Full human-based multi-scale constructs with jammed regenerative pockets for bone engineering

Informations projet

REBORN

N° de convention de subvention: 883370

DOI

10.3030/883370

Date de signature de la CE 9 Septembre 2020

Date de début 1 Novembre 2021

Date de fin 31 Octobre 2026

Financé au titre de

• EXCELLENT SCIENCE - European Research Council (ERC)

Coût total

€ 2 499 683,00

Contribution de l’UE

€ 2 499 683,00

Coordonné par

UNIVERSIDADE DE AVEIRO
Portugal

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Publications

Thesis and dissertations (10)

Bioengineered pancreatic tumor-stroma models for preclinical screening of therapeutics

Auteurs: Monteiro, Maria Vinhas
Publié dans: 2023
Éditeur: Universidade de Aveiro

Human plasma derived hydrogels for myocardial tissue engineering

Auteurs: Santos, Sara Catarina Nunes da Silva
Publié dans: 2024
Éditeur: Universidade de Aveiro

Single-cell microcapsules for biomedical applications

Auteurs: Santos, Manuel Pires dos
Publié dans: 2023
Éditeur: Universidade de Aveiro

Fabrication of bicontinuous microporous hydrogels using aqueous emulsion templating

Auteurs: Fernandes, Hugo Edgar Vilar
Publié dans: 2023
Éditeur: Universidade de Aveiro

Magnetic nanoparticles in the engineering of hybrid structures for cell and tissue engineering

Auteurs: Mendes, Maria Cândida Balão
Publié dans: 2025
Éditeur: Universidade de Aveiro

Osteosarcoma-on-a-chip: a physiologically relevant human-based microfluidic platform for drug screening

Auteurs: Cátia F. Monteiro
Publié dans: 2024
Éditeur: Universidade de Aveiro

Bioengenharia e controlo dinâmico em hidrogéis e materiais celulares com adaptabilidade

Auteurs: Lavrador, Pedro Oliveira
Publié dans: 2023
Éditeur: Universidade de Aveiro

Production of photo-engineered cell-rich materials exhibiting living features

Auteurs: Pinto, José Carlos Almeida
Publié dans: 2023
Éditeur: Universidade de Aveiro

Biomedical system based on controlled enzymatically degradation of hydrogels

Auteurs: Mehrzad Zargarzadeh
Publié dans: 2024
Éditeur: Universidade de Aveiro

Mechanosensing microcapsules to direct stem cell differentiation for tissue regeneration applications

Auteurs: Hasankolaei, Maryam Ghasemzadeh
Publié dans: Numéro 1, 2024
Éditeur: Universidade de Aveiro

Peer reviewed articles (43)

Supramolecular assembly of multi-purpose tissue engineering platforms from human extracellular matrix

Auteurs: Bruno Ladeira, Maria Gomes, Kongchang Wei, Catarina Custódio, João Mano
Publié dans: Biomaterials, Numéro 320, 2026, Page(s) 123270, ISSN 0142-9612
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2025.123270

Biomaterials of human source for 3D printing strategies

Auteurs: João Rocha Maia, Rita Sobreiro-Almeida, Franck Cleymand, João F Mano
Publié dans: Journal of Physics: Materials, 2023, ISSN 2515-7639
Éditeur: IOP Publishing
DOI: 10.1088/2515-7639/acada1

Emerging modulators for osteogenic differentiation: a combination of chemical and topographical cues for bone

Auteurs: Diana Jesus, Ana R. Pinho, Maria C. Gomes, Cláudia S. Oliveira, João F. Mano
Publié dans: Soft Matter, 2022, ISSN 1744-683X
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d2sm00009a

Photocrosslinkable microgels derived from human platelet lysates: injectable biomaterials for cardiac cell culture

Auteurs: Sara C. Santos , Catarina A. Custódio, João F. Mano
Publié dans: Biomaterials Science, 2024, ISSN 2047-4830
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d3bm01933k

Double-Interlinked Colloidal Gels for Programable Fabrication of Supraparticle Architectures

