PERSONALISATION OF IMMUNOSUPPRESSION BY MONITORING VIRAL LOAD POST KIDNEY TRANSPLANTATION - A RANDOMISED CONTROLLED PHASE II TRIAL

Informacje na temat projektu

TTV GUIDE TX

Identyfikator umowy o grant: 896932

DOI

10.3030/896932

Data podpisania przez KE 2 Lutego 2021

Data rozpoczęcia 1 Maja 2021

Data zakończenia 30 Kwietnia 2026

Finansowanie w ramach

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Koszt całkowity

€ 6 099 831,00

Wkład UE

€ 6 099 831,00

Koordynowany przez

MEDIZINISCHE UNIVERSITAET WIEN
Austria

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Documents, reports (5)

M48 Review Report

Public report on activities of the project

M30 Review Report

Public report on activities of the project

Ethics and Governance framework
Conclusions from the Kick-off
M18 Review report

Public report on activities of the project

Websites, patent fillings, videos etc. (1)

TTV GUIDE TX public website

Publikacje

Peer reviewed articles (34)

Comparison of Torque Teno Virus DNA Load in Plasma and Whole Blood

Autorzy: Aurélie Truffot, Lara Cabezas, Manon Gnesotto, Julien Lupo, Patrice Morand, Thomas Jouve, Johan Noble, Raphaële Germi
Opublikowane w: Kidney International Reports, 2025, ISSN 2468-0249
Wydawca: Elsevier BV
DOI: 10.1016/j.ekir.2025.04.033

Attenuation of Torque teno viral load over time in kidney transplantation recipients treated with calcineurin inhibitors is mitigated after conversion to belatacept

Autorzy: O. W. Bredewold, W. T. Moest, J. W. de Fijter, E. Meijers, A. Bruchfeld, K. Skov, M. H. S. Svensson, J. Chan, L. Mjornstedt, S. S. Sorensen, B. Fellstrom, M. C. W. Feltkamp, A. J. van Zonneveld, J. I. Rotmans
Opublikowane w: Journal of Medical Virology, Numer 96, 2024, ISSN 0146-6615
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/jmv.29905

Evaluation of Torque Teno Virus DNA Load as a Predictive Biomarker in Kidney Transplant Recipients Converted from Calcineurin Inhibitors to Belatacept

Autorzy: Lara Cabezas 1 2, Aurelie Truffot 3 4, Raphaele Germi 3 4, Mathilde Bugnazet 1, Paolo Malvezzi 1 2, Manon Gnesotto 4, Lionel Rostaing 1 2, Thomas Jouve 1 2, Johan Noble
Opublikowane w: KI Reports, 2024, ISSN 0085-2538
Wydawca: Blackwell Publishing Inc.
DOI: 10.1016/j.ekir.2024.03.006

Torquetenovirus Loads in Peripheral Blood Predict Both the Humoral and Cell-Mediated Responses to SARS-CoV-2 Elicited by the mRNA Vaccine in Liver Transplant Recipients

Autorzy: Claudia Minosse, Giulia Matusali, Silvia Meschi, Germana Grassi, Massimo Francalancia, Gianpiero D’Offizi, Pietro Giorgio Spezia, Anna Rosa Garbuglia, Marzia Montalbano, Daniele Focosi, Enrico Girardi, Francesco Vaia, Giuseppe Maria Ettorre, Fabrizio Maggi
Opublikowane w: Vaccines, Numer 11, 2023, Strona(/y) 1656, ISSN 2076-393X
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines11111656

Smoking, Alcohol Intake and Torque Teno Virus in Stable Kidney Transplant Recipients

Autorzy: Caecilia S. E. Doorenbos, Jip Jonker, Jiasi Hao, Edmund J. Gore, Daan Kremer, Tim J. Knobbe, Anoek A. E. de Joode, Jan Stephan F. Sanders, Olivier Thaunat, Hubert G. M. Niesters, Coretta C. Van Leer-Buter, Stephan J. L. Bakker
Opublikowane w: Viruses, Numer 15, 2023, Strona(/y) 2387, ISSN 1999-4915
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v15122387

