Full human-based multi-scale constructs with jammed regenerative pockets for bone engineering

Información del proyecto

REBORN

Identificador del acuerdo de subvención: 883370

DOI

10.3030/883370

Fecha de la firma de la CE 9 Septiembre 2020

Fecha de inicio 1 Noviembre 2021

Fecha de finalización 31 Octubre 2026

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 499 683,00

Aportación de la UE

€ 2 499 683,00

Coordinado por

UNIVERSIDADE DE AVEIRO
Portugal

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Thesis and dissertations (10)

Bioengineered pancreatic tumor-stroma models for preclinical screening of therapeutics

Autores: Monteiro, Maria Vinhas
Publicado en: 2023
Editor: Universidade de Aveiro

Human plasma derived hydrogels for myocardial tissue engineering

Autores: Santos, Sara Catarina Nunes da Silva
Publicado en: 2024
Editor: Universidade de Aveiro

Single-cell microcapsules for biomedical applications

Autores: Santos, Manuel Pires dos
Publicado en: 2023
Editor: Universidade de Aveiro

Fabrication of bicontinuous microporous hydrogels using aqueous emulsion templating

Autores: Fernandes, Hugo Edgar Vilar
Publicado en: 2023
Editor: Universidade de Aveiro

Magnetic nanoparticles in the engineering of hybrid structures for cell and tissue engineering

Autores: Mendes, Maria Cândida Balão
Publicado en: 2025
Editor: Universidade de Aveiro

Osteosarcoma-on-a-chip: a physiologically relevant human-based microfluidic platform for drug screening

Autores: Cátia F. Monteiro
Publicado en: 2024
Editor: Universidade de Aveiro

Bioengenharia e controlo dinâmico em hidrogéis e materiais celulares com adaptabilidade

Autores: Lavrador, Pedro Oliveira
Publicado en: 2023
Editor: Universidade de Aveiro

Production of photo-engineered cell-rich materials exhibiting living features

Autores: Pinto, José Carlos Almeida
Publicado en: 2023
Editor: Universidade de Aveiro

Biomedical system based on controlled enzymatically degradation of hydrogels

Autores: Mehrzad Zargarzadeh
Publicado en: 2024
Editor: Universidade de Aveiro

Mechanosensing microcapsules to direct stem cell differentiation for tissue regeneration applications

Autores: Hasankolaei, Maryam Ghasemzadeh
Publicado en: Edición 1, 2024
Editor: Universidade de Aveiro

Peer reviewed articles (43)

Supramolecular assembly of multi-purpose tissue engineering platforms from human extracellular matrix

Autores: Bruno Ladeira, Maria Gomes, Kongchang Wei, Catarina Custódio, João Mano
Publicado en: Biomaterials, Edición 320, 2026, Página(s) 123270, ISSN 0142-9612
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2025.123270

Biomaterials of human source for 3D printing strategies

Autores: João Rocha Maia, Rita Sobreiro-Almeida, Franck Cleymand, João F Mano
Publicado en: Journal of Physics: Materials, 2023, ISSN 2515-7639
Editor: IOP Publishing
DOI: 10.1088/2515-7639/acada1

Emerging modulators for osteogenic differentiation: a combination of chemical and topographical cues for bone

Autores: Diana Jesus, Ana R. Pinho, Maria C. Gomes, Cláudia S. Oliveira, João F. Mano
Publicado en: Soft Matter, 2022, ISSN 1744-683X
Editor: Royal Society of Chemistry
DOI: 10.1039/d2sm00009a

Photocrosslinkable microgels derived from human platelet lysates: injectable biomaterials for cardiac cell culture

Autores: Sara C. Santos , Catarina A. Custódio, João F. Mano
Publicado en: Biomaterials Science, 2024, ISSN 2047-4830
Editor: Royal Society of Chemistry
DOI: 10.1039/d3bm01933k

Double-Interlinked Colloidal Gels for Programable Fabrication of Supraparticle Architectures

Autores: Leandro Gonçalves, Pedro Lavrador, Adérito J. R. Amaral, Luís P. Ferreira, Vítor M. Gaspar, João F. Mano
Publicado en: Advanced Functional Materials, 2023, ISSN 1616-301X
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202304628

