Investigating the role of the inner retina in age-related macular degeneration (AMD)

Informacje na temat projektu

Retina Rhythm

Identyfikator umowy o grant: 864522

DOI

10.3030/864522

Data podpisania przez KE 4 Maja 2020

Data rozpoczęcia 1 Lipca 2020

Data zakończenia 31 Marca 2026

Finansowanie w ramach

• EXCELLENT SCIENCE - European Research Council (ERC)

Koszt całkowity

€ 1 999 455,00

Wkład UE

€ 1 999 455,00

Koordynowany przez

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Publikacje

Peer reviewed articles (32)

Matrix metalloproteinase-3 (MMP-3)–mediated gene therapy for glaucoma

Autorzy: Jeffrey O’Callaghan, Conor Delaney, Merissa O’Connor, Joseph van Batenburg-Sherwood, Martin Schicht, Elke Lütjen-Drecoll, Natalie Hudson, Sorcha Ni Dhubhghaill, Peter Humphries, Chris Stanley, Annahita Keravala, Thomas Chalberg, Matthew S. Lawrence, Matthew Campbell
Opublikowane w: Science Advances, Numer 9, 2024, ISSN 2375-2548
Wydawca: Science Advances
DOI: 10.1126/sciadv.adf6537

Imaging blood–brain barrier dysfunction in drug‐resistant epilepsy: A multi‐center feasibility study

Autorzy: Nir Cafri, Sheida Mirloo, Daniel Zarhin, Lyna Kamintsky, Yonatan Serlin, Laith Alhadeed, Ilan Goldberg, Mark A. Maclean, Ben Whatley, Ilia Urman, Colin P. Doherty, Chris Greene, Claire Behan, Declan Brennan, Matthew Campbell, Chris Bowen, Gal Ben‐Arie, Ilan Shelef, Britta Wandschneider, Matthias Koepp, Alon Friedman, Felix Benninger
Opublikowane w: Epilepsia, Numer 66, 2025, Strona(/y) 195-206, ISSN 0013-9580
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/epi.18145

Eyes on glutamate in angiogenesis and barrier formation

Autorzy: Yosuke Hashimoto, Matthew Campbell
Opublikowane w: Neuron, Numer 112, 2024, Strona(/y) 1895-1897, ISSN 0896-6273
Wydawca: Cell Press
DOI: 10.1016/j.neuron.2024.05.020

Vascular Expression of Permeability-Resistant Occludin Mutant Preserves Visual Function in Diabetes.

Autorzy: Andreia Goncalves, Alyssa Dreffs, Cheng-Mao Lin, Sarah Sheskey, Natalie Hudson, Jason Keil, Matthew Campbell, David A Antonetti
Opublikowane w: Diabetes, 2021, ISSN 0012-1797
Wydawca: American Diabetes Association
DOI: 10.2337/db20-1220

Blood-brain barrier disruption in Long COVID-associated cognitive impairment

Autorzy: Chris Greene, Ruairi Connolly, Declan Brennan, Aoife Laffan, Eoin O'Keeffe, Lilia Zaporojan, Emma Connolly, Cliona Ni Cheallaigh, Niall Conlon, Colin Doherty, Matthew Campbell
Opublikowane w: Nature Neuroscience, 2024, ISSN 1546-1726
Wydawca: Nature
DOI: 10.21203/rs.3.rs-2069710/v2

Pumilio-1 mediated translational control of claudin-5 at the blood-brain barrier

Autorzy: Yosuke Hashimoto, Chris Greene, Nicole Hanley, Natalie Hudson, David Henshall, Kieron J. Sweeney, Donncha F. O’Brien, Matthew Campbell
Opublikowane w: Fluids and Barriers of the CNS, Numer 21, 2024, ISSN 2045-8118
Wydawca: BioMed Central
DOI: 10.1186/s12987-024-00553-5

Fibrotic Changes to Schlemm's Canal Endothelial Cells in Glaucoma.

Autorzy: Kelly RA, Perkumas KM, Campbell M, Farrar GJ, Stamer WD, Humphries P, O'Callaghan J, O'Brien CJ.
Opublikowane w: Int J Mol Sci, 2021, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22179446

S100B, GFAP, UCH-L1 and NSE as predictors of abnormalities on CT imaging following mild traumatic brain injury: a systematic review and meta-analysis of diagnostic test accuracy.

