The human retina at single cell resolution: functional architecture, disease mechanism and therapy development

Informazioni relative al progetto

HURET

ID dell’accordo di sovvenzione: 883781

DOI

10.3030/883781

Data della firma CE 12 Maggio 2020

Data di avvio 1 Novembre 2020

Data di completamento 31 Ottobre 2025

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 500 000,00

Contributo UE

€ 2 500 000,00

Coordinato da

INSTITUT FUR MOLEKULARE UND KLINISCHE OPHTHALMOLOGIE BASEL
Switzerland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (13)

Individual thalamic inhibitory interneurons are functionally specialized towards distinct visual features.

Autori: Muellner F, Roska B
Pubblicato in: Neuron, 2024, ISSN 0896-6273
Editore: Cell Press
DOI: 10.1101/2023.03.22.533751

The sodium-bicarbonate cotransporter Slc4a5 mediates feedback at the first synapse of vision

Autori: Rei Morikawa, Tiago M. Rodrigues, Helene Marianne Schreyer, Cameron S. Cowan, Sarah Nadeau, Alexandra Graff-Meyer, Claudia P. Patino-Alvarez, Mohammad Hossein Khani, Josephine Jüttner, Botond Roska
Pubblicato in: Neuron, Numero 112, 2025, Pagina/e 3715-3733.e9, ISSN 0896-6273
Editore: Cell Press
DOI: 10.1016/j.neuron.2024.08.015

Whole-brain functional ultrasound imaging in awake head-fixed mice

Autori: Clément Brunner, Micheline Grillet, Alan Urban, Botond Roska, Gabriel Montaldo & Emilie Macé
Pubblicato in: Nature Protocols, 2021, ISSN 1754-2189
Editore: Nature Publishing Group
DOI: 10.1038/s41596-021-00548-8

Partial recovery of visual function in a blind patient after optogenetic therapy

Autori: José-Alain Sahel, Elise Boulanger-Scemama, Chloé Pagot, Angelo Arleo, Francesco Galluppi, Joseph N. Martel, Simona Degli Esposti, Alexandre Delaux, Jean-Baptiste de Saint Aubert, Caroline de Montleau, Emmanuel Gutman, Isabelle Audo, Jens Duebel, Serge Picaud, Deniz Dalkara, Laure Blouin, Magali Taiel, Botond Roska
Pubblicato in: Nature Medicine, 2021, ISSN 1078-8956
Editore: Nature Publishing Group
DOI: 10.1038/s41591-021-01351-4

Sharp-wave ripple doublets induce complex dendritic spikes in parvalbumin interneurons in vivo

Autori: Linda Judák, Balázs Chiovini, Gábor Juhász, Dénes Pálfi, Zsolt Mezriczky, Zoltán Szadai, Gergely Katona, Benedek Szmola, Katalin Ócsai, Bernadett Martinecz, Anna Mihály, Ádám Dénes, Bálint Kerekes, Áron Szepesi, Gergely Szalay, István Ulbert, Zoltán Mucsi, Botond Roska & Balázs Rózsa
Pubblicato in: Nature Communications, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-34520-1

Restoring light sensitivity using tunable near-infrared sensors

Autori: Dasha Nelidova, Rei K Morikawa, Cameron S Cowan, Zoltan Raics, David Goldblum, Hendrik P N Scholl, Tamas Szikra, Arnold Szabo, Daniel Hillier, Botond Roska
Pubblicato in: Science, 2020, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.aaz5887

Ectopic expression of a mechanosensitive channel confers spatiotemporal resolution to ultrasound stimulations of neurons for visual restoration

Autori: Sara Cadoni, Charlie Demené, Ignacio Alcala, Matthieu Provansal, Diep Nguyen, Dasha Nelidova, Guillaume Labernède, Jules Lubetzki, Ruben Goulet, Emma Burban, Julie Dégardin, Manuel Simonutti, Gregory Gauvain, Fabrice Arcizet, Olivier Marre, Deniz Dalkara, Botond Roska, José Alain Sahel, Mickael Tanter & Serge Picaud
Pubblicato in: Nat Nanotechnol., 2023, ISSN 1748-3387
Editore: Nature Publishing Group
DOI: 10.1038/s41565-023-01359-6

Pyramidal neurons form active, transient, multilayered circuits perturbed by autism-associated mutations at the inception of neocortex