Emerging lipid–polymer hybrid nanoparticles for genome editing

Autores: Mariana Gameiro, João F. Mano, Vítor M. Gaspar
Publicado en: Polymer Chemistry, Edición 15, 2024, Página(s) 3436-3468, ISSN 1759-9954
Editor: Royal Society of Chemistry
DOI: 10.1039/d4py00298a

Interconnected Porous Hydrogels with Tunable Anisotropy Through Aqueous Emulsion Bioprinting

Autores: Hugo Edgar‐Vilar, Francisca P. Correia, Inês M. Freitas, Vítor M. Gaspar, João F. Mano
Publicado en: Advanced Functional Materials, Edición 36, 2026, ISSN 1616-301X
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202521050

Endo- and Exometabolome Crosstalk in Mesenchymal Stem Cells Undergoing Osteogenic Differentiation

Autores: Daniela S. C. Bispo, Lenka Michálková, Marlene Correia, Catarina S. H. Jesus, Iola F. Duarte, Brian J. Goodfellow, Mariana B. Oliveira, João F. Mano, Ana M. Gil
Publicado en: Cells, 2022, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells11081257

Osteogenic Differentiation Triggered by Intracellular Magnetoelectric Stimulation of Core–Shell Nanotransducers under Remotely Applied Magnetic Fields

Autores: Maria C. Mendes, Elisa A. G. Martins, Roman V. Chernozem, Polina V. Chernozem, Catarina C. Custódio, Roman A. Surmenev, Andrei L. Kholkin, Ana S. Silva, João F. Mano
Publicado en: ACS Nano, Edición 19, 2026, Página(s) 42022-42045, ISSN 1936-0851
Editor: American Chemical Society
DOI: 10.1021/acsnano.5c10509

Spontaneous Formation of Solid Shell Polymeric Multicompartments at All‐Aqueous Interfaces

Autores: Francisca G. Perfeito, Sara Vilabril, Andreia Cerqueira, Mariana B. Oliveira, João F. Mano
Publicado en: Advanced Science, Edición 11, 2024, ISSN 2198-3844
Editor: Wiley-VCH Verlag
DOI: 10.1002/advs.202402592

Human Chorionic Membrane‐derived Tunable Hydrogels for Vascular Tissue Engineering Strategies

Autores: Elisa A.G. Martins, Inês A. Deus, Maria C. Gomes, Ana S. Silva, João F. Mano, Catarina A. Custódio
Publicado en: Advanced Healthcare Materials, 2024, ISSN 2192-2640
Editor: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202401510

Merging Natural Biopolymers with Supramolecular Chemistry: Emulating the Native Extracellular Matrix’s Complexity

Autores: Vera Sousa, Bruno Ladeira, Elisabeth Garanger, Sébastien Lecommandoux, E. W. Meijer, Patricia Y. W. Dankers, João F. Mano, João Borges
Publicado en: ACS Nano, Edición 19, 2026, Página(s) 29833-29859, ISSN 1936-0851
Editor: American Chemical Society
DOI: 10.1021/acsnano.5c10088

Advancing tissue decellularized hydrogels for engineering human organoids

Autores: Beatriz S. Moura, Maria V. Monteiro, Luís P. Ferreira, Pedro Lavrador, Vítor M. Gaspar, João F. Mano
Publicado en: Advanced Functional Materials, 2022, ISSN 1616-301X
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202202825

Biomimetic Adhesive Micropatterned Hydrogel Patches for Drug Release

Autores: Katia R. Amaral, A. Sofia Silva, Lúcia F. Santos, Edgar J. Castanheira, Maria C. Mendes, Dora C.S. Costa, João M. M. Rodrigues, Joana Marto, João F. Mano
Publicado en: Advanced Healthcare Materials, 2023, ISSN 2192-2640
Editor: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202301513

Pierceable, Storable, and Manipulable Liquid Capsules for Precise Monitoring and Efficient Cargo Transport in Biotechnological Advances