Validation, implementation and quality control of a Torque Teno Virus qPCR in a multinational clinical trial

Autorzy: E.J. Gore, L. Gard, P. Bourgeois, D. Kulifaj, E. McCulloch, P.G. Spezia, H.G.M. Niesters, F. Maggi, G. Bond, C. Van Leer-Buter
Opublikowane w: Journal of Clinical Virology, Numer 175, 2024, Strona(/y) 105738, ISSN 1386-6532
Wydawca: Elsevier BV
DOI: 10.1016/j.jcv.2024.105738

Integrated Immunologic Monitoring in Solid Organ Transplantation: The Road Toward Torque Teno Virus-guided Immunosuppression

Autorzy: Peter Jaksch, Irene Görzer, Elisabeth Puchhammer-Stöckl, Gregor Bond
Opublikowane w: Transplantation, Numer 106, 2023, Strona(/y) 1940-1951, ISSN 0041-1337
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/tp.0000000000004153

Torque Teno Virus: A Promising Biomarker in Kidney Transplant Recipients

Autorzy: Sara Dal Lago, Paola Brani, Giuseppe Ietto, Daniela Dalla Gasperina, Francesco Gianfagna, Cristina Giaroni, Annalisa Bosi, Francesca Drago Ferrante, Angelo Genoni, Hafza Zahira Manzoor, Andrea Ambrosini, Marco De Cicco, Corradina Dina Quartarone, Sara Khemara, Giulio Carcano, Fabrizio Maggi, Andreina Baj
Opublikowane w: International Journal of Molecular Sciences, Numer 25, 2024, Strona(/y) 7744, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25147744

Torque Teno Virus DNA Load in Blood as an Immune Status Biomarker in Adult Hematological Patients: The State of the Art and Future Prospects

Autorzy: Eliseo Albert, Estela Giménez, Rafael Hernani, José Luis Piñana, Carlos Solano, David Navarro
Opublikowane w: Viruses, Numer 16, 2024, Strona(/y) 459, ISSN 1999-4915
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v16030459

Torque teno virus viral load predicts SARS‐CoV‐2 vaccine response in kidney transplant recipients

Autorzy: Morgane Solis, Ilies Benotmane, Floriane Gallais, Sophie Caillard, Samira Fafi‐Kremer
Opublikowane w: Journal of Medical Virology, Numer 95, 2023, ISSN 0146-6615
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/jmv.28936

Torque Teno Virus Control by the Classical Pathway of Complement Activation—A Retrospective Analysis From a First‐in‐Human Trial Utilizing Sutimlimab

Autorzy: Sebastian Kapps, Jakob Mühlbacher, Dorian Kulifaj, Sophie Courjal, Farsad Eskandary, Martin Schiemann, Bernd Jilma, Georg A. Böhmig, Gregor Bond, Markus Wahrmann
Opublikowane w: Journal of Medical Virology, Numer 96, 2024, ISSN 0146-6615
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/jmv.70039

The association of Torque Teno viral load with CMV and BKV infection in pediatric and adolescent kidney transplant patients.

Autorzy: Fabian Eibensteiner, Ines Messner, Phoebe Uhl, Gregor Bond, Elisabeth Puchhammer-Stoeckl, Thomas Mueller-Sacherer, Christoph Aufricht, Krisztina Rusai
Opublikowane w: Journal of Clinical Virology, Numer 172, 2024, Strona(/y) 105673, ISSN 1386-6532
Wydawca: Elsevier BV
DOI: 10.1016/j.jcv.2024.105673

Torque Teno Virus (TTV) in Renal Transplant Recipients: Species Diversity and Variability

Autorzy: Noelia Soledad Reyes, Pietro Giorgio Spezia, Raquel Jara, Fabio Filippini, Natalia Boccia, Gonzalo García, Eliana Hermida, Fernando Adrian Poletta, Mauro Pistello, Gustavo Laham, Fabrizio Maggi, Marcela Echavarria
Opublikowane w: Viruses, Numer 16, 2024, Strona(/y) 432, ISSN 1999-4915
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v16030432

