Full human-based multi-scale constructs with jammed regenerative pockets for bone engineering

Informacje na temat projektu

REBORN

Identyfikator umowy o grant: 883370

DOI

10.3030/883370

Data podpisania przez KE 9 Września 2020

Data rozpoczęcia 1 Listopada 2021

Data zakończenia 31 Października 2026

Finansowanie w ramach

• EXCELLENT SCIENCE - European Research Council (ERC)

Koszt całkowity

€ 2 499 683,00

Wkład UE

€ 2 499 683,00

Koordynowany przez

UNIVERSIDADE DE AVEIRO
Portugal

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Publikacje

Thesis and dissertations (10)

Bioengineered pancreatic tumor-stroma models for preclinical screening of therapeutics

Autorzy: Monteiro, Maria Vinhas
Opublikowane w: 2023
Wydawca: Universidade de Aveiro

Human plasma derived hydrogels for myocardial tissue engineering

Autorzy: Santos, Sara Catarina Nunes da Silva
Opublikowane w: 2024
Wydawca: Universidade de Aveiro

Single-cell microcapsules for biomedical applications

Autorzy: Santos, Manuel Pires dos
Opublikowane w: 2023
Wydawca: Universidade de Aveiro

Fabrication of bicontinuous microporous hydrogels using aqueous emulsion templating

Autorzy: Fernandes, Hugo Edgar Vilar
Opublikowane w: 2023
Wydawca: Universidade de Aveiro

Magnetic nanoparticles in the engineering of hybrid structures for cell and tissue engineering

Autorzy: Mendes, Maria Cândida Balão
Opublikowane w: 2025
Wydawca: Universidade de Aveiro

Osteosarcoma-on-a-chip: a physiologically relevant human-based microfluidic platform for drug screening

Autorzy: Cátia F. Monteiro
Opublikowane w: 2024
Wydawca: Universidade de Aveiro

Bioengenharia e controlo dinâmico em hidrogéis e materiais celulares com adaptabilidade

Autorzy: Lavrador, Pedro Oliveira
Opublikowane w: 2023
Wydawca: Universidade de Aveiro

Production of photo-engineered cell-rich materials exhibiting living features

Autorzy: Pinto, José Carlos Almeida
Opublikowane w: 2023
Wydawca: Universidade de Aveiro

Biomedical system based on controlled enzymatically degradation of hydrogels

Autorzy: Mehrzad Zargarzadeh
Opublikowane w: 2024
Wydawca: Universidade de Aveiro

Mechanosensing microcapsules to direct stem cell differentiation for tissue regeneration applications

Autorzy: Hasankolaei, Maryam Ghasemzadeh
Opublikowane w: Numer 1, 2024
Wydawca: Universidade de Aveiro

Peer reviewed articles (43)

Supramolecular assembly of multi-purpose tissue engineering platforms from human extracellular matrix

Autorzy: Bruno Ladeira, Maria Gomes, Kongchang Wei, Catarina Custódio, João Mano
Opublikowane w: Biomaterials, Numer 320, 2026, Strona(/y) 123270, ISSN 0142-9612
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2025.123270

Biomaterials of human source for 3D printing strategies

Autorzy: João Rocha Maia, Rita Sobreiro-Almeida, Franck Cleymand, João F Mano
Opublikowane w: Journal of Physics: Materials, 2023, ISSN 2515-7639
Wydawca: IOP Publishing
DOI: 10.1088/2515-7639/acada1

Emerging modulators for osteogenic differentiation: a combination of chemical and topographical cues for bone

Autorzy: Diana Jesus, Ana R. Pinho, Maria C. Gomes, Cláudia S. Oliveira, João F. Mano
Opublikowane w: Soft Matter, 2022, ISSN 1744-683X
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d2sm00009a

Photocrosslinkable microgels derived from human platelet lysates: injectable biomaterials for cardiac cell culture

Autorzy: Sara C. Santos , Catarina A. Custódio, João F. Mano
Opublikowane w: Biomaterials Science, 2024, ISSN 2047-4830
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d3bm01933k

Double-Interlinked Colloidal Gels for Programable Fabrication of Supraparticle Architectures