Autores: Ana Rita Pinho, Chunming Wang, Maria Clara Gomes, João Filipe Mano
Publicado en: Advanced Functional Materials, Edición 35, 2026, ISSN 1616-301X
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202425715

Exploring the potential of all-aqueous immiscible systems for preparing complex biomaterials and cellular constructs

Autores: Raquel C. Gonçalves, Mariana B. Oliveira, João F. Mano
Publicado en: Materials Horizons, Edición 11, 2024, Página(s) 4573-4599, ISSN 2051-6347
Editor: Royal Society of Chemistry
DOI: 10.1039/d4mh00431k

Contactless 3D acoustic assembly of liquid capsules for bottom-up tissue engineering

Autores: Maria Eduarda Rocha Luiz, Mariana Carreira, Sara Nadine, Riccardo Tognato, Romedi Parolini, Syeda M. Bakht, Tiziano Serra, João F. Mano
Publicado en: Biomaterials, Edición 325, 2026, Página(s) 123555, ISSN 0142-9612
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2025.123555

Viscous microcapsules as microbioreactors to study mesenchymal stem/stromal cells osteolineage commitment

Autores: Maryam Ghasemzadeh-Hasankolaei, João M. Miranda, Clara R. Correia, João F. Mano
Publicado en: Small Methods, Edición 2201503, 2023, ISSN 2366-9608
Editor: Wiley
DOI: 10.1002/smtd.202201503

Advances in Cell-Rich Inks for Biofabricating Living Architectures

Autores: José Almeida-Pinto, Beatriz S. Moura, Vítor M. Gaspar, João F. Mano
Publicado en: Advanced Materials, 2024, ISSN 1521-4095
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/adma.202313776

Cell Shuttling in Multifunctional Microsized Needles

Autores: Marta M. Maciel, José N. M. Silvares, Tiago R. Correia, Carlos M. N. Mendonça, Ana P. Martins, Eduardo T. C. C. Silva, Nuno J. O. Silva, Filipa L. Sousa, João F. Mano
Publicado en: Small Structures, Edición 7, 2026, ISSN 2688-4062
Editor: Wiley
DOI: 10.1002/sstr.202500370

Magnetic-Based Strategies for Regenerative Medicine and Tissue Engineering

Autores: Lúcia F. Santos, Ana S. Silva, João F. Mano
Publicado en: Advanced Healthcare Materials, 2023, ISSN 2192-2640
Editor: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202300605

Tumor‐On‐A‐Chip Model Incorporating Human‐Based Hydrogels for Easy Assessment of Metastatic Tumor Inter‐Heterogeneity

Autores: Cátia F. Monteiro, Inês A. Deus, Inês B. Silva, Iola F. Duarte, Catarina A. Custódio, João F. Mano
Publicado en: Advanced Functional Materials, 2024, ISSN 1616-301X
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202315940

Liquefied capsules containing nanogrooved microdiscs and umbilical cord-derived cells for bone tissue engineering

Autores: Mariana Carreira; Manuel Pires-Santos; Clara R Correia; Sara Nadine; João F Mano
Publicado en: Open Research Europe, 2024, ISSN 2732-5121
Editor: [London]: [F1000 Research Limited on behalf of the European Commission]
DOI: 10.12688/openreseurope.17000.1

High-Throughput Production of Microsponges from Platelet Lysate for Tissue Engineering Applications

Autores: Bruno M.F. Ladeira, Maria C. Gomes, Catarina A. Custódio, João F. Mano
Publicado en: Tissue Engineering Part C: Methods, 2022, ISSN 1937-3384
Editor: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tec.2022.0029

Rapid Generation of Fusable Cell Beads for Multi‐Scale Human Living Materials Assembly

Autores: Beatriz S. Moura, Maria V. Monteiro, Joana F. Soeiro, Nuno J. O. Silva, Vítor M. Gaspar, João F. Mano
Publicado en: Small Methods, Edición 10, 2026, ISSN 2366-9608
Editor: Wiley
DOI: 10.1002/smtd.202501450

Thiol-ene click chemistry: Enabling 3D printing of natural-based inks for biomedical applications