Torque teno virus load as marker of rejection and infection in solid organ transplantation – A systematic review and meta‐analysis

Autorzy: AL van Rijn, R Roos, FW Dekker, JI Rotmans, MCW Feltkamp
Opublikowane w: Reviews in Medical Virology, Numer 33, 2024, ISSN 1052-9276
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/rmv.2393

Torquetenovirus Viremia Quantification Using Real-Time PCR Developed on a Fully Automated, Random-Access Platform

Autorzy: Pietro Giorgio Spezia, Fabrizio Carletti, Federica Novazzi, Eliana Specchiarello, Angelo Genoni, Francesca Drago Ferrante, Claudia Minosse, Giulia Matusali, Nicasio Mancini, Daniele Focosi, Guido Antonelli, Enrico Girardi, Fabrizio Maggi
Opublikowane w: Viruses, Numer 16, 2024, Strona(/y) 963, ISSN 1999-4915
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v16060963

The Emerging Tool of the Human Anellovirome

Autorzy: Daniele Focosi, Pietro Giorgio Spezia, Fabrizio Maggi
Opublikowane w: Viruses, Numer 16, 2024, Strona(/y) 990, ISSN 1999-4915
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v16060990

Torque Teno Viral Plasma Load for Immunologic Monitoring in Solid Organ Transplantation: One Step Further

Autorzy: Frederik Haupenthal, Gregor Bond
Opublikowane w: Transplantation, 2023, ISSN 1999-4915
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.1097/tp.0000000000004817

Self-reported Non-adherence to Immunosuppressive Medication Detected by the BAASIS Predicts Allograft Rejections in Kidney Transplant Recipients

Autorzy: Frederik Haupenthal , Konstantin Doberer , Sebastian Kapps , Johannes Kläger , Florian Bauernfeind , Kris Denhaerynck , Alexander Kainz , Sabina De Geest , Gregor Bond
Opublikowane w: Nephrology Dialysis Transplantation, 2025, ISSN 1460-2385
Wydawca: Oxford University Press

TTV and other anelloviruses: The astonishingly wide spread of a viral infection

Autorzy: Pietro Giorgio Spezia, Daniele Focosi, Andreina Baj, Federica Novazzi, Francesca Drago Ferrante, Fabrizio Carletti, Claudia Minosse, Giulia Matusali, Fabrizio Maggi
Opublikowane w: Aspects of Molecular Medicine, 2023, ISSN 2949-6888
Wydawca: Elsevier
DOI: 10.1016/j.amolm.2023.100006

Evaluate the host cellular immune response to better prevent and diagnose viral infections

Autorzy: William Mouton, Jean-Marc Gombert, Anne Barra, Morgane Solis, Samira Fafi-Kremer, Nicolas Lévêque, Sophie Trouillet-Assant, Marine Mommert-Tripon, Edouard Tuaillon, Patrice Morand
Opublikowane w: Virologie, Numer 28, 2024, Strona(/y) 327-339, ISSN 1267-8694
Wydawca: John Libbey Eurotext
DOI: 10.1684/vir.2024.1064

Polyomavirus Nephropathy in ABO Blood Group-Incompatible Kidney Transplantation: Torque Teno Virus and Immunosuppressive Burden as an Approximation to the Problem

Autorzy: Michael Eder, Tarek A. Schrag, Ella F. Havel, Alexander Kainz, Haris Omic, Konstantin Doberer, Nicolas Kozakowski, Günther F. Körmöczi, Marlies Schönbacher, Gottfried Fischer, Robert Strassl, Monika Breuer, Lukas Weseslindtner, Frederik Haupenthal, Georg A. Böhmig, Elisabeth Puchhammer-Stöckl, Gregor Bond, Irene Görzer and Farsad Eskandary
Opublikowane w: KI Reports, 2024, ISSN 1178-7058
Wydawca: Dove Medical Press Limited
DOI: 10.1016/j.ekir.2024.04.003

