Full human-based multi-scale constructs with jammed regenerative pockets for bone engineering

Project Information

REBORN

Grant agreement ID: 883370

DOI 10.3030/883370

EC signature date 9 September 2020

Start date 1 November 2021

End date 31 October 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 499 683,00

EU contribution € 2 499 683,00

Coordinated by

UNIVERSIDADE DE AVEIRO
Portugal

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (32)

Biomaterials of human source for 3D printing strategies

Author(s): João Rocha Maia, Rita Sobreiro-Almeida, Franck Cleymand, João F Mano
Published in: Journal of Physics: Materials, 2023, ISSN 2515-7639
Publisher: IOP Publishing
DOI: 10.1088/2515-7639/acada1

Emerging modulators for osteogenic differentiation: a combination of chemical and topographical cues for bone

Author(s): Diana Jesus, Ana R. Pinho, Maria C. Gomes, Cláudia S. Oliveira, João F. Mano
Published in: Soft Matter, 2022, ISSN 1744-683X
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2sm00009a

Photocrosslinkable microgels derived from human platelet lysates: injectable biomaterials for cardiac cell culture

Author(s): Sara C. Santos , Catarina A. Custódio, João F. Mano
Published in: Biomaterials Science, 2024, ISSN 2047-4830
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3bm01933k

Double-Interlinked Colloidal Gels for Programable Fabrication of Supraparticle Architectures

Author(s): Leandro Gonçalves, Pedro Lavrador, Adérito J. R. Amaral, Luís P. Ferreira, Vítor M. Gaspar, João F. Mano
Published in: Advanced Functional Materials, 2023, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202304628

Emerging lipid–polymer hybrid nanoparticles for genome editing

Author(s): Mariana Gameiro, João F. Mano, Vítor M. Gaspar
Published in: Polymer Chemistry, Issue 15, 2024, Page(s) 3436-3468, ISSN 1759-9954
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4py00298a

Endo- and Exometabolome Crosstalk in Mesenchymal Stem Cells Undergoing Osteogenic Differentiation

Author(s): Daniela S. C. Bispo, Lenka Michálková, Marlene Correia, Catarina S. H. Jesus, Iola F. Duarte, Brian J. Goodfellow, Mariana B. Oliveira, João F. Mano, Ana M. Gil
Published in: Cells, 2022, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells11081257

Spontaneous Formation of Solid Shell Polymeric Multicompartments at All‐Aqueous Interfaces

Author(s): Francisca G. Perfeito, Sara Vilabril, Andreia Cerqueira, Mariana B. Oliveira, João F. Mano
Published in: Advanced Science, Issue 11, 2024, ISSN 2198-3844
Publisher: Wiley-VCH Verlag
DOI: 10.1002/advs.202402592

Human Chorionic Membrane‐derived Tunable Hydrogels for Vascular Tissue Engineering Strategies

Author(s): Elisa A.G. Martins, Inês A. Deus, Maria C. Gomes, Ana S. Silva, João F. Mano, Catarina A. Custódio
Published in: Advanced Healthcare Materials, 2024, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202401510

Advancing tissue decellularized hydrogels for engineering human organoids

Author(s): Beatriz S. Moura, Maria V. Monteiro, Luís P. Ferreira, Pedro Lavrador, Vítor M. Gaspar, João F. Mano
Published in: Advanced Functional Materials, 2022, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202202825

Biomimetic Adhesive Micropatterned Hydrogel Patches for Drug Release

Author(s): Katia R. Amaral, A. Sofia Silva, Lúcia F. Santos, Edgar J. Castanheira, Maria C. Mendes, Dora C.S. Costa, João M. M. Rodrigues, Joana Marto, João F. Mano
Published in: Advanced Healthcare Materials, 2023, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202301513

Exploring the potential of all-aqueous immiscible systems for preparing complex biomaterials and cellular constructs

Author(s): Raquel C. Gonçalves, Mariana B. Oliveira, João F. Mano
Published in: Materials Horizons, Issue 11, 2024, Page(s) 4573-4599, ISSN 2051-6347
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4mh00431k

Viscous microcapsules as microbioreactors to study mesenchymal stem/stromal cells osteolineage commitment

