PERSONALISATION OF IMMUNOSUPPRESSION BY MONITORING VIRAL LOAD POST KIDNEY TRANSPLANTATION - A RANDOMISED CONTROLLED PHASE II TRIAL | TTV GUIDE TX | Project | Results | H2020 | CORDIS

Deliverables

Public report on activities of the project

Ethics and Governance framework
Conclusions from the Kick-off
M18 Review report

Public report on activities of the project

Publications

Attenuation of Torque teno viral load over time in kidney transplantation recipients treated with calcineurin inhibitors is mitigated after conversion to belatacept

Author(s): O. W. Bredewold, W. T. Moest, J. W. de Fijter, E. Meijers, A. Bruchfeld, K. Skov, M. H. S. Svensson, J. Chan, L. Mjornstedt, S. S. Sorensen, B. Fellstrom, M. C. W. Feltkamp, A. J. van Zonneveld, J. I. Rotmans
Published in: Journal of Medical Virology, Issue 96, 2024, ISSN 0146-6615
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/jmv.29905

Evaluation of Torque Teno Virus DNA Load as a Predictive Biomarker in Kidney Transplant Recipients Converted from Calcineurin Inhibitors to Belatacept

Author(s): Lara Cabezas 1 2, Aurelie Truffot 3 4, Raphaele Germi 3 4, Mathilde Bugnazet 1, Paolo Malvezzi 1 2, Manon Gnesotto 4, Lionel Rostaing 1 2, Thomas Jouve 1 2, Johan Noble
Published in: KI Reports, 2024, ISSN 0085-2538
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.ekir.2024.03.006

Smoking, Alcohol Intake and Torque Teno Virus in Stable Kidney Transplant Recipients

Author(s): Caecilia S. E. Doorenbos, Jip Jonker, Jiasi Hao, Edmund J. Gore, Daan Kremer, Tim J. Knobbe, Anoek A. E. de Joode, Jan Stephan F. Sanders, Olivier Thaunat, Hubert G. M. Niesters, Coretta C. Van Leer-Buter, Stephan J. L. Bakker
Published in: Viruses, Issue 15, 2023, Page(s) 2387, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v15122387

Validation, implementation and quality control of a Torque Teno Virus qPCR in a multinational clinical trial

Author(s): E.J. Gore, L. Gard, P. Bourgeois, D. Kulifaj, E. McCulloch, P.G. Spezia, H.G.M. Niesters, F. Maggi, G. Bond, C. Van Leer-Buter
Published in: Journal of Clinical Virology, Issue 175, 2024, Page(s) 105738, ISSN 1386-6532
Publisher: Elsevier BV
DOI: 10.1016/j.jcv.2024.105738

Integrated Immunologic Monitoring in Solid Organ Transplantation: The Road Toward Torque Teno Virus-guided Immunosuppression

Author(s): Peter Jaksch, Irene Görzer, Elisabeth Puchhammer-Stöckl, Gregor Bond
Published in: Transplantation, Issue 106, 2023, Page(s) 1940-1951, ISSN 0041-1337
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/tp.0000000000004153

Torque Teno Virus: A Promising Biomarker in Kidney Transplant Recipients

Author(s): Sara Dal Lago, Paola Brani, Giuseppe Ietto, Daniela Dalla Gasperina, Francesco Gianfagna, Cristina Giaroni, Annalisa Bosi, Francesca Drago Ferrante, Angelo Genoni, Hafza Zahira Manzoor, Andrea Ambrosini, Marco De Cicco, Corradina Dina Quartarone, Sara Khemara, Giulio Carcano, Fabrizio Maggi, Andreina Baj
Published in: International Journal of Molecular Sciences, Issue 25, 2024, Page(s) 7744, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25147744

Torque Teno Virus DNA Load in Blood as an Immune Status Biomarker in Adult Hematological Patients: The State of the Art and Future Prospects

Author(s): Eliseo Albert, Estela Giménez, Rafael Hernani, José Luis Piñana, Carlos Solano, David Navarro
Published in: Viruses, Issue 16, 2024, Page(s) 459, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v16030459

Torque teno virus viral load predicts SARS‐CoV‐2 vaccine response in kidney transplant recipients

Author(s): Morgane Solis, Ilies Benotmane, Floriane Gallais, Sophie Caillard, Samira Fafi‐Kremer
Published in: Journal of Medical Virology, Issue 95, 2023, ISSN 0146-6615
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/jmv.28936

Torque Teno Virus Control by the Classical Pathway of Complement Activation—A Retrospective Analysis From a First‐in‐Human Trial Utilizing Sutimlimab

Author(s): Sebastian Kapps, Jakob Mühlbacher, Dorian Kulifaj, Sophie Courjal, Farsad Eskandary, Martin Schiemann, Bernd Jilma, Georg A. Böhmig, Gregor Bond, Markus Wahrmann
Published in: Journal of Medical Virology, Issue 96, 2024, ISSN 0146-6615
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/jmv.70039

The association of Torque Teno viral load with CMV and BKV infection in pediatric and adolescent kidney transplant patients.

