High-Dimensional single cell mapping of inflammatory disease signatures in monozygotic twins

Project description

Multiple sclerosis immune cell characterisation to provide new disease biomarker

Currently, there is no biomarker for monitoring the progression of the chronic inflammatory disease multiple sclerosis (MS). To address this, scientists of the EU-funded IMPACT project will investigate the immune compartment of patients at a single cell level using machine learning approaches. They will also eliminate the impact of an individual's genetic makeup on disease signature by studying a unique cohort of monozygotic twin pairs. Results will help unveil disease-specific signals and undertake a more precise characterisation of immune cell populations implicated in MS pathology. Ultimately, the study will lead to the identification of biomarkers that could be routinely used in the clinic.

Fields of science

Host institution

UNIVERSITAT ZURICH

Net EU contribution

€ 2 492 221,00

Address

Ramistrasse 71
8006 Zurich
Switzerland

Contact the organisation

Activity type

Higher or Secondary Education Establishments

Non-EU contribution

€ 0,00

Region

Schweiz/Suisse/Svizzera Zürich Zürich

Website

Participation in EU R&I programmes

Beneficiaries (1)