Autorzy: Leandro Gonçalves, Pedro Lavrador, Adérito J. R. Amaral, Luís P. Ferreira, Vítor M. Gaspar, João F. Mano
Opublikowane w: Advanced Functional Materials, 2023, ISSN 1616-301X
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202304628

Emerging lipid–polymer hybrid nanoparticles for genome editing

Autorzy: Mariana Gameiro, João F. Mano, Vítor M. Gaspar
Opublikowane w: Polymer Chemistry, Numer 15, 2024, Strona(/y) 3436-3468, ISSN 1759-9954
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d4py00298a

Interconnected Porous Hydrogels with Tunable Anisotropy Through Aqueous Emulsion Bioprinting

Autorzy: Hugo Edgar‐Vilar, Francisca P. Correia, Inês M. Freitas, Vítor M. Gaspar, João F. Mano
Opublikowane w: Advanced Functional Materials, Numer 36, 2026, ISSN 1616-301X
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202521050

Endo- and Exometabolome Crosstalk in Mesenchymal Stem Cells Undergoing Osteogenic Differentiation

Autorzy: Daniela S. C. Bispo, Lenka Michálková, Marlene Correia, Catarina S. H. Jesus, Iola F. Duarte, Brian J. Goodfellow, Mariana B. Oliveira, João F. Mano, Ana M. Gil
Opublikowane w: Cells, 2022, ISSN 2073-4409
Wydawca: MDPI
DOI: 10.3390/cells11081257

Osteogenic Differentiation Triggered by Intracellular Magnetoelectric Stimulation of Core–Shell Nanotransducers under Remotely Applied Magnetic Fields

Autorzy: Maria C. Mendes, Elisa A. G. Martins, Roman V. Chernozem, Polina V. Chernozem, Catarina C. Custódio, Roman A. Surmenev, Andrei L. Kholkin, Ana S. Silva, João F. Mano
Opublikowane w: ACS Nano, Numer 19, 2026, Strona(/y) 42022-42045, ISSN 1936-0851
Wydawca: American Chemical Society
DOI: 10.1021/acsnano.5c10509

Spontaneous Formation of Solid Shell Polymeric Multicompartments at All‐Aqueous Interfaces

Autorzy: Francisca G. Perfeito, Sara Vilabril, Andreia Cerqueira, Mariana B. Oliveira, João F. Mano
Opublikowane w: Advanced Science, Numer 11, 2024, ISSN 2198-3844
Wydawca: Wiley-VCH Verlag
DOI: 10.1002/advs.202402592

Human Chorionic Membrane‐derived Tunable Hydrogels for Vascular Tissue Engineering Strategies

Autorzy: Elisa A.G. Martins, Inês A. Deus, Maria C. Gomes, Ana S. Silva, João F. Mano, Catarina A. Custódio
Opublikowane w: Advanced Healthcare Materials, 2024, ISSN 2192-2640
Wydawca: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202401510

Merging Natural Biopolymers with Supramolecular Chemistry: Emulating the Native Extracellular Matrix’s Complexity

Autorzy: Vera Sousa, Bruno Ladeira, Elisabeth Garanger, Sébastien Lecommandoux, E. W. Meijer, Patricia Y. W. Dankers, João F. Mano, João Borges
Opublikowane w: ACS Nano, Numer 19, 2026, Strona(/y) 29833-29859, ISSN 1936-0851
Wydawca: American Chemical Society
DOI: 10.1021/acsnano.5c10088

Advancing tissue decellularized hydrogels for engineering human organoids

Autorzy: Beatriz S. Moura, Maria V. Monteiro, Luís P. Ferreira, Pedro Lavrador, Vítor M. Gaspar, João F. Mano
Opublikowane w: Advanced Functional Materials, 2022, ISSN 1616-301X
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202202825

Biomimetic Adhesive Micropatterned Hydrogel Patches for Drug Release

Autorzy: Katia R. Amaral, A. Sofia Silva, Lúcia F. Santos, Edgar J. Castanheira, Maria C. Mendes, Dora C.S. Costa, João M. M. Rodrigues, Joana Marto, João F. Mano
Opublikowane w: Advanced Healthcare Materials, 2023, ISSN 2192-2640
Wydawca: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202301513

Pierceable, Storable, and Manipulable Liquid Capsules for Precise Monitoring and Efficient Cargo Transport in Biotechnological Advances

