Computational biomechanics and bioengineering 3D printing to develop a personalized regenerative biological ventricular assist device to provide lasting functional support to damaged hearts

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Market analysis

This report will summarize the results of the study of the market in terms of business potential drivers and barriers including externalities

Report on cardiac and vascular microtissue formation capacity of WP3´s materials

Materials (hydrogels and fibres) generated by WP3 will be tested for their capacity to generate cardiac and vascular microtissues, and the results will inform decision-making at WP3.

Production of hiPSC-derived CMs, stromal/vascular cells

Continuous production of hiPSCderived CMs stromalvascular cells following the SOP will take place to supply the needs of the devised activities

Presentation of the Data Management Plan

Preparation and presentation of the Data Management Plan

Data feed for WP2 activities

Data on fibre orientation cardiac function electrophysiology and biomechanics will be obtained from animals undergoing cardiac ischemia This information will feed activities on WP2

Surgery planned, surgeons trained

Transplantation of BioVADs onto infarted pigs will be evaluated and planned.

Stakeholder analysis

This report will include an identification of the most relevant stakeholders within and around the BRAV3 innovations and set up tailored engagement strategies. It will indicate the different Tiers to differentiate the determined stakeholders by modality and timing of their engagement during the project as well as the results of the stakeholder online survey and/or deep-dive interviews.

Project identity, templates and website

Design of the official BRAV3 logo and graphical chart to generate visual identity for the project. Also, an official webpage will be created for BRAV3, to inform public and scientific community about different issues related to the project.

Selection of the External Advisory Board

An External Advisory Board will be created with the consortium. The EAB will help provide support to the BRAV∃ project, which will be composed of a group of professionals with excellence in: Regenerative Medicine, clinical translation, technological development, ethics, businesses and patient organisation.

Pubblicazioni

The Past, Present, and Future of Tubular Melt Electrowritten Constructs to Mimic Small Diameter Blood Vessels – A Stable Process?

Autori: Michael Bartolf‐Kopp, Tomasz Jungst
Pubblicato in: Advanced Healthcare Materials, Numero 13, 2024, ISSN 2192-2640
Editore: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202400426

Biologically‐Inspired Melt Electrowriting for the Generation of Highly Biomimetic Functional Myocardium

Autori: Olalla Iglesias‐García, María Flandes‐Iparraguirre, Pilar Montero‐Calle, Ricardo M. Rosales, Asier Ullate‐Agote, Andrea Sánchez‐Bueno, Eduardo Larequi, Ilazki Anaut‐Lusar, Nicolás Laita, Aida Oliván‐Viguera, Elena Iglesias, Gloria Abizanda, Patxi San Martín‐Úriz, Paula Aguirre‐Ruiz, Xabier L. Aranguren, Manuel García de Yébenes, Juan José Gavira, Miguel Ángel Martínez
Pubblicato in: Advanced Functional Materials, 2025, ISSN 1616-301X
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202420106

A comprehensive experimental analysis of the local passive response across the healthy porcine left ventricle

Autori: Nicolás Laita, Alejandro Aparici-Gil, Aida Oliván-Viguera, Alba Pérez-Martínez, Miguel Ángel Martínez, Manuel Doblaré, Estefanía Peña
Pubblicato in: Acta Biomaterialia, Numero 187, 2024, Pagina/e 261-277, ISSN 1742-7061
Editore: Elsevier BV
DOI: 10.1016/j.actbio.2024.08.028

Combining 3D Printing and Cryostructuring to Tackle Infection and Spine Fusion

Autori: Tiziana Fischetti, Gabriela Graziani, Daniele Ghezzi, Friederike Kaiser, Stefanie Hoelscher‐Doht, Martina Cappelletti, Giovanni Barbanti‐Bròdano, Jürgen Groll, Nicola Baldini, Uwe Gbureck, Tomasz Jungst
Pubblicato in: Advanced Materials Technologies, Numero 9, 2024, ISSN 2365-709X
Editore: Wiley
DOI: 10.1002/admt.202301301

Transcriptome and proteome profiling of activated cardiac fibroblasts supports target prioritization in cardiac fibrosis

