Advanced Multimodal Photonics Laser Imaging Tool for Urothelial Diagnosis in Endoscopy

Informations projet

AMPLITUDE

N° de convention de subvention: 871277

DOI

10.3030/871277

Projet clôturé

Date de signature de la CE 6 Decembre 2019

Date de début 1 Janvier 2020

Date de fin 31 Decembre 2024

Financé au titre de

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT)

Coût total

€ 4 656 750,00

Contribution de l’UE

€ 4 486 750,00

Coordonné par

TAMPEREEN KORKEAKOULUSAATIO SR
Finland

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (5)

Multi-modal imaging at deep penetration depths in the 3rd bio-window with 850nm AF using one primary laser source

A de-scanned configuration (passing also through a confocal pinhole) will be used form measuring the elastic scattered light. A non-descanned configuration will be used to measure either the THG or the SHG signal from the sample. Importantly, the three signals will be generated simultaneously, and therefore, perfectly overlapping. The collected data will give the information about best laser output parameters (wavelength, output power, repetition rate, peak power).

Imaging of bladder cancer metabolic biomarkers using TPEF, ThPEF and Raman

Results of preliminary imaging of bladder cancer using standalone Raman, TPEF and ThPEF techniques using the first iteration of the laser prototypes.

Proof of principal imaging through an endoscopic probe

Results showing high resolution and quality multimodal nonlinear imaging within a large and deep scanning area.

Imaging bladder cancer cells in the 3rd bio-window

Report on the use of the 1700nm laser for imaging BC cells in the 3rd bio-window and at large penetration depths (elastic scattering, THG, SHG, TPEF, ThPEF)

Metabolomic and transcriptomic analysis of preclinical models of bladder cancer

Metabolic profile obtained by integrating fluorescence and Raman analysis, metabolomics and transcriptomics data, using mathematical models trained by co-cultures results, will be used to create a scoring algorithm able to assess the metabolic-based aggressiveness or rate of tumour progression profile relevant for diagnostic purpose.

Demonstrators, pilots, prototypes (1)

Endoscopic multi-modal imaging showcase workshop at UNIFI

Workshop with clinicians and relevant stakeholders to demonstrate and discuss the developed diagnostic solutions.

Websites, patent fillings, videos etc. (1)

Promotional video

Video presentation of the AMPLITUDE project

Publications

Peer reviewed articles (19)

Systems metabolomics: from metabolomic snapshots to design principles

Auteurs: Chiara Damiani, Daniela Gaglio, Elena Sacco, Lilia Alberghina, Marco Vanoni
Publié dans: Current Opinion in Biotechnology, Numéro 63, 2020, Page(s) 190-199, ISSN 0958-1669
Éditeur: Elsevier BV
DOI: 10.1016/j.copbio.2020.02.013

A review of label-free photonics-based techniques for cancer detection in the digestive and urinary systems

Auteurs: G Castro-Olvera, E Baria, D Stoliarov, S Morselli, B Orlandini, M Vanoni, H Sayinc, A Koviarov, D Galiakhmetova, J Dickie, R Cicchi, S Serni, M Gacci, M J Ribal, F S Pavone, P Loza-Alvarez, E Rafailov, R Gumenyuk
Publié dans: Journal of Physics: Photonics, Numéro 7, 2024, Page(s) 012002, ISSN 2515-7647
Éditeur: IOP Publishing Ltd
DOI: 10.1088/2515-7647/ad8613

Cell-type-specific inhibition of the dendritic plateau potential in striatal spiny projection neurons

Auteurs: Kai Du, Yu-Wei Wu, Robert Lindroos, Yu Liu, Balázs Rózsa, Gergely Katona, Jun B. Ding, and Jeanette Hellgren Kotaleski
Publié dans: Proceedings of the National Academy of Sciences of the United States of America (PNAS), 2017, ISSN 1091-6490
Éditeur: National Academy of Science
DOI: 10.1073/pnas.1704893114

An Optimized Workflow for the Analysis of Metabolic Fluxes in Cancer Spheroids Using Seahorse Technology

