A modular strategy for the repair of critical sized bone fractures

Informazioni relative al progetto

HEALIKICK

ID dell’accordo di sovvenzione: 874889

DOI 10.3030/874889

Data della firma CE 4 Maggio 2020

Data di avvio 1 Giugno 2020

Data di completamento 31 Maggio 2025

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale € 5 243 535,50

Contributo UE € 5 243 535,50

Coordinato da

UNIVERSITY OF GLASGOW
United Kingdom

Risultati finali

Demonstrators, pilots, prototypes (3)

Nanovibrational bioreactors to supply WP2.

Nanovibrational bioreactors to supply WP2

In vitro data demonstrating the effect of nanovibration on ovine aMSCs.
In vitro data demonstrating the effect of nanovibration on human aMSCs.

Open Research Data Pilot (1)

A consortium data management plan.

A consortium data management plan

Other (1)

A confirmed clinical team for first human trial of the two technologies.

Pubblicazioni

Peer reviewed articles (3)

An engineered periosteum for efficient delivery of rhBMP-2 and mesenchymal progenitor cells during bone regeneration

Autori: Juan Antonio Romero-Torrecilla; José María Lamo-Espinosa; Purificación Ripalda-Cemboráin; Tania López-Martínez; Gloria Abizanda; Luis Riera-Álvarez; Sergio Ruiz de Galarreta-Moriones; Asier López-Barberena; Naiara Rodríguez-Flórez; Reyes Elizalde; Vineetha Jayawarna; José Valdés-Fernández; Miguel Echanove-González de Anleo; Peter Childs; Elena de Juan-Pardo; Manuel Salmeron-Sanchez;
Pubblicato in: NPJ Regenerative Medicine, 2023, ISSN 2057-3995
Editore: Springer Nature
DOI: 10.1038/s41536-023-00330-2

An ossifying landscape: materials and growth factor strategies for osteogenic signalling and bone regeneration

Autori: Udesh Dhawan; Hussain Jaffery; Manuel Salmerón-Sánchez; Matthew J. Dalby
Pubblicato in: Current Opinion in Biotechnology, Numero 1, 2021, ISSN 0958-1669
Editore: Elsevier BV
DOI: 10.1016/j.copbio.2021.10.010

Molecular and Cellular Mechanisms of Delayed Fracture Healing in Mmp10 (Stromelysin 2) Knockout Mice

Autori: José Valdés‐Fernández, Tania López‐Martínez, Purificación Ripalda‐Cemboráin, Isabel A Calvo, Borja Sáez, Juan Antonio Romero‐Torrecilla, Javier Aldazabal, Emma Muiños‐López, Verónica Montiel, Josune Orbe, José Antonio Rodríguez, José Antonio Páramo, Felipe Prósper, Froilán Granero‐Moltó
Pubblicato in: Journal of Bone and Mineral Research, Numero 36/11, 2021, Pagina/e 2203-2213, ISSN 0884-0431
Editore: American Society for Bone and Mineral Research
DOI: 10.1002/jbmr.4403