Photo-Organocatalytic CO2 Valorisation into Bioactive Added-Value Molecules

Projektbeschreibung

Effiziente Katalysatoren zur Umwandlung von CO2 in Chemikalien mit hohem Mehrwert

Die lichtgetriebene chemische Umwandlung von Kohlendioxid (unter Verwendung chiraler Katalysatoren) in organische Verbindungen mit hohem Mehrwert ist ein heißes Thema in der synthetischen Chemie. Das EU-finanzierte Projekt Photo2Bio wird Fortschritte in der Photoredox- und Organokatalyse zur Schaffung eines dualen katalytischen Systems nutzen, das gleichzeitig sowohl das organische Substrat als auch Kohlendioxid aktivieren kann. Die neuen Katalysatoren auf Basis aktiver chiraler Moleküle werden neue Erkenntnisse zur katalytischen asymmetrischen CO2-Fixierung liefern. Das Projekt wird nicht nur für Wissenschaft und Industrie, sondern auch für die Gesellschaft vorteilhaft sein. Es werden Initiativen zur Demonstration ergriffen, wie Technologien in der synthetischen Chemie zur Verringerung der den Klimawandel antreibenden Treibhausgasemissionen beitragen und die Wahrnehmung der Menschen verändern, dass Chemie giftig und gefährlich sei.

Ziel

In my research proposal Photo2Bio, I introduce a conceptually new chemical paradigm for the organocatalytic asymmetric CO2 fixation via synergistic catalysis. This strategy demonstrates its straight to the synthesis of amino acids and diverse complex molecular architectures using renewable sources: light and CO2. The key features of this strategy is to develop a dual catalytic system which can simultaneous activate both coupling partner: the organic substrate and CO2, thus combining two powerful fields of molecular activation: visible light photoredoxcatalysis and organocatalysis. After the development of the discovery phase - development of the dual catalytic system and application to the synthesis of biomolecules - a more applicative execution phase will take place, where organocatalytic magnetic nanoparticles (MN) will be implemented and functionalize to overcome the recovery and catalyst loading issues. This will open the way to environmentally benign industrial applications.
The successful development of proposal is ensured by the merging of diverse skills from hosting group at the University of Padova, led by Prof. Marcella Bonchio i) CO2 valorisation, ii) photocatalyst; the ITM-CNR expert in MN Dr. Alberto Figoli: i) magnetic nanoparticle design and assembly and me: i) photoredox catalysis, ii) asymmetric synthesis and reaction development. Funding of the Photo2Bio will generate great benefit not only for academia and industry through the synthesis of chiral biomolecules but also for the society. At short term new sustainable way to bioactive molecules will be accessed; at a long term this will serve to prove the concept that chemistry useful and can solve global warming by the development of sustainable synthetic methods, thus changing the common people perception of chemistry as toxic and/or dangerous. This will be accomplished by a series of large audience initiative and discussions with scientists and common people.