High-Dimensional single cell mapping of inflammatory disease signatures in monozygotic twins

Informacje na temat projektu

IMPACT

Identyfikator umowy o grant: 882424

DOI

10.3030/882424

Data podpisania przez KE 29 Lipca 2020

Data rozpoczęcia 1 Stycznia 2021

Data zakończenia 31 Grudnia 2026

Finansowanie w ramach

• EXCELLENT SCIENCE - European Research Council (ERC)

Koszt całkowity

€ 2 492 221,00

Wkład UE

€ 2 492 221,00

Koordynowany przez

UNIVERSITAT ZURICH
Switzerland

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Publikacje

Peer reviewed articles (26)

Impact of the Multiple Sclerosis-Associated Genetic Variant <i>CD226</i> Gly307Ser on Human CD8 T-Cell Functions

Autorzy: Elena Morandi, Véronique Adoue, Isabelle Bernard, Ekaterina Friebel, Nicolas Nunez, Yann Aubert, Frederick Masson, Anne S. Dejean, Burkhard Becher, Anne Astier, Ludovic Martinet, Abdelhadi Saoudi
Opublikowane w: Neurology Neuroimmunology &amp; Neuroinflammation, Numer 11, 2025, ISSN 2332-7812
Wydawca: Wolters Kluwer Health
DOI: 10.1212/nxi.0000000000200306

Mononuclear phagocytes in autoimmune neuroinflammation

Autorzy: Violetta S. Gogoleva, Sarah Mundt, Donatella De Feo, Burkhard Becher
Opublikowane w: Trends in Immunology, Numer 45, 2024, Strona(/y) 814-823, ISSN 1471-4906
Wydawca: Elsevier BV
DOI: 10.1016/j.it.2024.08.005

Twin study reveals non-heritable immune perturbations in multiple sclerosis

Autorzy: Ingelfinger F, Gerdes LA, Kavaka V, Krishnarajah S, Friebel E, Galli E, Zwicky P, Furrer R, Peukert C, Dutertre CA, Eglseer KM, Ginhoux F, Flierl-Hecht A, Kümpfel T, De Feo D, Schreiner B, Mundt S, Kerschensteiner M, Hohlfeld R, Beltrán E, Becher B
Opublikowane w: Nature, 2022, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/s41586-022-04419-4

B cell depletion attenuates CD27 signaling of T helper cells in multiple sclerosis

Autorzy: Can Ulutekin, Edoardo Galli, Bettina Schreiner, Mohsen Khademi , Ilaria Callegari, Fredrik Piehl, Nicholas Sanderson, Daniel Kirschenbaum, Sarah Mundt, Massimo Filippi, Roberto Furlan, Tomas Olsson, Tobias Derfuss, Florian Ingelfinger, Burkhard Becher
Opublikowane w: Cell Rep Med, 2024, ISSN 2666-3791
Wydawca: Cell Press (Elsevier)
DOI: 10.1016/j.xcrm.2023.101351

Pre-existing comorbidities shape the immune response associated with severe COVID-19

Autorzy: Kreutmair S, Kauffmann M, Unger S, Ingelfinger F, Núñez NG, Alberti C, De Feo D, Krishnarajah S, Friebel E, Ulutekin C, Babaei S, Gaborit B, Lutz M, Jurado NP, Malek NP, Göpel S, Rosenberger P, Häberle HA, Ayoub I, Al-Hajj S, Claassen M, Liblau R, Martin-Blondel G, Bitzer M, Roquilly A, Becher B.
Opublikowane w: Journal of Allergy and Clinical Immunology, 2022, ISSN 0091-6749
Wydawca: Mosby Inc.
DOI: 10.1016/j.jaci.2022.05.019

Twin study dissects CXCR3+ memory B cells as non-heritable feature in multiple sclerosis

Autorzy: Florian Ingelfinger, Kirsten L. Kuiper, Can Ulutekin, Lukas Rindlisbacher, Sarah Mundt, Lisa Ann Gerdes, Joost Smolders, Marvin M. van Luijn, Burkhard Becher
Opublikowane w: Med, Numer 5, 2024, Strona(/y) 368-373.e3, ISSN 2666-6340
Wydawca: Elsevier
DOI: 10.1016/j.medj.2024.02.013

