Project description
A first version of the Human Cell Atlas of the pancreas
Diseases affecting the pancreas include pancreatic adenocarcinoma, a devastating cancer, and pancreatitis, a potentially life-threatening disorder. Diabetes is an extremely widespread chronic condition affecting the pancreas. The goal of the EU-funded ESPACE consortium is to build a first version of the Human Cell Atlas (HCA) of the pancreas. Research will integrate molecular profiles, and transcriptome and epigenomics data from more than 1 million single cells with tissue proteomics data addressing fundamental questions of cell phenotype, in healthy adults and during embryonic development. ESPACE will focus on types 2 diabetes in HCA work towards understanding pancreatic diseases. The creation of a first-of-a-kind comprehensive atlas of the human pancreas will advance methods and standards of high relevance for the HCA project in other organs, too.
Objective
The human pancreas is a physiologically unique organ involved in the secretion of several hormones, such as insulin, thus regulating blood sugar levels, as well as the secretion of enzymes for the digestive system. Several human diseases are associated with the pancreas: Pancreatic andenocarcinoma is one of the most aggressive cancers in humans and pancreatitis is a common potentially life-threatening disorder related to adverse lifestyle conditions. A very common chronical disease affecting the pancreas is Diabetes mellitus, a metabolic disorder that is characterised by high blood sugar levels due to the lack of insulin produced in the pancreas. Despite its high physiological importance, the high autolytic activity makes the pancreas a challenging tissue to study. The Expression and Spatial analysis Pancreas Atlas Consortium Europe, ESPACE, has formed as merger of three prior Human Cell Atlas (HCA) early pilot studies of the pancreas funded by the Chan Zuckerberg initiative. Based on the there developed methods and standards for sample procurement, single cell profiling, spatial proteomics, and computational pipelines we will here build a first version of the Human Cell Atlas of the Pancreas. We will integrate molecular profiles, including transcriptome and epigenomics data from more than 1 million single cells jointly together with tissue proteomics allowing to address fundamental questions of cell state and phenotype in healthy adults and during foetal development. Thus, we will provide a first version of an open single cell repository of the pancreas built upon the Data Coordination Platform of the HCA. Exploring the benefit of the HCA of the pancreas for tackling pancreatic diseases, ESPACE will reach out into types 2 diabetes. Besides creating a unique and first of its kind comprehensive atlas of the human pancreas the methods and standards developed by ESPACE will be of high relevance for HCA projects in other organs.
Fields of science
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomics
- medical and health sciencesclinical medicineendocrinologydiabetes
- medical and health sciencesclinical medicineoncology
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes
- natural sciencesbiological sciencesgeneticsepigenetics
Programme(s)
Funding Scheme
RIA - Research and Innovation actionCoordinator
10117 Berlin
Germany