Computational biomechanics and bioengineering 3D printing to develop a personalized regenerative biological ventricular assist device to provide lasting functional support to damaged hearts

Leistungen

This report will summarize the results of the study of the market in terms of business potential drivers and barriers including externalities

Report on cardiac and vascular microtissue formation capacity of WP3´s materials

Materials (hydrogels and fibres) generated by WP3 will be tested for their capacity to generate cardiac and vascular microtissues, and the results will inform decision-making at WP3.

Production of hiPSC-derived CMs, stromal/vascular cells

Continuous production of hiPSCderived CMs stromalvascular cells following the SOP will take place to supply the needs of the devised activities

Presentation of the Data Management Plan

Preparation and presentation of the Data Management Plan

Data feed for WP2 activities

Data on fibre orientation cardiac function electrophysiology and biomechanics will be obtained from animals undergoing cardiac ischemia This information will feed activities on WP2

Surgery planned, surgeons trained

Transplantation of BioVADs onto infarted pigs will be evaluated and planned.

Stakeholder analysis

This report will include an identification of the most relevant stakeholders within and around the BRAV3 innovations and set up tailored engagement strategies. It will indicate the different Tiers to differentiate the determined stakeholders by modality and timing of their engagement during the project as well as the results of the stakeholder online survey and/or deep-dive interviews.

Project identity, templates and website

Design of the official BRAV3 logo and graphical chart to generate visual identity for the project. Also, an official webpage will be created for BRAV3, to inform public and scientific community about different issues related to the project.

Selection of the External Advisory Board

An External Advisory Board will be created with the consortium. The EAB will help provide support to the BRAV∃ project, which will be composed of a group of professionals with excellence in: Regenerative Medicine, clinical translation, technological development, ethics, businesses and patient organisation.

Veröffentlichungen

A Roadmap to Cardiac Tissue-Engineered Construct Preservation: Insights from Cells, Tissues, and Organs.

Autoren: Sampaio-Pinto V, Janssen J, Chirico N, Serra M, Alves PM, Doevendans PA, Voets IK, Sluijter JPG, van Laake LW, van Mil A
Veröffentlicht in: Adv Mater, Ausgabe 09359648, 2021, ISSN 0935-9648
Herausgeber: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202008517

Cells, Materials, and Fabrication Processes for Cardiac Tissue Engineering

Autoren: Pilar Montero; María Flandes-Iparraguirre; Saioa Musquiz; Saioa Musquiz; María Pérez Araluce; María Pérez Araluce; Daniel Plano; Daniel Plano; Carmen Sanmartín; Carmen Sanmartín; Gorka Orive; Gorka Orive; Gorka Orive; Gorka Orive; Juan José Gavira; Juan José Gavira; Felipe Prosper; Felipe Prosper; Felipe Prosper; Manuel M. Mazo; Manuel M. Mazo; Manuel M. Mazo
Veröffentlicht in: Frontiers in Bioengineering and Biotechnology, Vol 8 (2020), Ausgabe 22964185, 2020, ISSN 2296-4185
Herausgeber: Frontiers Media SA
DOI: 10.3389/fbioe.2020.00955

Cardiac circadian rhythms in time and space: The future is in 4D

Autoren: Chirico N, Van Laake LW, Sluijter JPG, van Mil A, Dierickx P
Veröffentlicht in: Curr Opin Pharmacol, Ausgabe 14714892, 2021, Seite(n) 49-59, ISSN 1471-4892
Herausgeber: Elsevier BV
DOI: 10.1016/j.coph.2020.11.006

Autoren: Pesce M, Agostoni P, Bøtker HE, Brundel B, Davidson SM, De Caterina R, Ferdinandy P, Girao H, Gyöngyösi M, Hulot JS, Lecour S, Perrino C, Schulz R, Sluijter JPG, Steffens S, Tancevski I, Gollmann-Tepeköylü C, Tschöpe C, van Linthout S, Madonna R
Veröffentlicht in: Cardiovasc Res, Ausgabe 00086363, 2021, ISSN 0008-6363
Herausgeber: Elsevier BV
DOI: 10.1093/cvr/cvab201

Interindividual heterogeneity affects the outcome of human cardiac tissue decellularization

Autoren: Tenreiro MF, Almeida HV, Calmeiro T, Fortunato E, Ferreira L, Alves PM, Serra M
Veröffentlicht in: Scientific Reports, Ausgabe 20452322, 2021, Seite(n) 20834, ISSN 2045-2322
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41598-021-00226-5

Expression of Extracellular Vesicle PIWI-Interacting RNAs Throughout hiPSC-Cardiomyocyte Differentiation

Autoren: Louro AF, Virgolini N, Paiva MA, Isidro IA, Alves PM, Gomes-Alves P, Serra M
Veröffentlicht in: Front Physiol, Ausgabe 1664042X, 2022, Seite(n) 926528, ISSN 1664-042X
Herausgeber: Frontiers Research Foundation
DOI: 10.3389/fphys.2022.926528

Engineering and assessing cardiac tissue complexity

Autoren: Tadevosyan, K. (Karine); Iglesias-García, O. (Olalla); Mazo, M. (Manuel); Prosper, F. (Felipe); Raya, Á. (Ángel)
Veröffentlicht in: Int J Mol Sci, Ausgabe 14220067, 2021, Seite(n) 1479, ISSN 1422-0067
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22031479

Next generation of heart regenerative therapies: progress and promise of cardiac tissue engineering.