Autorzy: Amoo M, Henry J, O'Halloran PJ, Brennan P, Husien MB, Campbell M, Caird J, Javadpour M, Curley GF.
Opublikowane w: Neurosurgical Review, 2021, ISSN 1437-2320
Wydawca: Springer
DOI: 10.1007/s10143-021-01678-z

Microglia-Neutrophil Interactions Drive Dry AMD-like Pathology in a Mouse Model.

Autorzy: Boyce M, Xin Y, Chowdhury O, Shang P, Liu H, Koontz V, Strizhakova A, Nemani M, Hose S, Zigler JS Jr, Campbell M, Sinha D, Handa JT, Kaarniranta K, Qian J, Ghosh S.
Opublikowane w: Cells, 2022, ISSN 2073-4409
Wydawca: MDPI

The blood-retina barrier in health and disease

Autorzy: Fionn O'Leary and Matthew Campbell
Opublikowane w: FEBS Journal, Numer Dec 18, 2021, ISSN 1742-464X
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/febs.16330

Decreased CSF1R Signaling and the Accumulation of Reticular Pseudo-Drusen?

Autorzy: Deirdre A Harford, Conor Delaney, Jeffrey O'Callaghan, Natalie Hudson, Ruairi Connolly, Sarah Doyle, Michael Farrell, Colin P Doherty, Mark Cahill, Matthew Campbell
Opublikowane w: OSLI Retina, Numer Dec;52(12):666-671., 2021, ISSN 2325-8160
Wydawca: Slack Incorporated
DOI: 10.3928/23258160-20211101-01

The CLDN5 gene at the blood-brain barrier in health and disease

Autorzy: Yosuke Hashimoto, Chris Greene, Arnold Munnich, Matthew Campbell
Opublikowane w: Fluids and Barriers of the CNS, Numer 20, 2023, ISSN 2045-8118
Wydawca: BioMed Central
DOI: 10.1186/s12987-023-00424-5

Claudin-5: A Pharmacological Target to Modify the Permeability of the Blood-Brain Barrier.

Autorzy: Hashimoto Y, Campbell M, Tachibana K, Okada Y, Kondoh M.
Opublikowane w: Biol Pharm Bull, 2021, ISSN 1347-5215
Wydawca: J-Stage
DOI: 10.1248/bpb.b21-00408

Synergistic induction of blood-brain barrier properties

Autorzy: Gergő Porkoláb, Mária Mészáros, Anikó Szecskó, Judit P. Vigh, Fruzsina R. Walter, Ricardo Figueiredo, Ildikó Kálomista, Zsófia Hoyk, Gaszton Vizsnyiczai, Ilona Gróf, Jeng-Shiung Jan, Fabien Gosselet, Melinda K. Pirity, Monika Vastag, Natalie Hudson, Matthew Campbell, Szilvia Veszelka, Mária A. Deli
Opublikowane w: PNAS, 2024, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.1101/2023.02.09.527899

Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue.

Autorzy: Dion-Albert L, Cadoret A, Doney E, Kaufmann FN, Dudek KA, Daigle B, Parise LF, Cathomas F, Samba N, Hudson N, Lebel M; Signature Consortium; Campbell M, Turecki G, Mechawar N, Menard C.
Opublikowane w: Nature Communications, 2022, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-021-27604-x

Tight Junctions of the Neurovascular Unit

Autorzy: Natalie Hudson, Matthew Campbell
Opublikowane w: Front Mol Neurosci, Numer Nov 19;14:752781, 2021, ISSN 1662-5099
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fnmol.2021.752781

Methamphetamine enhances caveolar transport of therapeutic agents across the rodent blood-brain barrier

Autorzy: Chang JH, Greene C, Frudd K, Araujo Dos Santos L, Futter C, Nichols BJ, Campbell M, Turowski P.
Opublikowane w: Cell Reports Medicine, 2022, ISSN 2666-3791
Wydawca: Elsevier
DOI: 10.1016/j.xcrm.2021.100497

Non-canonical inflammasome activation mediates the adjuvanticity of nanoparticles