Auteurs: Leandro Gonçalves, Pedro Lavrador, Adérito J. R. Amaral, Luís P. Ferreira, Vítor M. Gaspar, João F. Mano
Publié dans: Advanced Functional Materials, 2023, ISSN 1616-301X
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202304628

Emerging lipid–polymer hybrid nanoparticles for genome editing

Auteurs: Mariana Gameiro, João F. Mano, Vítor M. Gaspar
Publié dans: Polymer Chemistry, Numéro 15, 2024, Page(s) 3436-3468, ISSN 1759-9954
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d4py00298a

Interconnected Porous Hydrogels with Tunable Anisotropy Through Aqueous Emulsion Bioprinting

Auteurs: Hugo Edgar‐Vilar, Francisca P. Correia, Inês M. Freitas, Vítor M. Gaspar, João F. Mano
Publié dans: Advanced Functional Materials, Numéro 36, 2026, ISSN 1616-301X
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202521050

Endo- and Exometabolome Crosstalk in Mesenchymal Stem Cells Undergoing Osteogenic Differentiation

Auteurs: Daniela S. C. Bispo, Lenka Michálková, Marlene Correia, Catarina S. H. Jesus, Iola F. Duarte, Brian J. Goodfellow, Mariana B. Oliveira, João F. Mano, Ana M. Gil
Publié dans: Cells, 2022, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells11081257

Osteogenic Differentiation Triggered by Intracellular Magnetoelectric Stimulation of Core–Shell Nanotransducers under Remotely Applied Magnetic Fields

Auteurs: Maria C. Mendes, Elisa A. G. Martins, Roman V. Chernozem, Polina V. Chernozem, Catarina C. Custódio, Roman A. Surmenev, Andrei L. Kholkin, Ana S. Silva, João F. Mano
Publié dans: ACS Nano, Numéro 19, 2026, Page(s) 42022-42045, ISSN 1936-0851
Éditeur: American Chemical Society
DOI: 10.1021/acsnano.5c10509

Spontaneous Formation of Solid Shell Polymeric Multicompartments at All‐Aqueous Interfaces

Auteurs: Francisca G. Perfeito, Sara Vilabril, Andreia Cerqueira, Mariana B. Oliveira, João F. Mano
Publié dans: Advanced Science, Numéro 11, 2024, ISSN 2198-3844
Éditeur: Wiley-VCH Verlag
DOI: 10.1002/advs.202402592

Human Chorionic Membrane‐derived Tunable Hydrogels for Vascular Tissue Engineering Strategies

Auteurs: Elisa A.G. Martins, Inês A. Deus, Maria C. Gomes, Ana S. Silva, João F. Mano, Catarina A. Custódio
Publié dans: Advanced Healthcare Materials, 2024, ISSN 2192-2640
Éditeur: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202401510

Merging Natural Biopolymers with Supramolecular Chemistry: Emulating the Native Extracellular Matrix’s Complexity

Auteurs: Vera Sousa, Bruno Ladeira, Elisabeth Garanger, Sébastien Lecommandoux, E. W. Meijer, Patricia Y. W. Dankers, João F. Mano, João Borges
Publié dans: ACS Nano, Numéro 19, 2026, Page(s) 29833-29859, ISSN 1936-0851
Éditeur: American Chemical Society
DOI: 10.1021/acsnano.5c10088

Advancing tissue decellularized hydrogels for engineering human organoids

Auteurs: Beatriz S. Moura, Maria V. Monteiro, Luís P. Ferreira, Pedro Lavrador, Vítor M. Gaspar, João F. Mano
Publié dans: Advanced Functional Materials, 2022, ISSN 1616-301X
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202202825

Biomimetic Adhesive Micropatterned Hydrogel Patches for Drug Release

Auteurs: Katia R. Amaral, A. Sofia Silva, Lúcia F. Santos, Edgar J. Castanheira, Maria C. Mendes, Dora C.S. Costa, João M. M. Rodrigues, Joana Marto, João F. Mano
Publié dans: Advanced Healthcare Materials, 2023, ISSN 2192-2640
Éditeur: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202301513

Pierceable, Storable, and Manipulable Liquid Capsules for Precise Monitoring and Efficient Cargo Transport in Biotechnological Advances

