PERSONALISATION OF IMMUNOSUPPRESSION BY MONITORING VIRAL LOAD POST KIDNEY TRANSPLANTATION - A RANDOMISED CONTROLLED PHASE II TRIAL

Informazioni relative al progetto

TTV GUIDE TX

ID dell’accordo di sovvenzione: 896932

DOI

10.3030/896932

Data della firma CE 2 Febbraio 2021

Data di avvio 1 Maggio 2021

Data di completamento 30 Aprile 2026

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

€ 6 099 831,00

Contributo UE

€ 6 099 831,00

Coordinato da

MEDIZINISCHE UNIVERSITAET WIEN
Austria

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (5)

M48 Review Report

Public report on activities of the project

M30 Review Report

Public report on activities of the project

Ethics and Governance framework
Conclusions from the Kick-off
M18 Review report

Public report on activities of the project

Websites, patent fillings, videos etc. (1)

TTV GUIDE TX public website

Pubblicazioni

Peer reviewed articles (34)

Comparison of Torque Teno Virus DNA Load in Plasma and Whole Blood

Autori: Aurélie Truffot, Lara Cabezas, Manon Gnesotto, Julien Lupo, Patrice Morand, Thomas Jouve, Johan Noble, Raphaële Germi
Pubblicato in: Kidney International Reports, 2025, ISSN 2468-0249
Editore: Elsevier BV
DOI: 10.1016/j.ekir.2025.04.033

Attenuation of Torque teno viral load over time in kidney transplantation recipients treated with calcineurin inhibitors is mitigated after conversion to belatacept

Autori: O. W. Bredewold, W. T. Moest, J. W. de Fijter, E. Meijers, A. Bruchfeld, K. Skov, M. H. S. Svensson, J. Chan, L. Mjornstedt, S. S. Sorensen, B. Fellstrom, M. C. W. Feltkamp, A. J. van Zonneveld, J. I. Rotmans
Pubblicato in: Journal of Medical Virology, Numero 96, 2024, ISSN 0146-6615
Editore: John Wiley & Sons Inc.
DOI: 10.1002/jmv.29905

Evaluation of Torque Teno Virus DNA Load as a Predictive Biomarker in Kidney Transplant Recipients Converted from Calcineurin Inhibitors to Belatacept

Autori: Lara Cabezas 1 2, Aurelie Truffot 3 4, Raphaele Germi 3 4, Mathilde Bugnazet 1, Paolo Malvezzi 1 2, Manon Gnesotto 4, Lionel Rostaing 1 2, Thomas Jouve 1 2, Johan Noble
Pubblicato in: KI Reports, 2024, ISSN 0085-2538
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.ekir.2024.03.006

Torquetenovirus Loads in Peripheral Blood Predict Both the Humoral and Cell-Mediated Responses to SARS-CoV-2 Elicited by the mRNA Vaccine in Liver Transplant Recipients

Autori: Claudia Minosse, Giulia Matusali, Silvia Meschi, Germana Grassi, Massimo Francalancia, Gianpiero D’Offizi, Pietro Giorgio Spezia, Anna Rosa Garbuglia, Marzia Montalbano, Daniele Focosi, Enrico Girardi, Francesco Vaia, Giuseppe Maria Ettorre, Fabrizio Maggi
Pubblicato in: Vaccines, Numero 11, 2023, Pagina/e 1656, ISSN 2076-393X
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines11111656

Smoking, Alcohol Intake and Torque Teno Virus in Stable Kidney Transplant Recipients

Autori: Caecilia S. E. Doorenbos, Jip Jonker, Jiasi Hao, Edmund J. Gore, Daan Kremer, Tim J. Knobbe, Anoek A. E. de Joode, Jan Stephan F. Sanders, Olivier Thaunat, Hubert G. M. Niesters, Coretta C. Van Leer-Buter, Stephan J. L. Bakker
Pubblicato in: Viruses, Numero 15, 2023, Pagina/e 2387, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v15122387