A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation

Autorzy: Lynn Bonetti, Veronika Horkova, Melanie Grusdat, Joseph Longworth, Luana Guerra, Henry Kurniawan, Davide G. Franchina, Leticia Soriano-Baguet, Carole Binsfeld, Charlène Verschueren, Sabine Spath, Anouk Ewen, Eric Koncina, Jean-Jacques Gérardy, Takumi Kobayashi, Catherine Dostert, Sophie Farinelle, Janika Härm, Yu-Tong Fan, Ying Chen, Isaac S. Harris, Philipp A. Lang, Vasilis Vasiliou, Ari Waism
Opublikowane w: Cell Metabolism, Numer 36, 2025, Strona(/y) 1726-1744.e10, ISSN 1550-4131
Wydawca: Cell Press
DOI: 10.1016/j.cmet.2024.06.010

Single-cell profiling of myasthenia gravis identifies a pathogenic T cell signature

Autorzy: Florian Ingelfinger; Sinduya Krishnarajah; Michael Kramer; Sebastian G. Utz; Edoardo Galli; Mirjam Lutz; Pascale Zwicky; Ayse Akarca; Nicole Puertas Jurado; Can Ulutekin; David Bamert; Corinne C Widmer; Luca Piccoli; Federica Sallusto; Federica Sallusto; Nicolás Gonzalo Núñez; Teresa Marafioti; Didier Schneiter; Isabelle Opitz; Antonio Lanzavecchia; Hans H. Jung; Donatella De Feo; Sarah Mundt;
Opublikowane w: Acta Neuropathologica, 141 (6), Numer 00016322, 2021, ISSN 0001-6322
Wydawca: Springer Verlag
DOI: 10.1007/s00401-021-02299-y

Identification of single-cell blasts in pediatric acute myeloid leukemia using an autoencoder

Autorzy: Alice Driessen, Susanne Unger, An-phi Nguyen, Rhonda E Ries, Soheil Meshinchi, Stefanie Kreutmair, Chiara Alberti, Pavel Sumazin, Richard Aplenc, Michele S Redell, Burkhard Becher, María Rodríguez Martínez
Opublikowane w: Life Science Alliance, Numer 7, 2024, Strona(/y) e202402674, ISSN 2575-1077
Wydawca: Alliance of EMBO Press, Rockefeller University Press, and Cold Spring Harbor Laboratory Press
DOI: 10.26508/lsa.202402674

Single-cell multiomics in neuroinflammation

Autorzy: Ingelfinger F, Beltrán E, Gerdes LA, Becher B
Opublikowane w: Current Opinion in Immunology, Numer 09527915, 2022, ISSN 0952-7915
Wydawca: Elsevier BV
DOI: 10.1016/j.coi.2022.102180

Tebentafusp elicits on-target cutaneous immune responses driven by cytotoxic T cells in uveal melanoma patients

Autorzy: Ramon Staeger, Aizhan Tastanova, Adhideb Ghosh, Nicola Winkelbeiner, Prachi Shukla, Isabel Kolm, Patrick Turko, Adel Benlahrech, Jane Harper, Anna Broomfield, Antonio Camera, Marianna Ambrosio, Veronika Haunerdinger, Phil F. Cheng, Egle Ramelyte, James Pham, Stefanie Kreutmair, Burkhard Becher, Mitchell P. Levesque, Reinhard Dummer, Barbara Meier-Schiesser
Opublikowane w: Journal of Clinical Investigation, Numer 135, 2025, ISSN 1558-8238
Wydawca: American Society for Clinical Investigation
DOI: 10.1172/jci181464

The aryl hydrocarbon receptor shapes monocyte transcriptional responses to interleukin-4 by prolonging STAT6 binding to promoters

Autorzy: Alba de Juan, Darawan Tabtim-On, Alice Coillard, Burkhard Becher, Christel Goudot, Elodie Segura
Opublikowane w: Science Signaling, Numer 17, 2024, ISSN 1937-9145
Wydawca: American Association for the Advancement of Science
DOI: 10.1126/scisignal.adn6324

Adiponectin reduces immune checkpoint inhibitor-induced inflammation without blocking anti-tumor immunity