Autori: Martin Munz, Arjun Bharioke, Georg Kosche, Verónica Moreno-Juan, Alexandra Brignall, Tiago M Rodrigues, Alexandra Graff-Meyer, Talia Ulmer, Stephanie Haeuselmann, Dinko Pavlinic, Nicole Ledergerber, Brigitte Gross-Scherf, Balázs Rózsa, Jacek Krol, Simone Picelli, Cameron S Cowan, Botond Roska
Pubblicato in: Cell, 2023, ISSN 1097-4172
Editore: Cell Press / Elsevier Inc.
DOI: 10.1016/j.cell.2023.03.025

Joint visual-vestibular computation of head direction and reflexive eye movement

Autori: Tamas Dalmay, Luke Ewig, Botond Roska, Rava Azeredo da Silveira
Pubblicato in: BioRxiv, 2025, ISSN 2692-8205
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.02.11.637650

Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution

Autori: Cameron S Cowan, Magdalena Renner, Martina De Gennaro, Brigitte Gross-Scherf, David Goldblum, Yanyan Hou, Martin Munz, Tiago M Rodrigues, Jacek Krol, Tamas Szikra, Rachel Cuttat, Annick Waldt, Panagiotis Papasaikas, Roland Diggelmann, Claudia P Patino-Alvarez, Patricia Galliker, Stefan E Spirig, Dinko Pavlinic, Nadine Gerber-Hollbach, Sven Schuierer, Aldin Srdanovic, Marton Balogh, Riccardo Panero
Pubblicato in: Cell, 2020, ISSN 1097-4172
Editore: Cell Press
DOI: 10.1016/j.cell.2020.08.013

High-efficiency base editing in the retina in primates and human tissues

Autori: Alissa Muller, Jack Sullivan, Wibke Schwarzer, Mantian Wang, Cindy Park-Windhol, Pascal W. Hasler, Lucas Janeschitz-Kriegl, Mert Duman, Beryll Klingler, Jane Matsell, Simon Manuel Hostettler, Patricia Galliker, Yanyan Hou, Pierre Balmer, Tamás Virág, Luis Alberto Barrera, Lauren Young, Quan Xu, Dániel Péter Magda, Ferenc Kilin, Arogya Khadka, Pierre-Henri Moreau, Lyne Fellmann, Thierry Azoulay
Pubblicato in: Nature Medicine, Numero 31, 2025, Pagina/e 490-501, ISSN 1078-8956
Editore: Nature Publishing Group
DOI: 10.1038/s41591-024-03422-8

General anesthesia globally synchronizes activity selectively in layer 5 cortical pyramidal neurons

Autori: Arjun Bharioke, Martin Munz, Alexandra Brignall, Georg Kosche, Max Ferdinand Eizinger, Nicole Ledergerber, Daniel Hillier, Brigitte Gross-Scherf, Karl-Klaus Conzelmann, Emilie Macé, Botond Roska
Pubblicato in: Neuron, 2022, ISSN 0896-6273
Editore: Cell Press
DOI: 10.1016/j.neuron.2022.03.032

Multimodal spatiotemporal phenotyping of human retinal organoid development

Autori: Philipp Wahle, Giovanna Brancati, Christoph Harmel, Zhisong He, Gabriele Gut, Jacobo Sarabia del Castillo, Aline Xavier da Silveira dos Santos, Qianhui Yu, Pascal Noser, Jonas Simon Fleck, Bruno Gjeta, Dinko Pavlinić, Simone Picelli, Max Hess, Gregor W. Schmidt, Tom T. A. Lummen, Yanyan Hou, Patricia Galliker, David Goldblum, Marton Balogh, Cameron S. Cowan, Hendrik P. N. Scholl, Botond Roska, Ma
Pubblicato in: Nat Biotechnol., 2023, ISSN 1087-0156
Editore: Nature Publishing Group
DOI: 10.1038/s41587-023-01747-2

Non-peer reviewed articles (1)

Cell type-focused compound screen in human organoids reveals molecules and pathways controlling cone photoreceptor death

Autori: Spirig SE, Arteaga-Moreta VJ, Raics Z, Posada-Céspedes S, Chreng S, Galuba O, Galuba I, Claerr I, Renner S, Kleindienst T, Volak A, Imbach J, Malysheva S, Siwicki RA, Hahaut V, Hou Y, Picelli S, Cattaneo M, Jüttner J, Cowan CS, Duckely M, Baeschlin DK, Renner M, Unterreiner V, Roska B.
Pubblicato in: BioRxiv, 2023, ISSN 2692-8205
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.10.09.561525