Autorzy: Ana Rita Pinho, Chunming Wang, Maria Clara Gomes, João Filipe Mano
Opublikowane w: Advanced Functional Materials, Numer 35, 2026, ISSN 1616-301X
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202425715

Exploring the potential of all-aqueous immiscible systems for preparing complex biomaterials and cellular constructs

Autorzy: Raquel C. Gonçalves, Mariana B. Oliveira, João F. Mano
Opublikowane w: Materials Horizons, Numer 11, 2024, Strona(/y) 4573-4599, ISSN 2051-6347
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d4mh00431k

Contactless 3D acoustic assembly of liquid capsules for bottom-up tissue engineering

Autorzy: Maria Eduarda Rocha Luiz, Mariana Carreira, Sara Nadine, Riccardo Tognato, Romedi Parolini, Syeda M. Bakht, Tiziano Serra, João F. Mano
Opublikowane w: Biomaterials, Numer 325, 2026, Strona(/y) 123555, ISSN 0142-9612
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2025.123555

Viscous microcapsules as microbioreactors to study mesenchymal stem/stromal cells osteolineage commitment

Autorzy: Maryam Ghasemzadeh-Hasankolaei, João M. Miranda, Clara R. Correia, João F. Mano
Opublikowane w: Small Methods, Numer 2201503, 2023, ISSN 2366-9608
Wydawca: Wiley
DOI: 10.1002/smtd.202201503

Advances in Cell-Rich Inks for Biofabricating Living Architectures

Autorzy: José Almeida-Pinto, Beatriz S. Moura, Vítor M. Gaspar, João F. Mano
Opublikowane w: Advanced Materials, 2024, ISSN 1521-4095
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/adma.202313776

Cell Shuttling in Multifunctional Microsized Needles

Autorzy: Marta M. Maciel, José N. M. Silvares, Tiago R. Correia, Carlos M. N. Mendonça, Ana P. Martins, Eduardo T. C. C. Silva, Nuno J. O. Silva, Filipa L. Sousa, João F. Mano
Opublikowane w: Small Structures, Numer 7, 2026, ISSN 2688-4062
Wydawca: Wiley
DOI: 10.1002/sstr.202500370

Magnetic-Based Strategies for Regenerative Medicine and Tissue Engineering

Autorzy: Lúcia F. Santos, Ana S. Silva, João F. Mano
Opublikowane w: Advanced Healthcare Materials, 2023, ISSN 2192-2640
Wydawca: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202300605

Tumor‐On‐A‐Chip Model Incorporating Human‐Based Hydrogels for Easy Assessment of Metastatic Tumor Inter‐Heterogeneity

Autorzy: Cátia F. Monteiro, Inês A. Deus, Inês B. Silva, Iola F. Duarte, Catarina A. Custódio, João F. Mano
Opublikowane w: Advanced Functional Materials, 2024, ISSN 1616-301X
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202315940

Liquefied capsules containing nanogrooved microdiscs and umbilical cord-derived cells for bone tissue engineering

Autorzy: Mariana Carreira; Manuel Pires-Santos; Clara R Correia; Sara Nadine; João F Mano
Opublikowane w: Open Research Europe, 2024, ISSN 2732-5121
Wydawca: [London]: [F1000 Research Limited on behalf of the European Commission]
DOI: 10.12688/openreseurope.17000.1

High-Throughput Production of Microsponges from Platelet Lysate for Tissue Engineering Applications

Autorzy: Bruno M.F. Ladeira, Maria C. Gomes, Catarina A. Custódio, João F. Mano
Opublikowane w: Tissue Engineering Part C: Methods, 2022, ISSN 1937-3384
Wydawca: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tec.2022.0029

Rapid Generation of Fusable Cell Beads for Multi‐Scale Human Living Materials Assembly

Autorzy: Beatriz S. Moura, Maria V. Monteiro, Joana F. Soeiro, Nuno J. O. Silva, Vítor M. Gaspar, João F. Mano
Opublikowane w: Small Methods, Numer 10, 2026, ISSN 2366-9608
Wydawca: Wiley
DOI: 10.1002/smtd.202501450

Thiol-ene click chemistry: Enabling 3D printing of natural-based inks for biomedical applications