Auteurs: Ana Rita Pinho, Chunming Wang, Maria Clara Gomes, João Filipe Mano
Publié dans: Advanced Functional Materials, Numéro 35, 2026, ISSN 1616-301X
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202425715

Exploring the potential of all-aqueous immiscible systems for preparing complex biomaterials and cellular constructs

Auteurs: Raquel C. Gonçalves, Mariana B. Oliveira, João F. Mano
Publié dans: Materials Horizons, Numéro 11, 2024, Page(s) 4573-4599, ISSN 2051-6347
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d4mh00431k

Contactless 3D acoustic assembly of liquid capsules for bottom-up tissue engineering

Auteurs: Maria Eduarda Rocha Luiz, Mariana Carreira, Sara Nadine, Riccardo Tognato, Romedi Parolini, Syeda M. Bakht, Tiziano Serra, João F. Mano
Publié dans: Biomaterials, Numéro 325, 2026, Page(s) 123555, ISSN 0142-9612
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2025.123555

Viscous microcapsules as microbioreactors to study mesenchymal stem/stromal cells osteolineage commitment

Auteurs: Maryam Ghasemzadeh-Hasankolaei, João M. Miranda, Clara R. Correia, João F. Mano
Publié dans: Small Methods, Numéro 2201503, 2023, ISSN 2366-9608
Éditeur: Wiley
DOI: 10.1002/smtd.202201503

Advances in Cell-Rich Inks for Biofabricating Living Architectures

Auteurs: José Almeida-Pinto, Beatriz S. Moura, Vítor M. Gaspar, João F. Mano
Publié dans: Advanced Materials, 2024, ISSN 1521-4095
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/adma.202313776

Cell Shuttling in Multifunctional Microsized Needles

Auteurs: Marta M. Maciel, José N. M. Silvares, Tiago R. Correia, Carlos M. N. Mendonça, Ana P. Martins, Eduardo T. C. C. Silva, Nuno J. O. Silva, Filipa L. Sousa, João F. Mano
Publié dans: Small Structures, Numéro 7, 2026, ISSN 2688-4062
Éditeur: Wiley
DOI: 10.1002/sstr.202500370

Magnetic-Based Strategies for Regenerative Medicine and Tissue Engineering

Auteurs: Lúcia F. Santos, Ana S. Silva, João F. Mano
Publié dans: Advanced Healthcare Materials, 2023, ISSN 2192-2640
Éditeur: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202300605

Tumor‐On‐A‐Chip Model Incorporating Human‐Based Hydrogels for Easy Assessment of Metastatic Tumor Inter‐Heterogeneity

Auteurs: Cátia F. Monteiro, Inês A. Deus, Inês B. Silva, Iola F. Duarte, Catarina A. Custódio, João F. Mano
Publié dans: Advanced Functional Materials, 2024, ISSN 1616-301X
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202315940

Liquefied capsules containing nanogrooved microdiscs and umbilical cord-derived cells for bone tissue engineering

Auteurs: Mariana Carreira; Manuel Pires-Santos; Clara R Correia; Sara Nadine; João F Mano
Publié dans: Open Research Europe, 2024, ISSN 2732-5121
Éditeur: [London]: [F1000 Research Limited on behalf of the European Commission]
DOI: 10.12688/openreseurope.17000.1

High-Throughput Production of Microsponges from Platelet Lysate for Tissue Engineering Applications

Auteurs: Bruno M.F. Ladeira, Maria C. Gomes, Catarina A. Custódio, João F. Mano
Publié dans: Tissue Engineering Part C: Methods, 2022, ISSN 1937-3384
Éditeur: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tec.2022.0029

Rapid Generation of Fusable Cell Beads for Multi‐Scale Human Living Materials Assembly

Auteurs: Beatriz S. Moura, Maria V. Monteiro, Joana F. Soeiro, Nuno J. O. Silva, Vítor M. Gaspar, João F. Mano
Publié dans: Small Methods, Numéro 10, 2026, ISSN 2366-9608
Éditeur: Wiley
DOI: 10.1002/smtd.202501450

Thiol-ene click chemistry: Enabling 3D printing of natural-based inks for biomedical applications

