A modular strategy for the repair of critical sized bone fractures

Informazioni relative al progetto

HEALIKICK

ID dell’accordo di sovvenzione: 874889

DOI

10.3030/874889

Progetto chiuso

Data della firma CE 4 Maggio 2020

Data di avvio 1 Giugno 2020

Data di completamento 31 Maggio 2026

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

€ 5 243 535,50

Contributo UE

€ 5 243 535,50

Coordinato da

UNIVERSITY OF GLASGOW
United Kingdom

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Demonstrators, pilots, prototypes (3)

Nanovibrational bioreactors to supply WP2.

Nanovibrational bioreactors to supply WP2

In vitro data demonstrating the effect of nanovibration on ovine aMSCs.
In vitro data demonstrating the effect of nanovibration on human aMSCs.

Open Research Data Pilot (1)

A consortium data management plan.

A consortium data management plan

Other (1)

A confirmed clinical team for first human trial of the two technologies.

Pubblicazioni

Peer reviewed articles (9)

An engineered periosteum for efficient delivery of rhBMP-2 and mesenchymal progenitor cells during bone regeneration

Autori: Juan Antonio Romero-Torrecilla; José María Lamo-Espinosa; Purificación Ripalda-Cemboráin; Tania López-Martínez; Gloria Abizanda; Luis Riera-Álvarez; Sergio Ruiz de Galarreta-Moriones; Asier López-Barberena; Naiara Rodríguez-Flórez; Reyes Elizalde; Vineetha Jayawarna; José Valdés-Fernández; Miguel Echanove-González de Anleo; Peter Childs; Elena de Juan-Pardo; Manuel Salmeron-Sanchez;
Pubblicato in: NPJ Regenerative Medicine, 2023, ISSN 2057-3995
Editore: Springer Nature
DOI: 10.1038/s41536-023-00330-2

3D-printed polycaprolactone scaffolds functionalized with poly(lactic-co-glycolic) acid microparticles enhance bone regeneration through tunable drug release

Autori: Juan Antonio Romero-Torrecilla, Miguel Echanove-González de Anleo, Cristina Martínez-Ohárriz, Purificación Ripalda-Cemboráin, Tania López-Martínez, Gloria Abizanda, José Valdés-Fernández, Jakub Prandota, Emma Muiños-López, Elisa Garbayo, Felipe Prósper, María J. Blanco-Prieto, Froilán Granero-Moltó
Pubblicato in: Acta Biomaterialia, Numero 198, 2025, Pagina/e 219-233, ISSN 1742-7061
Editore: Elsevier BV
DOI: 10.1016/j.actbio.2025.04.021

Nano-scale evidence for osteocyte network integration across bone remodeling interfaces in human bone revealed by synchrotron nanoCT

Autori: Sophie Anuth, Emely Bortel, Julie Villanova, Jussi-Petteri Suuronen, Sven Geissler, Amaia Cipitria, Peter Fratzl, Tobias Fretwurst, Katja Nelson, Susanne Nahles, Bernhard Hesse
Pubblicato in: Materials Today Bio, Numero 37, 2026, Pagina/e 102813, ISSN 2590-0064
Editore: Elsevier BV
DOI: 10.1016/j.mtbio.2026.102813

APEX1, a transcriptional hub for endochondral ossification and fracture repair

Autori: José Valdés-Fernández, Miguel Echanove-González de Anleo, Juan Antonio Romero-Torrecilla, Tania López-Martínez, Purificación Ripalda-Cemboráin, María Erendira Calleja-Cervantes, Asier Ullate-Agote, Elena Iglesias, Belén Prados-Pinto, José Luis de la Pompa, Felipe Prósper, Emma Muiños-López, Froilán Granero-Moltó
Pubblicato in: Bone Research, Numero 14, 2026, ISSN 2095-6231
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s41413-025-00486-1

N-cadherin crosstalk with integrin weakens the molecular clutch in response to surface viscosity

Autori: Manuel Salmeron-Sanchez, Eva Barcelona-Estaje, Aleixandre Rodrigo-Navarro, Paul Genever, Matthew Dalby, Pere Roca-Cusachs, Marco Cantini
Pubblicato in: N-cadherin crosstalk with integrin weakens the molecular clutch in response to surface viscosity, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.21203/rs.3.rs-3429093/v1

An ossifying landscape: materials and growth factor strategies for osteogenic signalling and bone regeneration

Autori: Udesh Dhawan; Hussain Jaffery; Manuel Salmerón-Sánchez; Matthew J. Dalby
Pubblicato in: Current Opinion in Biotechnology, Numero 1, 2021, ISSN 0958-1669
Editore: Elsevier BV
DOI: 10.1016/j.copbio.2021.10.010

Tenascin-c functionalised self-assembling peptide hydrogels for critical-sized bone defect reconstruction

Autori: Alexandre Trubert-Paneli, Jonathan A. Williams, James F.C. Windmill, Leire Iturriaga, Eonan W. Pringle, Theodora Rogkoti, Siyuan Dong, Amaia Cipitria, Aline F. Miller, Cristina Gonzalez-Garcia, Alberto Saiani, Manuel Salmeron-Sanchez
Pubblicato in: Biomaterials, Numero 325, 2026, Pagina/e 123553, ISSN 0142-9612
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2025.123553

Engineered Surfaces That Promote Capture of Latent Proteins to Facilitate Integrin‐Mediated Mechanical Activation of Growth Factors

Autori: Udesh Dhawan, Jonathan A. Williams, James F. C. Windmill, Peter Childs, Cristina Gonzalez‐Garcia, Matthew J. Dalby, Manuel Salmeron‐Sanchez
Pubblicato in: Advanced Materials, Numero 36, 2024, ISSN 0935-9648
Editore: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202310789

Molecular and Cellular Mechanisms of Delayed Fracture Healing in Mmp10 (Stromelysin 2) Knockout Mice

Autori: José Valdés‐Fernández, Tania López‐Martínez, Purificación Ripalda‐Cemboráin, Isabel A Calvo, Borja Sáez, Juan Antonio Romero‐Torrecilla, Javier Aldazabal, Emma Muiños‐López, Verónica Montiel, Josune Orbe, José Antonio Rodríguez, José Antonio Páramo, Felipe Prósper, Froilán Granero‐Moltó
Pubblicato in: Journal of Bone and Mineral Research, Numero 36/11, 2021, Pagina/e 2203-2213, ISSN 0884-0431
Editore: American Society for Bone and Mineral Research
DOI: 10.1002/jbmr.4403