The human retina at single cell resolution: functional architecture, disease mechanism and therapy development

Project Information

HURET

Grant agreement ID: 883781

DOI 10.3030/883781

EC signature date 12 May 2020

Start date 1 November 2020

End date 31 October 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 500 000,00

EU contribution € 2 500 000,00

Coordinated by

INSTITUT FUR MOLEKULARE UND KLINISCHE OPHTHALMOLOGIE BASEL
Switzerland

Publications

Non-peer reviewed articles (2)

Individual thalamic inhibitory interneurons are functionally specialized towards distinct visual features.

Author(s): Muellner F, Roska B
Published in: BioRxiv, 2023, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.03.22.533751

Cell type-focused compound screen in human organoids reveals molecules and pathways controlling cone photoreceptor death

Author(s): Spirig SE, Arteaga-Moreta VJ, Raics Z, Posada-Céspedes S, Chreng S, Galuba O, Galuba I, Claerr I, Renner S, Kleindienst T, Volak A, Imbach J, Malysheva S, Siwicki RA, Hahaut V, Hou Y, Picelli S, Cattaneo M, Jüttner J, Cowan CS, Duckely M, Baeschlin DK, Renner M, Unterreiner V, Roska B.
Published in: BioRxiv, 2023, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.10.09.561525

Peer reviewed articles (9)

Whole-brain functional ultrasound imaging in awake head-fixed mice

Author(s): Clément Brunner, Micheline Grillet, Alan Urban, Botond Roska, Gabriel Montaldo & Emilie Macé
Published in: Nature Protocols, 2021, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-021-00548-8

Partial recovery of visual function in a blind patient after optogenetic therapy

Author(s): José-Alain Sahel, Elise Boulanger-Scemama, Chloé Pagot, Angelo Arleo, Francesco Galluppi, Joseph N. Martel, Simona Degli Esposti, Alexandre Delaux, Jean-Baptiste de Saint Aubert, Caroline de Montleau, Emmanuel Gutman, Isabelle Audo, Jens Duebel, Serge Picaud, Deniz Dalkara, Laure Blouin, Magali Taiel, Botond Roska
Published in: Nature Medicine, 2021, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-021-01351-4

Sharp-wave ripple doublets induce complex dendritic spikes in parvalbumin interneurons in vivo

Author(s): Linda Judák, Balázs Chiovini, Gábor Juhász, Dénes Pálfi, Zsolt Mezriczky, Zoltán Szadai, Gergely Katona, Benedek Szmola, Katalin Ócsai, Bernadett Martinecz, Anna Mihály, Ádám Dénes, Bálint Kerekes, Áron Szepesi, Gergely Szalay, István Ulbert, Zoltán Mucsi, Botond Roska & Balázs Rózsa
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-34520-1

Restoring light sensitivity using tunable near-infrared sensors

Author(s): Dasha Nelidova, Rei K Morikawa, Cameron S Cowan, Zoltan Raics, David Goldblum, Hendrik P N Scholl, Tamas Szikra, Arnold Szabo, Daniel Hillier, Botond Roska
Published in: Science, 2020, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aaz5887

Ectopic expression of a mechanosensitive channel confers spatiotemporal resolution to ultrasound stimulations of neurons for visual restoration

Author(s): Sara Cadoni, Charlie Demené, Ignacio Alcala, Matthieu Provansal, Diep Nguyen, Dasha Nelidova, Guillaume Labernède, Jules Lubetzki, Ruben Goulet, Emma Burban, Julie Dégardin, Manuel Simonutti, Gregory Gauvain, Fabrice Arcizet, Olivier Marre, Deniz Dalkara, Botond Roska, José Alain Sahel, Mickael Tanter & Serge Picaud
Published in: Nat Nanotechnol., 2023, ISSN 1748-3387
Publisher: Nature Publishing Group
DOI: 10.1038/s41565-023-01359-6

Pyramidal neurons form active, transient, multilayered circuits perturbed by autism-associated mutations at the inception of neocortex

Author(s): Martin Munz, Arjun Bharioke, Georg Kosche, Verónica Moreno-Juan, Alexandra Brignall, Tiago M Rodrigues, Alexandra Graff-Meyer, Talia Ulmer, Stephanie Haeuselmann, Dinko Pavlinic, Nicole Ledergerber, Brigitte Gross-Scherf, Balázs Rózsa, Jacek Krol, Simone Picelli, Cameron S Cowan, Botond Roska
Published in: Cell, 2023, ISSN 1097-4172
Publisher: Cell Press / Elsevier Inc.
DOI: 10.1016/j.cell.2023.03.025

Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution

Author(s): Cameron S Cowan, Magdalena Renner, Martina De Gennaro, Brigitte Gross-Scherf, David Goldblum, Yanyan Hou, Martin Munz, Tiago M Rodrigues, Jacek Krol, Tamas Szikra, Rachel Cuttat, Annick Waldt, Panagiotis Papasaikas, Roland Diggelmann, Claudia P Patino-Alvarez, Patricia Galliker, Stefan E Spirig, Dinko Pavlinic, Nadine Gerber-Hollbach, Sven Schuierer, Aldin Srdanovic, Marton Balogh, Riccardo Panero
Published in: Cell, 2020, ISSN 1097-4172
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.08.013

General anesthesia globally synchronizes activity selectively in layer 5 cortical pyramidal neurons

Author(s): Arjun Bharioke, Martin Munz, Alexandra Brignall, Georg Kosche, Max Ferdinand Eizinger, Nicole Ledergerber, Daniel Hillier, Brigitte Gross-Scherf, Karl-Klaus Conzelmann, Emilie Macé, Botond Roska
Published in: Neuron, 2022, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2022.03.032

Multimodal spatiotemporal phenotyping of human retinal organoid development

Author(s): Philipp Wahle, Giovanna Brancati, Christoph Harmel, Zhisong He, Gabriele Gut, Jacobo Sarabia del Castillo, Aline Xavier da Silveira dos Santos, Qianhui Yu, Pascal Noser, Jonas Simon Fleck, Bruno Gjeta, Dinko Pavlinić, Simone Picelli, Max Hess, Gregor W. Schmidt, Tom T. A. Lummen, Yanyan Hou, Patricia Galliker, David Goldblum, Marton Balogh, Cameron S. Cowan, Hendrik P. N. Scholl, Botond Roska, Ma
Published in: Nat Biotechnol., 2023, ISSN 1087-0156
Publisher: Nature Publishing Group
DOI: 10.1038/s41587-023-01747-2