Autorzy: Andreia P. Malafaia, Rita Sobreiro-Almeida, João M.M. Rodrigues, João F. Mano
Opublikowane w: Biomaterials Advances, Numer 167, 2024, Strona(/y) 214105, ISSN 2772-9508
Wydawca: Elsevier
DOI: 10.1016/j.bioadv.2024.214105

Modeling 3D Tumor Invasiveness to Modulate Macrophage Phenotype in a Human‐Based Hydrogel Platform

Autorzy: Cátia F. Monteiro, Catarina R. Almeida, Catarina A. Custódio, João F. Mano
Opublikowane w: Macromolecular Bioscience, Numer 24, 2024, ISSN 1616-5187
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/mabi.202400227

Human Platelet Lysate-Derived Nanofibrils as Building Blocks to Produce Free-Standing Membranes for Cell Self-Aggregation

Autorzy: Cátia F. Monteiro, Maria C. Gomes, Pankaj Bharmoria, Mara G. Freire, João A. P. Coutinho, Catarina A. Custódio, and João F. Mano
Opublikowane w: ACS Nano, 2024, ISSN 1936-0851
Wydawca: American Chemical Society
DOI: 10.1021/acsnano.4c02790

Roadmap for animate matter

Autorzy: Giorgio Volpe, Nuno A M Araújo, Maria Guix, Mark Miodownik, Nicolas Martin, Laura Alvarez, Juliane Simmchen, Roberto Di Leonardo, Nicola Pellicciotta, Quentin Martinet, Jérémie Palacci, Wai Kit Ng, Dhruv Saxena, Riccardo Sapienza, Sara Nadine, João F Mano, Reza Mahdavi, Caroline Beck Adiels, Joe Forth, Christian Santangelo, Stefano Palagi, Ji Min Seok, Victoria A Webster-Wood, Shuhong Wang, Li
Opublikowane w: Journal of Physics: Condensed Matter, Numer 37, 2025, Strona(/y) 333501, ISSN 0953-8984
Wydawca: Institute of Physics Publishing
DOI: 10.1088/1361-648x/adebd3

A Self-Sustaining Hydrogels with Autonomous Supply of Nutrients and Bioactive Domains for 3D Cell Culture

Autorzy: Mehrzad Zargarzadeh, Maria C. Gomes, Sónia G. Patrício, Catarina A. Custódio, João F. Mano
Opublikowane w: Advanced Functional Materials, 2023, ISSN 1616-301X
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202214372

Bioactive Self‐Regulated Liquified Microcompartments to Bioengineer Bone‐Like Microtissues

Autorzy: Ana R. Pinho; Maria C. Gomes; Dora C. S. Costa; João F. Mano
Opublikowane w: Small, 2023, ISSN 1613-6810
Wydawca: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202305029

Effect of high cyclic hydrostatic pressure on osteogenesis of mesenchymal stem cells cultured in liquefied micro-compartments

Autorzy: Maryam Ghasemzadeh-Hasankolaei, Carlos A. Pinto, Diana Jesus, Jorge A. Saraiva, João F. Mano
Opublikowane w: Materials Today Bio, 2023, ISSN 2590-0064
Wydawca: Elsevier
DOI: 10.1016/j.mtbio.2023.100861

Unveiling the Potential of Single-Cell Encapsulation in Biomedical Applications: Current Advances and Future Perspectives

Autorzy: Manuel Pires-Santos, Sara Nadine, João F. Mano
Opublikowane w: Small Science, 2024, ISSN 2688-4046
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/smsc.202300332

Cell Surface Engineering Tools for Programming Living Assemblies

Autorzy: José Almeida-Pinto, Matilde R. Lagarto, Pedro Lavrador, João F. Mano, Vítor M. Gaspar
Opublikowane w: Advanced Science, 2023, ISSN 2198-3844
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/advs.202304040

Self‐Assembly of Platelet Lysates Proteins into Microparticles by Unnatural Disulfide Bonds for Bottom‐Up Tissue Engineering

Autorzy: Maria C. Gomes; Ana Rita Pinho; Catarina Custódio; João F. Mano
Opublikowane w: Advanced Materials, 2023, ISSN 1521-4095
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/adma.202304659

Recent Developments in Layer-by-Layer Assembly for Drug Delivery and Tissue Engineering Applications

