Investigating the role of the inner retina in age-related macular degeneration (AMD)

Informazioni relative al progetto

Retina Rhythm

ID dell’accordo di sovvenzione: 864522

DOI

10.3030/864522

Data della firma CE 4 Maggio 2020

Data di avvio 1 Luglio 2020

Data di completamento 31 Marzo 2026

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 999 455,00

Contributo UE

€ 1 999 455,00

Coordinato da

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (32)

Matrix metalloproteinase-3 (MMP-3)–mediated gene therapy for glaucoma

Autori: Jeffrey O’Callaghan, Conor Delaney, Merissa O’Connor, Joseph van Batenburg-Sherwood, Martin Schicht, Elke Lütjen-Drecoll, Natalie Hudson, Sorcha Ni Dhubhghaill, Peter Humphries, Chris Stanley, Annahita Keravala, Thomas Chalberg, Matthew S. Lawrence, Matthew Campbell
Pubblicato in: Science Advances, Numero 9, 2024, ISSN 2375-2548
Editore: Science Advances
DOI: 10.1126/sciadv.adf6537

Imaging blood–brain barrier dysfunction in drug‐resistant epilepsy: A multi‐center feasibility study

Autori: Nir Cafri, Sheida Mirloo, Daniel Zarhin, Lyna Kamintsky, Yonatan Serlin, Laith Alhadeed, Ilan Goldberg, Mark A. Maclean, Ben Whatley, Ilia Urman, Colin P. Doherty, Chris Greene, Claire Behan, Declan Brennan, Matthew Campbell, Chris Bowen, Gal Ben‐Arie, Ilan Shelef, Britta Wandschneider, Matthias Koepp, Alon Friedman, Felix Benninger
Pubblicato in: Epilepsia, Numero 66, 2025, Pagina/e 195-206, ISSN 0013-9580
Editore: Blackwell Publishing Inc.
DOI: 10.1111/epi.18145

Eyes on glutamate in angiogenesis and barrier formation

Autori: Yosuke Hashimoto, Matthew Campbell
Pubblicato in: Neuron, Numero 112, 2024, Pagina/e 1895-1897, ISSN 0896-6273
Editore: Cell Press
DOI: 10.1016/j.neuron.2024.05.020

Vascular Expression of Permeability-Resistant Occludin Mutant Preserves Visual Function in Diabetes.

Autori: Andreia Goncalves, Alyssa Dreffs, Cheng-Mao Lin, Sarah Sheskey, Natalie Hudson, Jason Keil, Matthew Campbell, David A Antonetti
Pubblicato in: Diabetes, 2021, ISSN 0012-1797
Editore: American Diabetes Association
DOI: 10.2337/db20-1220

Blood-brain barrier disruption in Long COVID-associated cognitive impairment

Autori: Chris Greene, Ruairi Connolly, Declan Brennan, Aoife Laffan, Eoin O'Keeffe, Lilia Zaporojan, Emma Connolly, Cliona Ni Cheallaigh, Niall Conlon, Colin Doherty, Matthew Campbell
Pubblicato in: Nature Neuroscience, 2024, ISSN 1546-1726
Editore: Nature
DOI: 10.21203/rs.3.rs-2069710/v2

Pumilio-1 mediated translational control of claudin-5 at the blood-brain barrier

Autori: Yosuke Hashimoto, Chris Greene, Nicole Hanley, Natalie Hudson, David Henshall, Kieron J. Sweeney, Donncha F. O’Brien, Matthew Campbell
Pubblicato in: Fluids and Barriers of the CNS, Numero 21, 2024, ISSN 2045-8118
Editore: BioMed Central
DOI: 10.1186/s12987-024-00553-5

Fibrotic Changes to Schlemm's Canal Endothelial Cells in Glaucoma.

Autori: Kelly RA, Perkumas KM, Campbell M, Farrar GJ, Stamer WD, Humphries P, O'Callaghan J, O'Brien CJ.
Pubblicato in: Int J Mol Sci, 2021, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22179446

S100B, GFAP, UCH-L1 and NSE as predictors of abnormalities on CT imaging following mild traumatic brain injury: a systematic review and meta-analysis of diagnostic test accuracy.

