High-Dimensional single cell mapping of inflammatory disease signatures in monozygotic twins

Project Information

IMPACT

Grant agreement ID: 882424

DOI

10.3030/882424

EC signature date 29 July 2020

Start date 1 January 2021

End date 31 December 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 492 221,00

EU contribution

€ 2 492 221,00

Coordinated by

UNIVERSITAT ZURICH
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (26)

Impact of the Multiple Sclerosis-Associated Genetic Variant <i>CD226</i> Gly307Ser on Human CD8 T-Cell Functions

Author(s): Elena Morandi, Véronique Adoue, Isabelle Bernard, Ekaterina Friebel, Nicolas Nunez, Yann Aubert, Frederick Masson, Anne S. Dejean, Burkhard Becher, Anne Astier, Ludovic Martinet, Abdelhadi Saoudi
Published in: Neurology Neuroimmunology &amp; Neuroinflammation, Issue 11, 2025, ISSN 2332-7812
Publisher: Wolters Kluwer Health
DOI: 10.1212/nxi.0000000000200306

Mononuclear phagocytes in autoimmune neuroinflammation

Author(s): Violetta S. Gogoleva, Sarah Mundt, Donatella De Feo, Burkhard Becher
Published in: Trends in Immunology, Issue 45, 2024, Page(s) 814-823, ISSN 1471-4906
Publisher: Elsevier BV
DOI: 10.1016/j.it.2024.08.005

Twin study reveals non-heritable immune perturbations in multiple sclerosis

Author(s): Ingelfinger F, Gerdes LA, Kavaka V, Krishnarajah S, Friebel E, Galli E, Zwicky P, Furrer R, Peukert C, Dutertre CA, Eglseer KM, Ginhoux F, Flierl-Hecht A, Kümpfel T, De Feo D, Schreiner B, Mundt S, Kerschensteiner M, Hohlfeld R, Beltrán E, Becher B
Published in: Nature, 2022, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-04419-4

B cell depletion attenuates CD27 signaling of T helper cells in multiple sclerosis

Author(s): Can Ulutekin, Edoardo Galli, Bettina Schreiner, Mohsen Khademi , Ilaria Callegari, Fredrik Piehl, Nicholas Sanderson, Daniel Kirschenbaum, Sarah Mundt, Massimo Filippi, Roberto Furlan, Tomas Olsson, Tobias Derfuss, Florian Ingelfinger, Burkhard Becher
Published in: Cell Rep Med, 2024, ISSN 2666-3791
Publisher: Cell Press (Elsevier)
DOI: 10.1016/j.xcrm.2023.101351

Pre-existing comorbidities shape the immune response associated with severe COVID-19

Author(s): Kreutmair S, Kauffmann M, Unger S, Ingelfinger F, Núñez NG, Alberti C, De Feo D, Krishnarajah S, Friebel E, Ulutekin C, Babaei S, Gaborit B, Lutz M, Jurado NP, Malek NP, Göpel S, Rosenberger P, Häberle HA, Ayoub I, Al-Hajj S, Claassen M, Liblau R, Martin-Blondel G, Bitzer M, Roquilly A, Becher B.
Published in: Journal of Allergy and Clinical Immunology, 2022, ISSN 0091-6749
Publisher: Mosby Inc.
DOI: 10.1016/j.jaci.2022.05.019

Twin study dissects CXCR3+ memory B cells as non-heritable feature in multiple sclerosis

Author(s): Florian Ingelfinger, Kirsten L. Kuiper, Can Ulutekin, Lukas Rindlisbacher, Sarah Mundt, Lisa Ann Gerdes, Joost Smolders, Marvin M. van Luijn, Burkhard Becher
Published in: Med, Issue 5, 2024, Page(s) 368-373.e3, ISSN 2666-6340
Publisher: Elsevier
DOI: 10.1016/j.medj.2024.02.013