Validation, implementation and quality control of a Torque Teno Virus qPCR in a multinational clinical trial

Autori: E.J. Gore, L. Gard, P. Bourgeois, D. Kulifaj, E. McCulloch, P.G. Spezia, H.G.M. Niesters, F. Maggi, G. Bond, C. Van Leer-Buter
Pubblicato in: Journal of Clinical Virology, Numero 175, 2024, Pagina/e 105738, ISSN 1386-6532
Editore: Elsevier BV
DOI: 10.1016/j.jcv.2024.105738

Integrated Immunologic Monitoring in Solid Organ Transplantation: The Road Toward Torque Teno Virus-guided Immunosuppression

Autori: Peter Jaksch, Irene Görzer, Elisabeth Puchhammer-Stöckl, Gregor Bond
Pubblicato in: Transplantation, Numero 106, 2023, Pagina/e 1940-1951, ISSN 0041-1337
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/tp.0000000000004153

Torque Teno Virus: A Promising Biomarker in Kidney Transplant Recipients

Autori: Sara Dal Lago, Paola Brani, Giuseppe Ietto, Daniela Dalla Gasperina, Francesco Gianfagna, Cristina Giaroni, Annalisa Bosi, Francesca Drago Ferrante, Angelo Genoni, Hafza Zahira Manzoor, Andrea Ambrosini, Marco De Cicco, Corradina Dina Quartarone, Sara Khemara, Giulio Carcano, Fabrizio Maggi, Andreina Baj
Pubblicato in: International Journal of Molecular Sciences, Numero 25, 2024, Pagina/e 7744, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25147744

Torque Teno Virus DNA Load in Blood as an Immune Status Biomarker in Adult Hematological Patients: The State of the Art and Future Prospects

Autori: Eliseo Albert, Estela Giménez, Rafael Hernani, José Luis Piñana, Carlos Solano, David Navarro
Pubblicato in: Viruses, Numero 16, 2024, Pagina/e 459, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v16030459

Torque teno virus viral load predicts SARS‐CoV‐2 vaccine response in kidney transplant recipients

Autori: Morgane Solis, Ilies Benotmane, Floriane Gallais, Sophie Caillard, Samira Fafi‐Kremer
Pubblicato in: Journal of Medical Virology, Numero 95, 2023, ISSN 0146-6615
Editore: John Wiley & Sons Inc.
DOI: 10.1002/jmv.28936

Torque Teno Virus Control by the Classical Pathway of Complement Activation—A Retrospective Analysis From a First‐in‐Human Trial Utilizing Sutimlimab

Autori: Sebastian Kapps, Jakob Mühlbacher, Dorian Kulifaj, Sophie Courjal, Farsad Eskandary, Martin Schiemann, Bernd Jilma, Georg A. Böhmig, Gregor Bond, Markus Wahrmann
Pubblicato in: Journal of Medical Virology, Numero 96, 2024, ISSN 0146-6615
Editore: John Wiley & Sons Inc.
DOI: 10.1002/jmv.70039

The association of Torque Teno viral load with CMV and BKV infection in pediatric and adolescent kidney transplant patients.

Autori: Fabian Eibensteiner, Ines Messner, Phoebe Uhl, Gregor Bond, Elisabeth Puchhammer-Stoeckl, Thomas Mueller-Sacherer, Christoph Aufricht, Krisztina Rusai
Pubblicato in: Journal of Clinical Virology, Numero 172, 2024, Pagina/e 105673, ISSN 1386-6532
Editore: Elsevier BV
DOI: 10.1016/j.jcv.2024.105673

Torque Teno Virus (TTV) in Renal Transplant Recipients: Species Diversity and Variability

Autori: Noelia Soledad Reyes, Pietro Giorgio Spezia, Raquel Jara, Fabio Filippini, Natalia Boccia, Gonzalo García, Eliana Hermida, Fernando Adrian Poletta, Mauro Pistello, Gustavo Laham, Fabrizio Maggi, Marcela Echavarria
Pubblicato in: Viruses, Numero 16, 2024, Pagina/e 432, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v16030432

