Advanced Multimodal Photonics Laser Imaging Tool for Urothelial Diagnosis in Endoscopy

Información del proyecto

AMPLITUDE

Identificador del acuerdo de subvención: 871277

DOI

10.3030/871277

Proyecto cerrado

Fecha de la firma de la CE 6 Diciembre 2019

Fecha de inicio 1 Enero 2020

Fecha de finalización 31 Diciembre 2024

Financiado con arreglo a

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT)

Coste total

€ 4 656 750,00

Aportación de la UE

€ 4 486 750,00

Coordinado por

TAMPEREEN KORKEAKOULUSAATIO SR
Finland

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (5)

Multi-modal imaging at deep penetration depths in the 3rd bio-window with 850nm AF using one primary laser source

A de-scanned configuration (passing also through a confocal pinhole) will be used form measuring the elastic scattered light. A non-descanned configuration will be used to measure either the THG or the SHG signal from the sample. Importantly, the three signals will be generated simultaneously, and therefore, perfectly overlapping. The collected data will give the information about best laser output parameters (wavelength, output power, repetition rate, peak power).

Imaging of bladder cancer metabolic biomarkers using TPEF, ThPEF and Raman

Results of preliminary imaging of bladder cancer using standalone Raman, TPEF and ThPEF techniques using the first iteration of the laser prototypes.

Proof of principal imaging through an endoscopic probe

Results showing high resolution and quality multimodal nonlinear imaging within a large and deep scanning area.

Imaging bladder cancer cells in the 3rd bio-window

Report on the use of the 1700nm laser for imaging BC cells in the 3rd bio-window and at large penetration depths (elastic scattering, THG, SHG, TPEF, ThPEF)

Metabolomic and transcriptomic analysis of preclinical models of bladder cancer

Metabolic profile obtained by integrating fluorescence and Raman analysis, metabolomics and transcriptomics data, using mathematical models trained by co-cultures results, will be used to create a scoring algorithm able to assess the metabolic-based aggressiveness or rate of tumour progression profile relevant for diagnostic purpose.

Demonstrators, pilots, prototypes (1)

Endoscopic multi-modal imaging showcase workshop at UNIFI

Workshop with clinicians and relevant stakeholders to demonstrate and discuss the developed diagnostic solutions.

Websites, patent fillings, videos etc. (1)

Promotional video

Video presentation of the AMPLITUDE project

Publicaciones

Peer reviewed articles (19)

Systems metabolomics: from metabolomic snapshots to design principles

Autores: Chiara Damiani, Daniela Gaglio, Elena Sacco, Lilia Alberghina, Marco Vanoni
Publicado en: Current Opinion in Biotechnology, Edición 63, 2020, Página(s) 190-199, ISSN 0958-1669
Editor: Elsevier BV
DOI: 10.1016/j.copbio.2020.02.013

A review of label-free photonics-based techniques for cancer detection in the digestive and urinary systems

Autores: G Castro-Olvera, E Baria, D Stoliarov, S Morselli, B Orlandini, M Vanoni, H Sayinc, A Koviarov, D Galiakhmetova, J Dickie, R Cicchi, S Serni, M Gacci, M J Ribal, F S Pavone, P Loza-Alvarez, E Rafailov, R Gumenyuk
Publicado en: Journal of Physics: Photonics, Edición 7, 2024, Página(s) 012002, ISSN 2515-7647
Editor: IOP Publishing Ltd
DOI: 10.1088/2515-7647/ad8613

Cell-type-specific inhibition of the dendritic plateau potential in striatal spiny projection neurons

Autores: Kai Du, Yu-Wei Wu, Robert Lindroos, Yu Liu, Balázs Rózsa, Gergely Katona, Jun B. Ding, and Jeanette Hellgren Kotaleski
Publicado en: Proceedings of the National Academy of Sciences of the United States of America (PNAS), 2017, ISSN 1091-6490
Editor: National Academy of Science
DOI: 10.1073/pnas.1704893114

An Optimized Workflow for the Analysis of Metabolic Fluxes in Cancer Spheroids Using Seahorse Technology