Autori: Amoo M, Henry J, O'Halloran PJ, Brennan P, Husien MB, Campbell M, Caird J, Javadpour M, Curley GF.
Pubblicato in: Neurosurgical Review, 2021, ISSN 1437-2320
Editore: Springer
DOI: 10.1007/s10143-021-01678-z

Microglia-Neutrophil Interactions Drive Dry AMD-like Pathology in a Mouse Model.

Autori: Boyce M, Xin Y, Chowdhury O, Shang P, Liu H, Koontz V, Strizhakova A, Nemani M, Hose S, Zigler JS Jr, Campbell M, Sinha D, Handa JT, Kaarniranta K, Qian J, Ghosh S.
Pubblicato in: Cells, 2022, ISSN 2073-4409
Editore: MDPI

The blood-retina barrier in health and disease

Autori: Fionn O'Leary and Matthew Campbell
Pubblicato in: FEBS Journal, Numero Dec 18, 2021, ISSN 1742-464X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/febs.16330

Decreased CSF1R Signaling and the Accumulation of Reticular Pseudo-Drusen?

Autori: Deirdre A Harford, Conor Delaney, Jeffrey O'Callaghan, Natalie Hudson, Ruairi Connolly, Sarah Doyle, Michael Farrell, Colin P Doherty, Mark Cahill, Matthew Campbell
Pubblicato in: OSLI Retina, Numero Dec;52(12):666-671., 2021, ISSN 2325-8160
Editore: Slack Incorporated
DOI: 10.3928/23258160-20211101-01

The CLDN5 gene at the blood-brain barrier in health and disease

Autori: Yosuke Hashimoto, Chris Greene, Arnold Munnich, Matthew Campbell
Pubblicato in: Fluids and Barriers of the CNS, Numero 20, 2023, ISSN 2045-8118
Editore: BioMed Central
DOI: 10.1186/s12987-023-00424-5

Claudin-5: A Pharmacological Target to Modify the Permeability of the Blood-Brain Barrier.

Autori: Hashimoto Y, Campbell M, Tachibana K, Okada Y, Kondoh M.
Pubblicato in: Biol Pharm Bull, 2021, ISSN 1347-5215
Editore: J-Stage
DOI: 10.1248/bpb.b21-00408

Synergistic induction of blood-brain barrier properties

Autori: Gergő Porkoláb, Mária Mészáros, Anikó Szecskó, Judit P. Vigh, Fruzsina R. Walter, Ricardo Figueiredo, Ildikó Kálomista, Zsófia Hoyk, Gaszton Vizsnyiczai, Ilona Gróf, Jeng-Shiung Jan, Fabien Gosselet, Melinda K. Pirity, Monika Vastag, Natalie Hudson, Matthew Campbell, Szilvia Veszelka, Mária A. Deli
Pubblicato in: PNAS, 2024, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1101/2023.02.09.527899

Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue.

Autori: Dion-Albert L, Cadoret A, Doney E, Kaufmann FN, Dudek KA, Daigle B, Parise LF, Cathomas F, Samba N, Hudson N, Lebel M; Signature Consortium; Campbell M, Turecki G, Mechawar N, Menard C.
Pubblicato in: Nature Communications, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-27604-x

Tight Junctions of the Neurovascular Unit

Autori: Natalie Hudson, Matthew Campbell
Pubblicato in: Front Mol Neurosci, Numero Nov 19;14:752781, 2021, ISSN 1662-5099
Editore: Frontiers Research Foundation
DOI: 10.3389/fnmol.2021.752781

Methamphetamine enhances caveolar transport of therapeutic agents across the rodent blood-brain barrier

Autori: Chang JH, Greene C, Frudd K, Araujo Dos Santos L, Futter C, Nichols BJ, Campbell M, Turowski P.
Pubblicato in: Cell Reports Medicine, 2022, ISSN 2666-3791
Editore: Elsevier
DOI: 10.1016/j.xcrm.2021.100497

Non-canonical inflammasome activation mediates the adjuvanticity of nanoparticles