Autori: Maria Raquel Moita, Marta M. Silva, Cláudia Diniz, Margarida Serra, René M. Hoet, Ana Barbas, Daniel Simão
Pubblicato in: Frontiers in Cardiovascular Medicine, Numero 9, 2022, ISSN 2297-055X
Editore: Frontiers Media SA
DOI: 10.3389/fcvm.2022.1015473

Hypothermic and cryogenic preservation of cardiac tissue-engineered constructs

Autori: Jasmijn Janssen, Nino Chirico, Madison J. Ainsworth, Gerardo Cedillo-Servin, Martina Viola, Inge Dokter, Tina Vermonden, Pieter A. Doevendans, Margarida Serra, Ilja K. Voets, Jos Malda, Miguel Castilho, Linda W. van Laake, Joost P. G. Sluijter, Vasco Sampaio-Pinto, Alain van Mil
Pubblicato in: Biomaterials Science, Numero 12, 2024, Pagina/e 3866-3881, ISSN 2047-4830
Editore: Royal Society of Chemistry
DOI: 10.1039/d3bm01908j

Hybrid Co‐Spinning and Melt Electrowriting Approach Enables Fabrication of Heterotypic Tubular Scaffolds Resembling the Non‐Linear Mechanical Properties of Human Blood Vessels

Autori: Michael Bartolf‐Kopp, Leanne de Silva, Antoine J. W. P. Rosenberg, Jürgen Groll, Debby Gawlitta, Tomasz Jungst
Pubblicato in: Advanced Functional Materials, Numero 34, 2024, ISSN 1616-301X
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202311797

Post-Infarct Evolution of Ventricular and Myocardial Function

Autori: K.L.P.M. Janssens, M. Kraamer, L. Barbarotta, P.H.M. Bovendeerd
Pubblicato in: Biomechanics and Modeling in Mechanobiology, Numero 22, 2023, Pagina/e 1815-1828, ISSN 0000-0000
Editore: Springer
DOI: 10.21203/rs.3.rs-2499788/v1

Flexible Allyl‐Modified Gelatin Photoclick Resin Tailored for Volumetric Bioprinting of Matrices for Soft Tissue Engineering

Autori: Alessandro Cianciosi, Sabrina Stecher, Maxi Löffler, Petra Bauer‐Kreisel, Khoon S. Lim, Tim B. F. Woodfield, Jürgen Groll, Torsten Blunk, Tomasz Jungst
Pubblicato in: Advanced Healthcare Materials, Numero 12, 2023, ISSN 2192-2640
Editore: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202300977

A Roadmap to Cardiac Tissue-Engineered Construct Preservation: Insights from Cells, Tissues, and Organs.

Autori: Sampaio-Pinto V, Janssen J, Chirico N, Serra M, Alves PM, Doevendans PA, Voets IK, Sluijter JPG, van Laake LW, van Mil A
Pubblicato in: Adv Mater, Numero 09359648, 2021, ISSN 0935-9648
Editore: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202008517

Metabolic Maturation Increases Susceptibility to Hypoxia-induced Damage in Human iPSC-derived Cardiomyocytes

Autori: Marijn C Peters, Renee G C Maas, Iris van Adrichem, Pieter A M Doevendans, Mark Mercola, Tomo Šarić, Jan W Buikema, Alain van Mil, Steven A J Chamuleau, Joost P G Sluijter, Anna P Hnatiuk, Klaus Neef
Pubblicato in: Stem Cells Translational Medicine, Numero 11, 2025, Pagina/e 1040-1051, ISSN 2157-6564
Editore: AlphaMed Press
DOI: 10.1093/stcltm/szac061

Cells, Materials, and Fabrication Processes for Cardiac Tissue Engineering

Autori: Pilar Montero; María Flandes-Iparraguirre; Saioa Musquiz; Saioa Musquiz; María Pérez Araluce; María Pérez Araluce; Daniel Plano; Daniel Plano; Carmen Sanmartín; Carmen Sanmartín; Gorka Orive; Gorka Orive; Gorka Orive; Gorka Orive; Juan José Gavira; Juan José Gavira; Felipe Prosper; Felipe Prosper; Felipe Prosper; Manuel M. Mazo; Manuel M. Mazo; Manuel M. Mazo
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Vol 8 (2020), Numero 22964185, 2020, ISSN 2296-4185
Editore: Frontiers Media SA
DOI: 10.3389/fbioe.2020.00955