Autorzy: Natalia Muñoz-Wolf , Ross W Ward, Claire H Hearnden, Fiona A Sharp, Joan Geoghegan , Katie O'Grady, Craig P McEntee, Katharine A Shanahan, Coralie Guy, Andrew G Bowie, Matthew Campbell , Carla B Roces, Giulia Anderluzzi, Cameron Webb, Yvonne Perrie, Emma Creagh, Ed C Lavelle
Opublikowane w: Cell Reports Medicine, Numer 2, 2023, ISSN 2666-3791
Wydawca: Elsevier

A loss of function mutation in <i>CLDN25</i> causing Pelizaeus-Merzbacher-like leukodystrophy

Autorzy: Yosuke Hashimoto, Claude Besmond, Nathalie Boddaert, Arnold Munnich, Matthew Campbell
Opublikowane w: Human Molecular Genetics, Numer 33, 2024, Strona(/y) 1055-1063, ISSN 0964-6906
Wydawca: Oxford University Press
DOI: 10.1093/hmg/ddae038

Vascular Expression of Permeability-Resistant Occludin Mutant Preserves Visual Function in Diabetes

Autorzy: Andreia Goncalves; Alyssa Dreffs; Cheng-mao Lin; Sarah Sheskey; Natalie Hudson; Jason M. Keil; Matthew Campbell; David A. Antonetti
Opublikowane w: Diabetes, Numer 1, 2022, ISSN 1939-327X
Wydawca: American Diabetes Association
DOI: 10.2337/figshare.14364086

Minocycline suppresses disease-associated microglia (DAM) in a model of photoreceptor cell degeneration.

Autorzy: Ozaki E, Delaney C, Campbell M, Doyle SL.
Opublikowane w: Experimental Eye Research, 2022, ISSN 0014-4835
Wydawca: Academic Press
DOI: 10.1016/j.exer.2022.108953

Permeability of the Blood-Brain Barrier after Traumatic Brain Injury: Radiological Considerations.

Autorzy: Amoo M, O'Halloran PJ, Henry J, Ben Husien M, Brennan P, Campbell M, Caird J, Curley GF.
Opublikowane w: Journal of Neurotrauma, 2021, ISSN 1557-9042
Wydawca: Mary Ann Liebert
DOI: 10.1089/neu.2020.7545

Microvascular stabilization via blood-brain barrier regulation prevents seizure activity

Autorzy: Greene C, Hanley N, Reschke CR, Reddy A, Mäe MA, Connolly R, Behan C, O'Keeffe E, Bolger I, Hudson N, Delaney C, Farrell MA, O'Brien DF, Cryan J, Brett FM, Beausang A, Betsholtz C, Henshall DC, Doherty CP, Campbell M.
Opublikowane w: Nature Communications, 2022, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-022-29657-y

Concussion susceptibility is mediated by spreading depolarization-induced neurovascular dysfunction.

Autorzy: Parker E, Aboghazleh R, Mumby G, Veksler R, Ofer J, Newton J, Smith R, Kamintsky L, Jones CMA, O'Keeffe E, Kelly E, Doelle K, Roach I, Yang LT, Moradi P, Lin JM, Gleason AJ, Atkinson C, Bowen C, Brewer KD, Doherty CP, Campbell M, Clarke DB, van Hameren G, Kaufer D, Friedman A.
Opublikowane w: Brain, 2022, ISSN 1460-2156
Wydawca: Oxford Academic
DOI: 10.1093/brain/awab450

Reversibly Modulating the Blood-Brain Barrier by Laser Stimulation of Molecular-Targeted Nanoparticles.

