Full human-based multi-scale constructs with jammed regenerative pockets for bone engineering

Informazioni relative al progetto

REBORN

ID dell’accordo di sovvenzione: 883370

DOI

10.3030/883370

Data della firma CE 9 Settembre 2020

Data di avvio 1 Novembre 2021

Data di completamento 31 Ottobre 2026

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 499 683,00

Contributo UE

€ 2 499 683,00

Coordinato da

UNIVERSIDADE DE AVEIRO
Portugal

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (32)

Biomaterials of human source for 3D printing strategies

Autori: João Rocha Maia, Rita Sobreiro-Almeida, Franck Cleymand, João F Mano
Pubblicato in: Journal of Physics: Materials, 2023, ISSN 2515-7639
Editore: IOP Publishing
DOI: 10.1088/2515-7639/acada1

Emerging modulators for osteogenic differentiation: a combination of chemical and topographical cues for bone

Autori: Diana Jesus, Ana R. Pinho, Maria C. Gomes, Cláudia S. Oliveira, João F. Mano
Pubblicato in: Soft Matter, 2022, ISSN 1744-683X
Editore: Royal Society of Chemistry
DOI: 10.1039/d2sm00009a

Photocrosslinkable microgels derived from human platelet lysates: injectable biomaterials for cardiac cell culture

Autori: Sara C. Santos , Catarina A. Custódio, João F. Mano
Pubblicato in: Biomaterials Science, 2024, ISSN 2047-4830
Editore: Royal Society of Chemistry
DOI: 10.1039/d3bm01933k

Double-Interlinked Colloidal Gels for Programable Fabrication of Supraparticle Architectures

Autori: Leandro Gonçalves, Pedro Lavrador, Adérito J. R. Amaral, Luís P. Ferreira, Vítor M. Gaspar, João F. Mano
Pubblicato in: Advanced Functional Materials, 2023, ISSN 1616-301X
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202304628

Emerging lipid–polymer hybrid nanoparticles for genome editing

Autori: Mariana Gameiro, João F. Mano, Vítor M. Gaspar
Pubblicato in: Polymer Chemistry, Numero 15, 2024, Pagina/e 3436-3468, ISSN 1759-9954
Editore: Royal Society of Chemistry
DOI: 10.1039/d4py00298a

Endo- and Exometabolome Crosstalk in Mesenchymal Stem Cells Undergoing Osteogenic Differentiation

Autori: Daniela S. C. Bispo, Lenka Michálková, Marlene Correia, Catarina S. H. Jesus, Iola F. Duarte, Brian J. Goodfellow, Mariana B. Oliveira, João F. Mano, Ana M. Gil
Pubblicato in: Cells, 2022, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells11081257

Spontaneous Formation of Solid Shell Polymeric Multicompartments at All‐Aqueous Interfaces

Autori: Francisca G. Perfeito, Sara Vilabril, Andreia Cerqueira, Mariana B. Oliveira, João F. Mano
Pubblicato in: Advanced Science, Numero 11, 2024, ISSN 2198-3844
Editore: Wiley-VCH Verlag
DOI: 10.1002/advs.202402592

Human Chorionic Membrane‐derived Tunable Hydrogels for Vascular Tissue Engineering Strategies

Autori: Elisa A.G. Martins, Inês A. Deus, Maria C. Gomes, Ana S. Silva, João F. Mano, Catarina A. Custódio
Pubblicato in: Advanced Healthcare Materials, 2024, ISSN 2192-2640
Editore: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202401510

Advancing tissue decellularized hydrogels for engineering human organoids

Autori: Beatriz S. Moura, Maria V. Monteiro, Luís P. Ferreira, Pedro Lavrador, Vítor M. Gaspar, João F. Mano
Pubblicato in: Advanced Functional Materials, 2022, ISSN 1616-301X
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202202825

Biomimetic Adhesive Micropatterned Hydrogel Patches for Drug Release

Autori: Katia R. Amaral, A. Sofia Silva, Lúcia F. Santos, Edgar J. Castanheira, Maria C. Mendes, Dora C.S. Costa, João M. M. Rodrigues, Joana Marto, João F. Mano
Pubblicato in: Advanced Healthcare Materials, 2023, ISSN 2192-2640
Editore: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202301513

Exploring the potential of all-aqueous immiscible systems for preparing complex biomaterials and cellular constructs

Autori: Raquel C. Gonçalves, Mariana B. Oliveira, João F. Mano
Pubblicato in: Materials Horizons, Numero 11, 2024, Pagina/e 4573-4599, ISSN 2051-6347
Editore: Royal Society of Chemistry
DOI: 10.1039/d4mh00431k