Autores: Gloria Campioni, Valentina Pasquale, Stefano Busti, Giacomo Ducci, Elena Sacco, Marco Vanoni
Publicado en: Cells, Edición 11/5, 2022, Página(s) 866, ISSN 2073-4409
Editor: MDPI Publishing
DOI: 10.3390/cells11050866

Tumor heterogeneity: preclinical models, emerging technologies, and future applications

Autores: Marco Proietto, Martina Crippa, Chiara Damiani, Valentina Pasquale, Elena Sacco, Marco Vanoni, Mara Gilardi
Publicado en: Frontiers in Oncology, Edición 13, 2023, ISSN 2234-943X
Editor: Frontiers Media S. A.
DOI: 10.3389/fonc.2023.1164535

Soft, Thiol-ene/Acrylate-Based Electrode Array for Long-Term Recording of Intracranial EEG Signals with ImprovedBiocompatibility in Mice

Autores: Flóra Zsófia Fedor, Miklós Madarász, Anita Zátonyi, Ágnes Szabó, Tibor Lőrincz, Vindhya Danda, Lisa Spurgin, Connie Manz, Balázs Rózsa, Zoltán Fekete
Publicado en: Advanced Materials Technologies, 2021, ISSN 2365-709X
Editor: John Wiley & Sons Inc.
DOI: 10.1002/admt.202100942

Advanced multimodal laser imaging tool for urothelial carcinoma diagnosis (AMPLITUDE)

Autores: Sergey Kurilchik, Mauro Gacci, Riccardo Cicchi, Francesco S Pavone, Simone Morselli, Sergio Serni, MH Chou, Mikko Närhi, Edik Rafailov, Neil Stewart, Cordelia Lennon, Regina Gumenyuk
Publicado en: Journal of Physics: Photonics, Edición 2/2, 2020, Página(s) 021001, ISSN 2515-7647
Editor: IOP Publishing
DOI: 10.1088/2515-7647/ab7bab

Transient dynamics in mode-locked all-PM Er-doped fiber laser with NALM

Autores: D. Stoliarov, I. Kudelin, A. Koviarov, E. Rafailov
Publicado en: Optics Communications, Edición 547, 2023, Página(s) 129852, ISSN 0030-4018
Editor: Elsevier BV
DOI: 10.1016/j.optcom.2023.129852

Dendrite-Specific Amplification of Weak Synaptic Input during Network Activity In Vivo

Autores: Leiron Ferrarese, Jean-Sebastien Jouhanneau, Michiel W.H. Remme, Jens Kremkow, Gergely Katona, Balázs Rózsa, Susanne Schreiber, James F.A. Poulet
Publicado en: Cell Reports, 2018, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2018.08.088

Sharp-wave ripple doublets induce complex dendritic spikes in parvalbumin interneurons in vivo

Autores: Linda Judák, Balázs Chiovini, Gábor Juhász, Dénes Pálfi, Zsolt Mezriczky, Zoltán Szadai, Gergely Katona, Benedek Szmola, Katalin Ócsai, Bernadett Martinecz, Anna Mihály, Ádám Dénes, Bálint Kerekes, Áron Szepesi, Gergely Szalay, István Ulbert, Zoltán Mucsi, Botond Roska & Balázs Rózsa
Publicado en: Nature Communications, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-34520-1

Three‐Photon Infrared Stimulation of Endogenous Neuroreceptors in Vivo

Autores: Rosalba Sortino, Marina Cunquero, Gustavo Castro‐Olvera, Ricard Gelabert, Miquel Moreno, Fabio Riefolo, Carlo Matera, Noèlia Fernàndez‐Castillo, Luca Agnetta, Michael Decker, José M. Lluch, Jordi Hernando, Pablo Loza‐Alvarez, Pau Gorostiza
Publicado en: Angewandte Chemie, Edición 135, 2024, ISSN 0044-8249
Editor: Wiley-VCH GmbH
DOI: 10.1002/ange.202311181

Transparent Thiol-ene/Acrylate-Based MicroECoG DevicesUsed for Concurrent Recording of Fluorescent CalciumSignals and Electrophysiology in Awake Animals

