Advanced Multimodal Photonics Laser Imaging Tool for Urothelial Diagnosis in Endoscopy

Informazioni relative al progetto

AMPLITUDE

ID dell’accordo di sovvenzione: 871277

DOI

10.3030/871277

Progetto chiuso

Data della firma CE 6 Dicembre 2019

Data di avvio 1 Gennaio 2020

Data di completamento 31 Dicembre 2024

Finanziato da

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT)

Costo totale

€ 4 656 750,00

Contributo UE

€ 4 486 750,00

Coordinato da

TAMPEREEN KORKEAKOULUSAATIO SR
Finland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (5)

Multi-modal imaging at deep penetration depths in the 3rd bio-window with 850nm AF using one primary laser source

A de-scanned configuration (passing also through a confocal pinhole) will be used form measuring the elastic scattered light. A non-descanned configuration will be used to measure either the THG or the SHG signal from the sample. Importantly, the three signals will be generated simultaneously, and therefore, perfectly overlapping. The collected data will give the information about best laser output parameters (wavelength, output power, repetition rate, peak power).

Imaging of bladder cancer metabolic biomarkers using TPEF, ThPEF and Raman

Results of preliminary imaging of bladder cancer using standalone Raman, TPEF and ThPEF techniques using the first iteration of the laser prototypes.

Proof of principal imaging through an endoscopic probe

Results showing high resolution and quality multimodal nonlinear imaging within a large and deep scanning area.

Imaging bladder cancer cells in the 3rd bio-window

Report on the use of the 1700nm laser for imaging BC cells in the 3rd bio-window and at large penetration depths (elastic scattering, THG, SHG, TPEF, ThPEF)

Metabolomic and transcriptomic analysis of preclinical models of bladder cancer

Metabolic profile obtained by integrating fluorescence and Raman analysis, metabolomics and transcriptomics data, using mathematical models trained by co-cultures results, will be used to create a scoring algorithm able to assess the metabolic-based aggressiveness or rate of tumour progression profile relevant for diagnostic purpose.

Demonstrators, pilots, prototypes (1)

Endoscopic multi-modal imaging showcase workshop at UNIFI

Workshop with clinicians and relevant stakeholders to demonstrate and discuss the developed diagnostic solutions.

Websites, patent fillings, videos etc. (1)

Promotional video

Video presentation of the AMPLITUDE project

Pubblicazioni

Peer reviewed articles (19)

Systems metabolomics: from metabolomic snapshots to design principles

Autori: Chiara Damiani, Daniela Gaglio, Elena Sacco, Lilia Alberghina, Marco Vanoni
Pubblicato in: Current Opinion in Biotechnology, Numero 63, 2020, Pagina/e 190-199, ISSN 0958-1669
Editore: Elsevier BV
DOI: 10.1016/j.copbio.2020.02.013

A review of label-free photonics-based techniques for cancer detection in the digestive and urinary systems

Autori: G Castro-Olvera, E Baria, D Stoliarov, S Morselli, B Orlandini, M Vanoni, H Sayinc, A Koviarov, D Galiakhmetova, J Dickie, R Cicchi, S Serni, M Gacci, M J Ribal, F S Pavone, P Loza-Alvarez, E Rafailov, R Gumenyuk
Pubblicato in: Journal of Physics: Photonics, Numero 7, 2024, Pagina/e 012002, ISSN 2515-7647
Editore: IOP Publishing Ltd
DOI: 10.1088/2515-7647/ad8613

Cell-type-specific inhibition of the dendritic plateau potential in striatal spiny projection neurons

Autori: Kai Du, Yu-Wei Wu, Robert Lindroos, Yu Liu, Balázs Rózsa, Gergely Katona, Jun B. Ding, and Jeanette Hellgren Kotaleski
Pubblicato in: Proceedings of the National Academy of Sciences of the United States of America (PNAS), 2017, ISSN 1091-6490
Editore: National Academy of Science
DOI: 10.1073/pnas.1704893114

An Optimized Workflow for the Analysis of Metabolic Fluxes in Cancer Spheroids Using Seahorse Technology