Autores: Andreia P. Malafaia, Rita Sobreiro-Almeida, João M.M. Rodrigues, João F. Mano
Publicado en: Biomaterials Advances, Edición 167, 2024, Página(s) 214105, ISSN 2772-9508
Editor: Elsevier
DOI: 10.1016/j.bioadv.2024.214105

Modeling 3D Tumor Invasiveness to Modulate Macrophage Phenotype in a Human‐Based Hydrogel Platform

Autores: Cátia F. Monteiro, Catarina R. Almeida, Catarina A. Custódio, João F. Mano
Publicado en: Macromolecular Bioscience, Edición 24, 2024, ISSN 1616-5187
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/mabi.202400227

Human Platelet Lysate-Derived Nanofibrils as Building Blocks to Produce Free-Standing Membranes for Cell Self-Aggregation

Autores: Cátia F. Monteiro, Maria C. Gomes, Pankaj Bharmoria, Mara G. Freire, João A. P. Coutinho, Catarina A. Custódio, and João F. Mano
Publicado en: ACS Nano, 2024, ISSN 1936-0851
Editor: American Chemical Society
DOI: 10.1021/acsnano.4c02790

Roadmap for animate matter

Autores: Giorgio Volpe, Nuno A M Araújo, Maria Guix, Mark Miodownik, Nicolas Martin, Laura Alvarez, Juliane Simmchen, Roberto Di Leonardo, Nicola Pellicciotta, Quentin Martinet, Jérémie Palacci, Wai Kit Ng, Dhruv Saxena, Riccardo Sapienza, Sara Nadine, João F Mano, Reza Mahdavi, Caroline Beck Adiels, Joe Forth, Christian Santangelo, Stefano Palagi, Ji Min Seok, Victoria A Webster-Wood, Shuhong Wang, Li
Publicado en: Journal of Physics: Condensed Matter, Edición 37, 2025, Página(s) 333501, ISSN 0953-8984
Editor: Institute of Physics Publishing
DOI: 10.1088/1361-648x/adebd3

A Self-Sustaining Hydrogels with Autonomous Supply of Nutrients and Bioactive Domains for 3D Cell Culture

Autores: Mehrzad Zargarzadeh, Maria C. Gomes, Sónia G. Patrício, Catarina A. Custódio, João F. Mano
Publicado en: Advanced Functional Materials, 2023, ISSN 1616-301X
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202214372

Bioactive Self‐Regulated Liquified Microcompartments to Bioengineer Bone‐Like Microtissues

Autores: Ana R. Pinho; Maria C. Gomes; Dora C. S. Costa; João F. Mano
Publicado en: Small, 2023, ISSN 1613-6810
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202305029

Effect of high cyclic hydrostatic pressure on osteogenesis of mesenchymal stem cells cultured in liquefied micro-compartments

Autores: Maryam Ghasemzadeh-Hasankolaei, Carlos A. Pinto, Diana Jesus, Jorge A. Saraiva, João F. Mano
Publicado en: Materials Today Bio, 2023, ISSN 2590-0064
Editor: Elsevier
DOI: 10.1016/j.mtbio.2023.100861

Unveiling the Potential of Single-Cell Encapsulation in Biomedical Applications: Current Advances and Future Perspectives

Autores: Manuel Pires-Santos, Sara Nadine, João F. Mano
Publicado en: Small Science, 2024, ISSN 2688-4046
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/smsc.202300332

Cell Surface Engineering Tools for Programming Living Assemblies

Autores: José Almeida-Pinto, Matilde R. Lagarto, Pedro Lavrador, João F. Mano, Vítor M. Gaspar
Publicado en: Advanced Science, 2023, ISSN 2198-3844
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/advs.202304040

Self‐Assembly of Platelet Lysates Proteins into Microparticles by Unnatural Disulfide Bonds for Bottom‐Up Tissue Engineering

Autores: Maria C. Gomes; Ana Rita Pinho; Catarina Custódio; João F. Mano
Publicado en: Advanced Materials, 2023, ISSN 1521-4095
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/adma.202304659

Recent Developments in Layer-by-Layer Assembly for Drug Delivery and Tissue Engineering Applications

