Computational biomechanics and bioengineering 3D printing to develop a personalized regenerative biological ventricular assist device to provide lasting functional support to damaged hearts

Resultado final

This report will summarize the results of the study of the market in terms of business potential drivers and barriers including externalities

Report on cardiac and vascular microtissue formation capacity of WP3´s materials

Materials (hydrogels and fibres) generated by WP3 will be tested for their capacity to generate cardiac and vascular microtissues, and the results will inform decision-making at WP3.

Production of hiPSC-derived CMs, stromal/vascular cells

Continuous production of hiPSCderived CMs stromalvascular cells following the SOP will take place to supply the needs of the devised activities

Presentation of the Data Management Plan

Preparation and presentation of the Data Management Plan

Data feed for WP2 activities

Data on fibre orientation cardiac function electrophysiology and biomechanics will be obtained from animals undergoing cardiac ischemia This information will feed activities on WP2

Surgery planned, surgeons trained

Transplantation of BioVADs onto infarted pigs will be evaluated and planned.

Stakeholder analysis

This report will include an identification of the most relevant stakeholders within and around the BRAV3 innovations and set up tailored engagement strategies. It will indicate the different Tiers to differentiate the determined stakeholders by modality and timing of their engagement during the project as well as the results of the stakeholder online survey and/or deep-dive interviews.

Project identity, templates and website

Design of the official BRAV3 logo and graphical chart to generate visual identity for the project. Also, an official webpage will be created for BRAV3, to inform public and scientific community about different issues related to the project.

Selection of the External Advisory Board

An External Advisory Board will be created with the consortium. The EAB will help provide support to the BRAV∃ project, which will be composed of a group of professionals with excellence in: Regenerative Medicine, clinical translation, technological development, ethics, businesses and patient organisation.

Publicaciones

A Roadmap to Cardiac Tissue-Engineered Construct Preservation: Insights from Cells, Tissues, and Organs.

Autores: Sampaio-Pinto V, Janssen J, Chirico N, Serra M, Alves PM, Doevendans PA, Voets IK, Sluijter JPG, van Laake LW, van Mil A
Publicado en: Adv Mater, Edición 09359648, 2021, ISSN 0935-9648
Editor: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202008517

Cells, Materials, and Fabrication Processes for Cardiac Tissue Engineering

Autores: Pilar Montero; María Flandes-Iparraguirre; Saioa Musquiz; Saioa Musquiz; María Pérez Araluce; María Pérez Araluce; Daniel Plano; Daniel Plano; Carmen Sanmartín; Carmen Sanmartín; Gorka Orive; Gorka Orive; Gorka Orive; Gorka Orive; Juan José Gavira; Juan José Gavira; Felipe Prosper; Felipe Prosper; Felipe Prosper; Manuel M. Mazo; Manuel M. Mazo; Manuel M. Mazo
Publicado en: Frontiers in Bioengineering and Biotechnology, Vol 8 (2020), Edición 22964185, 2020, ISSN 2296-4185
Editor: Frontiers Media SA
DOI: 10.3389/fbioe.2020.00955

Cardiac circadian rhythms in time and space: The future is in 4D

Autores: Chirico N, Van Laake LW, Sluijter JPG, van Mil A, Dierickx P
Publicado en: Curr Opin Pharmacol, Edición 14714892, 2021, Página(s) 49-59, ISSN 1471-4892
Editor: Elsevier BV
DOI: 10.1016/j.coph.2020.11.006

Autores: Pesce M, Agostoni P, Bøtker HE, Brundel B, Davidson SM, De Caterina R, Ferdinandy P, Girao H, Gyöngyösi M, Hulot JS, Lecour S, Perrino C, Schulz R, Sluijter JPG, Steffens S, Tancevski I, Gollmann-Tepeköylü C, Tschöpe C, van Linthout S, Madonna R
Publicado en: Cardiovasc Res, Edición 00086363, 2021, ISSN 0008-6363
Editor: Elsevier BV
DOI: 10.1093/cvr/cvab201

Interindividual heterogeneity affects the outcome of human cardiac tissue decellularization

Autores: Tenreiro MF, Almeida HV, Calmeiro T, Fortunato E, Ferreira L, Alves PM, Serra M
Publicado en: Scientific Reports, Edición 20452322, 2021, Página(s) 20834, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-021-00226-5

Expression of Extracellular Vesicle PIWI-Interacting RNAs Throughout hiPSC-Cardiomyocyte Differentiation

Autores: Louro AF, Virgolini N, Paiva MA, Isidro IA, Alves PM, Gomes-Alves P, Serra M
Publicado en: Front Physiol, Edición 1664042X, 2022, Página(s) 926528, ISSN 1664-042X
Editor: Frontiers Research Foundation
DOI: 10.3389/fphys.2022.926528

Engineering and assessing cardiac tissue complexity

Autores: Tadevosyan, K. (Karine); Iglesias-García, O. (Olalla); Mazo, M. (Manuel); Prosper, F. (Felipe); Raya, Á. (Ángel)
Publicado en: Int J Mol Sci, Edición 14220067, 2021, Página(s) 1479, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22031479

Next generation of heart regenerative therapies: progress and promise of cardiac tissue engineering.