Autorzy: João Borges, Jinfeng Zeng, Xi Qiu Liu, Hao Chang, Claire Monge, Charlotte Garot, Ke-feng Ren, Paul Machillot, Nihal E. Vrana, Philippe Lavalle, Takami Akagi, Michiya Matsusaki, Jian Ji, Mitsuru Akashi, João F. Mano, Varvara Gribova, Catherine Picart
Opublikowane w: Advanced Healthcare Materials, 2023, ISSN 2192-2640
Wydawca: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202302713

Designer mammalian living materials through genetic engineering

Autorzy: Mariana Gameiro, José Almeida-Pinto, Beatriz S. Moura, João F. Mano, Vítor M. Gaspar
Opublikowane w: Bioactive Materials, Numer 48, 2025, Strona(/y) 135-148, ISSN 2452-199X
Wydawca: Elsevier BV
DOI: 10.1016/j.bioactmat.2025.02.007

Engineered nascent living human tissues with unit programmability

Autorzy: Pedro Lavrador, Beatriz S. Moura, José Almeida-Pinto, Vítor M. Gaspar, João F. Mano
Opublikowane w: Nature Materials, 2024, ISSN 1476-1122
Wydawca: Nature Publishing Group
DOI: 10.1038/s41563-024-01958-1

Magneto‐Enzymatic Microgels for Precise Hydrogel Sculpturing

Autorzy: Maria C. Mendes, João A. Pereira, Ana S. Silva, João F. Mano
Opublikowane w: Advanced Materials, 2024, ISSN 0935-9648
Wydawca: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202402988

Single‐Cell Liquid‐Core Microcapsules for Biomedical Applications

Autorzy: Manuel Pires‐Santos, Mariana Carreira, Bruno P. Morais, Francisca G. Perfeito, Mariana B. Oliveira, Cátia F. Monteiro, Sara Nadine, João F. Mano
Opublikowane w: Advanced Healthcare Materials, Numer 14, 2026, ISSN 2192-2640
Wydawca: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202403808

Strategies to decouple cell micro-scale and macro-scale environments for designing multifunctional biomimetic tissues

Autorzy: Maryam Ghasemzadeh-Hasankolaei, Diogo Pinheiro, Sara Nadine, João F. Mano
Opublikowane w: Soft Matter, Numer 20, 2024, Strona(/y) 6313-6326, ISSN 1744-683X
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d4sm00276h

Close-to-native bone repair via tissue-engineered endochondral ossification approaches

Autorzy: Sara Nadine, Inês J. Fernandes, Clara R. Correia, João F. Mano
Opublikowane w: iScience, 2022, ISSN 2589-0042
Wydawca: Cell Press
DOI: 10.1016/j.isci.2022.105370

Bioinstructive Liquefied Pockets in Hierarchical Hydrogels and Bioinks

Autorzy: Maryam Ghasemzadeh‐Hasankolaei, Tiago R. Correia, João F. Mano
Opublikowane w: Advanced Healthcare Materials, 2024, ISSN 2192-2640
Wydawca: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202400286

Prawa własności intelektualnej

Patent (4)

BIOMATERIAL FOR IMMUNOMODULATION, PROCESS FOR ITS PRODUCTION AND USES THEREOF

Numer wniosku/publikacji: 22 185533
Data: 2022-07-18
Wnioskodawca/wnioskodawcy: UNIVERSIDADE DE AVEIRO

PLATELET LYSATE-BASED MICROPARTICLES, METHODS AND USES THEREOF

Numer wniosku/publikacji: 20 23062242
Data: 2023-12-05
Wnioskodawca/wnioskodawcy: UNIVERSIDADE DE AVEIRO

PLATELET LYSATE-BASED MICROPARTICLES, METHODS AND USES THEREOF

Numer wniosku/publikacji: 20 23062242
Data: 2023-12-05
Wnioskodawca/wnioskodawcy: UNIVERSIDADE DE AVEIRO

BIOMATERIAL FOR IMMUNOMODULATION, PROCESS FOR ITS PRODUCTION AND USES THEREOF

Numer wniosku/publikacji: 22 185533
Data: 2022-07-18
Wnioskodawca/wnioskodawcy: UNIVERSIDADE DE AVEIRO