Autorzy: Li X, Vemireddy V, Cai Q, Xiong H, Kang P, Li X, Giannotta M, Hayenga HN, Pan E, Sirsi SR, Mateo C, Kleinfeld D, Greene C, Campbell M, Dejana E, Bachoo R, Qin Z.
Opublikowane w: Nano Letters, 2021, ISSN 1530-6984
Wydawca: American Chemical Society
DOI: 10.1021/acs.nanolett.1c02996

SARM1 Promotes Photoreceptor Degeneration in an Oxidative Stress Model of Retinal Degeneration

Autorzy: Luke Gibbons; Ema Ozaki; Chris Greene; Anne Trappe; Michael Carty; Judith A. Coppinger; Andrew G. Bowie; Matthew Campbell; Sarah L. Doyle
Opublikowane w: Frontiers in Neuroscience, Numer 1, 2022, ISSN 1662-453X
Wydawca: Frontiers
DOI: 10.3389/fnins.2022.852114

Recurrent de novo mutations in CLDN5 induce an anion-selective blood-brain barrier and alternating hemiplegia

Autorzy: Greene C, Hanley N, Reschke CR, Reddy A, Mäe MA, Connolly R, Behan C, O'Keeffe E, Bolger I, Hudson N, Delaney C, Farrell MA, O'Brien DF, Cryan J, Brett FM, Beausang A, Betsholtz C, Henshall DC, Doherty CP, Campbell M.
Opublikowane w: Brain, 2022, ISSN 1460-2156
Wydawca: Oxford Academic
DOI: 10.1093/brain/awac215

Interleukin-33 regulates metabolic reprogramming of the retinal pigment epithelium in response to immune stressors.

Autorzy: Scott LM, Vincent EE, Hudson N, Neal C, Jones N, Lavelle EC, Campbell M, Halestrap AP, Dick AD, Theodoropoulou S.
Opublikowane w: JCI Insight, 2021, ISSN 2379-3708
Wydawca: Journal of Clinical Investigation
DOI: 10.1172/jci.insight.129429

Systemic delivery of antagomirs during blood-brain barrier disruption is disease-modifying in experimental epilepsy.

Autorzy: Reschke CR, Silva LFA, Vangoor VR, Rosso M, David B, Cavanagh BL, Connolly NMC, Brennan GP, Sanz-Rodriguez A, Mooney C, Batool A, Greene C, Brennan M, Conroy RM, Rüber T, Prehn JHM, Campbell M, Pasterkamp RJ, Henshall DC.
Opublikowane w: Molecular Therapy, 2021, ISSN 1525-0016
Wydawca: Nature Publishing Group
DOI: 10.1016/j.ymthe.2021.02.021

Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment

Autorzy: Chris Greene, Ruairi Connolly, Declan Brennan, Aoife Laffan, Eoin O’Keeffe, Lilia Zaporojan, Jeffrey O’Callaghan, Bennett Thomson, Emma Connolly, Ruth Argue, James F. M. Meaney, Ignacio Martin-Loeches, Aideen Long, Cliona Ni Cheallaigh, Niall Conlon, Colin P. Doherty, Matthew Campbell
Opublikowane w: Nature Neuroscience, Numer 27, 2024, Strona(/y) 421-432, ISSN 1097-6256
Wydawca: Nature Publishing Group
DOI: 10.1038/s41593-024-01576-9

Attenuated CSF-1R signalling drives cerebrovascular pathology

Autorzy: Conor Delaney, Michael Farrell, Colin P Doherty, Kiva Brennan, Eoin O'Keeffe, Chris Greene, Kieva Byrne, Eoin Kelly Niamh Birmingham, Paula Hickey, Simon Cronin, Savvas N Savvides, Sarah L Doyle, Matthew Campbell
Opublikowane w: EMBO Molecular Medicine, Numer Feb 5;13(2):e12889, 2021, ISSN 1757-4676
Wydawca: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202012889

Non-canonical inflammasome activation mediates the adjuvanticity of nanoparticles

Autorzy: Natalia Muñoz-Wolf , Ross W Ward, Claire H Hearnden, Fiona A Sharp, Joan Geoghegan , Katie O'Grady, Craig P McEntee, Katharine A Shanahan, Coralie Guy, Andrew G Bowie, Matthew Campbell , Carla B Roces, Giulia Anderluzzi, Cameron Webb, Yvonne Perrie, Emma Creagh, Ed C Lavelle
Opublikowane w: Cell Reports Medicine, 2022, ISSN 2666-3791
Wydawca: Elsevier

Book chapters (1)

Immunohistochemical Analysis of Tight Junction Proteins.

Autorzy: Greene C, Campbell M.
Opublikowane w: Methods in Molecular Biology, 2022, Strona(/y) 2022;2492:307-314, ISSN 1064-3745
Wydawca: Springer