Auteurs: Andreia P. Malafaia, Rita Sobreiro-Almeida, João M.M. Rodrigues, João F. Mano
Publié dans: Biomaterials Advances, Numéro 167, 2024, Page(s) 214105, ISSN 2772-9508
Éditeur: Elsevier
DOI: 10.1016/j.bioadv.2024.214105

Modeling 3D Tumor Invasiveness to Modulate Macrophage Phenotype in a Human‐Based Hydrogel Platform

Auteurs: Cátia F. Monteiro, Catarina R. Almeida, Catarina A. Custódio, João F. Mano
Publié dans: Macromolecular Bioscience, Numéro 24, 2024, ISSN 1616-5187
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/mabi.202400227

Human Platelet Lysate-Derived Nanofibrils as Building Blocks to Produce Free-Standing Membranes for Cell Self-Aggregation

Auteurs: Cátia F. Monteiro, Maria C. Gomes, Pankaj Bharmoria, Mara G. Freire, João A. P. Coutinho, Catarina A. Custódio, and João F. Mano
Publié dans: ACS Nano, 2024, ISSN 1936-0851
Éditeur: American Chemical Society
DOI: 10.1021/acsnano.4c02790

Roadmap for animate matter

Auteurs: Giorgio Volpe, Nuno A M Araújo, Maria Guix, Mark Miodownik, Nicolas Martin, Laura Alvarez, Juliane Simmchen, Roberto Di Leonardo, Nicola Pellicciotta, Quentin Martinet, Jérémie Palacci, Wai Kit Ng, Dhruv Saxena, Riccardo Sapienza, Sara Nadine, João F Mano, Reza Mahdavi, Caroline Beck Adiels, Joe Forth, Christian Santangelo, Stefano Palagi, Ji Min Seok, Victoria A Webster-Wood, Shuhong Wang, Li
Publié dans: Journal of Physics: Condensed Matter, Numéro 37, 2025, Page(s) 333501, ISSN 0953-8984
Éditeur: Institute of Physics Publishing
DOI: 10.1088/1361-648x/adebd3

A Self-Sustaining Hydrogels with Autonomous Supply of Nutrients and Bioactive Domains for 3D Cell Culture

Auteurs: Mehrzad Zargarzadeh, Maria C. Gomes, Sónia G. Patrício, Catarina A. Custódio, João F. Mano
Publié dans: Advanced Functional Materials, 2023, ISSN 1616-301X
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202214372

Bioactive Self‐Regulated Liquified Microcompartments to Bioengineer Bone‐Like Microtissues

Auteurs: Ana R. Pinho; Maria C. Gomes; Dora C. S. Costa; João F. Mano
Publié dans: Small, 2023, ISSN 1613-6810
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202305029

Effect of high cyclic hydrostatic pressure on osteogenesis of mesenchymal stem cells cultured in liquefied micro-compartments

Auteurs: Maryam Ghasemzadeh-Hasankolaei, Carlos A. Pinto, Diana Jesus, Jorge A. Saraiva, João F. Mano
Publié dans: Materials Today Bio, 2023, ISSN 2590-0064
Éditeur: Elsevier
DOI: 10.1016/j.mtbio.2023.100861

Unveiling the Potential of Single-Cell Encapsulation in Biomedical Applications: Current Advances and Future Perspectives

Auteurs: Manuel Pires-Santos, Sara Nadine, João F. Mano
Publié dans: Small Science, 2024, ISSN 2688-4046
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/smsc.202300332

Cell Surface Engineering Tools for Programming Living Assemblies

Auteurs: José Almeida-Pinto, Matilde R. Lagarto, Pedro Lavrador, João F. Mano, Vítor M. Gaspar
Publié dans: Advanced Science, 2023, ISSN 2198-3844
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/advs.202304040

Self‐Assembly of Platelet Lysates Proteins into Microparticles by Unnatural Disulfide Bonds for Bottom‐Up Tissue Engineering

Auteurs: Maria C. Gomes; Ana Rita Pinho; Catarina Custódio; João F. Mano
Publié dans: Advanced Materials, 2023, ISSN 1521-4095
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/adma.202304659

