The human retina at single cell resolution: functional architecture, disease mechanism and therapy development

Project Information

HURET

Grant agreement ID: 883781

DOI

10.3030/883781

Project closed

EC signature date 12 May 2020

Start date 1 November 2020

End date 31 October 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 500 000,00

EU contribution

€ 2 500 000,00

Coordinated by

INSTITUT FUR MOLEKULARE UND KLINISCHE OPHTHALMOLOGIE BASEL
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Non-peer reviewed articles (2)

In vivo single-cell gene editing using RNA electroporation reveals sequential adaptation of cortical neurons to excitatory-inhibitory imbalance

Author(s): Georg Kosche, Alex Fratzl, Martin Munz, Botond Roska
Published in: bioRxiv, 2025, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory.
DOI: 10.1101/2025.09.13.672380

Cell type-focused compound screen in human organoids reveals molecules and pathways controlling cone photoreceptor death

Author(s): Spirig SE, Arteaga-Moreta VJ, Raics Z, Posada-Céspedes S, Chreng S, Galuba O, Galuba I, Claerr I, Renner S, Kleindienst T, Volak A, Imbach J, Malysheva S, Siwicki RA, Hahaut V, Hou Y, Picelli S, Cattaneo M, Jüttner J, Cowan CS, Duckely M, Baeschlin DK, Renner M, Unterreiner V, Roska B.
Published in: BioRxiv, 2023, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.10.09.561525

Peer reviewed articles (18)

Moculus: an immersive virtual reality system for mice incorporating stereo vision

Author(s): Linda Judák, Gergely Dobos, Katalin Ócsai, Eszter Báthory, Huba Szebik, Balázs Tarján, Pál Maák, Zoltán Szadai, István Takács, Balázs Chiovini, Tibor Lőrincz, Áron Szepesi, Botond Roska,
Published in: Nature Methods, Issue 22, 2025, Page(s) 386-398, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/s41592-024-02554-6

Individual thalamic inhibitory interneurons are functionally specialized towards distinct visual features.

Author(s): Muellner F, Roska B
Published in: Neuron, 2024, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1101/2023.03.22.533751

The sodium-bicarbonate cotransporter Slc4a5 mediates feedback at the first synapse of vision

Author(s): Rei Morikawa, Tiago M. Rodrigues, Helene Marianne Schreyer, Cameron S. Cowan, Sarah Nadeau, Alexandra Graff-Meyer, Claudia P. Patino-Alvarez, Mohammad Hossein Khani, Josephine Jüttner, Botond Roska
Published in: Neuron, Issue 112, 2025, Page(s) 3715-3733.e9, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2024.08.015

Whole-brain functional ultrasound imaging in awake head-fixed mice

Author(s): Clément Brunner, Micheline Grillet, Alan Urban, Botond Roska, Gabriel Montaldo & Emilie Macé
Published in: Nature Protocols, 2021, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-021-00548-8

Partial recovery of visual function in a blind patient after optogenetic therapy

Author(s): José-Alain Sahel, Elise Boulanger-Scemama, Chloé Pagot, Angelo Arleo, Francesco Galluppi, Joseph N. Martel, Simona Degli Esposti, Alexandre Delaux, Jean-Baptiste de Saint Aubert, Caroline de Montleau, Emmanuel Gutman, Isabelle Audo, Jens Duebel, Serge Picaud, Deniz Dalkara, Laure Blouin, Magali Taiel, Botond Roska
Published in: Nature Medicine, 2021, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-021-01351-4

Engineering infrared light detection in blind human retina using ultrasensitive human TRPV1 channels

Author(s): Morgan Chevalier, Firas Fadel, Tímea Májer, Dániel Péter Magda, Lili Gerendás, Ferenc Kilin, Zoltán Zsolt Nagy, Arnold Szabó, Botond Roska, Guilherme Testa-Silva
Published in: Trends in Biotechnology, Issue 43, 2025, Page(s) 3236-3252, ISSN 0167-7799
Publisher: Elsevier BV
DOI: 10.1016/j.tibtech.2025.07.033

Sharp-wave ripple doublets induce complex dendritic spikes in parvalbumin interneurons in vivo

Author(s): Linda Judák, Balázs Chiovini, Gábor Juhász, Dénes Pálfi, Zsolt Mezriczky, Zoltán Szadai, Gergely Katona, Benedek Szmola, Katalin Ócsai, Bernadett Martinecz, Anna Mihály, Ádám Dénes, Bálint Kerekes, Áron Szepesi, Gergely Szalay, István Ulbert, Zoltán Mucsi, Botond Roska & Balázs Rózsa
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-34520-1

Restoring light sensitivity using tunable near-infrared sensors

Author(s): Dasha Nelidova, Rei K Morikawa, Cameron S Cowan, Zoltan Raics, David Goldblum, Hendrik P N Scholl, Tamas Szikra, Arnold Szabo, Daniel Hillier, Botond Roska
Published in: Science, 2020, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aaz5887

Individual thalamic inhibitory interneurons are functionally specialized toward distinct visual features

Author(s): Fiona E. Müllner, Botond Roska
Published in: Neuron, Issue 112, 2024, Page(s) 2765-2782.e9, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2024.06.001