Author(s): Maryam Ghasemzadeh-Hasankolaei, João M. Miranda, Clara R. Correia, João F. Mano
Published in: Small Methods, Issue 2201503, 2023, ISSN 2366-9608
Publisher: Wiley
DOI: 10.1002/smtd.202201503

Advances in Cell-Rich Inks for Biofabricating Living Architectures

Author(s): José Almeida-Pinto, Beatriz S. Moura, Vítor M. Gaspar, João F. Mano
Published in: Advanced Materials, 2024, ISSN 1521-4095
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adma.202313776

Magnetic-Based Strategies for Regenerative Medicine and Tissue Engineering

Author(s): Lúcia F. Santos, Ana S. Silva, João F. Mano
Published in: Advanced Healthcare Materials, 2023, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202300605

Tumor‐On‐A‐Chip Model Incorporating Human‐Based Hydrogels for Easy Assessment of Metastatic Tumor Inter‐Heterogeneity

Author(s): Cátia F. Monteiro, Inês A. Deus, Inês B. Silva, Iola F. Duarte, Catarina A. Custódio, João F. Mano
Published in: Advanced Functional Materials, 2024, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202315940

Liquefied capsules containing nanogrooved microdiscs and umbilical cord-derived cells for bone tissue engineering

Author(s): Mariana Carreira; Manuel Pires-Santos; Clara R Correia; Sara Nadine; João F Mano
Published in: Open Research Europe, 2024, ISSN 2732-5121
Publisher: [London]: [F1000 Research Limited on behalf of the European Commission]
DOI: 10.12688/openreseurope.17000.1

High-Throughput Production of Microsponges from Platelet Lysate for Tissue Engineering Applications

Author(s): Bruno M.F. Ladeira, Maria C. Gomes, Catarina A. Custódio, João F. Mano
Published in: Tissue Engineering Part C: Methods, 2022, ISSN 1937-3384
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tec.2022.0029

Thiol-ene click chemistry: Enabling 3D printing of natural-based inks for biomedical applications

Author(s): Andreia P. Malafaia, Rita Sobreiro-Almeida, João M.M. Rodrigues, João F. Mano
Published in: Biomaterials Advances, Issue 167, 2024, Page(s) 214105, ISSN 2772-9508
Publisher: Elsevier
DOI: 10.1016/j.bioadv.2024.214105

Modeling 3D Tumor Invasiveness to Modulate Macrophage Phenotype in a Human‐Based Hydrogel Platform

Author(s): Cátia F. Monteiro, Catarina R. Almeida, Catarina A. Custódio, João F. Mano
Published in: Macromolecular Bioscience, Issue 24, 2024, ISSN 1616-5187
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/mabi.202400227

Human Platelet Lysate-Derived Nanofibrils as Building Blocks to Produce Free-Standing Membranes for Cell Self-Aggregation

Author(s): Cátia F. Monteiro, Maria C. Gomes, Pankaj Bharmoria, Mara G. Freire, João A. P. Coutinho, Catarina A. Custódio, and João F. Mano
Published in: ACS Nano, 2024, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.4c02790

A Self-Sustaining Hydrogels with Autonomous Supply of Nutrients and Bioactive Domains for 3D Cell Culture

Author(s): Mehrzad Zargarzadeh, Maria C. Gomes, Sónia G. Patrício, Catarina A. Custódio, João F. Mano
Published in: Advanced Functional Materials, 2023, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202214372

Bioactive Self‐Regulated Liquified Microcompartments to Bioengineer Bone‐Like Microtissues

Author(s): Ana R. Pinho; Maria C. Gomes; Dora C. S. Costa; João F. Mano
Published in: Small, 2023, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202305029

Effect of high cyclic hydrostatic pressure on osteogenesis of mesenchymal stem cells cultured in liquefied micro-compartments

Author(s): Maryam Ghasemzadeh-Hasankolaei, Carlos A. Pinto, Diana Jesus, Jorge A. Saraiva, João F. Mano
Published in: Materials Today Bio, 2023, ISSN 2590-0064
Publisher: Elsevier
DOI: 10.1016/j.mtbio.2023.100861

Unveiling the Potential of Single-Cell Encapsulation in Biomedical Applications: Current Advances and Future Perspectives