Viscous microcapsules as microbioreactors to study mesenchymal stem/stromal cells osteolineage commitment

Autori: Maryam Ghasemzadeh-Hasankolaei, João M. Miranda, Clara R. Correia, João F. Mano
Pubblicato in: Small Methods, Numero 2201503, 2023, ISSN 2366-9608
Editore: Wiley
DOI: 10.1002/smtd.202201503

Advances in Cell-Rich Inks for Biofabricating Living Architectures

Autori: José Almeida-Pinto, Beatriz S. Moura, Vítor M. Gaspar, João F. Mano
Pubblicato in: Advanced Materials, 2024, ISSN 1521-4095
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adma.202313776

Magnetic-Based Strategies for Regenerative Medicine and Tissue Engineering

Autori: Lúcia F. Santos, Ana S. Silva, João F. Mano
Pubblicato in: Advanced Healthcare Materials, 2023, ISSN 2192-2640
Editore: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202300605

Tumor‐On‐A‐Chip Model Incorporating Human‐Based Hydrogels for Easy Assessment of Metastatic Tumor Inter‐Heterogeneity

Autori: Cátia F. Monteiro, Inês A. Deus, Inês B. Silva, Iola F. Duarte, Catarina A. Custódio, João F. Mano
Pubblicato in: Advanced Functional Materials, 2024, ISSN 1616-301X
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202315940

Liquefied capsules containing nanogrooved microdiscs and umbilical cord-derived cells for bone tissue engineering

Autori: Mariana Carreira; Manuel Pires-Santos; Clara R Correia; Sara Nadine; João F Mano
Pubblicato in: Open Research Europe, 2024, ISSN 2732-5121
Editore: [London]: [F1000 Research Limited on behalf of the European Commission]
DOI: 10.12688/openreseurope.17000.1

High-Throughput Production of Microsponges from Platelet Lysate for Tissue Engineering Applications

Autori: Bruno M.F. Ladeira, Maria C. Gomes, Catarina A. Custódio, João F. Mano
Pubblicato in: Tissue Engineering Part C: Methods, 2022, ISSN 1937-3384
Editore: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tec.2022.0029

Thiol-ene click chemistry: Enabling 3D printing of natural-based inks for biomedical applications

Autori: Andreia P. Malafaia, Rita Sobreiro-Almeida, João M.M. Rodrigues, João F. Mano
Pubblicato in: Biomaterials Advances, Numero 167, 2024, Pagina/e 214105, ISSN 2772-9508
Editore: Elsevier
DOI: 10.1016/j.bioadv.2024.214105

Modeling 3D Tumor Invasiveness to Modulate Macrophage Phenotype in a Human‐Based Hydrogel Platform

Autori: Cátia F. Monteiro, Catarina R. Almeida, Catarina A. Custódio, João F. Mano
Pubblicato in: Macromolecular Bioscience, Numero 24, 2024, ISSN 1616-5187
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/mabi.202400227

Human Platelet Lysate-Derived Nanofibrils as Building Blocks to Produce Free-Standing Membranes for Cell Self-Aggregation

Autori: Cátia F. Monteiro, Maria C. Gomes, Pankaj Bharmoria, Mara G. Freire, João A. P. Coutinho, Catarina A. Custódio, and João F. Mano
Pubblicato in: ACS Nano, 2024, ISSN 1936-0851
Editore: American Chemical Society
DOI: 10.1021/acsnano.4c02790

A Self-Sustaining Hydrogels with Autonomous Supply of Nutrients and Bioactive Domains for 3D Cell Culture

Autori: Mehrzad Zargarzadeh, Maria C. Gomes, Sónia G. Patrício, Catarina A. Custódio, João F. Mano
Pubblicato in: Advanced Functional Materials, 2023, ISSN 1616-301X
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202214372

Bioactive Self‐Regulated Liquified Microcompartments to Bioengineer Bone‐Like Microtissues

Autori: Ana R. Pinho; Maria C. Gomes; Dora C. S. Costa; João F. Mano
Pubblicato in: Small, 2023, ISSN 1613-6810
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202305029

Effect of high cyclic hydrostatic pressure on osteogenesis of mesenchymal stem cells cultured in liquefied micro-compartments

Autori: Maryam Ghasemzadeh-Hasankolaei, Carlos A. Pinto, Diana Jesus, Jorge A. Saraiva, João F. Mano
Pubblicato in: Materials Today Bio, 2023, ISSN 2590-0064
Editore: Elsevier
DOI: 10.1016/j.mtbio.2023.100861

Unveiling the Potential of Single-Cell Encapsulation in Biomedical Applications: Current Advances and Future Perspectives