Autores: João Borges, Jinfeng Zeng, Xi Qiu Liu, Hao Chang, Claire Monge, Charlotte Garot, Ke-feng Ren, Paul Machillot, Nihal E. Vrana, Philippe Lavalle, Takami Akagi, Michiya Matsusaki, Jian Ji, Mitsuru Akashi, João F. Mano, Varvara Gribova, Catherine Picart
Publicado en: Advanced Healthcare Materials, 2023, ISSN 2192-2640
Editor: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202302713

Designer mammalian living materials through genetic engineering

Autores: Mariana Gameiro, José Almeida-Pinto, Beatriz S. Moura, João F. Mano, Vítor M. Gaspar
Publicado en: Bioactive Materials, Edición 48, 2025, Página(s) 135-148, ISSN 2452-199X
Editor: Elsevier BV
DOI: 10.1016/j.bioactmat.2025.02.007

Engineered nascent living human tissues with unit programmability

Autores: Pedro Lavrador, Beatriz S. Moura, José Almeida-Pinto, Vítor M. Gaspar, João F. Mano
Publicado en: Nature Materials, 2024, ISSN 1476-1122
Editor: Nature Publishing Group
DOI: 10.1038/s41563-024-01958-1

Magneto‐Enzymatic Microgels for Precise Hydrogel Sculpturing

Autores: Maria C. Mendes, João A. Pereira, Ana S. Silva, João F. Mano
Publicado en: Advanced Materials, 2024, ISSN 0935-9648
Editor: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202402988

Single‐Cell Liquid‐Core Microcapsules for Biomedical Applications

Autores: Manuel Pires‐Santos, Mariana Carreira, Bruno P. Morais, Francisca G. Perfeito, Mariana B. Oliveira, Cátia F. Monteiro, Sara Nadine, João F. Mano
Publicado en: Advanced Healthcare Materials, Edición 14, 2026, ISSN 2192-2640
Editor: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202403808

Strategies to decouple cell micro-scale and macro-scale environments for designing multifunctional biomimetic tissues

Autores: Maryam Ghasemzadeh-Hasankolaei, Diogo Pinheiro, Sara Nadine, João F. Mano
Publicado en: Soft Matter, Edición 20, 2024, Página(s) 6313-6326, ISSN 1744-683X
Editor: Royal Society of Chemistry
DOI: 10.1039/d4sm00276h

Close-to-native bone repair via tissue-engineered endochondral ossification approaches

Autores: Sara Nadine, Inês J. Fernandes, Clara R. Correia, João F. Mano
Publicado en: iScience, 2022, ISSN 2589-0042
Editor: Cell Press
DOI: 10.1016/j.isci.2022.105370

Bioinstructive Liquefied Pockets in Hierarchical Hydrogels and Bioinks

Autores: Maryam Ghasemzadeh‐Hasankolaei, Tiago R. Correia, João F. Mano
Publicado en: Advanced Healthcare Materials, 2024, ISSN 2192-2640
Editor: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202400286

Derechos de propiedad intelectual

Patent (4)

BIOMATERIAL FOR IMMUNOMODULATION, PROCESS FOR ITS PRODUCTION AND USES THEREOF

Número de solicitud/publicación: 22 185533
Fecha: 2022-07-18
Solicitante(s): UNIVERSIDADE DE AVEIRO

PLATELET LYSATE-BASED MICROPARTICLES, METHODS AND USES THEREOF

Número de solicitud/publicación: 20 23062242
Fecha: 2023-12-05
Solicitante(s): UNIVERSIDADE DE AVEIRO

PLATELET LYSATE-BASED MICROPARTICLES, METHODS AND USES THEREOF

Número de solicitud/publicación: 20 23062242
Fecha: 2023-12-05
Solicitante(s): UNIVERSIDADE DE AVEIRO

BIOMATERIAL FOR IMMUNOMODULATION, PROCESS FOR ITS PRODUCTION AND USES THEREOF

Número de solicitud/publicación: 22 185533
Fecha: 2022-07-18
Solicitante(s): UNIVERSIDADE DE AVEIRO