A modular strategy for the repair of critical sized bone fractures

Project Information

HEALIKICK

Grant agreement ID: 874889

DOI

10.3030/874889

Project closed

EC signature date 4 May 2020

Start date 1 June 2020

End date 31 May 2026

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 5 243 535,50

EU contribution

€ 5 243 535,50

Coordinated by

UNIVERSITY OF GLASGOW
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Demonstrators, pilots, prototypes (3)

Nanovibrational bioreactors to supply WP2.

Nanovibrational bioreactors to supply WP2

In vitro data demonstrating the effect of nanovibration on ovine aMSCs.
In vitro data demonstrating the effect of nanovibration on human aMSCs.

Open Research Data Pilot (1)

A consortium data management plan.

A consortium data management plan

Other (1)

A confirmed clinical team for first human trial of the two technologies.

Publications

Peer reviewed articles (9)

An engineered periosteum for efficient delivery of rhBMP-2 and mesenchymal progenitor cells during bone regeneration

Author(s): Juan Antonio Romero-Torrecilla; José María Lamo-Espinosa; Purificación Ripalda-Cemboráin; Tania López-Martínez; Gloria Abizanda; Luis Riera-Álvarez; Sergio Ruiz de Galarreta-Moriones; Asier López-Barberena; Naiara Rodríguez-Flórez; Reyes Elizalde; Vineetha Jayawarna; José Valdés-Fernández; Miguel Echanove-González de Anleo; Peter Childs; Elena de Juan-Pardo; Manuel Salmeron-Sanchez;
Published in: NPJ Regenerative Medicine, 2023, ISSN 2057-3995
Publisher: Springer Nature
DOI: 10.1038/s41536-023-00330-2

3D-printed polycaprolactone scaffolds functionalized with poly(lactic-co-glycolic) acid microparticles enhance bone regeneration through tunable drug release

Author(s): Juan Antonio Romero-Torrecilla, Miguel Echanove-González de Anleo, Cristina Martínez-Ohárriz, Purificación Ripalda-Cemboráin, Tania López-Martínez, Gloria Abizanda, José Valdés-Fernández, Jakub Prandota, Emma Muiños-López, Elisa Garbayo, Felipe Prósper, María J. Blanco-Prieto, Froilán Granero-Moltó
Published in: Acta Biomaterialia, Issue 198, 2025, Page(s) 219-233, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2025.04.021

Nano-scale evidence for osteocyte network integration across bone remodeling interfaces in human bone revealed by synchrotron nanoCT

Author(s): Sophie Anuth, Emely Bortel, Julie Villanova, Jussi-Petteri Suuronen, Sven Geissler, Amaia Cipitria, Peter Fratzl, Tobias Fretwurst, Katja Nelson, Susanne Nahles, Bernhard Hesse
Published in: Materials Today Bio, Issue 37, 2026, Page(s) 102813, ISSN 2590-0064
Publisher: Elsevier BV
DOI: 10.1016/j.mtbio.2026.102813

APEX1, a transcriptional hub for endochondral ossification and fracture repair

Author(s): José Valdés-Fernández, Miguel Echanove-González de Anleo, Juan Antonio Romero-Torrecilla, Tania López-Martínez, Purificación Ripalda-Cemboráin, María Erendira Calleja-Cervantes, Asier Ullate-Agote, Elena Iglesias, Belén Prados-Pinto, José Luis de la Pompa, Felipe Prósper, Emma Muiños-López, Froilán Granero-Moltó
Published in: Bone Research, Issue 14, 2026, ISSN 2095-6231
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s41413-025-00486-1

N-cadherin crosstalk with integrin weakens the molecular clutch in response to surface viscosity

Author(s): Manuel Salmeron-Sanchez, Eva Barcelona-Estaje, Aleixandre Rodrigo-Navarro, Paul Genever, Matthew Dalby, Pere Roca-Cusachs, Marco Cantini
Published in: N-cadherin crosstalk with integrin weakens the molecular clutch in response to surface viscosity, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.21203/rs.3.rs-3429093/v1

An ossifying landscape: materials and growth factor strategies for osteogenic signalling and bone regeneration

Author(s): Udesh Dhawan; Hussain Jaffery; Manuel Salmerón-Sánchez; Matthew J. Dalby
Published in: Current Opinion in Biotechnology, Issue 1, 2021, ISSN 0958-1669
Publisher: Elsevier BV
DOI: 10.1016/j.copbio.2021.10.010

Tenascin-c functionalised self-assembling peptide hydrogels for critical-sized bone defect reconstruction

Author(s): Alexandre Trubert-Paneli, Jonathan A. Williams, James F.C. Windmill, Leire Iturriaga, Eonan W. Pringle, Theodora Rogkoti, Siyuan Dong, Amaia Cipitria, Aline F. Miller, Cristina Gonzalez-Garcia, Alberto Saiani, Manuel Salmeron-Sanchez
Published in: Biomaterials, Issue 325, 2026, Page(s) 123553, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2025.123553

Engineered Surfaces That Promote Capture of Latent Proteins to Facilitate Integrin‐Mediated Mechanical Activation of Growth Factors

Author(s): Udesh Dhawan, Jonathan A. Williams, James F. C. Windmill, Peter Childs, Cristina Gonzalez‐Garcia, Matthew J. Dalby, Manuel Salmeron‐Sanchez
Published in: Advanced Materials, Issue 36, 2024, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202310789

Molecular and Cellular Mechanisms of Delayed Fracture Healing in Mmp10 (Stromelysin 2) Knockout Mice

Author(s): José Valdés‐Fernández, Tania López‐Martínez, Purificación Ripalda‐Cemboráin, Isabel A Calvo, Borja Sáez, Juan Antonio Romero‐Torrecilla, Javier Aldazabal, Emma Muiños‐López, Verónica Montiel, Josune Orbe, José Antonio Rodríguez, José Antonio Páramo, Felipe Prósper, Froilán Granero‐Moltó
Published in: Journal of Bone and Mineral Research, Issue 36/11, 2021, Page(s) 2203-2213, ISSN 0884-0431
Publisher: American Society for Bone and Mineral Research
DOI: 10.1002/jbmr.4403