Role of liver macrophages in the development of non-alcoholic steatohepatitis
Non-alcoholic steatohepatitis (NASH) is the most common chronic liver disease worldwide with debilitating consequences for patients and a lack of approved therapies. Obesity-associated insulin resistance represents a high-risk factor for the development of NASH. The current explanation for NASH development involves lipid accumulation in the liver of obese patients leading to oxidative stress and increased production of inflammatory cytokines by liver macrophages (LMs). The working hypothesis of the EU-funded MacinNASH project is that LMs predispose insulin-resistant patients to NASH independently of their inflammatory status. The multidisciplinary project will use multiple single-cell and in situ omics technologies tailored to identify genes and pathways involved in the development of NASH in obese insulin-resistant patients.
Fields of science
Funding SchemeERC-COG - Consolidator Grant
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