High-Dimensional single cell mapping of inflammatory disease signatures in monozygotic twins

Publicaciones

Twin study reveals non-heritable immune perturbations in multiple sclerosis

Autores: Ingelfinger F, Gerdes LA, Kavaka V, Krishnarajah S, Friebel E, Galli E, Zwicky P, Furrer R, Peukert C, Dutertre CA, Eglseer KM, Ginhoux F, Flierl-Hecht A, Kümpfel T, De Feo D, Schreiner B, Mundt S, Kerschensteiner M, Hohlfeld R, Beltrán E, Becher B
Publicado en: Nature, 2022, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-022-04419-4

B cell depletion attenuates CD27 signaling of T helper cells in multiple sclerosis

Autores: Can Ulutekin, Edoardo Galli, Bettina Schreiner, Mohsen Khademi , Ilaria Callegari, Fredrik Piehl, Nicholas Sanderson, Daniel Kirschenbaum, Sarah Mundt, Massimo Filippi, Roberto Furlan, Tomas Olsson, Tobias Derfuss, Florian Ingelfinger, Burkhard Becher
Publicado en: Cell Rep Med, 2024, ISSN 2666-3791
Editor: Cell Press (Elsevier)
DOI: 10.1016/j.xcrm.2023.101351

Pre-existing comorbidities shape the immune response associated with severe COVID-19

Autores: Kreutmair S, Kauffmann M, Unger S, Ingelfinger F, Núñez NG, Alberti C, De Feo D, Krishnarajah S, Friebel E, Ulutekin C, Babaei S, Gaborit B, Lutz M, Jurado NP, Malek NP, Göpel S, Rosenberger P, Häberle HA, Ayoub I, Al-Hajj S, Claassen M, Liblau R, Martin-Blondel G, Bitzer M, Roquilly A, Becher B.
Publicado en: Journal of Allergy and Clinical Immunology, 2022, ISSN 0091-6749
Editor: Mosby Inc.
DOI: 10.1016/j.jaci.2022.05.019

Single-cell profiling of myasthenia gravis identifies a pathogenic T cell signature

Autores: Florian Ingelfinger; Sinduya Krishnarajah; Michael Kramer; Sebastian G. Utz; Edoardo Galli; Mirjam Lutz; Pascale Zwicky; Ayse Akarca; Nicole Puertas Jurado; Can Ulutekin; David Bamert; Corinne C Widmer; Luca Piccoli; Federica Sallusto; Federica Sallusto; Nicolás Gonzalo Núñez; Teresa Marafioti; Didier Schneiter; Isabelle Opitz; Antonio Lanzavecchia; Hans H. Jung; Donatella De Feo; Sarah Mundt;
Publicado en: Acta Neuropathologica, 141 (6), Edición 00016322, 2021, ISSN 0001-6322
Editor: Springer Verlag
DOI: 10.1007/s00401-021-02299-y

Single-cell multiomics in neuroinflammation

Autores: Ingelfinger F, Beltrán E, Gerdes LA, Becher B
Publicado en: Current Opinion in Immunology, Edición 09527915, 2022, ISSN 0952-7915
Editor: Elsevier BV
DOI: 10.1016/j.coi.2022.102180

GM-CSF: Master regulator of the T cell-phagocyte interface during inflammation

Autores: Florian Ingelfinger; Donatella De Feo; Burkhard Becher
Publicado en: Seminars in Immunology, Edición 10445323, 2021, ISSN 1044-5323
Editor: Academic Press
DOI: 10.1016/j.smim.2021.101518

Azathioprine therapy induces selective NK cell depletion and IFN-γ deficiency predisposing to herpesvirus reactivation

Autores: Ingelfinger F, Sparano C, Bamert D, Reyes-Leiva D, Sethi D, Rindlisbacher L, Zwicky P, Kreutmair S, Widmer C, Mundt S, Cortés-Vicente E, Tugues S, Becher B, Schreiner B
Publicado en: Journal of Allergy and Clinical Immunology, Edición 00916749, 2022, ISSN 0091-6749
Editor: Mosby Inc.
DOI: 10.1016/j.jaci.2022.09.010

TH Cells and Cytokines in Encephalitogenic Disorders

Autores: Krishnarajah S, Becher B
Publicado en: Frontiers in Immunology, Edición 26628465, 2022, ISSN 2662-8465
Editor: Frontiers
DOI: 10.3389/fimmu.2022.822919

Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia

Autores: Kreutmair S, Unger S, Núñez N, Ingelfinger F, Alberti C, De Feo D, Krishnarajah S, Kauffmann M, Friebel E, Babaei S, Gaborit B, Lutz M, PuertasJurado N, Malek N, Goepel S, Rosenberger P, Häberle H, Ayoub I, Al-Hajj S, Nilsson J, Claassen M, Liblau R, Blondel G, Bitzer M, Roquilly A, Becher B
Publicado en: Immunity, Edición 10747613, 2021, ISSN 1074-7613
Editor: Cell Press
DOI: 10.1016/j.immuni.2021.05.002

Antibodies Produced by CLL Phenotype B Cells in Patients With Myasthenia Gravis Are Not Directed Against Neuromuscular Endplates

Autores: Ingelfinger F, Kramer M, Lutz M, Widmer CC, Piccoli L, Kreutmair S, Wertheimer T, Woodhall M, Waters P, Sallusto F, Lanzavecchia A, Mundt S, Becher B, Schreiner B.
Publicado en: Neurology: Neuroimmunology & Neuroinflammation, 2023, ISSN 2332-7812
Editor: American Academy of Neurology
DOI: 10.1212/nxi.0000000000200087

High-dimensional analysis of 16 SARS-CoV-2 vaccine combinations reveals lymphocyte signatures correlating with immunogenicity

Autores: Nuñez NG, Schmid J, Power L, Alberti C, Krishnarajah S, Kreutmair S, Unger S, Blanco S, Konigheim B, Marín C, Onofrio L, Kienzler JC, Costa-Pereira S, Ingelfinger F; InmunoCovidCba; InViV working group; Pasinovich ME, Castelli JM, Vizzotti C, Schaefer M, Villar-Vesga J, Mundt S, Merten CH, Sethi A, Wertheimer T, Lutz M, Vanoaica D, Sotomayor C, Gruppi A, Münz C, Cardozo D, Barbás G, Lopez L, C
Publicado en: Nature Immunology, 2023, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/s41590-023-01499-w

High-dimensional immune profiling identifies a biomarker to monitor dimethyl fumarate response in multiple sclerosis

Autores: Diebold M , Galli E, Kopf A, Sanderson N, Callegari I, Benkert P, Núñez N, Ingelfinger F, Herms S, Cichon S, Kappos L, Kuhle J, Becher B, Claassen M, Derfuss T
Publicado en: PNAS, 2022, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2205042119

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