Full human-based multi-scale constructs with jammed regenerative pockets for bone engineering

Informazioni relative al progetto

REBORN

ID dell’accordo di sovvenzione: 883370

DOI

10.3030/883370

Data della firma CE 9 Settembre 2020

Data di avvio 1 Novembre 2021

Data di completamento 31 Ottobre 2026

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 499 683,00

Contributo UE

€ 2 499 683,00

Coordinato da

UNIVERSIDADE DE AVEIRO
Portugal

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Thesis and dissertations (10)

Bioengineered pancreatic tumor-stroma models for preclinical screening of therapeutics

Autori: Monteiro, Maria Vinhas
Pubblicato in: 2023
Editore: Universidade de Aveiro

Human plasma derived hydrogels for myocardial tissue engineering

Autori: Santos, Sara Catarina Nunes da Silva
Pubblicato in: 2024
Editore: Universidade de Aveiro

Single-cell microcapsules for biomedical applications

Autori: Santos, Manuel Pires dos
Pubblicato in: 2023
Editore: Universidade de Aveiro

Fabrication of bicontinuous microporous hydrogels using aqueous emulsion templating

Autori: Fernandes, Hugo Edgar Vilar
Pubblicato in: 2023
Editore: Universidade de Aveiro

Magnetic nanoparticles in the engineering of hybrid structures for cell and tissue engineering

Autori: Mendes, Maria Cândida Balão
Pubblicato in: 2025
Editore: Universidade de Aveiro

Osteosarcoma-on-a-chip: a physiologically relevant human-based microfluidic platform for drug screening

Autori: Cátia F. Monteiro
Pubblicato in: 2024
Editore: Universidade de Aveiro

Bioengenharia e controlo dinâmico em hidrogéis e materiais celulares com adaptabilidade

Autori: Lavrador, Pedro Oliveira
Pubblicato in: 2023
Editore: Universidade de Aveiro

Production of photo-engineered cell-rich materials exhibiting living features

Autori: Pinto, José Carlos Almeida
Pubblicato in: 2023
Editore: Universidade de Aveiro

Biomedical system based on controlled enzymatically degradation of hydrogels

Autori: Mehrzad Zargarzadeh
Pubblicato in: 2024
Editore: Universidade de Aveiro

Mechanosensing microcapsules to direct stem cell differentiation for tissue regeneration applications

Autori: Hasankolaei, Maryam Ghasemzadeh
Pubblicato in: Numero 1, 2024
Editore: Universidade de Aveiro

Peer reviewed articles (43)

Supramolecular assembly of multi-purpose tissue engineering platforms from human extracellular matrix

Autori: Bruno Ladeira, Maria Gomes, Kongchang Wei, Catarina Custódio, João Mano
Pubblicato in: Biomaterials, Numero 320, 2026, Pagina/e 123270, ISSN 0142-9612
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2025.123270

Biomaterials of human source for 3D printing strategies

Autori: João Rocha Maia, Rita Sobreiro-Almeida, Franck Cleymand, João F Mano
Pubblicato in: Journal of Physics: Materials, 2023, ISSN 2515-7639
Editore: IOP Publishing
DOI: 10.1088/2515-7639/acada1

Emerging modulators for osteogenic differentiation: a combination of chemical and topographical cues for bone

Autori: Diana Jesus, Ana R. Pinho, Maria C. Gomes, Cláudia S. Oliveira, João F. Mano
Pubblicato in: Soft Matter, 2022, ISSN 1744-683X
Editore: Royal Society of Chemistry
DOI: 10.1039/d2sm00009a

Photocrosslinkable microgels derived from human platelet lysates: injectable biomaterials for cardiac cell culture

Autori: Sara C. Santos , Catarina A. Custódio, João F. Mano
Pubblicato in: Biomaterials Science, 2024, ISSN 2047-4830
Editore: Royal Society of Chemistry
DOI: 10.1039/d3bm01933k

Double-Interlinked Colloidal Gels for Programable Fabrication of Supraparticle Architectures

Autori: Leandro Gonçalves, Pedro Lavrador, Adérito J. R. Amaral, Luís P. Ferreira, Vítor M. Gaspar, João F. Mano
Pubblicato in: Advanced Functional Materials, 2023, ISSN 1616-301X
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202304628