Auteurs: Gloria Campioni, Valentina Pasquale, Stefano Busti, Giacomo Ducci, Elena Sacco, Marco Vanoni
Publié dans: Cells, Numéro 11/5, 2022, Page(s) 866, ISSN 2073-4409
Éditeur: MDPI Publishing
DOI: 10.3390/cells11050866

Tumor heterogeneity: preclinical models, emerging technologies, and future applications

Auteurs: Marco Proietto, Martina Crippa, Chiara Damiani, Valentina Pasquale, Elena Sacco, Marco Vanoni, Mara Gilardi
Publié dans: Frontiers in Oncology, Numéro 13, 2023, ISSN 2234-943X
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fonc.2023.1164535

Soft, Thiol-ene/Acrylate-Based Electrode Array for Long-Term Recording of Intracranial EEG Signals with ImprovedBiocompatibility in Mice

Auteurs: Flóra Zsófia Fedor, Miklós Madarász, Anita Zátonyi, Ágnes Szabó, Tibor Lőrincz, Vindhya Danda, Lisa Spurgin, Connie Manz, Balázs Rózsa, Zoltán Fekete
Publié dans: Advanced Materials Technologies, 2021, ISSN 2365-709X
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/admt.202100942

Advanced multimodal laser imaging tool for urothelial carcinoma diagnosis (AMPLITUDE)

Auteurs: Sergey Kurilchik, Mauro Gacci, Riccardo Cicchi, Francesco S Pavone, Simone Morselli, Sergio Serni, MH Chou, Mikko Närhi, Edik Rafailov, Neil Stewart, Cordelia Lennon, Regina Gumenyuk
Publié dans: Journal of Physics: Photonics, Numéro 2/2, 2020, Page(s) 021001, ISSN 2515-7647
Éditeur: IOP Publishing
DOI: 10.1088/2515-7647/ab7bab

Transient dynamics in mode-locked all-PM Er-doped fiber laser with NALM

Auteurs: D. Stoliarov, I. Kudelin, A. Koviarov, E. Rafailov
Publié dans: Optics Communications, Numéro 547, 2023, Page(s) 129852, ISSN 0030-4018
Éditeur: Elsevier BV
DOI: 10.1016/j.optcom.2023.129852

Dendrite-Specific Amplification of Weak Synaptic Input during Network Activity In Vivo

Auteurs: Leiron Ferrarese, Jean-Sebastien Jouhanneau, Michiel W.H. Remme, Jens Kremkow, Gergely Katona, Balázs Rózsa, Susanne Schreiber, James F.A. Poulet
Publié dans: Cell Reports, 2018, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2018.08.088

Sharp-wave ripple doublets induce complex dendritic spikes in parvalbumin interneurons in vivo

Auteurs: Linda Judák, Balázs Chiovini, Gábor Juhász, Dénes Pálfi, Zsolt Mezriczky, Zoltán Szadai, Gergely Katona, Benedek Szmola, Katalin Ócsai, Bernadett Martinecz, Anna Mihály, Ádám Dénes, Bálint Kerekes, Áron Szepesi, Gergely Szalay, István Ulbert, Zoltán Mucsi, Botond Roska & Balázs Rózsa
Publié dans: Nature Communications, 2022, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-022-34520-1

Three‐Photon Infrared Stimulation of Endogenous Neuroreceptors in Vivo

Auteurs: Rosalba Sortino, Marina Cunquero, Gustavo Castro‐Olvera, Ricard Gelabert, Miquel Moreno, Fabio Riefolo, Carlo Matera, Noèlia Fernàndez‐Castillo, Luca Agnetta, Michael Decker, José M. Lluch, Jordi Hernando, Pablo Loza‐Alvarez, Pau Gorostiza
Publié dans: Angewandte Chemie, Numéro 135, 2024, ISSN 0044-8249
Éditeur: Wiley-VCH GmbH
DOI: 10.1002/ange.202311181

Transparent Thiol-ene/Acrylate-Based MicroECoG DevicesUsed for Concurrent Recording of Fluorescent CalciumSignals and Electrophysiology in Awake Animals