Autori: Gloria Campioni, Valentina Pasquale, Stefano Busti, Giacomo Ducci, Elena Sacco, Marco Vanoni
Pubblicato in: Cells, Numero 11/5, 2022, Pagina/e 866, ISSN 2073-4409
Editore: MDPI Publishing
DOI: 10.3390/cells11050866

Tumor heterogeneity: preclinical models, emerging technologies, and future applications

Autori: Marco Proietto, Martina Crippa, Chiara Damiani, Valentina Pasquale, Elena Sacco, Marco Vanoni, Mara Gilardi
Pubblicato in: Frontiers in Oncology, Numero 13, 2023, ISSN 2234-943X
Editore: Frontiers Media S. A.
DOI: 10.3389/fonc.2023.1164535

Soft, Thiol-ene/Acrylate-Based Electrode Array for Long-Term Recording of Intracranial EEG Signals with ImprovedBiocompatibility in Mice

Autori: Flóra Zsófia Fedor, Miklós Madarász, Anita Zátonyi, Ágnes Szabó, Tibor Lőrincz, Vindhya Danda, Lisa Spurgin, Connie Manz, Balázs Rózsa, Zoltán Fekete
Pubblicato in: Advanced Materials Technologies, 2021, ISSN 2365-709X
Editore: John Wiley & Sons Inc.
DOI: 10.1002/admt.202100942

Advanced multimodal laser imaging tool for urothelial carcinoma diagnosis (AMPLITUDE)

Autori: Sergey Kurilchik, Mauro Gacci, Riccardo Cicchi, Francesco S Pavone, Simone Morselli, Sergio Serni, MH Chou, Mikko Närhi, Edik Rafailov, Neil Stewart, Cordelia Lennon, Regina Gumenyuk
Pubblicato in: Journal of Physics: Photonics, Numero 2/2, 2020, Pagina/e 021001, ISSN 2515-7647
Editore: IOP Publishing
DOI: 10.1088/2515-7647/ab7bab

Transient dynamics in mode-locked all-PM Er-doped fiber laser with NALM

Autori: D. Stoliarov, I. Kudelin, A. Koviarov, E. Rafailov
Pubblicato in: Optics Communications, Numero 547, 2023, Pagina/e 129852, ISSN 0030-4018
Editore: Elsevier BV
DOI: 10.1016/j.optcom.2023.129852

Dendrite-Specific Amplification of Weak Synaptic Input during Network Activity In Vivo

Autori: Leiron Ferrarese, Jean-Sebastien Jouhanneau, Michiel W.H. Remme, Jens Kremkow, Gergely Katona, Balázs Rózsa, Susanne Schreiber, James F.A. Poulet
Pubblicato in: Cell Reports, 2018, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2018.08.088

Sharp-wave ripple doublets induce complex dendritic spikes in parvalbumin interneurons in vivo

Autori: Linda Judák, Balázs Chiovini, Gábor Juhász, Dénes Pálfi, Zsolt Mezriczky, Zoltán Szadai, Gergely Katona, Benedek Szmola, Katalin Ócsai, Bernadett Martinecz, Anna Mihály, Ádám Dénes, Bálint Kerekes, Áron Szepesi, Gergely Szalay, István Ulbert, Zoltán Mucsi, Botond Roska & Balázs Rózsa
Pubblicato in: Nature Communications, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-34520-1

Three‐Photon Infrared Stimulation of Endogenous Neuroreceptors in Vivo

Autori: Rosalba Sortino, Marina Cunquero, Gustavo Castro‐Olvera, Ricard Gelabert, Miquel Moreno, Fabio Riefolo, Carlo Matera, Noèlia Fernàndez‐Castillo, Luca Agnetta, Michael Decker, José M. Lluch, Jordi Hernando, Pablo Loza‐Alvarez, Pau Gorostiza
Pubblicato in: Angewandte Chemie, Numero 135, 2024, ISSN 0044-8249
Editore: Wiley-VCH GmbH
DOI: 10.1002/ange.202311181

Transparent Thiol-ene/Acrylate-Based MicroECoG DevicesUsed for Concurrent Recording of Fluorescent CalciumSignals and Electrophysiology in Awake Animals