Cardiac circadian rhythms in time and space: The future is in 4D

Autori: Chirico N, Van Laake LW, Sluijter JPG, van Mil A, Dierickx P
Pubblicato in: Curr Opin Pharmacol, Numero 14714892, 2021, Pagina/e 49-59, ISSN 1471-4892
Editore: Elsevier BV
DOI: 10.1016/j.coph.2020.11.006

Cardiac Electrophysiology Meshfree Modeling through the Mixed Collocation Method

Autori: Konstantinos A. Mountris, Esther Pueyo
Pubblicato in: Applied Sciences, Numero 13, 2025, Pagina/e 11460, ISSN 2076-3417
Editore: MDPI AG
DOI: 10.3390/app132011460

Convergence of melt electrowriting and extrusion-based bioprinting for vascular patterning of a myocardial construct

Autori: Madison Jade Ainsworth, Nino Chirico, Mylène de Ruijter, Andrei Hrynevich, Inge Dokter, Joost P G Sluijter, Jos Malda, Alain van Mil, Miguel Castilho
Pubblicato in: Biofabrication, Numero 15, 2023, Pagina/e 035025, ISSN 1758-5082
Editore: IOS Press
DOI: 10.1088/1758-5090/ace07f

Melt Electrowriting of a Photo‐Crosslinkable Poly(<i>ε</i>‐caprolactone)‐Based Material into Tubular Constructs with Predefined Architecture and Tunable Mechanical Properties

Autori: Nele Pien, Michael Bartolf‐Kopp, Laurens Parmentier, Jasper Delaey, Lobke De Vos, Diego Mantovani, Sandra Van Vlierberghe, Peter Dubruel, Tomasz Jungst
Pubblicato in: Macromolecular Materials and Engineering, Numero 307, 2023, ISSN 1438-7492
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/mame.202270028

Autori: Pesce M, Agostoni P, Bøtker HE, Brundel B, Davidson SM, De Caterina R, Ferdinandy P, Girao H, Gyöngyösi M, Hulot JS, Lecour S, Perrino C, Schulz R, Sluijter JPG, Steffens S, Tancevski I, Gollmann-Tepeköylü C, Tschöpe C, van Linthout S, Madonna R
Pubblicato in: Cardiovasc Res, Numero 00086363, 2021, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvab201

Interindividual heterogeneity affects the outcome of human cardiac tissue decellularization

Autori: Tenreiro MF, Almeida HV, Calmeiro T, Fortunato E, Ferreira L, Alves PM, Serra M
Pubblicato in: Scientific Reports, Numero 20452322, 2021, Pagina/e 20834, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-021-00226-5

An isogeometric analysis framework for ventricular cardiac mechanics

Autori: Robin Willems, Koen L. P. M. Janssens, Peter H. M. Bovendeerd, Clemens V. Verhoosel, Olaf van der Sluis
Pubblicato in: Computational Mechanics, Numero 73, 2024, Pagina/e 465-506, ISSN 0178-7675
Editore: Springer Verlag
DOI: 10.1007/s00466-023-02376-x

The Role of Infarct Stiffness in Cardiac Patch Therapy: A Computational Study Using an Idealized Left Ventricular Geometry

Autori: Koen L. P. M. Janssens, Peter H. M. Bovendeerd
Pubblicato in: Journal of Biomechanical Engineering, Numero 147, 2025, Pagina/e 147(8):081005, ISSN 0148-0731
Editore: ASME
DOI: 10.1115/1.4068829

Pristine Photopolymerizable Gelatin Hydrogels: A Low-Cost and Easily Modifiable Platform for Biomedical Applications

Autori: Maria Pérez-Araluce, Alessandro Cianciosi, Olalla Iglesias-García, Tomasz Jüngst, Carmen Sanmartín, Íñigo Navarro-Blasco, Felipe Prósper, Daniel Plano, Manuel M. Mazo
Pubblicato in: Antioxidants, Numero 13, 2025, Pagina/e 1238, ISSN 2076-3921
Editore: MDPI AG
DOI: 10.3390/antiox13101238

Generation of Self-Induced Myocardial Ischemia in Large-Sized Cardiac Spheroids without Alteration of Environmental Conditions Recreates Fibrotic Remodeling and Tissue Stiffening Revealed by Constriction Assays