A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation

Author(s): Lynn Bonetti, Veronika Horkova, Melanie Grusdat, Joseph Longworth, Luana Guerra, Henry Kurniawan, Davide G. Franchina, Leticia Soriano-Baguet, Carole Binsfeld, Charlène Verschueren, Sabine Spath, Anouk Ewen, Eric Koncina, Jean-Jacques Gérardy, Takumi Kobayashi, Catherine Dostert, Sophie Farinelle, Janika Härm, Yu-Tong Fan, Ying Chen, Isaac S. Harris, Philipp A. Lang, Vasilis Vasiliou, Ari Waism
Published in: Cell Metabolism, Issue 36, 2025, Page(s) 1726-1744.e10, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2024.06.010

Single-cell profiling of myasthenia gravis identifies a pathogenic T cell signature

Author(s): Florian Ingelfinger; Sinduya Krishnarajah; Michael Kramer; Sebastian G. Utz; Edoardo Galli; Mirjam Lutz; Pascale Zwicky; Ayse Akarca; Nicole Puertas Jurado; Can Ulutekin; David Bamert; Corinne C Widmer; Luca Piccoli; Federica Sallusto; Federica Sallusto; Nicolás Gonzalo Núñez; Teresa Marafioti; Didier Schneiter; Isabelle Opitz; Antonio Lanzavecchia; Hans H. Jung; Donatella De Feo; Sarah Mundt;
Published in: Acta Neuropathologica, 141 (6), Issue 00016322, 2021, ISSN 0001-6322
Publisher: Springer Verlag
DOI: 10.1007/s00401-021-02299-y

Identification of single-cell blasts in pediatric acute myeloid leukemia using an autoencoder

Author(s): Alice Driessen, Susanne Unger, An-phi Nguyen, Rhonda E Ries, Soheil Meshinchi, Stefanie Kreutmair, Chiara Alberti, Pavel Sumazin, Richard Aplenc, Michele S Redell, Burkhard Becher, María Rodríguez Martínez
Published in: Life Science Alliance, Issue 7, 2024, Page(s) e202402674, ISSN 2575-1077
Publisher: Alliance of EMBO Press, Rockefeller University Press, and Cold Spring Harbor Laboratory Press
DOI: 10.26508/lsa.202402674

Single-cell multiomics in neuroinflammation

Author(s): Ingelfinger F, Beltrán E, Gerdes LA, Becher B
Published in: Current Opinion in Immunology, Issue 09527915, 2022, ISSN 0952-7915
Publisher: Elsevier BV
DOI: 10.1016/j.coi.2022.102180

Tebentafusp elicits on-target cutaneous immune responses driven by cytotoxic T cells in uveal melanoma patients

Author(s): Ramon Staeger, Aizhan Tastanova, Adhideb Ghosh, Nicola Winkelbeiner, Prachi Shukla, Isabel Kolm, Patrick Turko, Adel Benlahrech, Jane Harper, Anna Broomfield, Antonio Camera, Marianna Ambrosio, Veronika Haunerdinger, Phil F. Cheng, Egle Ramelyte, James Pham, Stefanie Kreutmair, Burkhard Becher, Mitchell P. Levesque, Reinhard Dummer, Barbara Meier-Schiesser
Published in: Journal of Clinical Investigation, Issue 135, 2025, ISSN 1558-8238
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci181464

The aryl hydrocarbon receptor shapes monocyte transcriptional responses to interleukin-4 by prolonging STAT6 binding to promoters

Author(s): Alba de Juan, Darawan Tabtim-On, Alice Coillard, Burkhard Becher, Christel Goudot, Elodie Segura
Published in: Science Signaling, Issue 17, 2024, ISSN 1937-9145
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scisignal.adn6324

Adiponectin reduces immune checkpoint inhibitor-induced inflammation without blocking anti-tumor immunity

