Advanced Multimodal Photonics Laser Imaging Tool for Urothelial Diagnosis in Endoscopy

Informacje na temat projektu

AMPLITUDE

Identyfikator umowy o grant: 871277

DOI

10.3030/871277

Projekt został zamknięty

Data podpisania przez KE 6 Grudnia 2019

Data rozpoczęcia 1 Stycznia 2020

Data zakończenia 31 Grudnia 2024

Finansowanie w ramach

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT)

Koszt całkowity

€ 4 656 750,00

Wkład UE

€ 4 486 750,00

Koordynowany przez

TAMPEREEN KORKEAKOULUSAATIO SR
Finland

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Documents, reports (5)

Multi-modal imaging at deep penetration depths in the 3rd bio-window with 850nm AF using one primary laser source

A de-scanned configuration (passing also through a confocal pinhole) will be used form measuring the elastic scattered light. A non-descanned configuration will be used to measure either the THG or the SHG signal from the sample. Importantly, the three signals will be generated simultaneously, and therefore, perfectly overlapping. The collected data will give the information about best laser output parameters (wavelength, output power, repetition rate, peak power).

Imaging of bladder cancer metabolic biomarkers using TPEF, ThPEF and Raman

Results of preliminary imaging of bladder cancer using standalone Raman, TPEF and ThPEF techniques using the first iteration of the laser prototypes.

Proof of principal imaging through an endoscopic probe

Results showing high resolution and quality multimodal nonlinear imaging within a large and deep scanning area.

Imaging bladder cancer cells in the 3rd bio-window

Report on the use of the 1700nm laser for imaging BC cells in the 3rd bio-window and at large penetration depths (elastic scattering, THG, SHG, TPEF, ThPEF)

Metabolomic and transcriptomic analysis of preclinical models of bladder cancer

Metabolic profile obtained by integrating fluorescence and Raman analysis, metabolomics and transcriptomics data, using mathematical models trained by co-cultures results, will be used to create a scoring algorithm able to assess the metabolic-based aggressiveness or rate of tumour progression profile relevant for diagnostic purpose.

Demonstrators, pilots, prototypes (1)

Endoscopic multi-modal imaging showcase workshop at UNIFI

Workshop with clinicians and relevant stakeholders to demonstrate and discuss the developed diagnostic solutions.

Websites, patent fillings, videos etc. (1)

Promotional video

Video presentation of the AMPLITUDE project

Publikacje

Peer reviewed articles (19)

Systems metabolomics: from metabolomic snapshots to design principles

Autorzy: Chiara Damiani, Daniela Gaglio, Elena Sacco, Lilia Alberghina, Marco Vanoni
Opublikowane w: Current Opinion in Biotechnology, Numer 63, 2020, Strona(/y) 190-199, ISSN 0958-1669
Wydawca: Elsevier BV
DOI: 10.1016/j.copbio.2020.02.013

A review of label-free photonics-based techniques for cancer detection in the digestive and urinary systems

Autorzy: G Castro-Olvera, E Baria, D Stoliarov, S Morselli, B Orlandini, M Vanoni, H Sayinc, A Koviarov, D Galiakhmetova, J Dickie, R Cicchi, S Serni, M Gacci, M J Ribal, F S Pavone, P Loza-Alvarez, E Rafailov, R Gumenyuk
Opublikowane w: Journal of Physics: Photonics, Numer 7, 2024, Strona(/y) 012002, ISSN 2515-7647
Wydawca: IOP Publishing Ltd
DOI: 10.1088/2515-7647/ad8613

Cell-type-specific inhibition of the dendritic plateau potential in striatal spiny projection neurons

Autorzy: Kai Du, Yu-Wei Wu, Robert Lindroos, Yu Liu, Balázs Rózsa, Gergely Katona, Jun B. Ding, and Jeanette Hellgren Kotaleski
Opublikowane w: Proceedings of the National Academy of Sciences of the United States of America (PNAS), 2017, ISSN 1091-6490
Wydawca: National Academy of Science
DOI: 10.1073/pnas.1704893114

An Optimized Workflow for the Analysis of Metabolic Fluxes in Cancer Spheroids Using Seahorse Technology

