Skip to main content

Molecules Inhibiting Translation in Cancer cells

Project description

Translation inhibition in cancer cells

Understanding the precise regulation of translation to design inhibiting drug candidates is a very complicated task that requires a high level of accuracy and modern techniques. Y box binding protein 1 (YB-1), a major mRNA binding protein and a master regulator of translation in cancer cells, has been considered as a therapeutic target for the treatment of drug-resistant cancer. However, no small molecules with high affinity and specificity against YB-1 have been proposed so far, and the structural data essential to test drug relevance are missing. The EU-funded MITiC project will focus on studying the inhibition mechanism of YB-1 to design anti-cancer drugs able to overcome resistance, using computational and experimental data and combining them with data mining techniques.

Call for proposal

See other projects for this call


Boulevard Francois Mitterand 23
91025 Evry
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 184 707,84