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PERSONALISATION OF IMMUNOSUPPRESSION BY MONITORING VIRAL LOAD POST KIDNEY TRANSPLANTATION - A RANDOMISED CONTROLLED PHASE II TRIAL

Project description

New method to personalise immunosuppression in kidney transplants

Kidney transplantation represents the treatment standard for end-stage renal disease. Graft rejection due to inadequate immunosuppression is the leading cause for chronic graft dysfunction, and infectious disease due to reduced immune function is a major cause of death. Optimisation of immunosuppressive drugs is crucial to minimising the risk of infection and rejection and thereby prolonging patient and graft survival. The peripheral blood copy number of the prevalent and non-pathogenic Torque Teno virus (TTV) is associated with the grade of the immunosuppression of the host. Non-interventional studies suggest superiority of TTV copy number guided immunosuppression compared to standard strategies. EU-funded TTV GUIDE TX will test safety and preliminary efficacy of TTV-guided immunosuppression within a phase II randomised and controlled clinical trial.

Call for proposal

H2020-SC1-BHC-2018-2020

See other projects for this call

Sub call

H2020-SC1-2020-Two-Stage-RTD

Coordinator

MEDIZINISCHE UNIVERSITAET WIEN
Net EU contribution
€ 973 306,25
Address
Spitalgasse 23
1090 Wien
Austria
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (20)

BIOMERIEUX SA
France
Net EU contribution
€ 801 750,00
Address
Chemin De L'orme
69280 Marcy L'etoile
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
EUTEMA RESEARCH SERVICES GMBH
Austria
Net EU contribution
€ 435 750,00
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
Karl Toldt Weg 6D
1140 Vienna
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK
France
Net EU contribution
€ 108 136,00
Address
5 Rue Watt
75013 Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

Masarykova univerzita
Czechia
Net EU contribution
€ 27 860,00
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
Zerotinovo Namesti 9
601 77 Brno
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
MEDIZINISCHE UNIVERSITAT INNSBRUCK
Austria
Net EU contribution
€ 288 750,00
Address
Christoph Probst Platz 1
6020 Innsbruck
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
MEDIZINISCHE UNIVERSITAT GRAZ
Austria
Net EU contribution
€ 191 562,50
Address
Auenbruggerplatz 2
8036 Graz
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
ORDENSKLINIKUM LINZ GMBH
Austria
Net EU contribution
€ 191 562,50
Address
Harrachstrasse 17
4020 Linz
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Region
Westösterreich Oberösterreich Linz-Wels
 
TECHNISCHE UNIVERSITAET DRESDEN
Germany
Net EU contribution
€ 722 268,75
Address
Helmholtzstrasse 10
01069 Dresden
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
KLINIKUM DER UNIVERSITAET REGENSBURG
Germany
Net EU contribution
€ 206 562,50
Address
Frans Josef Strauss Allee 11
93053 Regensburg
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Bayern Oberpfalz Regensburg, Kreisfreie Stadt
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
Net EU contribution
€ 191 562,50
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Institut klinické a experimentální mediciny
Czechia
Net EU contribution
€ 288 750,00
Address
Videnska 1958/9
14021 Prague 4
Activity type
Research Organisations
Non-EU contribution
€ 0,00
FUNDACION PARA LA INVESTIGACION DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA
Spain
Net EU contribution
€ 129 062,50
Address
Av Fernando Abril Martorell 106
46026 Valencia
Activity type
Research Organisations
Non-EU contribution
€ 0,00
FUNDACION PARA LA INVESTIGACION DEL HOSPITAL CLINICO DE LA COMUNITAT VALENCIANA, FUNDACION INCLIVA
Spain
Net EU contribution
€ 85 625,00
Address
Av Menendez Pelayo 4
46010 Valencia
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Region
Este Comunitat Valenciana Valencia/València
 
CENTRE HOSPITALIER UNIVERSITAIRE DE GRENOBLE
France
Net EU contribution
€ 236 760,00
Address
Boulevard De La Chantourne
38700 La Tronche
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,00
Region
Auvergne-Rhône-Alpes Rhône-Alpes Isère
 
HOPITAUX UNIVERSITAIRES DE STRASBOURG
France
Net EU contribution
€ 191 562,50
Address
Place De L Hopital 1
67091 Strasbourg Cedex
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Region
Grand Est Alsace Bas-Rhin
 
UNIVERSITA DI PISA

Participation ended

Italy
Net EU contribution
€ 0,00
Address
Lungarno Pacinotti 43/44
56126 Pisa
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
Net EU contribution
€ 303 750,00
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
Net EU contribution
€ 393 437,50
Address
Hanzeplein 1
9713 GZ Groningen
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSIDAD DE GRANADA
Spain
Net EU contribution
€ 194 687,50
Address
Cuesta Del Hospicio Sn
18071 Granada
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITA DEGLI STUDI DELL'INSUBRIA
Italy
Net EU contribution
€ 137 125,00
Address
Via Ravasi 2
21100 Varese
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00