Autori: Laura Paz-Artigas, Sandra González-Lana, Nicolás Polo, Pedro Vicente, Pilar Montero-Calle, Miguel A. Martínez, Gregorio Rábago, Margarida Serra, Felipe Prósper, Manuel M. Mazo, Arantxa González, Ignacio Ochoa, Jesús Ciriza
Pubblicato in: ACS Biomaterials Science & Engineering, Numero 10, 2024, Pagina/e 987-997, ISSN 2373-9878
Editore: American Chemical Society (ACS)
DOI: 10.1021/acsbiomaterials.3c01302

Fabrication of human myocardium using multidimensional modelling of engineered tissues

Autori: Pilar Montero-Calle, María Flandes-Iparraguirre, Konstantinos Mountris, Ana S de la Nava, Nicolás Laita, Ricardo M Rosales, Olalla Iglesias-García, Elena M de-Juan-Pardo, Felipe Atienza, María Eugenia Fernández-Santos, Estefanía Peña, Manuel Doblaré, Juan J Gavira, Francisco Fernández-Avilés, Felipe Prósper, Esther Pueyo, Manuel M Mazo
Pubblicato in: Biofabrication, Numero 14, 2022, Pagina/e 045017, ISSN 1758-5082
Editore: IOS Press
DOI: 10.1088/1758-5090/ac8cb3

Volumetric Printing Across Melt Electrowritten Scaffolds Fabricates Multi‐Material Living Constructs with Tunable Architecture and Mechanics

Autori: Gabriel Größbacher, Michael Bartolf‐Kopp, Csaba Gergely, Paulina Núñez Bernal, Sammy Florczak, Mylène de Ruijter, Núria Ginés Rodriguez, Jürgen Groll, Jos Malda, Tomasz Jungst, Riccardo Levato
Pubblicato in: Advanced Materials, Numero 35, 2023, ISSN 0935-9648
Editore: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202300756

Microfiber-reinforced hydrogels prolong the release of human induced pluripotent stem cell-derived extracellular vesicles to promote endothelial migration

Autori: Gerardo Cedillo-Servin, Ana Filipa Louro, Beatriz Gamelas, Ana Meliciano, Anne Zijl, Paula M. Alves, Jos Malda, Margarida Serra, Miguel Castilho
Pubblicato in: Biomaterials Advances, Numero 155, 2023, Pagina/e 213692, ISSN 2772-9508
Editore: Elsevier BV
DOI: 10.1016/j.bioadv.2023.213692

On the myocardium modeling under multimodal deformations: a comparison between costa’s, Holzapfel and Ogden’s formulations

Autori: Nicolás Laita, Miguel Ángel Martínez, Manuel Doblaré, Estefanía Peña
Pubblicato in: Meccanica, 2025, ISSN 0025-6455
Editore: Kluwer Academic Publishers
DOI: 10.1007/s11012-025-01959-7

Expression of Extracellular Vesicle PIWI-Interacting RNAs Throughout hiPSC-Cardiomyocyte Differentiation

Autori: Louro AF, Virgolini N, Paiva MA, Isidro IA, Alves PM, Gomes-Alves P, Serra M
Pubblicato in: Front Physiol, Numero 1664042X, 2022, Pagina/e 926528, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2022.926528

Engineering and assessing cardiac tissue complexity

Autori: Tadevosyan, K. (Karine); Iglesias-García, O. (Olalla); Mazo, M. (Manuel); Prosper, F. (Felipe); Raya, Á. (Ángel)
Pubblicato in: Int J Mol Sci, Numero 14220067, 2021, Pagina/e 1479, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22031479

Next generation of heart regenerative therapies: progress and promise of cardiac tissue engineering.