Autores: Ágnes Szabó, Miklós Madarász, Zsófia Lantos, Anita Zátonyi, Vindhya Danda, Lisa Spurgin, Connie Manz, Balázs Rózsa, Zoltán Fekete
Publicado en: Advanced Materials Interfaces, 2022, ISSN 2196-7350
Editor: John Wiley & Sons Inc.
DOI: 10.1002/admi.202200729

Presynaptic NMDARs cooperate with local spikes toward GABA release from the reciprocal olfactory bulb granule cell spine

Autores: Vanessa Lage-Rupprecht, Li Zhou, Gaia Bianchini, S Sara Aghvami, Max Mueller, Balázs Rózsa, Marco Sassoè-Pognetto, Veronica Egger
Publicado en: eLife, 2020, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.63737

Dysplasia and tumor discrimination in brain tissues by combined fluorescence, Raman, and diffuse reflectance spectroscopies

Autores: Enrico Baria; Flavio Giordano; Renzo Guerrini; Chiara Caporalini; Anna Maria Buccoliero; Riccardo Cicchi; Francesco Saverio Pavone
Publicado en: Biomedical Optics Express, Edición 7, 2023, ISSN 2156-7085
Editor: The Optical Society
DOI: 10.1364/boe.477035

Cortex-wide response mode of VIP-expressing inhibitory neurons by reward and punishment

Autores: Zoltán Szadai, Hyun-Jae Pi, Quentin Chevy, Katalin Ócsai, Dinu F Albeanu, Balázs Chiovini, Gergely Szalay, Gergely Katona, Adam Kepecs
Publicado en: eLife, 2022, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.78815

Wavelength-Tunable Chirped Pulse Amplification System (1720 nm–1800 nm) Based on Thulium-Doped Fiber

Autores: Xinyang Liu, Regina Gumenyuk
Publicado en: Photonics, Edición 11, 2024, Página(s) 439, ISSN 2304-6732
Editor: MDPI AG
DOI: 10.3390/photonics11050439

Profiling and Targeting of Energy and Redox Metabolism in Grade 2 Bladder Cancer Cells with Different Invasiveness Properties

Autores: Valentina Pasquale, Giacomo Ducci, Gloria Campioni, Adria Ventrici, Chiara Assalini, Stefano Busti, Marco Vanoni, Riccardo Vago, Elena Sacco
Publicado en: Cells, Edición 9/12, 2020, Página(s) 2669, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells9122669

Tunable dissipative soliton Tm-doped fiber laser operating from 1700 nm to 1900 nm

Autores: Xinyang Liu; Jayanta K. Sahu; Regina Gumenyuk
Publicado en: Optics Letters, Edición 48, 2023, Página(s) 612-615, ISSN 0146-9592
Editor: Optical Society of America
DOI: 10.1364/ol.478838

Large-Scale 3D Two-Photon Imaging of Molecularly Identified CA1 Interneuron Dynamics in Behaving Mice.

Autores: Tristan Geiller; Bert Vancura; Satoshi Terada; Eirini Troullinou; Eirini Troullinou; Spyridon Chavlis; Grigorios Tsagkatakis; Panagiotis Tsakalides; Panagiotis Tsakalides; Katalin Ócsai; Panayiota Poirazi; Balázs Rózsa; Attila Losonczy
Publicado en: Neuron, Edición 1, 2020, Página(s) 968–983, ISSN 0896-6273
Editor: Cell Press
DOI: 10.1016/j.neuron.2020.09.013

Book chapters (1)

Multimodal SWIR Laser Imaging for Assessment and Detection of Urothelial Carcinomas

Autores: Gustavo Castro-Olvera, Simone Morselli, Mauro Gacci, Sergio Serni, Andrea Liaci, Rossella Nicoletti, Pablo Loza-Alvarez
Publicado en: Short-Wavelength Infrared Windows for Biomedical Applications, 2021, ISBN 9781510646230
Editor: SPIE
DOI: 10.1117/3.2604326.ch8