Autorzy: Lukas M. Braun, Sophie Giesler, Geoffroy Andrieux, Roxane Riemer, Nana Talvard-Balland, Sandra Duquesne, Tamina Rückert, Susanne Unger, Stefanie Kreutmair, Melissa Zwick, Marie Follo, Alina Hartmann, Natascha Osswald, Wolfgang Melchinger, Stefanie Chapman, James A. Hutchinson, Sebastian Haferkamp, Leopold Torster, Julian Kött, Christoffer Gebhardt, Dirk Hellwig, Nikolaos Karantzelis, Till Wallra
Opublikowane w: Cancer Cell, Numer 43, 2025, Strona(/y) 269-291.e19, ISSN 1535-6108
Wydawca: Cell Press
DOI: 10.1016/j.ccell.2025.01.004

IL-23 stabilizes an effector Treg cell program in the tumor microenvironment

Autorzy: Tobias Wertheimer, Pascale Zwicky, Lukas Rindlisbacher, Colin Sparano, Marijne Vermeer, Bruno Marcel Silva de Melo, Claudia Haftmann, Tamina Rückert, Aakriti Sethi, Stefanie Schärli, Anna Huber, Florian Ingelfinger, Caroline Xu, Daehong Kim, Philipp Häne, André Fonseca da Silva, Andreas Muschaweckh, Nicolas Nunez, Sinduya Krishnarajah, Natalie Köhler, Robert Zeiser, Mohamed Oukka, Thomas Korn
Opublikowane w: Nature Immunology, Numer 25, 2024, Strona(/y) 512-524, ISSN 1529-2908
Wydawca: Nature Publishing Group
DOI: 10.1038/s41590-024-01755-7

GM-CSF: Master regulator of the T cell-phagocyte interface during inflammation

Autorzy: Florian Ingelfinger; Donatella De Feo; Burkhard Becher
Opublikowane w: Seminars in Immunology, Numer 10445323, 2021, ISSN 1044-5323
Wydawca: Academic Press
DOI: 10.1016/j.smim.2021.101518

Azathioprine therapy induces selective NK cell depletion and IFN-γ deficiency predisposing to herpesvirus reactivation

Autorzy: Ingelfinger F, Sparano C, Bamert D, Reyes-Leiva D, Sethi D, Rindlisbacher L, Zwicky P, Kreutmair S, Widmer C, Mundt S, Cortés-Vicente E, Tugues S, Becher B, Schreiner B
Opublikowane w: Journal of Allergy and Clinical Immunology, Numer 00916749, 2022, ISSN 0091-6749
Wydawca: Mosby Inc.
DOI: 10.1016/j.jaci.2022.09.010

IL-12 sensing in neurons induces neuroprotective CNS tissue adaptation and attenuates neuroinflammation in mice

Autorzy: Myrto Andreadou, Florian Ingelfinger, Donatella De Feo, Teresa L. M. Cramer, Selma Tuzlak, Ekaterina Friebel, Bettina Schreiner, Pascale Eede, Shirin Schneeberger, Maria Geesdorf, Frederike Ridder, Christina A. Welsh, Laura Power, Daniel Kirschenbaum, Shiva K. Tyagarajan, Melanie Greter, Frank L. Heppner, Sarah Mundt, Burkhard Becher
Opublikowane w: Nature Neuroscience, Numer 26, 2023, Strona(/y) 1701-1712, ISSN 1097-6256
Wydawca: Nature Publishing Group
DOI: 10.1038/s41593-023-01435-z

TH Cells and Cytokines in Encephalitogenic Disorders

Autorzy: Krishnarajah S, Becher B
Opublikowane w: Frontiers in Immunology, Numer 26628465, 2022, ISSN 2662-8465
Wydawca: Frontiers
DOI: 10.3389/fimmu.2022.822919

Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia

Autorzy: Kreutmair S, Unger S, Núñez N, Ingelfinger F, Alberti C, De Feo D, Krishnarajah S, Kauffmann M, Friebel E, Babaei S, Gaborit B, Lutz M, PuertasJurado N, Malek N, Goepel S, Rosenberger P, Häberle H, Ayoub I, Al-Hajj S, Nilsson J, Claassen M, Liblau R, Blondel G, Bitzer M, Roquilly A, Becher B
Opublikowane w: Immunity, Numer 10747613, 2021, ISSN 1074-7613
Wydawca: Cell Press
DOI: 10.1016/j.immuni.2021.05.002