Autori: 4. Tenreiro M, Louro AF, Alves PM, Serra M
Pubblicato in: NPJ Regen Med, Numero 20573995, 2021, ISSN 2057-3995
Editore: NPJ Nature Partner Journals
DOI: 10.1038/s41536-021-00140-4

Stem cells characterization: OMICS reinforcing analytics

Autori: Sebastião MJ, Serra M, Gomes-Alves P, Alves
Pubblicato in: Current Opinion in Biotechnology, Numero 09581669, 2021, Pagina/e 175-181, ISSN 0958-1669
Editore: Elsevier BV
DOI: 10.1016/j.copbio.2021.07.021

The Importance of Interfaces in Multi‐Material Biofabricated Tissue Structures

Autori: Martina Viola, Susanna Piluso, Jürgen Groll, Tina Vermonden, Jos Malda, Miguel Castilho
Pubblicato in: Advanced Healthcare Materials, Numero 10, 2023, ISSN 2192-2640
Editore: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202101021

Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart

Autori: Jolanda van der Velden, Folkert W Asselbergs, Jeroen Bakkers, Sandor Batkai, Luc Bertrand, Connie R Bezzina, Ilze Bot, Bianca J J M Brundel, Lucie Carrier, Steven Chamuleau, Michele Ciccarelli, Dana Dawson, Sean M Davidson, Andreas Dendorfer, Dirk J Duncker, Thomas Eschenhagen, Larissa Fabritz, Ines Falcão-Pires, Péter Ferdinandy, Mauro Giacca, Henrique Girao, Can Gollmann-Tepeköylü, Mariann G
Pubblicato in: Cardiovascular Research, Numero 118, 2024, Pagina/e 3016-3051, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvab370

Artificial Intelligence-Driven Algorithm for Drug Effect Prediction on Atrial Fibrillation: An in silico Population of Models Approach

Autori: Ana Maria Sanchez de la Nava; Ana Maria Sanchez de la Nava; Ana Maria Sanchez de la Nava; Ángel Arenal; Ángel Arenal; Ángel Arenal; Francisco Fernández-Avilés; Francisco Fernández-Avilés; Francisco Fernández-Avilés; Felipe Atienza; Felipe Atienza; Felipe Atienza
Pubblicato in: Frontiers in Physiology, Numero 1664042X, 2021, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.768468

Toward a Microencapsulated 3D hiPSC-Derived in vitro Cardiac Microtissue for Recapitulation of Human Heart Microenvironment Features.

Autori: Bernardo Abecasis; Bernardo Abecasis; Pedro G.M. Canhão; Pedro G.M. Canhão; Henrique V. Almeida; Henrique V. Almeida; Tomás Calmeiro; Elvira Fortunato; Patrícia Gomes-Alves; Patrícia Gomes-Alves; Margarida Serra; Margarida Serra; Paula M. Alves; Paula M. Alves
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Numero 22964185, 2020, ISSN 2296-4185
Editore: Frontiers Media S.A.
DOI: 10.3389/fbioe.2020.580744

Billion‐Scale Expansion of Functional hiPSC‐Derived Cardiomyocytes in Bioreactors Through Oxygen Control and Continuous Wnt Activation

Autori: Pedro Vicente, Lara R. Inocêncio, Asier Ullate‐Agote, Ana F. Louro, João Jacinto, Beatriz Gamelas, Olalla Iglesias‐García, Patxi San Martin‐Uriz, Paula Aguirre‐Ruiz, Gonzalo R. Ríos‐Muñoz, María Eugenia Fernández‐Santos, Alain van Mil, Joost P. G. Sluijter, Felipe Prósper, Manuel M Mazo Vega, Paula M. Alves, Margarida Serra
Pubblicato in: Advanced Science, Numero 12, 2025, ISSN 2198-3844
Editore: Wiley
DOI: 10.1002/advs.202410510

Biomaterials-Based Antioxidant Strategies for the Treatment of Oxidative Stress Diseases

Autori: Maria Perez-Araluce, Tomasz Jüngst, Carmen Sanmartin, Felipe Prosper, Daniel Plano, Manuel M. Mazo
Pubblicato in: Biomimetics, Numero 9, 2025, Pagina/e 23, ISSN 2313-7673
Editore: MDPI AG
DOI: 10.3390/biomimetics9010023

Adjusting Degree of Modification and Composition of gelAGE-Based Hydrogels Improves Long-Term Survival and Function of Primary Human Fibroblasts and Endothelial Cells in 3D Cultures

Autori: Hatice Genç, Alessandro Cianciosi, Raphael Lohse, Philipp Stahlhut, Jürgen Groll, Christoph Alexiou, Iwona Cicha, Tomasz Jüngst
Pubblicato in: Biomacromolecules, Numero 24, 2023, Pagina/e 1497-1510, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.2c01536

