A modular strategy for the repair of critical sized bone fractures

Project Information

HEALIKICK

Grant agreement ID: 874889

DOI 10.3030/874889

EC signature date 4 May 2020

Start date 1 June 2020

End date 31 May 2025

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost € 5 243 535,50

EU contribution € 5 243 535,50

Coordinated by

UNIVERSITY OF GLASGOW
United Kingdom

Deliverables

Demonstrators, pilots, prototypes (3)

Nanovibrational bioreactors to supply WP2.

Nanovibrational bioreactors to supply WP2

In vitro data demonstrating the effect of nanovibration on ovine aMSCs.
In vitro data demonstrating the effect of nanovibration on human aMSCs.

Open Research Data Pilot (1)

A consortium data management plan.

A consortium data management plan

Other (1)

A confirmed clinical team for first human trial of the two technologies.

Publications

Peer reviewed articles (3)

An engineered periosteum for efficient delivery of rhBMP-2 and mesenchymal progenitor cells during bone regeneration

Author(s): Juan Antonio Romero-Torrecilla; José María Lamo-Espinosa; Purificación Ripalda-Cemboráin; Tania López-Martínez; Gloria Abizanda; Luis Riera-Álvarez; Sergio Ruiz de Galarreta-Moriones; Asier López-Barberena; Naiara Rodríguez-Flórez; Reyes Elizalde; Vineetha Jayawarna; José Valdés-Fernández; Miguel Echanove-González de Anleo; Peter Childs; Elena de Juan-Pardo; Manuel Salmeron-Sanchez;
Published in: NPJ Regenerative Medicine, 2023, ISSN 2057-3995
Publisher: Springer Nature
DOI: 10.1038/s41536-023-00330-2

An ossifying landscape: materials and growth factor strategies for osteogenic signalling and bone regeneration

Author(s): Udesh Dhawan; Hussain Jaffery; Manuel Salmerón-Sánchez; Matthew J. Dalby
Published in: Current Opinion in Biotechnology, Issue 1, 2021, ISSN 0958-1669
Publisher: Elsevier BV
DOI: 10.1016/j.copbio.2021.10.010

Molecular and Cellular Mechanisms of Delayed Fracture Healing in Mmp10 (Stromelysin 2) Knockout Mice

Author(s): José Valdés‐Fernández, Tania López‐Martínez, Purificación Ripalda‐Cemboráin, Isabel A Calvo, Borja Sáez, Juan Antonio Romero‐Torrecilla, Javier Aldazabal, Emma Muiños‐López, Verónica Montiel, Josune Orbe, José Antonio Rodríguez, José Antonio Páramo, Felipe Prósper, Froilán Granero‐Moltó
Published in: Journal of Bone and Mineral Research, Issue 36/11, 2021, Page(s) 2203-2213, ISSN 0884-0431
Publisher: American Society for Bone and Mineral Research
DOI: 10.1002/jbmr.4403