Autorzy: Gloria Campioni, Valentina Pasquale, Stefano Busti, Giacomo Ducci, Elena Sacco, Marco Vanoni
Opublikowane w: Cells, Numer 11/5, 2022, Strona(/y) 866, ISSN 2073-4409
Wydawca: MDPI Publishing
DOI: 10.3390/cells11050866

Tumor heterogeneity: preclinical models, emerging technologies, and future applications

Autorzy: Marco Proietto, Martina Crippa, Chiara Damiani, Valentina Pasquale, Elena Sacco, Marco Vanoni, Mara Gilardi
Opublikowane w: Frontiers in Oncology, Numer 13, 2023, ISSN 2234-943X
Wydawca: Frontiers Media S. A.
DOI: 10.3389/fonc.2023.1164535

Soft, Thiol-ene/Acrylate-Based Electrode Array for Long-Term Recording of Intracranial EEG Signals with ImprovedBiocompatibility in Mice

Autorzy: Flóra Zsófia Fedor, Miklós Madarász, Anita Zátonyi, Ágnes Szabó, Tibor Lőrincz, Vindhya Danda, Lisa Spurgin, Connie Manz, Balázs Rózsa, Zoltán Fekete
Opublikowane w: Advanced Materials Technologies, 2021, ISSN 2365-709X
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/admt.202100942

Advanced multimodal laser imaging tool for urothelial carcinoma diagnosis (AMPLITUDE)

Autorzy: Sergey Kurilchik, Mauro Gacci, Riccardo Cicchi, Francesco S Pavone, Simone Morselli, Sergio Serni, MH Chou, Mikko Närhi, Edik Rafailov, Neil Stewart, Cordelia Lennon, Regina Gumenyuk
Opublikowane w: Journal of Physics: Photonics, Numer 2/2, 2020, Strona(/y) 021001, ISSN 2515-7647
Wydawca: IOP Publishing
DOI: 10.1088/2515-7647/ab7bab

Transient dynamics in mode-locked all-PM Er-doped fiber laser with NALM

Autorzy: D. Stoliarov, I. Kudelin, A. Koviarov, E. Rafailov
Opublikowane w: Optics Communications, Numer 547, 2023, Strona(/y) 129852, ISSN 0030-4018
Wydawca: Elsevier BV
DOI: 10.1016/j.optcom.2023.129852

Dendrite-Specific Amplification of Weak Synaptic Input during Network Activity In Vivo

Autorzy: Leiron Ferrarese, Jean-Sebastien Jouhanneau, Michiel W.H. Remme, Jens Kremkow, Gergely Katona, Balázs Rózsa, Susanne Schreiber, James F.A. Poulet
Opublikowane w: Cell Reports, 2018, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2018.08.088

Sharp-wave ripple doublets induce complex dendritic spikes in parvalbumin interneurons in vivo

Autorzy: Linda Judák, Balázs Chiovini, Gábor Juhász, Dénes Pálfi, Zsolt Mezriczky, Zoltán Szadai, Gergely Katona, Benedek Szmola, Katalin Ócsai, Bernadett Martinecz, Anna Mihály, Ádám Dénes, Bálint Kerekes, Áron Szepesi, Gergely Szalay, István Ulbert, Zoltán Mucsi, Botond Roska & Balázs Rózsa
Opublikowane w: Nature Communications, 2022, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-022-34520-1

Three‐Photon Infrared Stimulation of Endogenous Neuroreceptors in Vivo

Autorzy: Rosalba Sortino, Marina Cunquero, Gustavo Castro‐Olvera, Ricard Gelabert, Miquel Moreno, Fabio Riefolo, Carlo Matera, Noèlia Fernàndez‐Castillo, Luca Agnetta, Michael Decker, José M. Lluch, Jordi Hernando, Pablo Loza‐Alvarez, Pau Gorostiza
Opublikowane w: Angewandte Chemie, Numer 135, 2024, ISSN 0044-8249
Wydawca: Wiley-VCH GmbH
DOI: 10.1002/ange.202311181

Transparent Thiol-ene/Acrylate-Based MicroECoG DevicesUsed for Concurrent Recording of Fluorescent CalciumSignals and Electrophysiology in Awake Animals

