High-Dimensional single cell mapping of inflammatory disease signatures in monozygotic twins

Project Information

IMPACT

Grant agreement ID: 882424

DOI 10.3030/882424

EC signature date 29 July 2020

Start date 1 January 2021

End date 31 December 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 492 221,00

EU contribution € 2 492 221,00

Coordinated by

UNIVERSITAT ZURICH
Switzerland

Publications

Peer reviewed articles (12)

Twin study reveals non-heritable immune perturbations in multiple sclerosis

Author(s): Ingelfinger F, Gerdes LA, Kavaka V, Krishnarajah S, Friebel E, Galli E, Zwicky P, Furrer R, Peukert C, Dutertre CA, Eglseer KM, Ginhoux F, Flierl-Hecht A, Kümpfel T, De Feo D, Schreiner B, Mundt S, Kerschensteiner M, Hohlfeld R, Beltrán E, Becher B
Published in: Nature, 2022, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-04419-4

B cell depletion attenuates CD27 signaling of T helper cells in multiple sclerosis

Author(s): Can Ulutekin, Edoardo Galli, Bettina Schreiner, Mohsen Khademi , Ilaria Callegari, Fredrik Piehl, Nicholas Sanderson, Daniel Kirschenbaum, Sarah Mundt, Massimo Filippi, Roberto Furlan, Tomas Olsson, Tobias Derfuss, Florian Ingelfinger, Burkhard Becher
Published in: Cell Rep Med, 2024, ISSN 2666-3791
Publisher: Cell Press (Elsevier)
DOI: 10.1016/j.xcrm.2023.101351

Pre-existing comorbidities shape the immune response associated with severe COVID-19

Author(s): Kreutmair S, Kauffmann M, Unger S, Ingelfinger F, Núñez NG, Alberti C, De Feo D, Krishnarajah S, Friebel E, Ulutekin C, Babaei S, Gaborit B, Lutz M, Jurado NP, Malek NP, Göpel S, Rosenberger P, Häberle HA, Ayoub I, Al-Hajj S, Claassen M, Liblau R, Martin-Blondel G, Bitzer M, Roquilly A, Becher B.
Published in: Journal of Allergy and Clinical Immunology, 2022, ISSN 0091-6749
Publisher: Mosby Inc.
DOI: 10.1016/j.jaci.2022.05.019

Single-cell profiling of myasthenia gravis identifies a pathogenic T cell signature

Author(s): Florian Ingelfinger; Sinduya Krishnarajah; Michael Kramer; Sebastian G. Utz; Edoardo Galli; Mirjam Lutz; Pascale Zwicky; Ayse Akarca; Nicole Puertas Jurado; Can Ulutekin; David Bamert; Corinne C Widmer; Luca Piccoli; Federica Sallusto; Federica Sallusto; Nicolás Gonzalo Núñez; Teresa Marafioti; Didier Schneiter; Isabelle Opitz; Antonio Lanzavecchia; Hans H. Jung; Donatella De Feo; Sarah Mundt;
Published in: Acta Neuropathologica, 141 (6), Issue 00016322, 2021, ISSN 0001-6322
Publisher: Springer Verlag
DOI: 10.1007/s00401-021-02299-y

Single-cell multiomics in neuroinflammation

Author(s): Ingelfinger F, Beltrán E, Gerdes LA, Becher B
Published in: Current Opinion in Immunology, Issue 09527915, 2022, ISSN 0952-7915
Publisher: Elsevier BV
DOI: 10.1016/j.coi.2022.102180

GM-CSF: Master regulator of the T cell-phagocyte interface during inflammation

Author(s): Florian Ingelfinger; Donatella De Feo; Burkhard Becher
Published in: Seminars in Immunology, Issue 10445323, 2021, ISSN 1044-5323
Publisher: Academic Press
DOI: 10.1016/j.smim.2021.101518

Azathioprine therapy induces selective NK cell depletion and IFN-γ deficiency predisposing to herpesvirus reactivation

Author(s): Ingelfinger F, Sparano C, Bamert D, Reyes-Leiva D, Sethi D, Rindlisbacher L, Zwicky P, Kreutmair S, Widmer C, Mundt S, Cortés-Vicente E, Tugues S, Becher B, Schreiner B
Published in: Journal of Allergy and Clinical Immunology, Issue 00916749, 2022, ISSN 0091-6749
Publisher: Mosby Inc.
DOI: 10.1016/j.jaci.2022.09.010

TH Cells and Cytokines in Encephalitogenic Disorders

Author(s): Krishnarajah S, Becher B
Published in: Frontiers in Immunology, Issue 26628465, 2022, ISSN 2662-8465
Publisher: Frontiers
DOI: 10.3389/fimmu.2022.822919

Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia

Author(s): Kreutmair S, Unger S, Núñez N, Ingelfinger F, Alberti C, De Feo D, Krishnarajah S, Kauffmann M, Friebel E, Babaei S, Gaborit B, Lutz M, PuertasJurado N, Malek N, Goepel S, Rosenberger P, Häberle H, Ayoub I, Al-Hajj S, Nilsson J, Claassen M, Liblau R, Blondel G, Bitzer M, Roquilly A, Becher B
Published in: Immunity, Issue 10747613, 2021, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2021.05.002

Antibodies Produced by CLL Phenotype B Cells in Patients With Myasthenia Gravis Are Not Directed Against Neuromuscular Endplates

Author(s): Ingelfinger F, Kramer M, Lutz M, Widmer CC, Piccoli L, Kreutmair S, Wertheimer T, Woodhall M, Waters P, Sallusto F, Lanzavecchia A, Mundt S, Becher B, Schreiner B.
Published in: Neurology: Neuroimmunology & Neuroinflammation, 2023, ISSN 2332-7812
Publisher: American Academy of Neurology
DOI: 10.1212/nxi.0000000000200087

High-dimensional analysis of 16 SARS-CoV-2 vaccine combinations reveals lymphocyte signatures correlating with immunogenicity

Author(s): Nuñez NG, Schmid J, Power L, Alberti C, Krishnarajah S, Kreutmair S, Unger S, Blanco S, Konigheim B, Marín C, Onofrio L, Kienzler JC, Costa-Pereira S, Ingelfinger F; InmunoCovidCba; InViV working group; Pasinovich ME, Castelli JM, Vizzotti C, Schaefer M, Villar-Vesga J, Mundt S, Merten CH, Sethi A, Wertheimer T, Lutz M, Vanoaica D, Sotomayor C, Gruppi A, Münz C, Cardozo D, Barbás G, Lopez L, C
Published in: Nature Immunology, 2023, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-023-01499-w

High-dimensional immune profiling identifies a biomarker to monitor dimethyl fumarate response in multiple sclerosis

Author(s): Diebold M , Galli E, Kopf A, Sanderson N, Callegari I, Benkert P, Núñez N, Ingelfinger F, Herms S, Cichon S, Kappos L, Kuhle J, Becher B, Claassen M, Derfuss T
Published in: PNAS, 2022, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2205042119