Emerging lipid–polymer hybrid nanoparticles for genome editing

Autori: Mariana Gameiro, João F. Mano, Vítor M. Gaspar
Pubblicato in: Polymer Chemistry, Numero 15, 2024, Pagina/e 3436-3468, ISSN 1759-9954
Editore: Royal Society of Chemistry
DOI: 10.1039/d4py00298a

Interconnected Porous Hydrogels with Tunable Anisotropy Through Aqueous Emulsion Bioprinting

Autori: Hugo Edgar‐Vilar, Francisca P. Correia, Inês M. Freitas, Vítor M. Gaspar, João F. Mano
Pubblicato in: Advanced Functional Materials, Numero 36, 2026, ISSN 1616-301X
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202521050

Endo- and Exometabolome Crosstalk in Mesenchymal Stem Cells Undergoing Osteogenic Differentiation

Autori: Daniela S. C. Bispo, Lenka Michálková, Marlene Correia, Catarina S. H. Jesus, Iola F. Duarte, Brian J. Goodfellow, Mariana B. Oliveira, João F. Mano, Ana M. Gil
Pubblicato in: Cells, 2022, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells11081257

Osteogenic Differentiation Triggered by Intracellular Magnetoelectric Stimulation of Core–Shell Nanotransducers under Remotely Applied Magnetic Fields

Autori: Maria C. Mendes, Elisa A. G. Martins, Roman V. Chernozem, Polina V. Chernozem, Catarina C. Custódio, Roman A. Surmenev, Andrei L. Kholkin, Ana S. Silva, João F. Mano
Pubblicato in: ACS Nano, Numero 19, 2026, Pagina/e 42022-42045, ISSN 1936-0851
Editore: American Chemical Society
DOI: 10.1021/acsnano.5c10509

Spontaneous Formation of Solid Shell Polymeric Multicompartments at All‐Aqueous Interfaces

Autori: Francisca G. Perfeito, Sara Vilabril, Andreia Cerqueira, Mariana B. Oliveira, João F. Mano
Pubblicato in: Advanced Science, Numero 11, 2024, ISSN 2198-3844
Editore: Wiley-VCH Verlag
DOI: 10.1002/advs.202402592

Human Chorionic Membrane‐derived Tunable Hydrogels for Vascular Tissue Engineering Strategies

Autori: Elisa A.G. Martins, Inês A. Deus, Maria C. Gomes, Ana S. Silva, João F. Mano, Catarina A. Custódio
Pubblicato in: Advanced Healthcare Materials, 2024, ISSN 2192-2640
Editore: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202401510

Merging Natural Biopolymers with Supramolecular Chemistry: Emulating the Native Extracellular Matrix’s Complexity

Autori: Vera Sousa, Bruno Ladeira, Elisabeth Garanger, Sébastien Lecommandoux, E. W. Meijer, Patricia Y. W. Dankers, João F. Mano, João Borges
Pubblicato in: ACS Nano, Numero 19, 2026, Pagina/e 29833-29859, ISSN 1936-0851
Editore: American Chemical Society
DOI: 10.1021/acsnano.5c10088

Advancing tissue decellularized hydrogels for engineering human organoids

Autori: Beatriz S. Moura, Maria V. Monteiro, Luís P. Ferreira, Pedro Lavrador, Vítor M. Gaspar, João F. Mano
Pubblicato in: Advanced Functional Materials, 2022, ISSN 1616-301X
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202202825

Biomimetic Adhesive Micropatterned Hydrogel Patches for Drug Release

Autori: Katia R. Amaral, A. Sofia Silva, Lúcia F. Santos, Edgar J. Castanheira, Maria C. Mendes, Dora C.S. Costa, João M. M. Rodrigues, Joana Marto, João F. Mano
Pubblicato in: Advanced Healthcare Materials, 2023, ISSN 2192-2640
Editore: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202301513

Pierceable, Storable, and Manipulable Liquid Capsules for Precise Monitoring and Efficient Cargo Transport in Biotechnological Advances