Autori: Manuel Pires-Santos, Sara Nadine, João F. Mano
Pubblicato in: Small Science, 2024, ISSN 2688-4046
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/smsc.202300332

Cell Surface Engineering Tools for Programming Living Assemblies

Autori: José Almeida-Pinto, Matilde R. Lagarto, Pedro Lavrador, João F. Mano, Vítor M. Gaspar
Pubblicato in: Advanced Science, 2023, ISSN 2198-3844
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/advs.202304040

Self‐Assembly of Platelet Lysates Proteins into Microparticles by Unnatural Disulfide Bonds for Bottom‐Up Tissue Engineering

Autori: Maria C. Gomes; Ana Rita Pinho; Catarina Custódio; João F. Mano
Pubblicato in: Advanced Materials, 2023, ISSN 1521-4095
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adma.202304659

Recent Developments in Layer-by-Layer Assembly for Drug Delivery and Tissue Engineering Applications

Autori: João Borges, Jinfeng Zeng, Xi Qiu Liu, Hao Chang, Claire Monge, Charlotte Garot, Ke-feng Ren, Paul Machillot, Nihal E. Vrana, Philippe Lavalle, Takami Akagi, Michiya Matsusaki, Jian Ji, Mitsuru Akashi, João F. Mano, Varvara Gribova, Catherine Picart
Pubblicato in: Advanced Healthcare Materials, 2023, ISSN 2192-2640
Editore: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202302713

Engineered nascent living human tissues with unit programmability

Autori: Pedro Lavrador, Beatriz S. Moura, José Almeida-Pinto, Vítor M. Gaspar, João F. Mano
Pubblicato in: Nature Materials, 2024, ISSN 1476-1122
Editore: Nature Publishing Group
DOI: 10.1038/s41563-024-01958-1

Magneto‐Enzymatic Microgels for Precise Hydrogel Sculpturing

Autori: Maria C. Mendes, João A. Pereira, Ana S. Silva, João F. Mano
Pubblicato in: Advanced Materials, 2024, ISSN 0935-9648
Editore: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202402988

Strategies to decouple cell micro-scale and macro-scale environments for designing multifunctional biomimetic tissues

Autori: Maryam Ghasemzadeh-Hasankolaei, Diogo Pinheiro, Sara Nadine, João F. Mano
Pubblicato in: Soft Matter, Numero 20, 2024, Pagina/e 6313-6326, ISSN 1744-683X
Editore: Royal Society of Chemistry
DOI: 10.1039/d4sm00276h

Close-to-native bone repair via tissue-engineered endochondral ossification approaches

Autori: Sara Nadine, Inês J. Fernandes, Clara R. Correia, João F. Mano
Pubblicato in: iScience, 2022, ISSN 2589-0042
Editore: Cell Press
DOI: 10.1016/j.isci.2022.105370

Bioinstructive Liquefied Pockets in Hierarchical Hydrogels and Bioinks

Autori: Maryam Ghasemzadeh‐Hasankolaei, Tiago R. Correia, João F. Mano
Pubblicato in: Advanced Healthcare Materials, 2024, ISSN 2192-2640
Editore: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202400286

Thesis and dissertations (4)

Osteosarcoma-on-a-chip: a physiologically relevant human-based microfluidic platform for drug screening

Autori: Cátia F. Monteiro
Pubblicato in: 2024
Editore: Universidade de Aveiro

Bioengenharia e controlo dinâmico em hidrogéis e materiais celulares com adaptabilidade

Autori: Lavrador, Pedro Oliveira
Pubblicato in: 2023
Editore: Universidade de Aveiro

Biomedical system based on controlled enzymatically degradation of hydrogels

Autori: Mehrzad Zargarzadeh
Pubblicato in: 2024
Editore: Universidade de Aveiro

Mechanosensing microcapsules to direct stem cell differentiation for tissue regeneration applications

Autori: Hasankolaei, Maryam Ghasemzadeh
Pubblicato in: Numero 1, 2024
Editore: Universidade de Aveiro

Diritti di proprietà intellettuale

Patent (2)

BIOMATERIAL FOR IMMUNOMODULATION, PROCESS FOR ITS PRODUCTION AND USES THEREOF

Numero candidatura/pubblicazione: 22 185533
Data: 2022-07-18
Candidato/i: UNIVERSIDADE DE AVEIRO

PLATELET LYSATE-BASED MICROPARTICLES, METHODS AND USES THEREOF

Numero candidatura/pubblicazione: 20 23062242
Data: 2023-12-05
Candidato/i: UNIVERSIDADE DE AVEIRO