Author(s): Manuel Pires-Santos, Sara Nadine, João F. Mano
Published in: Small Science, 2024, ISSN 2688-4046
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/smsc.202300332

Cell Surface Engineering Tools for Programming Living Assemblies

Author(s): José Almeida-Pinto, Matilde R. Lagarto, Pedro Lavrador, João F. Mano, Vítor M. Gaspar
Published in: Advanced Science, 2023, ISSN 2198-3844
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/advs.202304040

Self‐Assembly of Platelet Lysates Proteins into Microparticles by Unnatural Disulfide Bonds for Bottom‐Up Tissue Engineering

Author(s): Maria C. Gomes; Ana Rita Pinho; Catarina Custódio; João F. Mano
Published in: Advanced Materials, 2023, ISSN 1521-4095
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adma.202304659

Recent Developments in Layer-by-Layer Assembly for Drug Delivery and Tissue Engineering Applications

Author(s): João Borges, Jinfeng Zeng, Xi Qiu Liu, Hao Chang, Claire Monge, Charlotte Garot, Ke-feng Ren, Paul Machillot, Nihal E. Vrana, Philippe Lavalle, Takami Akagi, Michiya Matsusaki, Jian Ji, Mitsuru Akashi, João F. Mano, Varvara Gribova, Catherine Picart
Published in: Advanced Healthcare Materials, 2023, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202302713

Engineered nascent living human tissues with unit programmability

Author(s): Pedro Lavrador, Beatriz S. Moura, José Almeida-Pinto, Vítor M. Gaspar, João F. Mano
Published in: Nature Materials, 2024, ISSN 1476-1122
Publisher: Nature Publishing Group
DOI: 10.1038/s41563-024-01958-1

Magneto‐Enzymatic Microgels for Precise Hydrogel Sculpturing

Author(s): Maria C. Mendes, João A. Pereira, Ana S. Silva, João F. Mano
Published in: Advanced Materials, 2024, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202402988

Strategies to decouple cell micro-scale and macro-scale environments for designing multifunctional biomimetic tissues

Author(s): Maryam Ghasemzadeh-Hasankolaei, Diogo Pinheiro, Sara Nadine, João F. Mano
Published in: Soft Matter, Issue 20, 2024, Page(s) 6313-6326, ISSN 1744-683X
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4sm00276h

Close-to-native bone repair via tissue-engineered endochondral ossification approaches

Author(s): Sara Nadine, Inês J. Fernandes, Clara R. Correia, João F. Mano
Published in: iScience, 2022, ISSN 2589-0042
Publisher: Cell Press
DOI: 10.1016/j.isci.2022.105370

Bioinstructive Liquefied Pockets in Hierarchical Hydrogels and Bioinks

Author(s): Maryam Ghasemzadeh‐Hasankolaei, Tiago R. Correia, João F. Mano
Published in: Advanced Healthcare Materials, 2024, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202400286

Thesis and dissertations (4)

Osteosarcoma-on-a-chip: a physiologically relevant human-based microfluidic platform for drug screening

Author(s): Cátia F. Monteiro
Published in: 2024
Publisher: Universidade de Aveiro

Bioengenharia e controlo dinâmico em hidrogéis e materiais celulares com adaptabilidade

Author(s): Lavrador, Pedro Oliveira
Published in: 2023
Publisher: Universidade de Aveiro

Biomedical system based on controlled enzymatically degradation of hydrogels

Author(s): Mehrzad Zargarzadeh
Published in: 2024
Publisher: Universidade de Aveiro

Mechanosensing microcapsules to direct stem cell differentiation for tissue regeneration applications

Author(s): Hasankolaei, Maryam Ghasemzadeh
Published in: Issue 1, 2024
Publisher: Universidade de Aveiro

Intellectual Property Rights

Patent (2)

BIOMATERIAL FOR IMMUNOMODULATION, PROCESS FOR ITS PRODUCTION AND USES THEREOF

Application/Publication number: 22 185533
Date: 2022-07-18
Applicant(s): UNIVERSIDADE DE AVEIRO

PLATELET LYSATE-BASED MICROPARTICLES, METHODS AND USES THEREOF

Application/Publication number: 20 23062242
Date: 2023-12-05
Applicant(s): UNIVERSIDADE DE AVEIRO