High-Dimensional single cell mapping of inflammatory disease signatures in monozygotic twins

Project description

Multiple sclerosis immune cell characterisation to provide new disease biomarker

Currently, there is no biomarker for monitoring the progression of the chronic inflammatory disease multiple sclerosis (MS). To address this, scientists of the EU-funded IMPACT project will investigate the immune compartment of patients at a single cell level using machine learning approaches. They will also eliminate the impact of an individual's genetic makeup on disease signature by studying a unique cohort of monozygotic twin pairs. Results will help unveil disease-specific signals and undertake a more precise characterisation of immune cell populations implicated in MS pathology. Ultimately, the study will lead to the identification of biomarkers that could be routinely used in the clinic.

Fields of science

• medical and health sciences › medical biotechnology › cells technologies › stem cells
• medical and health sciences › health sciences › inflammatory diseases
• medical and health sciences › basic medicine › neurology › multiple sclerosis
• natural sciences › biological sciences › neurobiology

Programme(s)

• H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)

Topic(s)

• ERC-2019-ADG - ERC Advanced Grant

Call for proposal

ERC-2019-ADG
See other projects for this call

Funding Scheme

ERC-ADG - Advanced Grant

Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Host institution

UNIVERSITAT ZURICH

Address

Ramistrasse 71
8006 Zurich
Switzerland

Activity type

Higher or Secondary Education Establishments

EU contribution

€ 2 492 221

Beneficiaries (1)

UNIVERSITAT ZURICH

Switzerland

EU contribution

€ 2 492 221

Address

Ramistrasse 71
8006 Zurich

Activity type

Higher or Secondary Education Establishments