Author(s): Fabian Eibensteiner, Ines Messner, Phoebe Uhl, Gregor Bond, Elisabeth Puchhammer-Stoeckl, Thomas Mueller-Sacherer, Christoph Aufricht, Krisztina Rusai
Published in: Journal of Clinical Virology, Issue 172, 2024, Page(s) 105673, ISSN 1386-6532
Publisher: Elsevier BV
DOI: 10.1016/j.jcv.2024.105673

Torque Teno Virus (TTV) in Renal Transplant Recipients: Species Diversity and Variability

Author(s): Noelia Soledad Reyes, Pietro Giorgio Spezia, Raquel Jara, Fabio Filippini, Natalia Boccia, Gonzalo García, Eliana Hermida, Fernando Adrian Poletta, Mauro Pistello, Gustavo Laham, Fabrizio Maggi, Marcela Echavarria
Published in: Viruses, Issue 16, 2024, Page(s) 432, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v16030432

Torquetenovirus Viremia Quantification Using Real-Time PCR Developed on a Fully Automated, Random-Access Platform

Author(s): Pietro Giorgio Spezia, Fabrizio Carletti, Federica Novazzi, Eliana Specchiarello, Angelo Genoni, Francesca Drago Ferrante, Claudia Minosse, Giulia Matusali, Nicasio Mancini, Daniele Focosi, Guido Antonelli, Enrico Girardi, Fabrizio Maggi
Published in: Viruses, Issue 16, 2024, Page(s) 963, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v16060963

The Emerging Tool of the Human Anellovirome

Author(s): Daniele Focosi, Pietro Giorgio Spezia, Fabrizio Maggi
Published in: Viruses, Issue 16, 2024, Page(s) 990, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v16060990

Torque Teno Viral Plasma Load for Immunologic Monitoring in Solid Organ Transplantation: One Step Further

Author(s): Frederik Haupenthal, Gregor Bond
Published in: Transplantation, 2023, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.1097/tp.0000000000004817

TTV and other anelloviruses: The astonishingly wide spread of a viral infection

Author(s): Pietro Giorgio Spezia, Daniele Focosi, Andreina Baj, Federica Novazzi, Francesca Drago Ferrante, Fabrizio Carletti, Claudia Minosse, Giulia Matusali, Fabrizio Maggi
Published in: Aspects of Molecular Medicine, 2023, ISSN 2949-6888
Publisher: Elsevier
DOI: 10.1016/j.amolm.2023.100006

Evaluate the host cellular immune response to better prevent and diagnose viral infections

Author(s): William Mouton, Jean-Marc Gombert, Anne Barra, Morgane Solis, Samira Fafi-Kremer, Nicolas Lévêque, Sophie Trouillet-Assant, Marine Mommert-Tripon, Edouard Tuaillon, Patrice Morand
Published in: Virologie, Issue 28, 2024, Page(s) 327-339, ISSN 1267-8694
Publisher: John Libbey Eurotext
DOI: 10.1684/vir.2024.1064

Polyomavirus Nephropathy in ABO Blood Group-Incompatible Kidney Transplantation: Torque Teno Virus and Immunosuppressive Burden as an Approximation to the Problem

Author(s): Michael Eder, Tarek A. Schrag, Ella F. Havel, Alexander Kainz, Haris Omic, Konstantin Doberer, Nicolas Kozakowski, Günther F. Körmöczi, Marlies Schönbacher, Gottfried Fischer, Robert Strassl, Monika Breuer, Lukas Weseslindtner, Frederik Haupenthal, Georg A. Böhmig, Elisabeth Puchhammer-Stöckl, Gregor Bond, Irene Görzer and Farsad Eskandary
Published in: KI Reports, 2024, ISSN 1178-7058
Publisher: Dove Medical Press Limited
DOI: 10.1016/j.ekir.2024.04.003

Longitudinal monitoring of Torque Teno virus DNAemia in kidney transplant recipients correlates with long‐term complications of inadequate immunosuppression

Author(s): Luc Chauvelot, Thomas Barba, Carole Saison, Evangelia Siska, Dorian Kulifaj, Stephan J. L. Bakker, Alice Koenig, Maud Rabeyrin, Fanny Buron, Cécile Picard, Frédérique Dijoud, Louis Manière, Bruno Lina, Emmanuel Morelon, Valerie Dubois, Olivier Thaunat
Published in: Journal of Medical Virology, Issue 96, 2024, ISSN 0146-6615
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/jmv.29806

The kinetics of Torque Teno virus plasma load following calcineurin inhibitor dose change in kidney transplant recipients

Author(s): Florina Regele, Frederik Haupenthal, Konstantin Doberer, Irene Görzer, Sebastian Kapps, Robert Strassl, Gregor Bond
Published in: Journal of Medical Virology, Issue 96, 2024, ISSN 0146-6615
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/jmv.29554

Validation of plasma Torque Teno viral load applying a CE-certified PCR for risk stratification of rejection and infection post kidney transplantation