Synchronization of visual perception within the human fovea

Author(s): Annalisa Bucci, Marc Büttner, Niklas Domdei, Federica B. Rosselli, Matej Znidaric, Julian Bartram, Tobias Gänswein, Roland Diggelmann, Martina De Gennaro, Cameron S. Cowan, Wolf Harmening, Andreas H
Published in: Nature Neuroscience, Issue 28, 2025, Page(s) 1959-1967, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-025-02011-3

Ectopic expression of a mechanosensitive channel confers spatiotemporal resolution to ultrasound stimulations of neurons for visual restoration

Author(s): Sara Cadoni, Charlie Demené, Ignacio Alcala, Matthieu Provansal, Diep Nguyen, Dasha Nelidova, Guillaume Labernède, Jules Lubetzki, Ruben Goulet, Emma Burban, Julie Dégardin, Manuel Simonutti, Gregory Gauvain, Fabrice Arcizet, Olivier Marre, Deniz Dalkara, Botond Roska, José Alain Sahel, Mickael Tanter & Serge Picaud
Published in: Nat Nanotechnol., 2023, ISSN 1748-3387
Publisher: Nature Publishing Group
DOI: 10.1038/s41565-023-01359-6

Pyramidal neurons form active, transient, multilayered circuits perturbed by autism-associated mutations at the inception of neocortex

Author(s): Martin Munz, Arjun Bharioke, Georg Kosche, Verónica Moreno-Juan, Alexandra Brignall, Tiago M Rodrigues, Alexandra Graff-Meyer, Talia Ulmer, Stephanie Haeuselmann, Dinko Pavlinic, Nicole Ledergerber, Brigitte Gross-Scherf, Balázs Rózsa, Jacek Krol, Simone Picelli, Cameron S Cowan, Botond Roska
Published in: Cell, 2023, ISSN 1097-4172
Publisher: Cell Press / Elsevier Inc.
DOI: 10.1016/j.cell.2023.03.025

Joint visual-vestibular computation of head direction and reflexive eye movement

Author(s): Tamas Dalmay, Luke Ewig, Botond Roska, Rava Azeredo da Silveira
Published in: BioRxiv, 2025, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.02.11.637650

Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution

Author(s): Cameron S Cowan, Magdalena Renner, Martina De Gennaro, Brigitte Gross-Scherf, David Goldblum, Yanyan Hou, Martin Munz, Tiago M Rodrigues, Jacek Krol, Tamas Szikra, Rachel Cuttat, Annick Waldt, Panagiotis Papasaikas, Roland Diggelmann, Claudia P Patino-Alvarez, Patricia Galliker, Stefan E Spirig, Dinko Pavlinic, Nadine Gerber-Hollbach, Sven Schuierer, Aldin Srdanovic, Marton Balogh, Riccardo Panero
Published in: Cell, 2020, ISSN 1097-4172
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.08.013

High-efficiency base editing in the retina in primates and human tissues

Author(s): Alissa Muller, Jack Sullivan, Wibke Schwarzer, Mantian Wang, Cindy Park-Windhol, Pascal W. Hasler, Lucas Janeschitz-Kriegl, Mert Duman, Beryll Klingler, Jane Matsell, Simon Manuel Hostettler, Patricia Galliker, Yanyan Hou, Pierre Balmer, Tamás Virág, Luis Alberto Barrera, Lauren Young, Quan Xu, Dániel Péter Magda, Ferenc Kilin, Arogya Khadka, Pierre-Henri Moreau, Lyne Fellmann, Thierry Azoulay
Published in: Nature Medicine, Issue 31, 2025, Page(s) 490-501, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-024-03422-8

Roadmap for direct and indirect translation of optogenetics into discoveries and therapies for humans

Author(s): Christian Lüscher, Valentina Emiliani, Nita Farahany, Aryn Gittis, Viviana Gradinaru, Katherine A. High, Botond Roska, José-Alain Sahel, Ofer Yizhar, Hongkui Zeng, Karl Deisseroth
Published in: Nature Neuroscience, Issue 28, 2025, Page(s) 2415-2431, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-025-02097-9

General anesthesia globally synchronizes activity selectively in layer 5 cortical pyramidal neurons

Author(s): Arjun Bharioke, Martin Munz, Alexandra Brignall, Georg Kosche, Max Ferdinand Eizinger, Nicole Ledergerber, Daniel Hillier, Brigitte Gross-Scherf, Karl-Klaus Conzelmann, Emilie Macé, Botond Roska
Published in: Neuron, 2022, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2022.03.032

Multimodal spatiotemporal phenotyping of human retinal organoid development

Author(s): Philipp Wahle, Giovanna Brancati, Christoph Harmel, Zhisong He, Gabriele Gut, Jacobo Sarabia del Castillo, Aline Xavier da Silveira dos Santos, Qianhui Yu, Pascal Noser, Jonas Simon Fleck, Bruno Gjeta, Dinko Pavlinić, Simone Picelli, Max Hess, Gregor W. Schmidt, Tom T. A. Lummen, Yanyan Hou, Patricia Galliker, David Goldblum, Marton Balogh, Cameron S. Cowan, Hendrik P. N. Scholl, Botond Roska, Ma
Published in: Nat Biotechnol., 2023, ISSN 1087-0156
Publisher: Nature Publishing Group
DOI: 10.1038/s41587-023-01747-2