Experimentally-guided in silico design of engineered heart tissues to improve cardiac electrical function after myocardial infarction

Autori: Ricardo M. Rosales, Konstantinos A. Mountris, Aida Oliván-Viguera, María Pérez-Zabalza, Gerardo Cedillo-Servin, Olalla Iglesias-García, Andrei Hrynevich, Miguel Castilho, Jos Malda, Felipe Prósper, Manuel Doblaré, Manuel M. Mazo, Esther Pueyo
Pubblicato in: Computers in Biology and Medicine, Numero 171, 2024, Pagina/e 108044, ISSN 0010-4825
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2024.108044

Human Extracellular-Matrix Functionalization of 3D hiPSC-Based Cardiac Tissues Improves Cardiomyocyte Maturation

Autori: Henrique V. Almeida; Miguel F. Tenreiro; Ana F. Louro; Bernardo Abecasis; Deolinda Santinha; Tomás Calmeiro; Elvira Fortunato; Lino Ferreira; Paula M. Alves; Margarida Serra
Pubblicato in: ACS Applied Bio Materials, Numero 25766422, 2021, Pagina/e 1888-1889, ISSN 2576-6422
Editore: ACS Publications
DOI: 10.1021/acsabm.0c01490

Impact of cardiac patch alignment on restoring post-infarct ventricular function

Autori: Koen L. P. M. Janssens, Peter H. M. Bovendeerd
Pubblicato in: Biomechanics and Modeling in Mechanobiology, Numero 23, 2024, Pagina/e 1963-1976, ISSN 1617-7959
Editore: Springer Verlag
DOI: 10.1007/s10237-024-01877-9

Bioactivity and miRNome Profiling of Native Extracellular Vesicles in Human Induced Pluripotent Stem Cell-Cardiomyocyte Differentiation

Autori: Louro AF, Paiva MA, Oliveira MR, Kasper KA, Alves PM, Gomes-Alves P, Serra M
Pubblicato in: Adv Sci, Numero 21983844, 2022, Pagina/e e2104296, ISSN 2198-3844
Editore: Wiley-VCH
DOI: 10.1002/advs.202104296

Protocol for SARS-CoV-2 infection of kidney organoids derived from human pluripotent stem cells

Autori: Elena Garreta, Daniel Moya-Rull, Megan L. Stanifer, Vanessa Monteil, Patricia Prado, Andrés Marco, Carolina Tarantino, Maria Gallo, Gustav Jonsson, Astrid Hagelkruys, Ali Mirazimi, Steeve Boulant, Josef M. Penninger, Nuria Montserrat
Pubblicato in: STAR Protocols, Numero 3, 2024, Pagina/e 101872, ISSN 2666-1667
Editore: Elsevier BV
DOI: 10.1016/j.xpro.2022.101872

Small molecule-mediated rapid maturation of human induced pluripotent stem cell-derived cardiomyocytes

Autori: Nino Chirico, Elise L. Kessler, Renée G. C. Maas, Juntao Fang, Jiabin Qin, Inge Dokter, Mark Daniels, Tomo Šarić, Klaus Neef, Jan-Willem Buikema, Zhiyong Lei, Pieter A. Doevendans, Joost P. G. Sluijter, Alain van Mil
Pubblicato in: Stem Cell Research & Therapy, Numero 13, 2022, ISSN 1757-6512
Editore: BioMed Central
DOI: 10.1186/s13287-022-03209-z

Optical Fiber‐Assisted Printing: A Platform Technology for Straightforward Photopolymer Resins Patterning and Freeform 3D Printing

Autori: Alessandro Cianciosi, Maximilian Pfeiffle, Philipp Wohlfahrt, Severin Nürnberger, Tomasz Jungst
Pubblicato in: Advanced Science, Numero 11, 2024, ISSN 2198-3844
Editore: Wiley
DOI: 10.1002/advs.202403049

Small molecule-mediated rapid maturation of human induced pluripotent stem cell derived cardiomyocytes

Autori: N Chirico, E L Kessler, RGC Maas, J Fang, J Qin, I Dokter, S Ciccone, T Saric, JW Buikema, Z Lei, P Doevendans, JPG Sluijter, A Van Mil
Pubblicato in: Cardiovascular Research, Numero 118, 2022, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvac066.012