Torque teno virus load as marker of rejection and infection in solid organ transplantation – A systematic review and meta‐analysis

Autori: AL van Rijn, R Roos, FW Dekker, JI Rotmans, MCW Feltkamp
Pubblicato in: Reviews in Medical Virology, Numero 33, 2024, ISSN 1052-9276
Editore: John Wiley & Sons Inc.
DOI: 10.1002/rmv.2393

Torquetenovirus Viremia Quantification Using Real-Time PCR Developed on a Fully Automated, Random-Access Platform

Autori: Pietro Giorgio Spezia, Fabrizio Carletti, Federica Novazzi, Eliana Specchiarello, Angelo Genoni, Francesca Drago Ferrante, Claudia Minosse, Giulia Matusali, Nicasio Mancini, Daniele Focosi, Guido Antonelli, Enrico Girardi, Fabrizio Maggi
Pubblicato in: Viruses, Numero 16, 2024, Pagina/e 963, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v16060963

The Emerging Tool of the Human Anellovirome

Autori: Daniele Focosi, Pietro Giorgio Spezia, Fabrizio Maggi
Pubblicato in: Viruses, Numero 16, 2024, Pagina/e 990, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v16060990

Torque Teno Viral Plasma Load for Immunologic Monitoring in Solid Organ Transplantation: One Step Further

Autori: Frederik Haupenthal, Gregor Bond
Pubblicato in: Transplantation, 2023, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.1097/tp.0000000000004817

Self-reported Non-adherence to Immunosuppressive Medication Detected by the BAASIS Predicts Allograft Rejections in Kidney Transplant Recipients

Autori: Frederik Haupenthal , Konstantin Doberer , Sebastian Kapps , Johannes Kläger , Florian Bauernfeind , Kris Denhaerynck , Alexander Kainz , Sabina De Geest , Gregor Bond
Pubblicato in: Nephrology Dialysis Transplantation, 2025, ISSN 1460-2385
Editore: Oxford University Press

TTV and other anelloviruses: The astonishingly wide spread of a viral infection

Autori: Pietro Giorgio Spezia, Daniele Focosi, Andreina Baj, Federica Novazzi, Francesca Drago Ferrante, Fabrizio Carletti, Claudia Minosse, Giulia Matusali, Fabrizio Maggi
Pubblicato in: Aspects of Molecular Medicine, 2023, ISSN 2949-6888
Editore: Elsevier
DOI: 10.1016/j.amolm.2023.100006

Evaluate the host cellular immune response to better prevent and diagnose viral infections

Autori: William Mouton, Jean-Marc Gombert, Anne Barra, Morgane Solis, Samira Fafi-Kremer, Nicolas Lévêque, Sophie Trouillet-Assant, Marine Mommert-Tripon, Edouard Tuaillon, Patrice Morand
Pubblicato in: Virologie, Numero 28, 2024, Pagina/e 327-339, ISSN 1267-8694
Editore: John Libbey Eurotext
DOI: 10.1684/vir.2024.1064

Polyomavirus Nephropathy in ABO Blood Group-Incompatible Kidney Transplantation: Torque Teno Virus and Immunosuppressive Burden as an Approximation to the Problem

Autori: Michael Eder, Tarek A. Schrag, Ella F. Havel, Alexander Kainz, Haris Omic, Konstantin Doberer, Nicolas Kozakowski, Günther F. Körmöczi, Marlies Schönbacher, Gottfried Fischer, Robert Strassl, Monika Breuer, Lukas Weseslindtner, Frederik Haupenthal, Georg A. Böhmig, Elisabeth Puchhammer-Stöckl, Gregor Bond, Irene Görzer and Farsad Eskandary
Pubblicato in: KI Reports, 2024, ISSN 1178-7058
Editore: Dove Medical Press Limited
DOI: 10.1016/j.ekir.2024.04.003