Autorzy: Ágnes Szabó, Miklós Madarász, Zsófia Lantos, Anita Zátonyi, Vindhya Danda, Lisa Spurgin, Connie Manz, Balázs Rózsa, Zoltán Fekete
Opublikowane w: Advanced Materials Interfaces, 2022, ISSN 2196-7350
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/admi.202200729

Presynaptic NMDARs cooperate with local spikes toward GABA release from the reciprocal olfactory bulb granule cell spine

Autorzy: Vanessa Lage-Rupprecht, Li Zhou, Gaia Bianchini, S Sara Aghvami, Max Mueller, Balázs Rózsa, Marco Sassoè-Pognetto, Veronica Egger
Opublikowane w: eLife, 2020, ISSN 2050-084X
Wydawca: eLife Sciences Publications
DOI: 10.7554/elife.63737

Dysplasia and tumor discrimination in brain tissues by combined fluorescence, Raman, and diffuse reflectance spectroscopies

Autorzy: Enrico Baria; Flavio Giordano; Renzo Guerrini; Chiara Caporalini; Anna Maria Buccoliero; Riccardo Cicchi; Francesco Saverio Pavone
Opublikowane w: Biomedical Optics Express, Numer 7, 2023, ISSN 2156-7085
Wydawca: The Optical Society
DOI: 10.1364/boe.477035

Cortex-wide response mode of VIP-expressing inhibitory neurons by reward and punishment

Autorzy: Zoltán Szadai, Hyun-Jae Pi, Quentin Chevy, Katalin Ócsai, Dinu F Albeanu, Balázs Chiovini, Gergely Szalay, Gergely Katona, Adam Kepecs
Opublikowane w: eLife, 2022, ISSN 2050-084X
Wydawca: eLife Sciences Publications
DOI: 10.7554/elife.78815

Wavelength-Tunable Chirped Pulse Amplification System (1720 nm–1800 nm) Based on Thulium-Doped Fiber

Autorzy: Xinyang Liu, Regina Gumenyuk
Opublikowane w: Photonics, Numer 11, 2024, Strona(/y) 439, ISSN 2304-6732
Wydawca: MDPI AG
DOI: 10.3390/photonics11050439

Profiling and Targeting of Energy and Redox Metabolism in Grade 2 Bladder Cancer Cells with Different Invasiveness Properties

Autorzy: Valentina Pasquale, Giacomo Ducci, Gloria Campioni, Adria Ventrici, Chiara Assalini, Stefano Busti, Marco Vanoni, Riccardo Vago, Elena Sacco
Opublikowane w: Cells, Numer 9/12, 2020, Strona(/y) 2669, ISSN 2073-4409
Wydawca: MDPI
DOI: 10.3390/cells9122669

Tunable dissipative soliton Tm-doped fiber laser operating from 1700 nm to 1900 nm

Autorzy: Xinyang Liu; Jayanta K. Sahu; Regina Gumenyuk
Opublikowane w: Optics Letters, Numer 48, 2023, Strona(/y) 612-615, ISSN 0146-9592
Wydawca: Optical Society of America
DOI: 10.1364/ol.478838

Large-Scale 3D Two-Photon Imaging of Molecularly Identified CA1 Interneuron Dynamics in Behaving Mice.

Autorzy: Tristan Geiller; Bert Vancura; Satoshi Terada; Eirini Troullinou; Eirini Troullinou; Spyridon Chavlis; Grigorios Tsagkatakis; Panagiotis Tsakalides; Panagiotis Tsakalides; Katalin Ócsai; Panayiota Poirazi; Balázs Rózsa; Attila Losonczy
Opublikowane w: Neuron, Numer 1, 2020, Strona(/y) 968–983, ISSN 0896-6273
Wydawca: Cell Press
DOI: 10.1016/j.neuron.2020.09.013

Book chapters (1)

Multimodal SWIR Laser Imaging for Assessment and Detection of Urothelial Carcinomas

Autorzy: Gustavo Castro-Olvera, Simone Morselli, Mauro Gacci, Sergio Serni, Andrea Liaci, Rossella Nicoletti, Pablo Loza-Alvarez
Opublikowane w: Short-Wavelength Infrared Windows for Biomedical Applications, 2021, ISBN 9781510646230
Wydawca: SPIE
DOI: 10.1117/3.2604326.ch8