Recent Developments in Layer-by-Layer Assembly for Drug Delivery and Tissue Engineering Applications

Auteurs: João Borges, Jinfeng Zeng, Xi Qiu Liu, Hao Chang, Claire Monge, Charlotte Garot, Ke-feng Ren, Paul Machillot, Nihal E. Vrana, Philippe Lavalle, Takami Akagi, Michiya Matsusaki, Jian Ji, Mitsuru Akashi, João F. Mano, Varvara Gribova, Catherine Picart
Publié dans: Advanced Healthcare Materials, 2023, ISSN 2192-2640
Éditeur: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202302713

Designer mammalian living materials through genetic engineering

Auteurs: Mariana Gameiro, José Almeida-Pinto, Beatriz S. Moura, João F. Mano, Vítor M. Gaspar
Publié dans: Bioactive Materials, Numéro 48, 2025, Page(s) 135-148, ISSN 2452-199X
Éditeur: Elsevier BV
DOI: 10.1016/j.bioactmat.2025.02.007

Engineered nascent living human tissues with unit programmability

Auteurs: Pedro Lavrador, Beatriz S. Moura, José Almeida-Pinto, Vítor M. Gaspar, João F. Mano
Publié dans: Nature Materials, 2024, ISSN 1476-1122
Éditeur: Nature Publishing Group
DOI: 10.1038/s41563-024-01958-1

Magneto‐Enzymatic Microgels for Precise Hydrogel Sculpturing

Auteurs: Maria C. Mendes, João A. Pereira, Ana S. Silva, João F. Mano
Publié dans: Advanced Materials, 2024, ISSN 0935-9648
Éditeur: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202402988

Single‐Cell Liquid‐Core Microcapsules for Biomedical Applications

Auteurs: Manuel Pires‐Santos, Mariana Carreira, Bruno P. Morais, Francisca G. Perfeito, Mariana B. Oliveira, Cátia F. Monteiro, Sara Nadine, João F. Mano
Publié dans: Advanced Healthcare Materials, Numéro 14, 2026, ISSN 2192-2640
Éditeur: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202403808

Strategies to decouple cell micro-scale and macro-scale environments for designing multifunctional biomimetic tissues

Auteurs: Maryam Ghasemzadeh-Hasankolaei, Diogo Pinheiro, Sara Nadine, João F. Mano
Publié dans: Soft Matter, Numéro 20, 2024, Page(s) 6313-6326, ISSN 1744-683X
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d4sm00276h

Close-to-native bone repair via tissue-engineered endochondral ossification approaches

Auteurs: Sara Nadine, Inês J. Fernandes, Clara R. Correia, João F. Mano
Publié dans: iScience, 2022, ISSN 2589-0042
Éditeur: Cell Press
DOI: 10.1016/j.isci.2022.105370

Bioinstructive Liquefied Pockets in Hierarchical Hydrogels and Bioinks

Auteurs: Maryam Ghasemzadeh‐Hasankolaei, Tiago R. Correia, João F. Mano
Publié dans: Advanced Healthcare Materials, 2024, ISSN 2192-2640
Éditeur: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202400286

Droits de propriété intellectuelle

Patent (4)

BIOMATERIAL FOR IMMUNOMODULATION, PROCESS FOR ITS PRODUCTION AND USES THEREOF

Numéro de demande/publication: 22 185533
Date: 2022-07-18
Demandeur(s): UNIVERSIDADE DE AVEIRO

PLATELET LYSATE-BASED MICROPARTICLES, METHODS AND USES THEREOF

Numéro de demande/publication: 20 23062242
Date: 2023-12-05
Demandeur(s): UNIVERSIDADE DE AVEIRO

PLATELET LYSATE-BASED MICROPARTICLES, METHODS AND USES THEREOF

Numéro de demande/publication: 20 23062242
Date: 2023-12-05
Demandeur(s): UNIVERSIDADE DE AVEIRO

BIOMATERIAL FOR IMMUNOMODULATION, PROCESS FOR ITS PRODUCTION AND USES THEREOF

Numéro de demande/publication: 22 185533
Date: 2022-07-18
Demandeur(s): UNIVERSIDADE DE AVEIRO