Longitudinal monitoring of Torque Teno virus DNAemia in kidney transplant recipients correlates with long‐term complications of inadequate immunosuppression

Autori: Luc Chauvelot, Thomas Barba, Carole Saison, Evangelia Siska, Dorian Kulifaj, Stephan J. L. Bakker, Alice Koenig, Maud Rabeyrin, Fanny Buron, Cécile Picard, Frédérique Dijoud, Louis Manière, Bruno Lina, Emmanuel Morelon, Valerie Dubois, Olivier Thaunat
Pubblicato in: Journal of Medical Virology, Numero 96, 2024, ISSN 0146-6615
Editore: John Wiley & Sons Inc.
DOI: 10.1002/jmv.29806

The kinetics of Torque Teno virus plasma load following calcineurin inhibitor dose change in kidney transplant recipients

Autori: Florina Regele, Frederik Haupenthal, Konstantin Doberer, Irene Görzer, Sebastian Kapps, Robert Strassl, Gregor Bond
Pubblicato in: Journal of Medical Virology, Numero 96, 2024, ISSN 0146-6615
Editore: John Wiley & Sons Inc.
DOI: 10.1002/jmv.29554

Validation of plasma Torque Teno viral load applying a CE-certified PCR for risk stratification of rejection and infection post kidney transplantation

Autori: Irene Görzer, Frederik Haupenthal, Fabrizio Maggi, Fanny Gelas, Dorian Kulifaj, Ludovic Brossault, Elisabeth Puchhammer-Stöckl, Gregor Bond
Pubblicato in: Journal of Clinical Virology, Numero 158, 2024, Pagina/e 105348, ISSN 1386-6532
Editore: Elsevier BV
DOI: 10.1016/j.jcv.2022.105348

Uncovering the persistent gap: The ongoing challenge of integrating sex and gender in biomedical research

Autori: Janet Delgado, Mónica Cano Abadía, Kaya Akyüz, Melanie Goisauf, David Rodríguez-Arias
Pubblicato in: The Journal of Biomedical Research, Numero 38, 2024, Pagina/e 1, ISSN 1674-8301
Editore: Elsevier
DOI: 10.7555/jbr.38.20240157

Torque Teno Virus–guided monitoring of immunosuppressive therapy

Autori: Sebastian Kapps, Frederik Haupenthal, Gregor Bond
Pubblicato in: Nephrology Dialysis Transplantation, 2024, ISSN 0931-0509
Editore: Oxford University Press
DOI: 10.1093/ndt/gfae149

High-Density Lipoprotein Particles and Torque Teno Virus in Stable Outpatient Kidney Transplant Recipients

Autori: Jip Jonker, Caecilia S. E. Doorenbos, Daan Kremer, Edmund J. Gore, Hubert G. M. Niesters, Coretta van Leer-Buter, Philippe Bourgeois, Margery A. Connelly, Robin P. F. Dullaart, Stefan P. Berger, Jan-Stephan F. Sanders, Stephan J. L. Bakker
Pubblicato in: Viruses, Numero 16, 2024, Pagina/e 143, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v16010143

Evaluation of Torquetenovirus (TTV) Particle Integrity Utilizing PMAxx™

Autori: Giuseppe Sberna, Claudia Minosse, Cosmina Mija, Eliana Specchiarello, Pietro Giorgio Spezia, Sara Belladonna, Giulia Berno, Lavinia Fabeni, Giulia Matusali, Silvia Meschi, Daniele Focosi, Fabrizio Maggi
Pubblicato in: International Journal of Molecular Sciences, Numero 26, 2025, Pagina/e 6542, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms26136542

Torque Teno Virus-Guided Immunosuppression in Kidney Transplantation: Expanding the Application