Autori: Ágnes Szabó, Miklós Madarász, Zsófia Lantos, Anita Zátonyi, Vindhya Danda, Lisa Spurgin, Connie Manz, Balázs Rózsa, Zoltán Fekete
Pubblicato in: Advanced Materials Interfaces, 2022, ISSN 2196-7350
Editore: John Wiley & Sons Inc.
DOI: 10.1002/admi.202200729

Presynaptic NMDARs cooperate with local spikes toward GABA release from the reciprocal olfactory bulb granule cell spine

Autori: Vanessa Lage-Rupprecht, Li Zhou, Gaia Bianchini, S Sara Aghvami, Max Mueller, Balázs Rózsa, Marco Sassoè-Pognetto, Veronica Egger
Pubblicato in: eLife, 2020, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.63737

Dysplasia and tumor discrimination in brain tissues by combined fluorescence, Raman, and diffuse reflectance spectroscopies

Autori: Enrico Baria; Flavio Giordano; Renzo Guerrini; Chiara Caporalini; Anna Maria Buccoliero; Riccardo Cicchi; Francesco Saverio Pavone
Pubblicato in: Biomedical Optics Express, Numero 7, 2023, ISSN 2156-7085
Editore: The Optical Society
DOI: 10.1364/boe.477035

Cortex-wide response mode of VIP-expressing inhibitory neurons by reward and punishment

Autori: Zoltán Szadai, Hyun-Jae Pi, Quentin Chevy, Katalin Ócsai, Dinu F Albeanu, Balázs Chiovini, Gergely Szalay, Gergely Katona, Adam Kepecs
Pubblicato in: eLife, 2022, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.78815

Wavelength-Tunable Chirped Pulse Amplification System (1720 nm–1800 nm) Based on Thulium-Doped Fiber

Autori: Xinyang Liu, Regina Gumenyuk
Pubblicato in: Photonics, Numero 11, 2024, Pagina/e 439, ISSN 2304-6732
Editore: MDPI AG
DOI: 10.3390/photonics11050439

Profiling and Targeting of Energy and Redox Metabolism in Grade 2 Bladder Cancer Cells with Different Invasiveness Properties

Autori: Valentina Pasquale, Giacomo Ducci, Gloria Campioni, Adria Ventrici, Chiara Assalini, Stefano Busti, Marco Vanoni, Riccardo Vago, Elena Sacco
Pubblicato in: Cells, Numero 9/12, 2020, Pagina/e 2669, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells9122669

Tunable dissipative soliton Tm-doped fiber laser operating from 1700 nm to 1900 nm

Autori: Xinyang Liu; Jayanta K. Sahu; Regina Gumenyuk
Pubblicato in: Optics Letters, Numero 48, 2023, Pagina/e 612-615, ISSN 0146-9592
Editore: Optical Society of America
DOI: 10.1364/ol.478838

Large-Scale 3D Two-Photon Imaging of Molecularly Identified CA1 Interneuron Dynamics in Behaving Mice.

Autori: Tristan Geiller; Bert Vancura; Satoshi Terada; Eirini Troullinou; Eirini Troullinou; Spyridon Chavlis; Grigorios Tsagkatakis; Panagiotis Tsakalides; Panagiotis Tsakalides; Katalin Ócsai; Panayiota Poirazi; Balázs Rózsa; Attila Losonczy
Pubblicato in: Neuron, Numero 1, 2020, Pagina/e 968–983, ISSN 0896-6273
Editore: Cell Press
DOI: 10.1016/j.neuron.2020.09.013

Book chapters (1)

Multimodal SWIR Laser Imaging for Assessment and Detection of Urothelial Carcinomas

Autori: Gustavo Castro-Olvera, Simone Morselli, Mauro Gacci, Sergio Serni, Andrea Liaci, Rossella Nicoletti, Pablo Loza-Alvarez
Pubblicato in: Short-Wavelength Infrared Windows for Biomedical Applications, 2021, ISBN 9781510646230
Editore: SPIE
DOI: 10.1117/3.2604326.ch8