Autori: Ana Rita Pinho, Chunming Wang, Maria Clara Gomes, João Filipe Mano
Pubblicato in: Advanced Functional Materials, Numero 35, 2026, ISSN 1616-301X
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202425715

Exploring the potential of all-aqueous immiscible systems for preparing complex biomaterials and cellular constructs

Autori: Raquel C. Gonçalves, Mariana B. Oliveira, João F. Mano
Pubblicato in: Materials Horizons, Numero 11, 2024, Pagina/e 4573-4599, ISSN 2051-6347
Editore: Royal Society of Chemistry
DOI: 10.1039/d4mh00431k

Contactless 3D acoustic assembly of liquid capsules for bottom-up tissue engineering

Autori: Maria Eduarda Rocha Luiz, Mariana Carreira, Sara Nadine, Riccardo Tognato, Romedi Parolini, Syeda M. Bakht, Tiziano Serra, João F. Mano
Pubblicato in: Biomaterials, Numero 325, 2026, Pagina/e 123555, ISSN 0142-9612
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2025.123555

Viscous microcapsules as microbioreactors to study mesenchymal stem/stromal cells osteolineage commitment

Autori: Maryam Ghasemzadeh-Hasankolaei, João M. Miranda, Clara R. Correia, João F. Mano
Pubblicato in: Small Methods, Numero 2201503, 2023, ISSN 2366-9608
Editore: Wiley
DOI: 10.1002/smtd.202201503

Advances in Cell-Rich Inks for Biofabricating Living Architectures

Autori: José Almeida-Pinto, Beatriz S. Moura, Vítor M. Gaspar, João F. Mano
Pubblicato in: Advanced Materials, 2024, ISSN 1521-4095
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adma.202313776

Cell Shuttling in Multifunctional Microsized Needles

Autori: Marta M. Maciel, José N. M. Silvares, Tiago R. Correia, Carlos M. N. Mendonça, Ana P. Martins, Eduardo T. C. C. Silva, Nuno J. O. Silva, Filipa L. Sousa, João F. Mano
Pubblicato in: Small Structures, Numero 7, 2026, ISSN 2688-4062
Editore: Wiley
DOI: 10.1002/sstr.202500370

Magnetic-Based Strategies for Regenerative Medicine and Tissue Engineering

Autori: Lúcia F. Santos, Ana S. Silva, João F. Mano
Pubblicato in: Advanced Healthcare Materials, 2023, ISSN 2192-2640
Editore: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202300605

Tumor‐On‐A‐Chip Model Incorporating Human‐Based Hydrogels for Easy Assessment of Metastatic Tumor Inter‐Heterogeneity

Autori: Cátia F. Monteiro, Inês A. Deus, Inês B. Silva, Iola F. Duarte, Catarina A. Custódio, João F. Mano
Pubblicato in: Advanced Functional Materials, 2024, ISSN 1616-301X
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202315940

Liquefied capsules containing nanogrooved microdiscs and umbilical cord-derived cells for bone tissue engineering

Autori: Mariana Carreira; Manuel Pires-Santos; Clara R Correia; Sara Nadine; João F Mano
Pubblicato in: Open Research Europe, 2024, ISSN 2732-5121
Editore: [London]: [F1000 Research Limited on behalf of the European Commission]
DOI: 10.12688/openreseurope.17000.1

High-Throughput Production of Microsponges from Platelet Lysate for Tissue Engineering Applications

Autori: Bruno M.F. Ladeira, Maria C. Gomes, Catarina A. Custódio, João F. Mano
Pubblicato in: Tissue Engineering Part C: Methods, 2022, ISSN 1937-3384
Editore: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tec.2022.0029

Rapid Generation of Fusable Cell Beads for Multi‐Scale Human Living Materials Assembly

Autori: Beatriz S. Moura, Maria V. Monteiro, Joana F. Soeiro, Nuno J. O. Silva, Vítor M. Gaspar, João F. Mano
Pubblicato in: Small Methods, Numero 10, 2026, ISSN 2366-9608
Editore: Wiley
DOI: 10.1002/smtd.202501450

Thiol-ene click chemistry: Enabling 3D printing of natural-based inks for biomedical applications

