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Revealing the contribution of liver macrophage populations to NASH in insulin resistance

Project description

Role of liver macrophages in the development of non-alcoholic steatohepatitis

Non-alcoholic steatohepatitis (NASH) is the most common chronic liver disease worldwide with debilitating consequences for patients and a lack of approved therapies. Obesity-associated insulin resistance represents a high-risk factor for the development of NASH. The current explanation for NASH development involves lipid accumulation in the liver of obese patients leading to oxidative stress and increased production of inflammatory cytokines by liver macrophages (LMs). The working hypothesis of the EU-funded MacinNASH project is that LMs predispose insulin-resistant patients to NASH independently of their inflammatory status. The multidisciplinary project will use multiple single-cell and in situ omics technologies tailored to identify genes and pathways involved in the development of NASH in obese insulin-resistant patients.

Host institution

KAROLINSKA INSTITUTET
Net EU contribution
€ 1 999 781,00
Address
Nobels Vag 5
17177 Stockholm
Sweden

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Beneficiaries (1)

KAROLINSKA INSTITUTET
Sweden
Net EU contribution
€ 1 999 781,00
Address
Nobels Vag 5
17177 Stockholm

See on map

Region
Östra Sverige Stockholm Stockholms län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00