Author(s): Lukas M. Braun, Sophie Giesler, Geoffroy Andrieux, Roxane Riemer, Nana Talvard-Balland, Sandra Duquesne, Tamina Rückert, Susanne Unger, Stefanie Kreutmair, Melissa Zwick, Marie Follo, Alina Hartmann, Natascha Osswald, Wolfgang Melchinger, Stefanie Chapman, James A. Hutchinson, Sebastian Haferkamp, Leopold Torster, Julian Kött, Christoffer Gebhardt, Dirk Hellwig, Nikolaos Karantzelis, Till Wallra
Published in: Cancer Cell, Issue 43, 2025, Page(s) 269-291.e19, ISSN 1535-6108
Publisher: Cell Press
DOI: 10.1016/j.ccell.2025.01.004

IL-23 stabilizes an effector Treg cell program in the tumor microenvironment

Author(s): Tobias Wertheimer, Pascale Zwicky, Lukas Rindlisbacher, Colin Sparano, Marijne Vermeer, Bruno Marcel Silva de Melo, Claudia Haftmann, Tamina Rückert, Aakriti Sethi, Stefanie Schärli, Anna Huber, Florian Ingelfinger, Caroline Xu, Daehong Kim, Philipp Häne, André Fonseca da Silva, Andreas Muschaweckh, Nicolas Nunez, Sinduya Krishnarajah, Natalie Köhler, Robert Zeiser, Mohamed Oukka, Thomas Korn
Published in: Nature Immunology, Issue 25, 2024, Page(s) 512-524, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-024-01755-7

GM-CSF: Master regulator of the T cell-phagocyte interface during inflammation

Author(s): Florian Ingelfinger; Donatella De Feo; Burkhard Becher
Published in: Seminars in Immunology, Issue 10445323, 2021, ISSN 1044-5323
Publisher: Academic Press
DOI: 10.1016/j.smim.2021.101518

Azathioprine therapy induces selective NK cell depletion and IFN-γ deficiency predisposing to herpesvirus reactivation

Author(s): Ingelfinger F, Sparano C, Bamert D, Reyes-Leiva D, Sethi D, Rindlisbacher L, Zwicky P, Kreutmair S, Widmer C, Mundt S, Cortés-Vicente E, Tugues S, Becher B, Schreiner B
Published in: Journal of Allergy and Clinical Immunology, Issue 00916749, 2022, ISSN 0091-6749
Publisher: Mosby Inc.
DOI: 10.1016/j.jaci.2022.09.010

IL-12 sensing in neurons induces neuroprotective CNS tissue adaptation and attenuates neuroinflammation in mice

Author(s): Myrto Andreadou, Florian Ingelfinger, Donatella De Feo, Teresa L. M. Cramer, Selma Tuzlak, Ekaterina Friebel, Bettina Schreiner, Pascale Eede, Shirin Schneeberger, Maria Geesdorf, Frederike Ridder, Christina A. Welsh, Laura Power, Daniel Kirschenbaum, Shiva K. Tyagarajan, Melanie Greter, Frank L. Heppner, Sarah Mundt, Burkhard Becher
Published in: Nature Neuroscience, Issue 26, 2023, Page(s) 1701-1712, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-023-01435-z

TH Cells and Cytokines in Encephalitogenic Disorders

Author(s): Krishnarajah S, Becher B
Published in: Frontiers in Immunology, Issue 26628465, 2022, ISSN 2662-8465
Publisher: Frontiers
DOI: 10.3389/fimmu.2022.822919

Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia

Author(s): Kreutmair S, Unger S, Núñez N, Ingelfinger F, Alberti C, De Feo D, Krishnarajah S, Kauffmann M, Friebel E, Babaei S, Gaborit B, Lutz M, PuertasJurado N, Malek N, Goepel S, Rosenberger P, Häberle H, Ayoub I, Al-Hajj S, Nilsson J, Claassen M, Liblau R, Blondel G, Bitzer M, Roquilly A, Becher B
Published in: Immunity, Issue 10747613, 2021, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2021.05.002