Immune signatures predict development of autoimmune toxicity in patients with cancer treated with immune checkpoint inhibitors

Autorzy: Nicolas Gonzalo Nuñez, Fiamma Berner, Ekaterina Friebel, Susanne Unger, Nina Wyss, Julia Martinez Gomez, Mette-Triin Purde, Rebekka Niederer, Maximilian Porsch, Christa Lichtensteiger, Rafaela Kramer, Michael Erdmann, Christina Schmitt, Lucie Heinzerling, Marie-Therese Abdou, Julia Karbach, Dirk Schadendorf, Lisa Zimmer, Selma Ugurel, Niklas Klümper, Michael Hölzel, Laura Power, Stefanie Kreutm
Opublikowane w: Med, Numer 4, 2023, Strona(/y) 113-129.e7, ISSN 2666-6340
Wydawca: Elsevier
DOI: 10.1016/j.medj.2022.12.007

Central Nervous System Macrophages in Health and Disease

Autorzy: Hannah Van Hove, Donatella De Feo, Melanie Greter, Burkhard Becher
Opublikowane w: Annual Review of Immunology, Numer 43, 2025, Strona(/y) 589-613, ISSN 0732-0582
Wydawca: Annual Reviews, Inc.
DOI: 10.1146/annurev-immunol-082423-041334

The CNS mononuclear phagocyte system in health and disease

Autorzy: Sarah Mundt, Melanie Greter, Burkhard Becher
Opublikowane w: Neuron, Numer 110, 2024, Strona(/y) 3497-3512, ISSN 0896-6273
Wydawca: Cell Press
DOI: 10.1016/j.neuron.2022.10.005

Antibodies Produced by CLL Phenotype B Cells in Patients With Myasthenia Gravis Are Not Directed Against Neuromuscular Endplates

Autorzy: Ingelfinger F, Kramer M, Lutz M, Widmer CC, Piccoli L, Kreutmair S, Wertheimer T, Woodhall M, Waters P, Sallusto F, Lanzavecchia A, Mundt S, Becher B, Schreiner B.
Opublikowane w: Neurology: Neuroimmunology & Neuroinflammation, 2023, ISSN 2332-7812
Wydawca: American Academy of Neurology
DOI: 10.1212/nxi.0000000000200087

High-dimensional analysis of 16 SARS-CoV-2 vaccine combinations reveals lymphocyte signatures correlating with immunogenicity

Autorzy: Nuñez NG, Schmid J, Power L, Alberti C, Krishnarajah S, Kreutmair S, Unger S, Blanco S, Konigheim B, Marín C, Onofrio L, Kienzler JC, Costa-Pereira S, Ingelfinger F; InmunoCovidCba; InViV working group; Pasinovich ME, Castelli JM, Vizzotti C, Schaefer M, Villar-Vesga J, Mundt S, Merten CH, Sethi A, Wertheimer T, Lutz M, Vanoaica D, Sotomayor C, Gruppi A, Münz C, Cardozo D, Barbás G, Lopez L, C
Opublikowane w: Nature Immunology, 2023, ISSN 1529-2908
Wydawca: Nature Publishing Group
DOI: 10.1038/s41590-023-01499-w

Regulatory T cells suppress GM-CSF-producing T helper cells via IL-2 modulation to restrain immunopathology

Autorzy: Sara Costa-Pereira, Margit Lanzinger, Nicolás Núñez, Juan Villar-Vesga, Myrto Andreadou, Francesco Prisco, Philipp Häne, Elsa Roussel, Sinduya Krishnarajah, Rachel Chanel Lindemann, Laura Oberbichler, Frederike Westermann, André Fonseca Da Silva, Virginia Cecconi, Mirjam Pinzger, Sonia Tugues, Sarah Mundt, Melanie Greter, Donatella De Feo, Burkhard Becher
Opublikowane w: Cell Reports, Numer 44, 2025, Strona(/y) 115642, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2025.115642

High-dimensional immune profiling identifies a biomarker to monitor dimethyl fumarate response in multiple sclerosis

Autorzy: Diebold M , Galli E, Kopf A, Sanderson N, Callegari I, Benkert P, Núñez N, Ingelfinger F, Herms S, Cichon S, Kappos L, Kuhle J, Becher B, Claassen M, Derfuss T
Opublikowane w: PNAS, 2022, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.1073/pnas.2205042119