Autori: Andreia P. Malafaia, Rita Sobreiro-Almeida, João M.M. Rodrigues, João F. Mano
Pubblicato in: Biomaterials Advances, Numero 167, 2024, Pagina/e 214105, ISSN 2772-9508
Editore: Elsevier
DOI: 10.1016/j.bioadv.2024.214105

Modeling 3D Tumor Invasiveness to Modulate Macrophage Phenotype in a Human‐Based Hydrogel Platform

Autori: Cátia F. Monteiro, Catarina R. Almeida, Catarina A. Custódio, João F. Mano
Pubblicato in: Macromolecular Bioscience, Numero 24, 2024, ISSN 1616-5187
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/mabi.202400227

Human Platelet Lysate-Derived Nanofibrils as Building Blocks to Produce Free-Standing Membranes for Cell Self-Aggregation

Autori: Cátia F. Monteiro, Maria C. Gomes, Pankaj Bharmoria, Mara G. Freire, João A. P. Coutinho, Catarina A. Custódio, and João F. Mano
Pubblicato in: ACS Nano, 2024, ISSN 1936-0851
Editore: American Chemical Society
DOI: 10.1021/acsnano.4c02790

Roadmap for animate matter

Autori: Giorgio Volpe, Nuno A M Araújo, Maria Guix, Mark Miodownik, Nicolas Martin, Laura Alvarez, Juliane Simmchen, Roberto Di Leonardo, Nicola Pellicciotta, Quentin Martinet, Jérémie Palacci, Wai Kit Ng, Dhruv Saxena, Riccardo Sapienza, Sara Nadine, João F Mano, Reza Mahdavi, Caroline Beck Adiels, Joe Forth, Christian Santangelo, Stefano Palagi, Ji Min Seok, Victoria A Webster-Wood, Shuhong Wang, Li
Pubblicato in: Journal of Physics: Condensed Matter, Numero 37, 2025, Pagina/e 333501, ISSN 0953-8984
Editore: Institute of Physics Publishing
DOI: 10.1088/1361-648x/adebd3

A Self-Sustaining Hydrogels with Autonomous Supply of Nutrients and Bioactive Domains for 3D Cell Culture

Autori: Mehrzad Zargarzadeh, Maria C. Gomes, Sónia G. Patrício, Catarina A. Custódio, João F. Mano
Pubblicato in: Advanced Functional Materials, 2023, ISSN 1616-301X
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202214372

Bioactive Self‐Regulated Liquified Microcompartments to Bioengineer Bone‐Like Microtissues

Autori: Ana R. Pinho; Maria C. Gomes; Dora C. S. Costa; João F. Mano
Pubblicato in: Small, 2023, ISSN 1613-6810
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202305029

Effect of high cyclic hydrostatic pressure on osteogenesis of mesenchymal stem cells cultured in liquefied micro-compartments

Autori: Maryam Ghasemzadeh-Hasankolaei, Carlos A. Pinto, Diana Jesus, Jorge A. Saraiva, João F. Mano
Pubblicato in: Materials Today Bio, 2023, ISSN 2590-0064
Editore: Elsevier
DOI: 10.1016/j.mtbio.2023.100861

Unveiling the Potential of Single-Cell Encapsulation in Biomedical Applications: Current Advances and Future Perspectives

Autori: Manuel Pires-Santos, Sara Nadine, João F. Mano
Pubblicato in: Small Science, 2024, ISSN 2688-4046
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/smsc.202300332

Cell Surface Engineering Tools for Programming Living Assemblies

Autori: José Almeida-Pinto, Matilde R. Lagarto, Pedro Lavrador, João F. Mano, Vítor M. Gaspar
Pubblicato in: Advanced Science, 2023, ISSN 2198-3844
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/advs.202304040

Self‐Assembly of Platelet Lysates Proteins into Microparticles by Unnatural Disulfide Bonds for Bottom‐Up Tissue Engineering

Autori: Maria C. Gomes; Ana Rita Pinho; Catarina Custódio; João F. Mano
Pubblicato in: Advanced Materials, 2023, ISSN 1521-4095
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adma.202304659

Recent Developments in Layer-by-Layer Assembly for Drug Delivery and Tissue Engineering Applications

