Translation inhibition in cancer cells
Understanding the precise regulation of translation to design inhibiting drug candidates is a very complicated task that requires a high level of accuracy and modern techniques. Y box binding protein 1 (YB-1), a major mRNA binding protein and a master regulator of translation in cancer cells, has been considered as a therapeutic target for the treatment of drug-resistant cancer. However, no small molecules with high affinity and specificity against YB-1 have been proposed so far, and the structural data essential to test drug relevance are missing. The EU-funded MITiC project will focus on studying the inhibition mechanism of YB-1 to design anti-cancer drugs able to overcome resistance, using computational and experimental data and combining them with data mining techniques.
Fields of science
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