Melt Electrowriting of Isomalt for High‐Resolution Templating of Embedded Microchannels

Autori: Ali Nadernezhad, Matthias Ryma, Hatice Genç, Iwona Cicha, Tomasz Jüngst, Jürgen Groll
Pubblicato in: Advanced Materials Technologies, Numero 6, 2023, ISSN 2365-709X
Editore: Wiley
DOI: 10.1002/admt.202100221

Massive expansion and cryopreservation of functional human induced pluripotent stem cell-derived cardiomyocytes

Autori: Maas RGC, Lee S, Harakalova M, Snijders Blok CJB, Goodyer WR, Hjortnaes J, Doevendans PAFM, Van Laake LW, van der Velden J, Asselbergs FW, Wu JC, Sluijter JPG, Wu SM, Buikema JW
Pubblicato in: STAR Protoc, Numero 26661667, 2021, Pagina/e 100334, ISSN 2666-1667
Editore: Cell Press
DOI: 10.1016/j.xpro.2021.100334

Cardiovascular Diseases in the Digital Health Era: A Translational Approach from the Lab to the Clinic

Autori: Sánchez de la Nava AM, Gómez-Cid L, Ríos-Muñoz GR, Fernández-Santos ME, Fernández AI, Arenal A, Sanz-Ruiz R, Grigorian-Shamagian L, Atienza F, Fernández-Avilés F
Pubblicato in: BioTech, Numero 26736284, 2022, Pagina/e 23, ISSN 2673-6284
Editore: Basel: MDPI AG
DOI: 10.3390/biotech11030023

Unveiling Human Proteome Signatures of Heart Failure with Preserved Ejection Fraction

Autori: Maria J. Sebastião, Henrique V. Almeida, Margarida Serra, Nazha Hamdani, Francisca Saraiva, André P. Lourenço, António S. Barros, Francisco Vasques-Nóvoa, Adelino Leite-Moreira, Paula M. Alves, Inês Falcão-Pires, Patrícia Gomes-Alves
Pubblicato in: Biomedicines, Numero 10, 2024, Pagina/e 2943, ISSN 2227-9059
Editore: MDPI AG
DOI: 10.3390/biomedicines10112943

Short- and long term preservation of cardiac tissue-engineered constructs

Autori: J Janssen, N Chirico, M Ainsworth, M Viola, G Cedillo-Servin, T Vermonden, P Doevendans, M Serra, I Voets, J Malda, M Castilho, L Laake, J Sluijter, V Sampaio-Pinto, A Van Mil
Pubblicato in: Cardiovascular Research, Numero 120, 2024, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvae088.144

Current approaches for the recreation of cardiac ischaemic environment in vitro

Autori: Laura Paz-Artigas, Pilar Montero-Calle, Olalla Iglesias-García, Manuel M. Mazo, Ignacio Ochoa, Jesús Ciriza
Pubblicato in: International Journal of Pharmaceutics, Numero 632, 2025, Pagina/e 122589, ISSN 0378-5173
Editore: Elsevier BV
DOI: 10.1016/j.ijpharm.2023.122589

Ventricular Conduction System Modeling for Electrophysiological Simulation of the Porcine Heart

Autori: """Ricardo Maximiliano Rosales, Konstantinos Mountris, Manuel Doblaré, Manuel Mazo, Esther Pueyo"""
Pubblicato in: Computing in Cardiology Conference (CinC), 2022 Computing in Cardiology Conference (CinC), Numero 49, 2023, ISSN 2325-887X
Editore: Computing in Cardiology
DOI: 10.22489/cinc.2022.030

Synthesis and Characterization of Novel Selenated Hydrogels for the Treatment of Chronic Wounds

Autori: Maria Perez-Araluce, Carmen Sanmartin, Felipe Prosper, Tomasz Jüngst, Daniel Plano, Manuel M. Mazo
Pubblicato in: IOCB 2024, 2024, Pagina/e 30
Editore: MDPI
DOI: 10.3390/proceedings2024107030

Modelling, design, fabrication and characterization of engineered human myocardium made with melt electrowriting and cardiac cells derived from hiPSCs

Autori: Flandes-Iparraguirre, M. (María)
Pubblicato in: instname:Universidad de Navarra, Numero 13, 2023
Editore: University of Navarra

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