Autori: João Borges, Jinfeng Zeng, Xi Qiu Liu, Hao Chang, Claire Monge, Charlotte Garot, Ke-feng Ren, Paul Machillot, Nihal E. Vrana, Philippe Lavalle, Takami Akagi, Michiya Matsusaki, Jian Ji, Mitsuru Akashi, João F. Mano, Varvara Gribova, Catherine Picart
Pubblicato in: Advanced Healthcare Materials, 2023, ISSN 2192-2640
Editore: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202302713

Designer mammalian living materials through genetic engineering

Autori: Mariana Gameiro, José Almeida-Pinto, Beatriz S. Moura, João F. Mano, Vítor M. Gaspar
Pubblicato in: Bioactive Materials, Numero 48, 2025, Pagina/e 135-148, ISSN 2452-199X
Editore: Elsevier BV
DOI: 10.1016/j.bioactmat.2025.02.007

Engineered nascent living human tissues with unit programmability

Autori: Pedro Lavrador, Beatriz S. Moura, José Almeida-Pinto, Vítor M. Gaspar, João F. Mano
Pubblicato in: Nature Materials, 2024, ISSN 1476-1122
Editore: Nature Publishing Group
DOI: 10.1038/s41563-024-01958-1

Magneto‐Enzymatic Microgels for Precise Hydrogel Sculpturing

Autori: Maria C. Mendes, João A. Pereira, Ana S. Silva, João F. Mano
Pubblicato in: Advanced Materials, 2024, ISSN 0935-9648
Editore: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202402988

Single‐Cell Liquid‐Core Microcapsules for Biomedical Applications

Autori: Manuel Pires‐Santos, Mariana Carreira, Bruno P. Morais, Francisca G. Perfeito, Mariana B. Oliveira, Cátia F. Monteiro, Sara Nadine, João F. Mano
Pubblicato in: Advanced Healthcare Materials, Numero 14, 2026, ISSN 2192-2640
Editore: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202403808

Strategies to decouple cell micro-scale and macro-scale environments for designing multifunctional biomimetic tissues

Autori: Maryam Ghasemzadeh-Hasankolaei, Diogo Pinheiro, Sara Nadine, João F. Mano
Pubblicato in: Soft Matter, Numero 20, 2024, Pagina/e 6313-6326, ISSN 1744-683X
Editore: Royal Society of Chemistry
DOI: 10.1039/d4sm00276h

Close-to-native bone repair via tissue-engineered endochondral ossification approaches

Autori: Sara Nadine, Inês J. Fernandes, Clara R. Correia, João F. Mano
Pubblicato in: iScience, 2022, ISSN 2589-0042
Editore: Cell Press
DOI: 10.1016/j.isci.2022.105370

Bioinstructive Liquefied Pockets in Hierarchical Hydrogels and Bioinks

Autori: Maryam Ghasemzadeh‐Hasankolaei, Tiago R. Correia, João F. Mano
Pubblicato in: Advanced Healthcare Materials, 2024, ISSN 2192-2640
Editore: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202400286

Diritti di proprietà intellettuale

Patent (4)

BIOMATERIAL FOR IMMUNOMODULATION, PROCESS FOR ITS PRODUCTION AND USES THEREOF

Numero candidatura/pubblicazione: 22 185533
Data: 2022-07-18
Candidato/i: UNIVERSIDADE DE AVEIRO

PLATELET LYSATE-BASED MICROPARTICLES, METHODS AND USES THEREOF

Numero candidatura/pubblicazione: 20 23062242
Data: 2023-12-05
Candidato/i: UNIVERSIDADE DE AVEIRO

PLATELET LYSATE-BASED MICROPARTICLES, METHODS AND USES THEREOF

Numero candidatura/pubblicazione: 20 23062242
Data: 2023-12-05
Candidato/i: UNIVERSIDADE DE AVEIRO

BIOMATERIAL FOR IMMUNOMODULATION, PROCESS FOR ITS PRODUCTION AND USES THEREOF

Numero candidatura/pubblicazione: 22 185533
Data: 2022-07-18
Candidato/i: UNIVERSIDADE DE AVEIRO