Descrizione del progetto
Una prima versione dello Human Cell Atlas del pancreas
Tra le malattie che colpiscono il pancreas rientrano l’adenocarcinoma pancreatico, un tumore devastante, e la pancreatite, un disturbo potenzialmente letale. Il diabete è una malattia cronica estremamente diffusa che interessa il pancreas. L’obiettivo del consorzio ESPACE, finanziato dall’UE, è quello di realizzare una prima versione dello Human Cell Atlas (HCA) del pancreas. La ricerca integrerà profili molecolari e dati di trascrittoma ed epigenomica da più di 1 milione di singole cellule con dati di proteomica tissutale che riguardano questioni fondamentali del fenotipo cellulare, in adulti sani e durante lo sviluppo embrionale. Nel suo lavoro per l’HCA, ESPACE si concentrerà sul diabete di tipo 2 per una migliore comprensione delle malattie del pancreas. La creazione di un primo atlante completo del pancreas umano favorirà lo sviluppo di metodi e standard di grande rilevanza per il progetto HCA anche su altri organi.
Obiettivo
The human pancreas is a physiologically unique organ involved in the secretion of several hormones, such as insulin, thus regulating blood sugar levels, as well as the secretion of enzymes for the digestive system. Several human diseases are associated with the pancreas: Pancreatic andenocarcinoma is one of the most aggressive cancers in humans and pancreatitis is a common potentially life-threatening disorder related to adverse lifestyle conditions. A very common chronical disease affecting the pancreas is Diabetes mellitus, a metabolic disorder that is characterised by high blood sugar levels due to the lack of insulin produced in the pancreas. Despite its high physiological importance, the high autolytic activity makes the pancreas a challenging tissue to study. The Expression and Spatial analysis Pancreas Atlas Consortium Europe, ESPACE, has formed as merger of three prior Human Cell Atlas (HCA) early pilot studies of the pancreas funded by the Chan Zuckerberg initiative. Based on the there developed methods and standards for sample procurement, single cell profiling, spatial proteomics, and computational pipelines we will here build a first version of the Human Cell Atlas of the Pancreas. We will integrate molecular profiles, including transcriptome and epigenomics data from more than 1 million single cells jointly together with tissue proteomics allowing to address fundamental questions of cell state and phenotype in healthy adults and during foetal development. Thus, we will provide a first version of an open single cell repository of the pancreas built upon the Data Coordination Platform of the HCA. Exploring the benefit of the HCA of the pancreas for tackling pancreatic diseases, ESPACE will reach out into types 2 diabetes. Besides creating a unique and first of its kind comprehensive atlas of the human pancreas the methods and standards developed by ESPACE will be of high relevance for HCA projects in other organs.
Campo scientifico
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomics
- medical and health sciencesclinical medicineendocrinologydiabetes
- medical and health sciencesclinical medicineoncology
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes
- natural sciencesbiological sciencesgeneticsepigenetics
Programma(i)
Invito a presentare proposte
Vedi altri progetti per questo bandoBando secondario
H2020-SC1-2019-Single-Stage-RTD
Meccanismo di finanziamento
RIA - Research and Innovation actionCoordinatore
10117 Berlin
Germania