Author(s): Irene Görzer, Frederik Haupenthal, Fabrizio Maggi, Fanny Gelas, Dorian Kulifaj, Ludovic Brossault, Elisabeth Puchhammer-Stöckl, Gregor Bond
Published in: Journal of Clinical Virology, Issue 158, 2024, Page(s) 105348, ISSN 1386-6532
Publisher: Elsevier BV
DOI: 10.1016/j.jcv.2022.105348

Uncovering the persistent gap: The ongoing challenge of integrating sex and gender in biomedical research

Author(s): Janet Delgado, Mónica Cano Abadía, Kaya Akyüz, Melanie Goisauf, David Rodríguez-Arias
Published in: The Journal of Biomedical Research, Issue 38, 2024, Page(s) 1, ISSN 1674-8301
Publisher: Elsevier
DOI: 10.7555/jbr.38.20240157

Torque Teno Virus–guided monitoring of immunosuppressive therapy

Author(s): Sebastian Kapps, Frederik Haupenthal, Gregor Bond
Published in: Nephrology Dialysis Transplantation, 2024, ISSN 0931-0509
Publisher: Oxford University Press
DOI: 10.1093/ndt/gfae149

High-Density Lipoprotein Particles and Torque Teno Virus in Stable Outpatient Kidney Transplant Recipients

Author(s): Jip Jonker, Caecilia S. E. Doorenbos, Daan Kremer, Edmund J. Gore, Hubert G. M. Niesters, Coretta van Leer-Buter, Philippe Bourgeois, Margery A. Connelly, Robin P. F. Dullaart, Stefan P. Berger, Jan-Stephan F. Sanders, Stephan J. L. Bakker
Published in: Viruses, Issue 16, 2024, Page(s) 143, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v16010143

Torque Teno Virus-Guided Immunosuppression in Kidney Transplantation: Expanding the Application

Author(s): Farsad Eskandary, Gregor Bond, Krithika Mohan
Published in: KI reports, 2024, ISSN 0085-2538
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.ekir.2024.04.057

A multicentre, patient- and assessor-blinded, non-inferiority, randomised and controlled phase II trial to compare standard and torque teno virus-guided immunosuppression in kidney transplant recipients in the first year after transplantation: TTVguideIT

Author(s): Frederik Haupenthal, Jette Rahn, Fabrizio Maggi, Fanny Gelas, Philippe Bourgeois, Christian Hugo, Bernd Jilma, Georg A. Böhmig, Harald Herkner, Michael Wolzt, Konstantin Doberer, Matthias Vossen, Daniele Focosi, Hannes Neuwirt, Miriam Banas, Bernhard Banas, Klemens Budde, Ondrej Viklicky, Paolo Malvezzi, Lionel Rostaing, Joris I. Rotmans, Stephan J. L. Bakker, Kathrin Eller, Daniel Cejka, Alberto
Published in: Trials, Issue 24, 2023, ISSN 1745-6215
Publisher: BioMed Central
DOI: 10.1186/s13063-023-07216-0

Pre-Transplant Frequencies of FoxP3+CD25+ in CD3+CD8+ T Cells as Potential Predictors for CMV in CMV-Intermediate Risk Kidney Transplant Recipients

Author(s): Agnes A. Mooslechner, Max Schuller, Verena Pfeifer, Konstantin A. Klötzer, Barbara Prietl, Alexander H. Kirsch, Philipp Stiegler, Robert Sucher, Harald Sourij, Alexander R. Rosenkranz, Kathrin Eller
Published in: Transplant International, Issue 37, 2024, ISSN 1432-2277
Publisher: Frontiers
DOI: 10.3389/ti.2024.12963

Prediction of humoral and cellular immune response to COVID-19 mRNA vaccination by TTV load in kidney transplant recipients and hemodialysis patients

Author(s): Marianne Graninger, Julian Stumpf, Gregor Bond, Irene Görzer, David N. Springer, Friederike Kessel, Hannah Kröger, Kerstin Frank, Torsten Tonn, Christian Hugo, Elisabeth Puchhammer-Stöckl
Published in: Journal of Clinical Virology, Issue 162, 2024, Page(s) 105428, ISSN 1386-6532
Publisher: Elsevier BV
DOI: 10.1016/j.jcv.2023.105428

Protocol for Surveying Participants and Professionals’ Experiences in an International Kidney Transplant Clinical Trial

Author(s): Janet Delgado, David Rodríguez-Arias, Alberto Molina-Pérez, Anibal Monasterio-Astobiza, Gonzalo Diaz-Cobacho, Gregor Bond, null null
Published in: Open Research Europe, Issue 4, 2024, Page(s) 241, ISSN 2732-5121
Publisher: OPen Research Europe
DOI: 10.12688/openreseurope.18665.1

PERSONALISATION OF IMMUNOSUPPRESSION BY MONITORING VIRAL LOAD POST KIDNEY TRANSPLANTATION - A RANDOMISED CONTROLLED PHASE II TRIAL

Deliverables

Publications

Share this page

Download