Autores: 4. Tenreiro M, Louro AF, Alves PM, Serra M
Publicado en: NPJ Regen Med, Edición 20573995, 2021, ISSN 2057-3995
Editor: NPJ Nature Partner Journals
DOI: 10.1038/s41536-021-00140-4

Stem cells characterization: OMICS reinforcing analytics

Autores: Sebastião MJ, Serra M, Gomes-Alves P, Alves
Publicado en: Current Opinion in Biotechnology, Edición 09581669, 2021, Página(s) 175-181, ISSN 0958-1669
Editor: Elsevier BV
DOI: 10.1016/j.copbio.2021.07.021

Artificial Intelligence-Driven Algorithm for Drug Effect Prediction on Atrial Fibrillation: An in silico Population of Models Approach

Autores: Ana Maria Sanchez de la Nava; Ana Maria Sanchez de la Nava; Ana Maria Sanchez de la Nava; Ángel Arenal; Ángel Arenal; Ángel Arenal; Francisco Fernández-Avilés; Francisco Fernández-Avilés; Francisco Fernández-Avilés; Felipe Atienza; Felipe Atienza; Felipe Atienza
Publicado en: Frontiers in Physiology, Edición 1664042X, 2021, ISSN 1664-042X
Editor: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.768468

Toward a Microencapsulated 3D hiPSC-Derived in vitro Cardiac Microtissue for Recapitulation of Human Heart Microenvironment Features.

Autores: Bernardo Abecasis; Bernardo Abecasis; Pedro G.M. Canhão; Pedro G.M. Canhão; Henrique V. Almeida; Henrique V. Almeida; Tomás Calmeiro; Elvira Fortunato; Patrícia Gomes-Alves; Patrícia Gomes-Alves; Margarida Serra; Margarida Serra; Paula M. Alves; Paula M. Alves
Publicado en: Frontiers in Bioengineering and Biotechnology, Edición 22964185, 2020, ISSN 2296-4185
Editor: Frontiers Media S.A.
DOI: 10.3389/fbioe.2020.580744

Human Extracellular-Matrix Functionalization of 3D hiPSC-Based Cardiac Tissues Improves Cardiomyocyte Maturation

Autores: Henrique V. Almeida; Miguel F. Tenreiro; Ana F. Louro; Bernardo Abecasis; Deolinda Santinha; Tomás Calmeiro; Elvira Fortunato; Lino Ferreira; Paula M. Alves; Margarida Serra
Publicado en: ACS Applied Bio Materials, Edición 25766422, 2021, Página(s) 1888-1889, ISSN 2576-6422
Editor: ACS Publications
DOI: 10.1021/acsabm.0c01490

Bioactivity and miRNome Profiling of Native Extracellular Vesicles in Human Induced Pluripotent Stem Cell-Cardiomyocyte Differentiation

Autores: Louro AF, Paiva MA, Oliveira MR, Kasper KA, Alves PM, Gomes-Alves P, Serra M
Publicado en: Adv Sci, Edición 21983844, 2022, Página(s) e2104296, ISSN 2198-3844
Editor: Wiley-VCH
DOI: 10.1002/advs.202104296

Massive expansion and cryopreservation of functional human induced pluripotent stem cell-derived cardiomyocytes

Autores: Maas RGC, Lee S, Harakalova M, Snijders Blok CJB, Goodyer WR, Hjortnaes J, Doevendans PAFM, Van Laake LW, van der Velden J, Asselbergs FW, Wu JC, Sluijter JPG, Wu SM, Buikema JW
Publicado en: STAR Protoc, Edición 26661667, 2021, Página(s) 100334, ISSN 2666-1667
Editor: Cell Press
DOI: 10.1016/j.xpro.2021.100334

Cardiovascular Diseases in the Digital Health Era: A Translational Approach from the Lab to the Clinic

Autores: Sánchez de la Nava AM, Gómez-Cid L, Ríos-Muñoz GR, Fernández-Santos ME, Fernández AI, Arenal A, Sanz-Ruiz R, Grigorian-Shamagian L, Atienza F, Fernández-Avilés F
Publicado en: BioTech, Edición 26736284, 2022, Página(s) 23, ISSN 2673-6284
Editor: Basel: MDPI AG
DOI: 10.3390/biotech11030023

Resultado final

Publicaciones

Compartir esta página

Descargar