Auteurs: Ágnes Szabó, Miklós Madarász, Zsófia Lantos, Anita Zátonyi, Vindhya Danda, Lisa Spurgin, Connie Manz, Balázs Rózsa, Zoltán Fekete
Publié dans: Advanced Materials Interfaces, 2022, ISSN 2196-7350
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/admi.202200729

Presynaptic NMDARs cooperate with local spikes toward GABA release from the reciprocal olfactory bulb granule cell spine

Auteurs: Vanessa Lage-Rupprecht, Li Zhou, Gaia Bianchini, S Sara Aghvami, Max Mueller, Balázs Rózsa, Marco Sassoè-Pognetto, Veronica Egger
Publié dans: eLife, 2020, ISSN 2050-084X
Éditeur: eLife Sciences Publications
DOI: 10.7554/elife.63737

Dysplasia and tumor discrimination in brain tissues by combined fluorescence, Raman, and diffuse reflectance spectroscopies

Auteurs: Enrico Baria; Flavio Giordano; Renzo Guerrini; Chiara Caporalini; Anna Maria Buccoliero; Riccardo Cicchi; Francesco Saverio Pavone
Publié dans: Biomedical Optics Express, Numéro 7, 2023, ISSN 2156-7085
Éditeur: The Optical Society
DOI: 10.1364/boe.477035

Cortex-wide response mode of VIP-expressing inhibitory neurons by reward and punishment

Auteurs: Zoltán Szadai, Hyun-Jae Pi, Quentin Chevy, Katalin Ócsai, Dinu F Albeanu, Balázs Chiovini, Gergely Szalay, Gergely Katona, Adam Kepecs
Publié dans: eLife, 2022, ISSN 2050-084X
Éditeur: eLife Sciences Publications
DOI: 10.7554/elife.78815

Wavelength-Tunable Chirped Pulse Amplification System (1720 nm–1800 nm) Based on Thulium-Doped Fiber

Auteurs: Xinyang Liu, Regina Gumenyuk
Publié dans: Photonics, Numéro 11, 2024, Page(s) 439, ISSN 2304-6732
Éditeur: MDPI AG
DOI: 10.3390/photonics11050439

Profiling and Targeting of Energy and Redox Metabolism in Grade 2 Bladder Cancer Cells with Different Invasiveness Properties

Auteurs: Valentina Pasquale, Giacomo Ducci, Gloria Campioni, Adria Ventrici, Chiara Assalini, Stefano Busti, Marco Vanoni, Riccardo Vago, Elena Sacco
Publié dans: Cells, Numéro 9/12, 2020, Page(s) 2669, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells9122669

Tunable dissipative soliton Tm-doped fiber laser operating from 1700 nm to 1900 nm

Auteurs: Xinyang Liu; Jayanta K. Sahu; Regina Gumenyuk
Publié dans: Optics Letters, Numéro 48, 2023, Page(s) 612-615, ISSN 0146-9592
Éditeur: Optical Society of America
DOI: 10.1364/ol.478838

Large-Scale 3D Two-Photon Imaging of Molecularly Identified CA1 Interneuron Dynamics in Behaving Mice.

Auteurs: Tristan Geiller; Bert Vancura; Satoshi Terada; Eirini Troullinou; Eirini Troullinou; Spyridon Chavlis; Grigorios Tsagkatakis; Panagiotis Tsakalides; Panagiotis Tsakalides; Katalin Ócsai; Panayiota Poirazi; Balázs Rózsa; Attila Losonczy
Publié dans: Neuron, Numéro 1, 2020, Page(s) 968–983, ISSN 0896-6273
Éditeur: Cell Press
DOI: 10.1016/j.neuron.2020.09.013

Book chapters (1)

Multimodal SWIR Laser Imaging for Assessment and Detection of Urothelial Carcinomas

Auteurs: Gustavo Castro-Olvera, Simone Morselli, Mauro Gacci, Sergio Serni, Andrea Liaci, Rossella Nicoletti, Pablo Loza-Alvarez
Publié dans: Short-Wavelength Infrared Windows for Biomedical Applications, 2021, ISBN 9781510646230
Éditeur: SPIE
DOI: 10.1117/3.2604326.ch8