Longitudinal monitoring of Torque Teno virus DNAemia in kidney transplant recipients correlates with long‐term complications of inadequate immunosuppression

Autorzy: Luc Chauvelot, Thomas Barba, Carole Saison, Evangelia Siska, Dorian Kulifaj, Stephan J. L. Bakker, Alice Koenig, Maud Rabeyrin, Fanny Buron, Cécile Picard, Frédérique Dijoud, Louis Manière, Bruno Lina, Emmanuel Morelon, Valerie Dubois, Olivier Thaunat
Opublikowane w: Journal of Medical Virology, Numer 96, 2024, ISSN 0146-6615
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/jmv.29806

The kinetics of Torque Teno virus plasma load following calcineurin inhibitor dose change in kidney transplant recipients

Autorzy: Florina Regele, Frederik Haupenthal, Konstantin Doberer, Irene Görzer, Sebastian Kapps, Robert Strassl, Gregor Bond
Opublikowane w: Journal of Medical Virology, Numer 96, 2024, ISSN 0146-6615
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/jmv.29554

Validation of plasma Torque Teno viral load applying a CE-certified PCR for risk stratification of rejection and infection post kidney transplantation

Autorzy: Irene Görzer, Frederik Haupenthal, Fabrizio Maggi, Fanny Gelas, Dorian Kulifaj, Ludovic Brossault, Elisabeth Puchhammer-Stöckl, Gregor Bond
Opublikowane w: Journal of Clinical Virology, Numer 158, 2024, Strona(/y) 105348, ISSN 1386-6532
Wydawca: Elsevier BV
DOI: 10.1016/j.jcv.2022.105348

Uncovering the persistent gap: The ongoing challenge of integrating sex and gender in biomedical research

Autorzy: Janet Delgado, Mónica Cano Abadía, Kaya Akyüz, Melanie Goisauf, David Rodríguez-Arias
Opublikowane w: The Journal of Biomedical Research, Numer 38, 2024, Strona(/y) 1, ISSN 1674-8301
Wydawca: Elsevier
DOI: 10.7555/jbr.38.20240157

Torque Teno Virus–guided monitoring of immunosuppressive therapy

Autorzy: Sebastian Kapps, Frederik Haupenthal, Gregor Bond
Opublikowane w: Nephrology Dialysis Transplantation, 2024, ISSN 0931-0509
Wydawca: Oxford University Press
DOI: 10.1093/ndt/gfae149

High-Density Lipoprotein Particles and Torque Teno Virus in Stable Outpatient Kidney Transplant Recipients

Autorzy: Jip Jonker, Caecilia S. E. Doorenbos, Daan Kremer, Edmund J. Gore, Hubert G. M. Niesters, Coretta van Leer-Buter, Philippe Bourgeois, Margery A. Connelly, Robin P. F. Dullaart, Stefan P. Berger, Jan-Stephan F. Sanders, Stephan J. L. Bakker
Opublikowane w: Viruses, Numer 16, 2024, Strona(/y) 143, ISSN 1999-4915
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v16010143

Evaluation of Torquetenovirus (TTV) Particle Integrity Utilizing PMAxx™

Autorzy: Giuseppe Sberna, Claudia Minosse, Cosmina Mija, Eliana Specchiarello, Pietro Giorgio Spezia, Sara Belladonna, Giulia Berno, Lavinia Fabeni, Giulia Matusali, Silvia Meschi, Daniele Focosi, Fabrizio Maggi
Opublikowane w: International Journal of Molecular Sciences, Numer 26, 2025, Strona(/y) 6542, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms26136542

Torque Teno Virus-Guided Immunosuppression in Kidney Transplantation: Expanding the Application

Autorzy: Farsad Eskandary, Gregor Bond, Krithika Mohan
Opublikowane w: KI reports, 2024, ISSN 0085-2538
Wydawca: Blackwell Publishing Inc.
DOI: 10.1016/j.ekir.2024.04.057

