High-Dimensional single cell mapping of inflammatory disease signatures in monozygotic twins

Pubblicazioni

Twin study reveals non-heritable immune perturbations in multiple sclerosis

Autori: Ingelfinger F, Gerdes LA, Kavaka V, Krishnarajah S, Friebel E, Galli E, Zwicky P, Furrer R, Peukert C, Dutertre CA, Eglseer KM, Ginhoux F, Flierl-Hecht A, Kümpfel T, De Feo D, Schreiner B, Mundt S, Kerschensteiner M, Hohlfeld R, Beltrán E, Becher B
Pubblicato in: Nature, 2022, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-022-04419-4

B cell depletion attenuates CD27 signaling of T helper cells in multiple sclerosis

Autori: Can Ulutekin, Edoardo Galli, Bettina Schreiner, Mohsen Khademi , Ilaria Callegari, Fredrik Piehl, Nicholas Sanderson, Daniel Kirschenbaum, Sarah Mundt, Massimo Filippi, Roberto Furlan, Tomas Olsson, Tobias Derfuss, Florian Ingelfinger, Burkhard Becher
Pubblicato in: Cell Rep Med, 2024, ISSN 2666-3791
Editore: Cell Press (Elsevier)
DOI: 10.1016/j.xcrm.2023.101351

Pre-existing comorbidities shape the immune response associated with severe COVID-19

Autori: Kreutmair S, Kauffmann M, Unger S, Ingelfinger F, Núñez NG, Alberti C, De Feo D, Krishnarajah S, Friebel E, Ulutekin C, Babaei S, Gaborit B, Lutz M, Jurado NP, Malek NP, Göpel S, Rosenberger P, Häberle HA, Ayoub I, Al-Hajj S, Claassen M, Liblau R, Martin-Blondel G, Bitzer M, Roquilly A, Becher B.
Pubblicato in: Journal of Allergy and Clinical Immunology, 2022, ISSN 0091-6749
Editore: Mosby Inc.
DOI: 10.1016/j.jaci.2022.05.019

Single-cell profiling of myasthenia gravis identifies a pathogenic T cell signature

Autori: Florian Ingelfinger; Sinduya Krishnarajah; Michael Kramer; Sebastian G. Utz; Edoardo Galli; Mirjam Lutz; Pascale Zwicky; Ayse Akarca; Nicole Puertas Jurado; Can Ulutekin; David Bamert; Corinne C Widmer; Luca Piccoli; Federica Sallusto; Federica Sallusto; Nicolás Gonzalo Núñez; Teresa Marafioti; Didier Schneiter; Isabelle Opitz; Antonio Lanzavecchia; Hans H. Jung; Donatella De Feo; Sarah Mundt;
Pubblicato in: Acta Neuropathologica, 141 (6), Numero 00016322, 2021, ISSN 0001-6322
Editore: Springer Verlag
DOI: 10.1007/s00401-021-02299-y

Single-cell multiomics in neuroinflammation

Autori: Ingelfinger F, Beltrán E, Gerdes LA, Becher B
Pubblicato in: Current Opinion in Immunology, Numero 09527915, 2022, ISSN 0952-7915
Editore: Elsevier BV
DOI: 10.1016/j.coi.2022.102180

GM-CSF: Master regulator of the T cell-phagocyte interface during inflammation

Autori: Florian Ingelfinger; Donatella De Feo; Burkhard Becher
Pubblicato in: Seminars in Immunology, Numero 10445323, 2021, ISSN 1044-5323
Editore: Academic Press
DOI: 10.1016/j.smim.2021.101518

Azathioprine therapy induces selective NK cell depletion and IFN-γ deficiency predisposing to herpesvirus reactivation

Autori: Ingelfinger F, Sparano C, Bamert D, Reyes-Leiva D, Sethi D, Rindlisbacher L, Zwicky P, Kreutmair S, Widmer C, Mundt S, Cortés-Vicente E, Tugues S, Becher B, Schreiner B
Pubblicato in: Journal of Allergy and Clinical Immunology, Numero 00916749, 2022, ISSN 0091-6749
Editore: Mosby Inc.
DOI: 10.1016/j.jaci.2022.09.010

TH Cells and Cytokines in Encephalitogenic Disorders

Autori: Krishnarajah S, Becher B
Pubblicato in: Frontiers in Immunology, Numero 26628465, 2022, ISSN 2662-8465
Editore: Frontiers
DOI: 10.3389/fimmu.2022.822919

Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia

Autori: Kreutmair S, Unger S, Núñez N, Ingelfinger F, Alberti C, De Feo D, Krishnarajah S, Kauffmann M, Friebel E, Babaei S, Gaborit B, Lutz M, PuertasJurado N, Malek N, Goepel S, Rosenberger P, Häberle H, Ayoub I, Al-Hajj S, Nilsson J, Claassen M, Liblau R, Blondel G, Bitzer M, Roquilly A, Becher B
Pubblicato in: Immunity, Numero 10747613, 2021, ISSN 1074-7613
Editore: Cell Press
DOI: 10.1016/j.immuni.2021.05.002

Antibodies Produced by CLL Phenotype B Cells in Patients With Myasthenia Gravis Are Not Directed Against Neuromuscular Endplates

Autori: Ingelfinger F, Kramer M, Lutz M, Widmer CC, Piccoli L, Kreutmair S, Wertheimer T, Woodhall M, Waters P, Sallusto F, Lanzavecchia A, Mundt S, Becher B, Schreiner B.
Pubblicato in: Neurology: Neuroimmunology & Neuroinflammation, 2023, ISSN 2332-7812
Editore: American Academy of Neurology
DOI: 10.1212/nxi.0000000000200087

High-dimensional analysis of 16 SARS-CoV-2 vaccine combinations reveals lymphocyte signatures correlating with immunogenicity

Autori: Nuñez NG, Schmid J, Power L, Alberti C, Krishnarajah S, Kreutmair S, Unger S, Blanco S, Konigheim B, Marín C, Onofrio L, Kienzler JC, Costa-Pereira S, Ingelfinger F; InmunoCovidCba; InViV working group; Pasinovich ME, Castelli JM, Vizzotti C, Schaefer M, Villar-Vesga J, Mundt S, Merten CH, Sethi A, Wertheimer T, Lutz M, Vanoaica D, Sotomayor C, Gruppi A, Münz C, Cardozo D, Barbás G, Lopez L, C
Pubblicato in: Nature Immunology, 2023, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/s41590-023-01499-w

High-dimensional immune profiling identifies a biomarker to monitor dimethyl fumarate response in multiple sclerosis

Autori: Diebold M , Galli E, Kopf A, Sanderson N, Callegari I, Benkert P, Núñez N, Ingelfinger F, Herms S, Cichon S, Kappos L, Kuhle J, Becher B, Claassen M, Derfuss T
Pubblicato in: PNAS, 2022, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2205042119

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