Autori: Natalia Muñoz-Wolf , Ross W Ward, Claire H Hearnden, Fiona A Sharp, Joan Geoghegan , Katie O'Grady, Craig P McEntee, Katharine A Shanahan, Coralie Guy, Andrew G Bowie, Matthew Campbell , Carla B Roces, Giulia Anderluzzi, Cameron Webb, Yvonne Perrie, Emma Creagh, Ed C Lavelle
Pubblicato in: Cell Reports Medicine, Numero 2, 2023, ISSN 2666-3791
Editore: Elsevier

A loss of function mutation in <i>CLDN25</i> causing Pelizaeus-Merzbacher-like leukodystrophy

Autori: Yosuke Hashimoto, Claude Besmond, Nathalie Boddaert, Arnold Munnich, Matthew Campbell
Pubblicato in: Human Molecular Genetics, Numero 33, 2024, Pagina/e 1055-1063, ISSN 0964-6906
Editore: Oxford University Press
DOI: 10.1093/hmg/ddae038

Vascular Expression of Permeability-Resistant Occludin Mutant Preserves Visual Function in Diabetes

Autori: Andreia Goncalves; Alyssa Dreffs; Cheng-mao Lin; Sarah Sheskey; Natalie Hudson; Jason M. Keil; Matthew Campbell; David A. Antonetti
Pubblicato in: Diabetes, Numero 1, 2022, ISSN 1939-327X
Editore: American Diabetes Association
DOI: 10.2337/figshare.14364086

Minocycline suppresses disease-associated microglia (DAM) in a model of photoreceptor cell degeneration.

Autori: Ozaki E, Delaney C, Campbell M, Doyle SL.
Pubblicato in: Experimental Eye Research, 2022, ISSN 0014-4835
Editore: Academic Press
DOI: 10.1016/j.exer.2022.108953

Permeability of the Blood-Brain Barrier after Traumatic Brain Injury: Radiological Considerations.

Autori: Amoo M, O'Halloran PJ, Henry J, Ben Husien M, Brennan P, Campbell M, Caird J, Curley GF.
Pubblicato in: Journal of Neurotrauma, 2021, ISSN 1557-9042
Editore: Mary Ann Liebert
DOI: 10.1089/neu.2020.7545

Microvascular stabilization via blood-brain barrier regulation prevents seizure activity

Autori: Greene C, Hanley N, Reschke CR, Reddy A, Mäe MA, Connolly R, Behan C, O'Keeffe E, Bolger I, Hudson N, Delaney C, Farrell MA, O'Brien DF, Cryan J, Brett FM, Beausang A, Betsholtz C, Henshall DC, Doherty CP, Campbell M.
Pubblicato in: Nature Communications, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-29657-y

Concussion susceptibility is mediated by spreading depolarization-induced neurovascular dysfunction.

Autori: Parker E, Aboghazleh R, Mumby G, Veksler R, Ofer J, Newton J, Smith R, Kamintsky L, Jones CMA, O'Keeffe E, Kelly E, Doelle K, Roach I, Yang LT, Moradi P, Lin JM, Gleason AJ, Atkinson C, Bowen C, Brewer KD, Doherty CP, Campbell M, Clarke DB, van Hameren G, Kaufer D, Friedman A.
Pubblicato in: Brain, 2022, ISSN 1460-2156
Editore: Oxford Academic
DOI: 10.1093/brain/awab450

Reversibly Modulating the Blood-Brain Barrier by Laser Stimulation of Molecular-Targeted Nanoparticles.

Autori: Li X, Vemireddy V, Cai Q, Xiong H, Kang P, Li X, Giannotta M, Hayenga HN, Pan E, Sirsi SR, Mateo C, Kleinfeld D, Greene C, Campbell M, Dejana E, Bachoo R, Qin Z.
Pubblicato in: Nano Letters, 2021, ISSN 1530-6984
Editore: American Chemical Society
DOI: 10.1021/acs.nanolett.1c02996

SARM1 Promotes Photoreceptor Degeneration in an Oxidative Stress Model of Retinal Degeneration

