci.insight.129429

Systemic delivery of antagomirs during blood-brain barrier disruption is disease-modifying in experimental epilepsy.

Autores: Reschke CR, Silva LFA, Vangoor VR, Rosso M, David B, Cavanagh BL, Connolly NMC, Brennan GP, Sanz-Rodriguez A, Mooney C, Batool A, Greene C, Brennan M, Conroy RM, Rüber T, Prehn JHM, Campbell M, Pasterkamp RJ, Henshall DC.
Publicado en: Molecular Therapy, 2021, ISSN 1525-0016
Editor: Nature Publishing Group
DOI: 10.1016/j.ymthe.2021.02.021

Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment

Autores: Chris Greene, Ruairi Connolly, Declan Brennan, Aoife Laffan, Eoin O’Keeffe, Lilia Zaporojan, Jeffrey O’Callaghan, Bennett Thomson, Emma Connolly, Ruth Argue, James F. M. Meaney, Ignacio Martin-Loeches, Aideen Long, Cliona Ni Cheallaigh, Niall Conlon, Colin P. Doherty, Matthew Campbell
Publicado en: Nature Neuroscience, Edición 27, 2024, Página(s) 421-432, ISSN 1097-6256
Editor: Nature Publishing Group
DOI: 10.1038/s41593-024-01576-9

Attenuated CSF-1R signalling drives cerebrovascular pathology

Autores: Conor Delaney, Michael Farrell, Colin P Doherty, Kiva Brennan, Eoin O'Keeffe, Chris Greene, Kieva Byrne, Eoin Kelly Niamh Birmingham, Paula Hickey, Simon Cronin, Savvas N Savvides, Sarah L Doyle, Matthew Campbell
Publicado en: EMBO Molecular Medicine, Edición Feb 5;13(2):e12889, 2021, ISSN 1757-4676
Editor: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202012889

Non-canonical inflammasome activation mediates the adjuvanticity of nanoparticles

Autores: Natalia Muñoz-Wolf , Ross W Ward, Claire H Hearnden, Fiona A Sharp, Joan Geoghegan , Katie O'Grady, Craig P McEntee, Katharine A Shanahan, Coralie Guy, Andrew G Bowie, Matthew Campbell , Carla B Roces, Giulia Anderluzzi, Cameron Webb, Yvonne Perrie, Emma Creagh, Ed C Lavelle
Publicado en: Cell Reports Medicine, 2022, ISSN 2666-3791
Editor: Elsevier

Book chapters (1)

Immunohistochemical Analysis of Tight Junction Proteins.

Autores: Greene C, Campbell M.
Publicado en: Methods in Molecular Biology, 2022, Página(s) 2022;2492:307-314, ISSN 1064-3745
Editor: Springer