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Targeting leukaemia by modulating hematopoietic stem cell competitiveness

Project description

Targeting leukemic stem cells

Acute myeloid leukemia (AML) remains a devastating disease with less than 30 % of patients surviving five years after diagnosis. The resistance of AML is driven by small subpopulations of leukemic stem cells (LSCs), which survive chemotherapy and elude immune surveillance. LSCs have growth advantages induced by oncogenic mutations but are in many ways similar to healthy hematopoietic stem cells (HSCs). LSCs are located in protective bone marrow niches promoting stemness and therapy resistance and modify these to displace HSCs for their own expansion. The EU-funded Hemstem project explores strategies to target LSCs based on the knowledge of the complex interactions between LSCs and HSCs and provides a rationale for novel treatments.

Host institution

EBERHARD KARLS UNIVERSITAET TUEBINGEN
Net EU contribution
€ 1 739 846,25
Address
Geschwister-scholl-platz
72074 Tuebingen
Germany

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Region
Baden-Württemberg Tübingen Tübingen, Landkreis
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Beneficiaries (3)

EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
Net EU contribution
€ 1 739 846,25
Address
Geschwister-scholl-platz
72074 Tuebingen

See on map

Region
Baden-Württemberg Tübingen Tübingen, Landkreis
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
UNIVERSITAT BASEL

Participation ended

Switzerland
Net EU contribution
€ 59 155,00
Address
Petersplatz 1
4051 Basel
Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

UNIVERSITATSSPITAL BASEL

Participation ended

Switzerland
Net EU contribution
€ 185 238,75
Address
Hebelstrasse 32
4031 Basel
Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 0,00