Assessment of Torquetenominivirus (TTMV) and Torquetenomidivirus (TTMDV) as Complementary Biomarkers to Torquetenovirus (TTV)

Autorzy: Lilia Cinti, Pietro Giorgio Spezia, Piergiorgio Roberto, Gianluca Russo, Quirino Lai, Carolina Carillo, Federica Frasca, Guido Antonelli, Fabrizio Maggi
Opublikowane w: International Journal of Molecular Sciences, Numer 26, 2025, Strona(/y) 1022, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms26031022

A multicentre, patient- and assessor-blinded, non-inferiority, randomised and controlled phase II trial to compare standard and torque teno virus-guided immunosuppression in kidney transplant recipients in the first year after transplantation: TTVguideIT

Autorzy: Frederik Haupenthal, Jette Rahn, Fabrizio Maggi, Fanny Gelas, Philippe Bourgeois, Christian Hugo, Bernd Jilma, Georg A. Böhmig, Harald Herkner, Michael Wolzt, Konstantin Doberer, Matthias Vossen, Daniele Focosi, Hannes Neuwirt, Miriam Banas, Bernhard Banas, Klemens Budde, Ondrej Viklicky, Paolo Malvezzi, Lionel Rostaing, Joris I. Rotmans, Stephan J. L. Bakker, Kathrin Eller, Daniel Cejka, Alberto
Opublikowane w: Trials, Numer 24, 2023, ISSN 1745-6215
Wydawca: BioMed Central
DOI: 10.1186/s13063-023-07216-0

Pre-Transplant Frequencies of FoxP3+CD25+ in CD3+CD8+ T Cells as Potential Predictors for CMV in CMV-Intermediate Risk Kidney Transplant Recipients

Autorzy: Agnes A. Mooslechner, Max Schuller, Verena Pfeifer, Konstantin A. Klötzer, Barbara Prietl, Alexander H. Kirsch, Philipp Stiegler, Robert Sucher, Harald Sourij, Alexander R. Rosenkranz, Kathrin Eller
Opublikowane w: Transplant International, Numer 37, 2024, ISSN 1432-2277
Wydawca: Frontiers
DOI: 10.3389/ti.2024.12963

Torque Teno Virus: Lights and Shades

Autorzy: Paola Brani, Hafza Zahira Manzoor, Pietro Giorgio Spezia, Andrea Vigezzi, Giuseppe Ietto, Daniela Dalla Gasperina, Claudia Minosse, Annalisa Bosi, Cristina Giaroni, Giulio Carcano, Fabrizio Maggi, Andreina Baj
Opublikowane w: Viruses, Numer 17, 2025, Strona(/y) 334, ISSN 1999-4915
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v17030334

Prediction of humoral and cellular immune response to COVID-19 mRNA vaccination by TTV load in kidney transplant recipients and hemodialysis patients

Autorzy: Marianne Graninger, Julian Stumpf, Gregor Bond, Irene Görzer, David N. Springer, Friederike Kessel, Hannah Kröger, Kerstin Frank, Torsten Tonn, Christian Hugo, Elisabeth Puchhammer-Stöckl
Opublikowane w: Journal of Clinical Virology, Numer 162, 2024, Strona(/y) 105428, ISSN 1386-6532
Wydawca: Elsevier BV
DOI: 10.1016/j.jcv.2023.105428

Non-peer reviewed articles (1)

Protocol for Surveying Participants and Professionals’ Experiences in an International Kidney Transplant Clinical Trial

Autorzy: Janet Delgado, David Rodríguez-Arias, Alberto Molina-Pérez, Anibal Monasterio-Astobiza, Gonzalo Diaz-Cobacho, Gregor Bond, null null
Opublikowane w: Open Research Europe, Numer 4, 2024, Strona(/y) 241, ISSN 2732-5121
Wydawca: OPen Research Europe
DOI: 10.12688/openreseurope.18665.1