Immune signatures predict development of autoimmune toxicity in patients with cancer treated with immune checkpoint inhibitors

Author(s): Nicolas Gonzalo Nuñez, Fiamma Berner, Ekaterina Friebel, Susanne Unger, Nina Wyss, Julia Martinez Gomez, Mette-Triin Purde, Rebekka Niederer, Maximilian Porsch, Christa Lichtensteiger, Rafaela Kramer, Michael Erdmann, Christina Schmitt, Lucie Heinzerling, Marie-Therese Abdou, Julia Karbach, Dirk Schadendorf, Lisa Zimmer, Selma Ugurel, Niklas Klümper, Michael Hölzel, Laura Power, Stefanie Kreutm
Published in: Med, Issue 4, 2023, Page(s) 113-129.e7, ISSN 2666-6340
Publisher: Elsevier
DOI: 10.1016/j.medj.2022.12.007

Central Nervous System Macrophages in Health and Disease

Author(s): Hannah Van Hove, Donatella De Feo, Melanie Greter, Burkhard Becher
Published in: Annual Review of Immunology, Issue 43, 2025, Page(s) 589-613, ISSN 0732-0582
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-immunol-082423-041334

The CNS mononuclear phagocyte system in health and disease

Author(s): Sarah Mundt, Melanie Greter, Burkhard Becher
Published in: Neuron, Issue 110, 2024, Page(s) 3497-3512, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2022.10.005

Antibodies Produced by CLL Phenotype B Cells in Patients With Myasthenia Gravis Are Not Directed Against Neuromuscular Endplates

Author(s): Ingelfinger F, Kramer M, Lutz M, Widmer CC, Piccoli L, Kreutmair S, Wertheimer T, Woodhall M, Waters P, Sallusto F, Lanzavecchia A, Mundt S, Becher B, Schreiner B.
Published in: Neurology: Neuroimmunology & Neuroinflammation, 2023, ISSN 2332-7812
Publisher: American Academy of Neurology
DOI: 10.1212/nxi.0000000000200087

High-dimensional analysis of 16 SARS-CoV-2 vaccine combinations reveals lymphocyte signatures correlating with immunogenicity

Author(s): Nuñez NG, Schmid J, Power L, Alberti C, Krishnarajah S, Kreutmair S, Unger S, Blanco S, Konigheim B, Marín C, Onofrio L, Kienzler JC, Costa-Pereira S, Ingelfinger F; InmunoCovidCba; InViV working group; Pasinovich ME, Castelli JM, Vizzotti C, Schaefer M, Villar-Vesga J, Mundt S, Merten CH, Sethi A, Wertheimer T, Lutz M, Vanoaica D, Sotomayor C, Gruppi A, Münz C, Cardozo D, Barbás G, Lopez L, C
Published in: Nature Immunology, 2023, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-023-01499-w

Regulatory T cells suppress GM-CSF-producing T helper cells via IL-2 modulation to restrain immunopathology

Author(s): Sara Costa-Pereira, Margit Lanzinger, Nicolás Núñez, Juan Villar-Vesga, Myrto Andreadou, Francesco Prisco, Philipp Häne, Elsa Roussel, Sinduya Krishnarajah, Rachel Chanel Lindemann, Laura Oberbichler, Frederike Westermann, André Fonseca Da Silva, Virginia Cecconi, Mirjam Pinzger, Sonia Tugues, Sarah Mundt, Melanie Greter, Donatella De Feo, Burkhard Becher
Published in: Cell Reports, Issue 44, 2025, Page(s) 115642, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2025.115642

High-dimensional immune profiling identifies a biomarker to monitor dimethyl fumarate response in multiple sclerosis

Author(s): Diebold M , Galli E, Kopf A, Sanderson N, Callegari I, Benkert P, Núñez N, Ingelfinger F, Herms S, Cichon S, Kappos L, Kuhle J, Becher B, Claassen M, Derfuss T
Published in: PNAS, 2022, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2205042119