Autoren: 4. Tenreiro M, Louro AF, Alves PM, Serra M
Veröffentlicht in: NPJ Regen Med, Ausgabe 20573995, 2021, ISSN 2057-3995
Herausgeber: NPJ Nature Partner Journals
DOI: 10.1038/s41536-021-00140-4

Stem cells characterization: OMICS reinforcing analytics

Autoren: Sebastião MJ, Serra M, Gomes-Alves P, Alves
Veröffentlicht in: Current Opinion in Biotechnology, Ausgabe 09581669, 2021, Seite(n) 175-181, ISSN 0958-1669
Herausgeber: Elsevier BV
DOI: 10.1016/j.copbio.2021.07.021

Artificial Intelligence-Driven Algorithm for Drug Effect Prediction on Atrial Fibrillation: An in silico Population of Models Approach

Autoren: Ana Maria Sanchez de la Nava; Ana Maria Sanchez de la Nava; Ana Maria Sanchez de la Nava; Ángel Arenal; Ángel Arenal; Ángel Arenal; Francisco Fernández-Avilés; Francisco Fernández-Avilés; Francisco Fernández-Avilés; Felipe Atienza; Felipe Atienza; Felipe Atienza
Veröffentlicht in: Frontiers in Physiology, Ausgabe 1664042X, 2021, ISSN 1664-042X
Herausgeber: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.768468

Toward a Microencapsulated 3D hiPSC-Derived in vitro Cardiac Microtissue for Recapitulation of Human Heart Microenvironment Features.

Autoren: Bernardo Abecasis; Bernardo Abecasis; Pedro G.M. Canhão; Pedro G.M. Canhão; Henrique V. Almeida; Henrique V. Almeida; Tomás Calmeiro; Elvira Fortunato; Patrícia Gomes-Alves; Patrícia Gomes-Alves; Margarida Serra; Margarida Serra; Paula M. Alves; Paula M. Alves
Veröffentlicht in: Frontiers in Bioengineering and Biotechnology, Ausgabe 22964185, 2020, ISSN 2296-4185
Herausgeber: Frontiers Media S.A.
DOI: 10.3389/fbioe.2020.580744

Human Extracellular-Matrix Functionalization of 3D hiPSC-Based Cardiac Tissues Improves Cardiomyocyte Maturation

Autoren: Henrique V. Almeida; Miguel F. Tenreiro; Ana F. Louro; Bernardo Abecasis; Deolinda Santinha; Tomás Calmeiro; Elvira Fortunato; Lino Ferreira; Paula M. Alves; Margarida Serra
Veröffentlicht in: ACS Applied Bio Materials, Ausgabe 25766422, 2021, Seite(n) 1888-1889, ISSN 2576-6422
Herausgeber: ACS Publications
DOI: 10.1021/acsabm.0c01490

Bioactivity and miRNome Profiling of Native Extracellular Vesicles in Human Induced Pluripotent Stem Cell-Cardiomyocyte Differentiation

Autoren: Louro AF, Paiva MA, Oliveira MR, Kasper KA, Alves PM, Gomes-Alves P, Serra M
Veröffentlicht in: Adv Sci, Ausgabe 21983844, 2022, Seite(n) e2104296, ISSN 2198-3844
Herausgeber: Wiley-VCH
DOI: 10.1002/advs.202104296

Massive expansion and cryopreservation of functional human induced pluripotent stem cell-derived cardiomyocytes

Autoren: Maas RGC, Lee S, Harakalova M, Snijders Blok CJB, Goodyer WR, Hjortnaes J, Doevendans PAFM, Van Laake LW, van der Velden J, Asselbergs FW, Wu JC, Sluijter JPG, Wu SM, Buikema JW
Veröffentlicht in: STAR Protoc, Ausgabe 26661667, 2021, Seite(n) 100334, ISSN 2666-1667
Herausgeber: Cell Press
DOI: 10.1016/j.xpro.2021.100334

Cardiovascular Diseases in the Digital Health Era: A Translational Approach from the Lab to the Clinic

Autoren: Sánchez de la Nava AM, Gómez-Cid L, Ríos-Muñoz GR, Fernández-Santos ME, Fernández AI, Arenal A, Sanz-Ruiz R, Grigorian-Shamagian L, Atienza F, Fernández-Avilés F
Veröffentlicht in: BioTech, Ausgabe 26736284, 2022, Seite(n) 23, ISSN 2673-6284
Herausgeber: Basel: MDPI AG
DOI: 10.3390/biotech11030023

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