Autori: Farsad Eskandary, Gregor Bond, Krithika Mohan
Pubblicato in: KI reports, 2024, ISSN 0085-2538
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.ekir.2024.04.057

Assessment of Torquetenominivirus (TTMV) and Torquetenomidivirus (TTMDV) as Complementary Biomarkers to Torquetenovirus (TTV)

Autori: Lilia Cinti, Pietro Giorgio Spezia, Piergiorgio Roberto, Gianluca Russo, Quirino Lai, Carolina Carillo, Federica Frasca, Guido Antonelli, Fabrizio Maggi
Pubblicato in: International Journal of Molecular Sciences, Numero 26, 2025, Pagina/e 1022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms26031022

A multicentre, patient- and assessor-blinded, non-inferiority, randomised and controlled phase II trial to compare standard and torque teno virus-guided immunosuppression in kidney transplant recipients in the first year after transplantation: TTVguideIT

Autori: Frederik Haupenthal, Jette Rahn, Fabrizio Maggi, Fanny Gelas, Philippe Bourgeois, Christian Hugo, Bernd Jilma, Georg A. Böhmig, Harald Herkner, Michael Wolzt, Konstantin Doberer, Matthias Vossen, Daniele Focosi, Hannes Neuwirt, Miriam Banas, Bernhard Banas, Klemens Budde, Ondrej Viklicky, Paolo Malvezzi, Lionel Rostaing, Joris I. Rotmans, Stephan J. L. Bakker, Kathrin Eller, Daniel Cejka, Alberto
Pubblicato in: Trials, Numero 24, 2023, ISSN 1745-6215
Editore: BioMed Central
DOI: 10.1186/s13063-023-07216-0

Pre-Transplant Frequencies of FoxP3+CD25+ in CD3+CD8+ T Cells as Potential Predictors for CMV in CMV-Intermediate Risk Kidney Transplant Recipients

Autori: Agnes A. Mooslechner, Max Schuller, Verena Pfeifer, Konstantin A. Klötzer, Barbara Prietl, Alexander H. Kirsch, Philipp Stiegler, Robert Sucher, Harald Sourij, Alexander R. Rosenkranz, Kathrin Eller
Pubblicato in: Transplant International, Numero 37, 2024, ISSN 1432-2277
Editore: Frontiers
DOI: 10.3389/ti.2024.12963

Torque Teno Virus: Lights and Shades

Autori: Paola Brani, Hafza Zahira Manzoor, Pietro Giorgio Spezia, Andrea Vigezzi, Giuseppe Ietto, Daniela Dalla Gasperina, Claudia Minosse, Annalisa Bosi, Cristina Giaroni, Giulio Carcano, Fabrizio Maggi, Andreina Baj
Pubblicato in: Viruses, Numero 17, 2025, Pagina/e 334, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v17030334

Prediction of humoral and cellular immune response to COVID-19 mRNA vaccination by TTV load in kidney transplant recipients and hemodialysis patients

Autori: Marianne Graninger, Julian Stumpf, Gregor Bond, Irene Görzer, David N. Springer, Friederike Kessel, Hannah Kröger, Kerstin Frank, Torsten Tonn, Christian Hugo, Elisabeth Puchhammer-Stöckl
Pubblicato in: Journal of Clinical Virology, Numero 162, 2024, Pagina/e 105428, ISSN 1386-6532
Editore: Elsevier BV
DOI: 10.1016/j.jcv.2023.105428

Non-peer reviewed articles (1)

Protocol for Surveying Participants and Professionals’ Experiences in an International Kidney Transplant Clinical Trial

Autori: Janet Delgado, David Rodríguez-Arias, Alberto Molina-Pérez, Anibal Monasterio-Astobiza, Gonzalo Diaz-Cobacho, Gregor Bond, null null
Pubblicato in: Open Research Europe, Numero 4, 2024, Pagina/e 241, ISSN 2732-5121
Editore: OPen Research Europe
DOI: 10.12688/openreseurope.18665.1