Autori: Luke Gibbons; Ema Ozaki; Chris Greene; Anne Trappe; Michael Carty; Judith A. Coppinger; Andrew G. Bowie; Matthew Campbell; Sarah L. Doyle
Pubblicato in: Frontiers in Neuroscience, Numero 1, 2022, ISSN 1662-453X
Editore: Frontiers
DOI: 10.3389/fnins.2022.852114

Recurrent de novo mutations in CLDN5 induce an anion-selective blood-brain barrier and alternating hemiplegia

Autori: Greene C, Hanley N, Reschke CR, Reddy A, Mäe MA, Connolly R, Behan C, O'Keeffe E, Bolger I, Hudson N, Delaney C, Farrell MA, O'Brien DF, Cryan J, Brett FM, Beausang A, Betsholtz C, Henshall DC, Doherty CP, Campbell M.
Pubblicato in: Brain, 2022, ISSN 1460-2156
Editore: Oxford Academic
DOI: 10.1093/brain/awac215

Interleukin-33 regulates metabolic reprogramming of the retinal pigment epithelium in response to immune stressors.

Autori: Scott LM, Vincent EE, Hudson N, Neal C, Jones N, Lavelle EC, Campbell M, Halestrap AP, Dick AD, Theodoropoulou S.
Pubblicato in: JCI Insight, 2021, ISSN 2379-3708
Editore: Journal of Clinical Investigation
DOI: 10.1172/jci.insight.129429

Systemic delivery of antagomirs during blood-brain barrier disruption is disease-modifying in experimental epilepsy.

Autori: Reschke CR, Silva LFA, Vangoor VR, Rosso M, David B, Cavanagh BL, Connolly NMC, Brennan GP, Sanz-Rodriguez A, Mooney C, Batool A, Greene C, Brennan M, Conroy RM, Rüber T, Prehn JHM, Campbell M, Pasterkamp RJ, Henshall DC.
Pubblicato in: Molecular Therapy, 2021, ISSN 1525-0016
Editore: Nature Publishing Group
DOI: 10.1016/j.ymthe.2021.02.021

Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment

Autori: Chris Greene, Ruairi Connolly, Declan Brennan, Aoife Laffan, Eoin O’Keeffe, Lilia Zaporojan, Jeffrey O’Callaghan, Bennett Thomson, Emma Connolly, Ruth Argue, James F. M. Meaney, Ignacio Martin-Loeches, Aideen Long, Cliona Ni Cheallaigh, Niall Conlon, Colin P. Doherty, Matthew Campbell
Pubblicato in: Nature Neuroscience, Numero 27, 2024, Pagina/e 421-432, ISSN 1097-6256
Editore: Nature Publishing Group
DOI: 10.1038/s41593-024-01576-9

Attenuated CSF-1R signalling drives cerebrovascular pathology

Autori: Conor Delaney, Michael Farrell, Colin P Doherty, Kiva Brennan, Eoin O'Keeffe, Chris Greene, Kieva Byrne, Eoin Kelly Niamh Birmingham, Paula Hickey, Simon Cronin, Savvas N Savvides, Sarah L Doyle, Matthew Campbell
Pubblicato in: EMBO Molecular Medicine, Numero Feb 5;13(2):e12889, 2021, ISSN 1757-4676
Editore: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202012889

Non-canonical inflammasome activation mediates the adjuvanticity of nanoparticles

Autori: Natalia Muñoz-Wolf , Ross W Ward, Claire H Hearnden, Fiona A Sharp, Joan Geoghegan , Katie O'Grady, Craig P McEntee, Katharine A Shanahan, Coralie Guy, Andrew G Bowie, Matthew Campbell , Carla B Roces, Giulia Anderluzzi, Cameron Webb, Yvonne Perrie, Emma Creagh, Ed C Lavelle
Pubblicato in: Cell Reports Medicine, 2022, ISSN 2666-3791
Editore: Elsevier

Book chapters (1)

Immunohistochemical Analysis of Tight Junction Proteins.

Autori: Greene C, Campbell M.
Pubblicato in: Methods in Molecular Biology, 2022, Pagina/e 2022;2492:307-314, ISSN 1064-3745
Editore: Springer